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Analysis of coenzyme Q<sub>10</sub> in human plasma by high performance liquid chromatography
박용선,박상범,송선미,김용우,이경률,Park, Yong-Sun,Park, Sang-Boem,Song, Sean-Mi,Kim, Yong-Woo,Lee, Kyoung-Ryul The Korean Society of Analytical Sciences 2009 분석과학 Vol.22 No.6
코엔자임 큐텐은 비타민과 유사한 물질로 체내 중 미토콘드리아에 주로 분포 되어 있으며 항산화 작용을 나타낸다고 알려져 있다. 본 연구는 27-44세의 건강한 성인 남 녀 24명을 대상으로 하였고 혈장내 코엔자임 큐텐의 농도를 정량 평가하기 위하여 UV 검출기가 장착된 고성능액체 크로마토그라피를 사용 하였다. 혈장 내 코엔자임 큐텐을 분리하기 위해서 메탄올로 지방단백질을 제거하였고 노말헥산을 이용하여 액체-액체 추출법으로 코엔자임 큐텐을 용해 시켰다. 그 후 원심분리를 실시하여 노말헥산과 제단백된 물질을 층분리 시키고 상층액을 다른 유리 시험관에 옮겨 담았다. 옮겨진 노말헥산 층은 질소 가스를 이용하여 증발 농축을 시켰으며 남은 잔사에 순수한 에탄올로 재용해 시켜 검사 장비 내로 주입 하였다. 이 때 사용된 컬럼은 C18 역상 컬럼이었고 275 nm의 파장이 이용되었으며 메탄올과 에탄올을 85:15로 섞은 이동상을 1.7 mL/min의 유속으로 흘렸다. 본 검사 방법의 정량한계(limit of quantitation : LOQ, N/S=10)는 0.02 mg/L로 평가 되었고 0.1-2.0 mg/L의 농도 범위에서 검량선을 작성 하였다. 대상군 24명의 혈장 중 코엔자임 큐텐의 농도는 0.41-0.98 mg/L의 범위에서 분포 하고 있었으며 평균 농도는 $0.62{\pm}0.13mg/L$ 였다. 본 연구의 결과 본 검사 방법은 특수성을 가지고 있었으며 혈장 내 $CoQ_{10}$을 분석하는데 충분한 정량한계를 가지고 있었기에 임상에 적용이 가능하고 연구 기관에서 사용하기에 적합하다고 사료 된다.
박용선,남욱원,공경남,성현일,정재훈,Park, Yong-Seon,Nam, Uk-Won,Gong, Gyeong-Nam,Seong, Hyeon-Il,Jeong, Jae-Hun 한국천문학회 1996 天文學論叢 Vol.11 No.1
We have developed a measurement system with which harmful radio noise can be detected. It was designed to cover 1GHz band width centered at l.5GHz and 22.2GHz ($H_2O$ line).The system consists of pyramid horn antennas, receivers, equatorial tracking system, spectrum analyzer, and PC for the control of the servo and data taking. As a test of the system, the site of Taeduk Radio Astronomy Observatory (TRAO) was investigated to see if there is any harmful radio interference. It is found that in 22GHz band there is no significant radio noise, but there are identified and unidentified artificial radio signals in 1-2GHz range. However a simple calculation of radiation power shows that it is week enough not to affect the observations in TRAO.
