오적산(五積散)을 투여한 흰쥐의 간장, 신장, 골중 금속농도 비교에 관한 연구

박철수,이선동,박해모,박영철,Park Chul-Soo,Lee Sun-Dong,Park Hae-Mo,Park Yeong-Chul 대한예방한의학회 2002 대한예방한의학회지 Vol.6 No.2

Traditional herbal medicine is used extensively among the Korean populations, and other Asian countries employ similar therapies as well In recent years, extensive focus was laid on adulteration of the herbal medicine with heavy metals. This may be mainly due to a soil contamination by an environmental pollution. The objective of this study is to identify the contents of various heavy metals in the blood from OhJeokSan-Decoction (OD) treated-rats. For this study, 13 kinds of metals including essential and heavy metals, i.e. Al, As, Cd, Co, Cr, Cu, Fe, Hg, Mn, Ni, Pb, Se and Zn were analyzed by a slight modification of EPA methods and the following results are obtained. ; 1. There is no significant difference between the OD-treated groups and control group in liver, kidney, bone, brain, weight, food intake. 2. The amount of each metal analyzed in the liver are as follows; Al ; $0.235{\sim}4.215mg/kg$, As ; $0.103{\sim}0.461mg/kg$, Cd ; $0.005{\sim}0.010mg/kg$, Co ; $0.017{\sim}0.046mg/kg$, Cr ; $0.137{\sim}0.403mg/kg$, Cu ; $1.736{\sim}4.827mg/kg$, Fe ; $54.472{\sim}381.447mg/kg$, Hg ; not detected, Mn ; $1.159{\sim}2.803mg/kg$, Ni ; $0.007{\sim}0.095mg/kg$, Pb ; not detected, Se ; $0.682{\sim}1.887mg/kg$, Zn ; $10.213{\sim}26.119mg/kg$, by groups, respectively. In control and other experimental group, several metal (Co, Cu, Mn, Zn, As, Cr) has a significant difference, but in experimental I and other experimental II, III, IV, V groups, there are no significant difference. 3. The amount of each metal analyzed in the kidney are as follows; Al ; $1.712{\sim}31.230mg/kg$, As ; $0.062{\sim}0.439mg/kg$, Cd ; $0.010{\sim}0.062mg/kg$, Co ; $0.000{\sim}0.101mg/kg$, Cr ; $0.125{\sim}0.636mg/kg$, Cu ; $3.385{\sim}12.502mg/kg$, Fe ; $41.148{\sim}99.709mg/kg$, Hg ; $0.000{\sim}0.270mg/kg$, Mn ; $0.433{\sim}2.301mg/kg$, Ni ; $0.000{\sim}0.221mg/kg$, Pb ; $0.000{\sim}0.584mg/kg$, Se ; $0.540{\sim}1.600mg/kg$, Zn ; $8.775{\sim}17.060mg/kg$, by groups, respectively. The concentration of Cu, Se, Cr, and Hg are variated significantly in control and other experimental group, and Cu, Se, Cd, Cr are variated significantly in experimental I and other experimental II, III, IV, V groups. 4. The amount of each metal analyzed in the bone(tibia and fibula) are as follows; Al ; $9.557{\sim}119.464mg/kg$, As ; $0.139{\sim}12.250mg/kg$, Cd ; $0.000{\sim}0.295mg/kg$, Co ; $0.022{\sim}0.243mg/kg$, Cr ; $0.239{\sim}1.999mg/kg$, Cu ; $0.000{\sim}2.291mg/kg$, Fe ; $240.249{\sim}841.956mg/kg$, Hg ; $0.000{\sim}0.983mg/kg$, Mn ; $0.214{\sim}7.353mg/kg$, Ni ; $5.473{\sim}11.453mg/kg$, Pb ; $0.000{\sim}8.502mg/kg$, Se ; $0.000{\sim}3.005mg/kg$, Zn ; $61.158{\sim}195.038mg/kg$, by groups, respectively. The concentration of Se, Cd are variated significantly in control and other experimental groups, and Se is variated significantly in experimental I and other experimental II, III, IV, V groups. 5. Exceptionally several metal concentration is increased or decreased. but there is no significant harmful difference of metal concentration in the liver, kidney and bone, from the OD-treated-rats compared to those of the control group even if higher dosage($1{\sim}8$ times dosage of person) of OD was administered. Thus, it is expected that the herbal decoction in the traditional herbal medicine would not lay any burden on the body and the heavy metal toxins would not affect our physiological system. However, other kinds of herbal treatment, such as i.v. and i.p. should be considered in terms of

