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      • KCI등재

        시호사물탕 메탄올 추출물의 항산화 활성

        박선동,문진영 대한본초학회 2001 大韓本草學會誌 Vol.16 No.1

        Sihosamultang has been used in treatment for puerperal fever, liver disease in traditional medicine. The present study was carried out to evaluate the antioxidant effects of Sihosamultang methnol extract(SME) in vitro. The inhibitory effect of SME on lipid peroxidation was examined in the linoleic acid autoxidation system. In this test, SME significantly inhibited the time course of the lipid peroxidation. And SME showed about 77% scavenging effect on DPPH radical, also exhibited about 89% inhibitory effect on lipid peroxide formation induced by hydroxyl radical derived from H₂O₂-Fe^2+ in the rat liver homogenate. And SME dose-dependently inhibited superoxide generation from xanthine-xanthine oxidase system. In addition, SME protected the hepatic cell death induced by tert-butyl hydroperoxide. These data indicated that SME might play a protective role against oxidative injury by free radicals.

      • KCI등재

        대시호탕(大柴胡湯)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響)

        박선동,윤병국,Park, Seon-Dong,Yun, Byeong-Guk 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1

        The purpose of this study was to reseach the effect of Daesihotang and its component groups on diabetes, free radical and antioxidative defense system in alloxan-induced diabetic rats. The experimental group was divided into three groups: Daesihotang (DS), Soyangyak (DS1), Yangmyungyak (DS2). The results were obtained as follows: The level of glucose, triglyceride, total cholesterol, creatinine in serum were considerablely reduced by Daesihotang. And the level of HDL cholesterol, albumin, total protein in serum were increased by Daesihotang significantly. And the level of BUN has some decreased, but with no significancy. In the study of Daesihotang on free radical scavenging effect in vitro, it has shown that Daesihotang and its components group have significant suppressing effect on peroxidation of linoleic acid on concentration. And in other experiments as scavenging effect of DPPH radical, inhibitory effect of superoxide in xanthine-xanthine oxidase system and inhibitory effect on lipid peroxidation reaction by hydroxy radical in $H_2O_2-Fe^{2+}$ system, Daesihatang have some activity, but with no significancy. In the study of Daesihotang on antioxidative defense system in vivo, the activity of GOT and GPT in serum were significantly increased; and the amounts of lipid peroxide in serum was reduced significantly but in liver no significancy. In hepatic catalase activity, Daesihotang has showed significant effect. In the level of hepatic glutathione, Daesihotang increased the amount of glutathione significantly. And in the activity of glutathione-s-transferase, Daesihotang has decreasing effect but has no significancy. These result suggest that Daesihotang has strong effect on diabetes and it is useful to prevent diabetes, but has less effect on peroxidative damage by free radical.

      • KCI등재
      • 북한의 대남전략ㆍ전술과 민족공조론 : 그 연관성에 관한 연구

        박선동 한국시민윤리학회 2008 한국시민윤리학회보 Vol.21 No.2

        북한의 대남전략의 궁극적 목표는 '전한반도의 주체사상화와 공산사회 실현'에 있다. 1980년대 후반 이후 한반도의 통일환경은 급격한 변화를 맞이하였다. 그로인하여 북한은 생존전략 차원에서 체제유지에 주력하는 전술적 변화를 모색하게 되었다. 따라서 1998년 북한권력을 공식적으로 승계한 김정일은 심각한 체제위기의 현실을 감안하여 체제유지적이고 방어적인 입장에서 대남관계에 강경노선과 유화노선을 적절히 배합하는 실리추구의 전술적 변화를 가져왔다. 특히 2000년 남북정상회담과 6․15공동선언을 기점으로 '우리 민족끼리' 통일담론을 유포시키면서 민족공조를 강조하기 시작하였으며, 2002년 10월 2차 북핵문제로 미북관계가 긴장국면으로 접어들자 북한은 민족이라는 혈연적 동질성을 내세워 핵위기를 미국과 전조선 민족의 갈등으로 규정하고 반미․반전을 위한 민족공조를 더욱 강조하기 시작하였다. 2000년대 이후 북한이 강조하고 있는 민족공조의 기본목적은 한반도 평화통일을 위하여 민족끼리 공조한다는 것이 아니라 반미․반전을 위해 통일전선을 구축하자는 것이다. 북한은 정권 수립 이후 남한혁명전략의 수행을 위해 다양한 전술을 구사하고 있으며, 그 대표적인 전술의 하나가 통일전선전술인 것이다. 북한은 이처럼 대남전략 목표를 달성하기 위해 새로운 전술로서 민족공조를 강조하고 있는 것이다. 따라서 우리 정부는 북한의 민족공조 주장의 본질을 정확히 파악하고 대북정책을 수립하고 추구해야 할 것이다. 우리의 대북정책은 국민적 합의를 배경으로 일관성을 견지하여야 하며, 대북협상에서는 성과주의에서 탈피하여 철저한 기본원칙하에 임해야 할 것이며, 대북경제지원은 상호주의원칙하에서 이루어져야 할 것이다. The ultimate purpose of North Korean strategy is the realization of socicalization and sovereignty on Korean peninsula. They continued to build up this strategy by mixing the tough and soft pushing alternatively. Since 1980's, after 6․15 joint declaration and summit talks, Kim Jeong-Il has changed his leadership into getting practical profits on the base of mutual racial-partnership. The deep structure of this idea might be based on; 1)the realization of reunification by North Korean style, 2)to keep up their regime against economic supporting of South Korea, 3)the retreat of U.S armed forces in South Korea, 4)to draw the nuclear weapons and anti-war in issues between U.S.A and North Korea, 5)to disperse the socical conflict in South Korea. It appears that they don't want the mutual racial-partnrship but anti-U.S.A and building up their own strategic battle front. This strategy affects to South Korea people as follows: 1)the dilution of national security, 2)the deepening of conflict, 3)the issues of anti-U.S.A and the retreat of U.S armed forces on fire 4)the dilution of reunfication. To face with this strategy, we must be alert on: 1)the national consolidarity, 2)the loyalty on the base of national prosperity, 3)the economic support based on the mutual interest.

