한국인 폐확산능 정상예측식의 임상적 유용성과 정확성

나승원 ( Seung Won Ra ),박태선 ( Tai Sun Park ),홍윤기 ( Yoon Ki Hong ),홍상범 ( Sang Bum Hong ),심태선 ( Tae Sun Shim ),임채만 ( Chae Man Lim ),이상도 ( Sang Do Lee ),고윤석 ( Youn Suck Koh ),김우성 ( Woo Sung Kim ),김동순 ( Dong 대한결핵 및 호흡기학회 2008 Tuberculosis and Respiratory Diseases Vol.64 No.2

연구배경: 폐확산능을 해석하는 데 필요한 정상예측식으로는 한국인을 대상으로 하여 박 등이 개발한 식(박 식)이 있으나 아직 외국 정상예측식을 많이 사용하고 있다. 이에 국내에서 많이 사용하는 외국 정상예측식인 Burrows 식과 박 식의 임상적 유용성과 정확성을 비교하고자 하였다. 방법: 1. 임상적 유용성 연구; 2006년 7월부터 12월까지 6개월간 폐확산능검사를 시행한 환자 중 두 식을 각각 정상예측식으로 적용하였을 때 폐확산능 해석이 다른 276명(대상군 A)을 대상으로 하였다. 대상군 A에게 두 식을 각각 적용하였을 때 폐확산능 해석과 임상적 판단과의 일치도를 비교하여 임상적 유용성을 평가하였다. 2. 간질성폐질환 진단의 정확성 비교; 2001년부터 2006년까지 폐조직검사를 시행하여 확진된 간질성폐질환군과 서울아산병원에서 모집한 정상군을 대상으로 하여 정상예측식으로 두 식을 각각 적용하였을 때 폐확산능 해석의 정확도를 비교하였고, 두 식이 차이가 나는지 맥니머의 카이스퀘어 검정을 하였다. 결과: 1. 임상적 판단과의 일치도 비교; 276명을 임상정보를 토대로 폐확산능을 예측하여 분류한 결과 정상 54명, 감소 220명, 불분명이 2명이었다. 예측식으로 박 식과 Burrows 식을 적용하였을 때 임상적 판단과 일치하는 환자는 각각 78%와 22%이었다(p<0.001). 2. 간질성폐질환 진단의 정확성 비교; 박 식은 민감도 90.1%, 특이도 100%이었고 Burrows 식은 민감도 64.2%, 특이도 100%로 민감도가 통계학적으로 유의하게 박 식이 높았다(p<0.001). 결론: 우리나라 정상예측식인 박 식이 외국 정상예측식인 Burrows 식을 정상예측식으로 적용하는 것보다 임상적 유용성이나 간질성폐질환 진단의 민감도에서 더 우월하였다. 향후 폐확산능검사의 정상예측식으로 박 식을 사용해야 할 것으로 사료된다. Background: Park et al. developed the Korean reference equation for the measurement of diffusing capacity in 1985. However, the equation has not been widely used in Korea and foreign reference equations have been popularly used. We intended to compare the clinical usefulness and the accuracy of the the Korean reference equation (Park`s equation) with that of the foreign equation (Burrows` equation) that is commonly used in Korea. Methods: 1. Evaluation of clinical usefulness; Among 1,584 patients who underwent diffusing capacity (DLCO) at the Asan Medical Center from July to December 2006, group A subjects included 276 patients who had different interpretations of DLCO in trials employing Burrows` equation and Park`s equation. Clinical assessment was decided by consensus of two respiratory physicians. In order to evaluate the clinical usefulness of Burrows` equation and Park`s equation, agreement of clinical assessment and DLCO interpretation were measured. 2. Evaluation of accuracy; Group B subjects were 81 patients with interstitial lung disease (ILD) and 39 normal subjects. The 81 ILD patients were diagnosed following a surgical lung biopsy. The accuracy of diagnosing ILD as well as sensitivity and specificity were evaluated according to the use of the reference equations (Burrows` equation and Park`s equation) for DLCO. Results: Agreement between clinical assessment and interpretation of DLCO was 22% for the use of Burrows` equation and 78% for the use of Park`s equation. The sensitivity and specificity of the Burrows` equation for diagnosing ILD were 64.2% and 100%. The sensitivity and specificity of the Park`s equation for diagnosing ILD were 90.1% and 100%. The sensitivity of the Park`s equation for diagnosing ILD was significantly higher than that of Burrows` equation (p<0.001). Conclusion: The Korean reference equation (Park`s equation) was more clinically useful and had higher sensitivity for diagnosing ILD than the foreign reference equation (Burrows` equation). (Tuberc Respir Dis 2008;64:80-86)