배풍등(排風藤)이 $CCl_4$ 유발된 mouse의 간손상(肝損傷)에 미치는 영향

박철수,이원훈,김선강,김종대,박선동,Park Chul-Soo,Lee Won-Hoon,Kim Seon-Kang,Kim Jong-Dae,Park Seon-Dong 대한한의학방제학회 2000 大韓韓醫學方劑學會誌 Vol.8 No.1

This study was carried out to investigate the effects of Solanum lyratum Extract (SLE) on the recovery of liver in $CCI_{4}-intoxicated$ mice. In this study, ICR-Mice were divided into 3 experimental groups; Normal group was fed basal diet and was fed bassal diet for 2 Weeks, sample group was injected $CCl_{4}\;(0.6m{\ell}/kg)$ and was fed basal diet for 2 weeks, sample group was injected $CCl_{4}\;(0.6m{\ell}/kg)$ and was fed the SLE 500mg/kg fod 2 Weeks. In sample group, the level of serum AST, ALT, ALP activity decreased significantly compared with control group. This results suggest that SLE has appreciable therapeutic effect on $CCI_4$ induced hepatotoxicity. In sample group, the level of LPO in liver homogenates decreased significantly compared with control group. In sample group. the level of GSH, catalase in liver homogenates increased significantly compared with control group. This results suggest that SLE has appreciable antioxidant effect on $CCI_4induced hepatotoxicity. In conclusion the results suggest that SLE has appreciable therapeutic effect and antioxidant effect on $CCI_4$ induced hepatotoxicity.

교류전기장이 프로판 난류제트 화염의 부상특성에 미치는 영향

박철수(Chul Soo Park),이상민(Sang Min Lee),차민석(Min Suk Cha),정석호(Suk Ho Chung) 한국연소학회 2004 KOSCOSYMPOSIUM논문집 Vol.- No.-

대구경 모노파일 항타기록 역해석 연구

박철수(Park, Chul Soo),김동준(Kim, Dong-Joon),김봉갑(Kim, Bonggab) 대한토목학회 2023 대한토목학회 학술대회 Vol.2023 No.10

사회간접자본스톡의 지역경제성장에 대한 기여도 분석

박철수(Chul Soo Park),전일수(Il soo Jun),박재홍(Jae Hong Park) 한국지역학회 1996 지역연구 Vol.12 No.1

Many attempts have been made to examine the role of public infrastructure promoting the regional economic activity in other countries. However, due to non availability of regional capital stock data, no analysis on this issue has been done in Korea. The objectives of this paper are three-fold: (1) to construct the public capital series for the period of 1972∼1991 at the 11 regional level by a combina. tion of the benchmark year method and the perpetual inventory techniques; (2) to determine the relative importance of inputs, including private capital, labor, and public capital to the growth of regional output; and (3) to identify whether the technological relationships between inputs are substitutes or come plements. To evaluate the respective impact of the public capital, we decompose publicly provided inputs into transportation infrastructure and non-transportation infrastructure. The relationship we analyze is a long-run regional production function, controlling for relevant province-specific effects and changes in technology. The sure of the estimated exponent coefficients is statistically significantly greater than 1, thus reflecting agglomeration economies. The results show that the estimated coefficients on the input variables are highly significant with the exception of non-transportation infrastructure. The relative sizes of the coefficients on the input variables reveal that labor input plays the major role in regional economic growth. Although the aggregate impact of pubic capitals appears to have about 60 percent compared to that of the private capital, public capital stock has a positive and statistically significant impact on regional output. In public capital inputs, the relative impact of transportation infrastructure is much greater than that of non-transportation infrastructure. With respect to technological relationships, we find that public capital and private capital are complements, and public capital and labor are also complements. These results can be interpreted as that public capital stock not only serves prerequisite to regional economic growth but also provides a base for the future expansion of regional employment. In conclusion, results from the finding in this study underline the importance of increasing public capital stock in order to support future regional economic activities.

광신호의 파형특성분석을 위한 광통신링크 모델링

박철수(Chul Soo Park),박세승(Sei-Seung Park),이충규(Chung Chiu Lee) 한국정보기술학회 2007 Proceedings of KIIT Conference Vol.2007 No.-

본 논문은 광신호의 파형특성분석을 위한 광통신링크 모델링에 관해 기술하고 있다. 2.5 Gb/s의 데이터 율로 쌍극광변조기를 통해 광신호가 생성되며, 반도체광증폭기의 상호이득변조 현상을 이용하여 파장변환을 수행하게 되는데, 이러한 광신호의 파형특성을 분석한다. 특히, 신호의 광스펙트럼, 아이다이어그램, 비트에 러율 등의 측정을 통해 파형의 특성을 분석하다. The paper describes a modeling of an optical communication link for waveform analysis. A 2.5 Gb/s data pattern is generated by a dual-electrode electro-optic modulator and the wavelength conversion is performed by cross-gain modulation in a semiconductor optical. amplifier, The waveform of the converted optical signal is analysed based on optical spectrum, eye diagram, bit error rate.