      • KCI등재

        동의보감(東醫寶鑑) 외형편(外形篇) 권(卷)1 [두(頭)]부분 관련처방의 재해석

        박선동,Park, Sun-Dong 대한한의학방제학회 2007 大韓韓醫學方劑學會誌 Vol.15 No.1

        許浚(Heo Jun), the best physician on his day, wrote 東醫寶鑑(DongEuiBoGam, 1613) based on his clinical experience as a court doctor and life-long study of over 500 medical books. Now most clinicians consult 東醫寶鑑(DongEuiBoGam) for its practicality. And it is also considered as one of the most valuable medical books for basic medical studies. As 許浚(Heo Jun) mentioned on the 東醫寶鑑(DongEuiBoGam) preface. we should practice flexibility on the interpretation of the medical classics instead of binding ourselves to the precedents. But worship of 東醫寶鑑(DongEuiBoGam) may hinder the studying of new pathways. The treatment and its understandings of a disease should be based on objectivity of observation. Finding the common traits of the recipes in 東醫寶鑑(DongEuiBoGam) is important for the study of 東醫寶鑑(DongEuiBoGam). Accordingly, group synthesis of symptoms and resultant classification of recipes are vital. In this research, symptoms listed in the head part(頭門) of External Shape vol. I(外形篇 卷1) of 東醫寶鑑(DongEuiBoGam) are synthesized into 3 different parts: head-wind syndrome(頭風證), dizziness(眩暈), headache(頭痛). Classification of prescriptions according to these 3 parts is also suggested.

      • KCI등재
      • KCI등재

        보중익기탕(補中益氣湯), 소음인(少陰人) 보중익기탕(補中益氣湯)과 그 구성약물군(構成藥物群)이 alloxan으로 유발(誘發)된 고혈당(高血糖) 백서(白鼠)에 미치는 영향(影響)

        박선동,고원도,신화석,Park, Seon-Dong,Go, Won-Do,Sin, Hwa-Seok 대한한의학방제학회 2001 大韓韓醫學方劑學會誌 Vol.9 No.1

        The purpose of this study was to investigate the effect of Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) and its component groups on diabetes in alloxan induced diabetic rats. Sprague-Dawley male rats weighing $200{\pm}10\;gm$ were randomly assigned to one normal, one control and five experimental groups. The experimental groups was classified into to Bojungikgitang(B1 group), Soeumin bojungikgitang(B2 group), Bogihyulyak(B0 group), Siho-sengma(B1+ group) and Gwakhyang- soyeup(B2+ group). Diabetes was experimentally induced by abdomenal injection of 100 mg/kg of body weight of alloxan. Animals were sacrificed at the 6th day and 11th day of diabetic states. The results were obtained as follows: In carbohydrate metabolism, the level of glucose in control group was three-fold higher after alloxan injection than that of normal group. In B1, B2 groups the level of glucose was decreased by 39% and 43% compared with that of control group, and in component groups it was decreased by 73%, 81%, and 80% respectively. In fat metabolism, the level of triglyceride and total cholesterol in serum were lower in B1 and B2 groups with high significant difference and had similar tendency in components groups compared with that of control group. The level of HDL cholesterol on serum were increased in B1 and B2 group with significant difference. And in component group it had similar tendency compared with that of control group. In protein metabolism, the level of total protein and albumin were higher in B1 and B2 group with significant difference, and in component group also increased but with no significancy compared with control group. In kidney function, the level of creatinine group with significant difference, and other compared with control group. In liver function, the level of GOT, GPT, ${\gamma}$-GTP. ALP and bilirubin were lower in B1 and B2 group with significant difference, and in component had similar tendency compared with control group. But in the level of LDH, it was decreased with no significancy. These results indicate that Bojungikgitang(補中益氣湯), Soeumin bojungikgitang(少陰人 補中益氣湯) has strong effect on diabetes and it is useful to prevent diabetes, and in component groups the difference between B1+ and B2+ group was not significant.

      • KCI등재
      • KCI등재

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