피치 정보를 이용한 GMM 기반의 화자 식별

박태선,한민수,Park Taesun,Hahn Minsoo 대한음성학회 2003 말소리 Vol.47 No.-

This paper describes the use of pitch information for speaker identification. The recognition system is a GMM based one with 4 connected Korean digits speech database. The mean of the pitch period in voiced sections of speech are shown to be ,useful at discriminating between speakers. Utilizing this feature with Gaussian mixture model in the speaker identification system gave a marked improvement, maximum 6% improvement comparing to the baseline Gaussian mixture model.

UV 잉크 시장 현황 및 전망

박태선,Park, Tae-Seon (사)한국포장협회 2006 包裝界 Vol.159 No.-

소적백출산(消積白朮散)이 면역세포(免疫細胞)의 동태(動態), 대식세포(大食細胞)의 走化性(주화성) 및 부착성(附着性)에 미치는 영향(影響)

박태선,조종관,Park, Tae-Seon,Jo, Jong-Gwan 대한암한의학회 1997 大韓癌韓醫學會誌 Vol.3 No.1

In order to investigate the effects of Sojeokbaekchoolsan on the various immune responses, the chemotactic and adherent ability of macrophages were studied in vivo and in vitro. The results obtained were follows: 1. The administration of Sojeokbaekchoolsan enhanced significantly the Chemotactic activity of macrophages and neutrophils. 2. The administration of Sojeokbaekchoolsan enhanced significantly the adherent activity of macrophages and neutrophils. From above findings, it is suggested that Sojeokbaekchoolsan seem to produce the increase of immune response such as the chemotactic activity and adherent activity of macrophage. According to the above results, it could be suggested that Jukyeopseokgo-tanggagambang extract has indirect autitumor effects by strengthening the effects of MMC on tumor cells.

전자선 조사가 포장방법을 달리한 한우육의 이화학적 특성에 미치는 영향

박태선,박구부,오성현,이정일,신택순,Park, Tae-Seon,Park, Gu-Bu,Oh, Seong-Hyeon,Lee, Jeong-Il,Sin, Taek-Sun 한국생명과학회 2007 생명과학회지 Vol.17 No.2