DMBA로 유도된 햄스터 협낭암종에서 p53 유전자 변이와 mdm-2 단백의 발현에 관한 연구
박용선,김경욱,이재훈,김창진,Park, Yong-Sun,Kim, Kyung-Wook,Lee, Jae-Hoon,Kim, Chang-Jin 대한구강악안면외과학회 2001 대한구강악안면외과학회지 Vol.27 No.5
Cellular proliferation is an intricately regulated process mediated by the coordinated interactions of critical growth control genes. Two of these factors in mammalian cells are the p53 and mdm-2 genes. A protein product of the mem-2 oncogene has been recently shown to associate with the protein encoded by the tumor suppressor gene p53. The p53 tumor suppressor protein is stabilized in response to DNA damage and other stress signals and causes the cell to undergo growth arrest or apoptosis, thus preventing the establishment of mutations in future cellular generations. Mutation or loss of p53 is a very common event in tumor progression. It occurs in about 50% of all tumors analysed including of colon, lung, breast and liver. The cellular mdm-2 gene, which has potential transforming activity that can be activated by overexpression, is amplified in a significant percentage of human sarcoma and in other mammalian tumors. Proteins encoded by the mdm-2 gene are able to bind to the p53 protein and, when overexpressed, can inhibit p53's transcriptional activation function, thus mdm-2 can act as a negative regulator of p53 function. Experimental study was performed to observe the relationship between p53 gene mutation and mdm-2 protein expression and apply the results to the clinical activity. 36 golden syrian hamster each weighing $60{\sim}80g$ were used and painted with 0.5% DMBA by 3 times weekly on the right buccal cheek(experimental side) for 6, 8, 10, 12, 14 and 16 weeks. Left buccal cheek(control side) was treated with mineral oil as the same manner to the right side. The hamsters were sacrificed on the 6, 8, 10, 12, 14 & 16 weeks. Normal and tumor tissues from paraffin block were examined for histology and immunohistochemistry observation, and were completely dissected by microdissection and DNA from both tissue were isolated by proteins K/phenol/chloroform extraction. Segments of the hamster p53 exons 5, 6, 7 and 8 were amplified by PCR using the oligonucleotide primers, and then confirmational change was observed by SSCP respectively. The results were as follows : 1. Dysplasia at 6 weeks, carcinoma in situ at 8 weeks and invasive carcinoma from 10 weeks could be observed in experimental groups. 2. p53 mutations were detected in 10 of the 36(28%) and the exons 6(6 of the 10 : 60%) was the most hot spot area among the highy conserved region(exons 5, 6, 7 & 8). 3. Immunohistochemical study confirmed 22 of the 36(61%) of p53 expression involving 10 of p53 mutations. 4. mdm-2 expression of was showed in 3 of the 36(8%) involving 1 of the 22 of p53 expression and 2 of the 14 of p53 non-expression. From the above results, mutation of p53 gene or expression of p53 protein may have the influence of the DMBA induced carcinoma of hamster buccal pouch but the expression of mdm-2 protein may not have relationship with tumorigenesis.
지방공무원의 개인특성과 직무특성이 경력몰입에 미치는 영향
박용선(朴容善)(Park, Yong-Sun),이규만(李揆萬)(Lee, Kyu-Man) 한국지방정부학회 2011 지방정부연구 Vol.15 No.2
경력은 조직구성원들에게 있어서 장기적이며 평생에 걸쳐 직업과 관련된 것으로 고용관계가 불확실한 현시점에서 그 중요성이 더욱 커져가고 있다. 본 연구의 목적은 개인특성과 직무특성이 경력몰입에 미치는 영향을 검증하는데 있다. 이를 위해 선행연구를 토대로 가설을 설정하여 실증연구를 실시하였다. 356명을 대상으로 분석한 결과 개인특성인 자기효능감과 승진욕구는 경력몰입에 정(+)의 영향을 미치는 것으로 나타났다. 또한 직무특성의 경우 직무적합성은 통계적으로 유의한 정(+)의 영향을 미치는 것으로 나타났으나, 직무자율성은 유의한 관계가 없는 것으로 나타났다. 분석결과를 바탕으로 연구의 한계점과 향후 연구방향을 제시하였다. As today’s organizations are no longer lifelong employment, individuals tend to put stress on psychological satisfaction with the need to manage one’s career and employability in the open labor market rather than pursuing rapid promotion or high compensation in a organizations. Traditionally, the job of local public servant was a relatively stable occupation. In recent years, however, local public servants should acquire new competency and develop their competency to respond to the changes of administrative environment. The purpose of this study is to examine the effects of individual and job characteristics on career commitment among local public officials in Korea. The data was obtained from public officials serving for the regions of Kangwon and Kyeong-In in Korea. A total of 500 questionnaires was distributed and 410 results were collected, finally, 356 questionnaires were used for the actual analysis. The major findings of the study are summarized as follows: Career commitment was positively related to self-efficacy, need for promotion, person-job fit while it was not related to job autonomy. This study discussed implications suggested by these results.