탄성계수 감소곡선에 근거한 철도노반의 회복탄성계수 모델 개발 및 평가

박철수(Park Chul Soo),황선근(Hwang Seon Keun),최찬용(Choi Chan Yong),목영진(Mok Young Jin) 대한토목학회 2009 대한토목학회논문집 C Vol.29 No.2

본 연구에서는 국내 철도 토공노반 재료로 가장 흔히 사용되는 입도조정쇄석, 화강풍화토, 암버럭-토사 혼합 재료에 대해 평균유효주응력과 축변형률의 함수로 표현되는 회복탄성계수 예측모델을 결정하였다. 회복탄성계수 예측모델은 대표적인 동적물성치인 변형률에 따른 전단탄성계수 감소곡선의 표현과 같이 최대영탄성계수와 정규화 영탄성계수 감소곡선으로 구성된다. 평균유효주응력의 함수로 표현되는 최대영탄성계수의 모델인자는 A<SUB>E</SUB>와 n<SUB>E</SUB>이고, 비선형 영역의 정규화 영탄성계수 감소곡선은 기준변형률(ε<SUB>r</SUB>)과 곡률계수(a)를 모델인자로 하는 수정 쌍곡선 모델로 표현된다. 제안된 회복탄성계수 예측모델을 검증하기 위해 3차원 다층탄성해석 프로그램(GEOTRACK)을 이용하여 평택 시험 철도노반의 탄성거동을 평가하였고, 화물열차 및 여객열차가 시험구간을 통과할 때 계측한 노반의 수직 탄성변위와 비교하였다. 현장계측은 자갈도상 아래의 재료가 각각 입도조정쇄석과 양질의 화강풍화토인 두 개소에서 수행되었다. 자갈도상 아래에서 계산된 수직 탄성변위는 대략 0.6㎜ 이내였고 계측 결과와 잘 일치하였다. 본 연구를 통해 제안된 회복탄성계수 예측모델이 열차하중에 의한 노반의 탄성거동을 적절히 표현하고 있음을 확인하였다. This study is to develope the resilient modulus prediction model, which is the function of mean effective principal stress and axial strain, for three types of railroad trackbed materials such as crushed stone, weathered granite soil, and crushed-rock soil mixture. The model consists of the maximum Young's modulus and nonlinear values for higher strain, analogous to dynamic shear modulus. The maximum value is modeled by model parameters, A<SUB>E</SUB> and the power of mean effective principal stress, n<SUB>E</SUB>ㆍThe nonlinear portion is represented by modified hyperbolic model, with the model parameters of reference strain, ε<SUB>r</SUB> and curvature coefficient, a. To assess the performance of the prediction models proposed herein, the elastic response of a test trackbed near PyeongTaek, Korea, was evaluated using a 3-D elastic multilayer computer program (GEOTRACK). The results were compared with measured elastic vertical displacement during the passages of freight and passenger trains at two locations, whose sub-ballasts were crushed stone and weathered granite soil, respectively. The calculated vertical displacements of the sub-ballasts are within the order of 0.6㎜, and agree well with measured values. The prediction models are thus concluded to work properly in the preliminary investigation.

강화노반 및 궤도하부노반 재료의 회복탄성계수

박철수(Chul-Soo Park),최찬용(Chan-Yong Choi),최충락(Choong-Lak Choi),목영진(Young-Jin Mok) 한국철도학회 2008 한국철도학회논문집 Vol.11 No.1

현수교 터널식 앵커리지 설계기술 개선을 위한 기초연구

박철수(Park, Chul Soo),박재현(Park, Jae Hyun),정문경(Chung, Moonkyung),오인규(Oh, In Kyu) 대한토목학회 2013 대한토목학회 학술대회 Vol.2013 No.10

돈암동 재정비 촉진구역 해제에 따른 마을정비 방향 연구

박철수(Park, Chul-Soo),김연준(Kim, Yeon-Joon),조용훈(Cho, Yong-Hoon) 한국주거학회 2018 한국주거학회 학술대회논문집 Vol.30 No.2

The area around 74-15, Donam-dong, Seongbuk-gu, Seoul, was selected as a promotion area of reorganization in 2004 due to the aging of houses and the dilapidation of physical conditions. However, due to difficulties in the progress of the project, the reorganization supporting system of local authority was canceled in October 2017. With the recognition that if a village is neglected it will cause various social problems, we propose an alternative strategy for transforming the area into a new one without the demolishing or reconstructing the total area.