본 연구는 한우 암소 지육 중 육질등급 $1^{+}$ 판정(근내지방도 No. 7, 육색 No. 4, 성숙도 No. 1, 조직감 No. 1)을 받은 지육($280{\sim}300$ kg) 6두를 1차로 수돗물로 고압 수세하고 2차로 50% 에틸알콜로 소독한 후 발골 정형하여 실험재료로 사용하였고, 등심 및 우둔부위를 채취하여 $0{\pm}1^{\circ}C$에서 숙성한 후 등심은 1.5 cm steak로 제조하고, 우둔은 patty를 제조한 후 진공포장 및 랩 포장한 다음 전자선 가속기를 이용하여 0, 3 , 4.5, 6, 7.5 kGy로 조사한 후 실험에 이용하였다. 진공포장구 및 함기포장구의 pH 는 전자선 조사선량에 따라 유의적인 차이를 보이지 않았으며(p>0.05), 함유수분은 전자선 조사구 및 비조사구 모두 steak에 비하여 patty가 높은 경향을 나타내었다. 조단백질은 steak의 경우 전자선 비조사구가 조사구에 비하여 높은 수치를 나타내었으며(p<0.05), Patty의 경우는 전자선 조사수준에 상관없이 유의적인 차이가 없었다. 육색의 명도($L^{\ast}$)는 전자선조사 처리구와 비조사 처리구간에는 차이가 없었다(p>0.05). 육색 중 적색도($a^{\ast}$)와 황색도($b^{\ast}$)는 전자선 조사수준이 증가함에 따라 점차 낮아지는 경향이었으며, 비조사구와 3 kGy 조사구는 유의적인 차이가 없었다(p>0.05). This study was carried out to investigate the effect of Electron Beam irradiation on physico-chemical characteristics of Hanwoo meat. A total of sir beef carcasses $(280{\sim}300\;kg)$ that were quality grade $1^+$(marbling score No. 7, meat color No. 4, maturity No. 1, texture No. 1) was purchased at the commercial slaughter house. The carcasses were transported and washed using high pressure water, and pasteurized with 50% ethyl alcohol in the laboratory. After the carcasses were deboned and trimmed, loin and round were taken out to make steak (1.5 cm thickness) or patty respectively. Samples were wrap or vacuum packaged and irradiated with 0, 3, 4.5, 6 and 7.5 kGy using electron-beam accelerator. Irradiated samples were used to measure pH, moisture, crude protein, crude fat, and meat color. There was no significant (p>0.05) difference in pH between vacuum packaged (VP) and wrap packaged (WP) treatment, and the pH was not changed by electron-beam irradiation levels. Both control and irradiated treatments of steak showed higher tendency in moisture content. In crude protein content, control was higher than irradiated treatment in steak, but there were no difference in patty. Lightness ($L^{\ast}$) of meat color has no difference between irradiated and non-irradiated treatment (p>0.05). The value of redness and Yellowness of meat was dropped by increasing irradiation (p<0.05), but there was no difference between control and 3 kGy treatment (p<0.05).

지난 30년, 학계를 뒤흔든 새 이론과 실험들-물리학-입자 및 천체 물리학

박태선,계범석,이범훈,Park, Tae-Seon,Gye, Beom-Seok,Lee, Beom-Hun 한국과학기술단체총연합회 2006 과학과 기술 Vol.39 No.12

Taurine-Responsive Genes Related to Signal Transduction as Identified by cDNA Microarray Analyses of HepG2 Cells

박태선,Sung-Hee Park,Haemi Lee,Kun Koo Park,Ha Won Kim 한국식품영양과학회 2006 Journal of medicinal food Vol.9 No.1

Taurine-induced changes in the expression profiles of HepG2 cells were assessed using a cDNA microarraytechnology, and confirmed by real-time reverse transcription-polymerase chain reaction (RT-PCR) analyses. Of 8,298 humangenes on the microarray, 128 genes (87 known genes) were up-regulated, and 349 (206 known genes) were down-regulatedmore than 2.0-fold by taurine. Among the 293 known genes regulated by taurine, a total of 44 genes were involved in signaltransduction; 16 genes were up-regulated greater than 2.0-fold, and 28 genes were down-regulated more than 2.0-fold by tau-rine. The results of RT-PCR analyses for the five genes selected were consistent with our microarray data, although the foldchanges in the expression level differed somewhat between the two analytical methods. Among signal transduction-relatedgenes affected by taurine, four genesmitogen-activated protein kinase (MAPK) kinase kinase 7, p21-activated kinase 4,sprouty homolog 2, and MAPK kinase 1are implicated in the MAPK signaling pathway. Taurine also regulated the ex-pression of signal transducer and activator of transcription (STAT) 3 gene involved in the Janus kinase-STAT pathway, anddiacylglycerol kinase, zeta 104 kDa, the downstream mediator of the protein kinase C transmembrane signaling pathway. Inconclusion, gene expression profiling of HepG2 cells treated with taurine provided us with new insights into the novel as-pects of taurine as a possible regulator of MAPK signaling cascades and protein kinase C signaling pathways involved in cel-lular processes such as cell growth, differentiation, and apoptosis.

하상준설에 의한 월류피해 경감효과 산정방법

박태선,Park, Tae-Seon 한국수자원학회 2009 물과 미래(한국수자원학회지) Vol.42 No.10

당뇨병성 자율신경병증 (II)

박태선,Park, Tae-Seon 사단법인 한국당뇨협회 2005 당뇨 Vol.186 No.-

오봉저수지 재해대비 보강개발사업

박태선,Park, Tae-Seon 한국관개배수위원회 2009 한국관개배수논문집 Vol.16 No.1