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박석열,김기훈,김창욱,김병천,이규석 대한피부과학회 2003 大韓皮膚科學會誌 Vol.41 No.6
Targetoid hemosiderotic hemangioma is a benign vascular tumor characterized by a small solitary lesion consisting of a brown to violaceous papule, surround-ed by a thin, pale area and a peripheral ecchymotic ring. We report a case of targetoid hemosiderotic hemangioma on left lower abdomen of a 33-year-old female. She had a 5 ㎜ x 5 ㎜ sized slightly raised violaceous papule surrounded by an ecchymotic halo on left lower abdomen. We took a biopsy of the lesion and identified it as targetoid hemosiderotic hemangioma. This case showed characteristic clinical and histologic findings of targetoid hemosiderotic hemangioma. (Korean J Dermatol 2003;41(6) : 795~798)
Crystal structure and its proposed nucleolytic site of the single domain catalytic antibody 3D8-VH
박석열,김보나,최동기,서필원,구도헌,김용성,김정선 한국구조생물학회 2016 Biodesign Vol.4 No.1
Catalytic antibodies are monoclonal antibodies with catalytic activities. An anti-DNA antibody can bind DNA and hydrolyzeit with modest catalytic activity. The monoclonal antibody 3D8 from the autoimmune-disease prone MRL-lpr/lpr mouse hasbeen used to make a recombinant single-chain variable-fragment antibody (3D8 scFv) that hydrolyzes DNA. The catalyticsite is composed of several hyper-variable loops. Two His residues from the variable domains of the heavy chain (VH) andthe light chain (VL) are responsible for DNA hydrolysis. Interestingly, two single domain antibodies derived from 3D8 scFv,called 3D8-VH and 3D8-VL, also bind and hydrolyze DNA although their activities are significantly lower than those of 3D8scFv. Here, we report the crystal structure of 3D8-VH, which revealed no significant difference compared to the VH domainfrom 3D8 scFv. The 3D8-VH antibody is also structurally very similar to 3D8-VL that has a catalytic metal ion on the newlyexposed surface-curvature. The observed structural features of 3D8-VH, along with the fact that it retained catalytic activitywhen the His residue that was catalytic in the 3D8 scFv was replaced, suggest that 3D8-VH also has its DNA bindingand cleavage activity on the newly exposed surface. These findings provide new insights into substrate recognition andcatalysis by single domain anti-DNA antibodies.
The Protein Crystallography Beamlines at the Pohang Light Source II
박석열,하성철,김연길 한국구조생물학회 2017 Biodesign Vol.5 No.1
Pohang Light Source II (PLS-II) is a 3.0 GeV national synchrotron radiation facility in Korea. Three protein crystallographybeamlines at PLS-II are available for national and international users in the structural biology community. All threebeamlines (BL-5C, BL-7A and BL-11C) are illuminated with an in-vacuum undulator source, which provides a tunablehigh brilliant X-ray. BL-5C and BL-7A are designed for routine protein crystallography with a default beam size of 100 μm,while BL-11C is designed for micro-crystallography with a default beam size of 10 μm. This report summarizes the primaryparameters of the three beamlines, and describes user productivity and recent experimental results.
Phase determination of a homogentisate dioxygenase from Comamonas sp. strain P19
박석열,소병율,채종찬,김정선 한국구조생물학회 2017 Biodesign Vol.5 No.3
In Comamonas sp. strain P19, homogentisate 1,2-dioxygenase (HGO) catalyzes the conversion of homogentisate to4-maleylacetoacetate by aromatic ring scission, in the breakdown of tyrosine and phenylalanine. To determine themolecular background of the enzymatic mechanism of HGO in this zinc-resistant organism, hmgA encoding HGO ofComamonas sp. strain P19 was cloned, and the expressed protein was purified. The protein was crystallized in solutions I[25% (w/v) polyethylene glycol 3350 and 0.1 M trisodium citrate at pH 5.6] and II [1.4 M ammonium tartrate and 0.1 M bis-Tris at pH 5.5]. X-ray diffraction data were collected to 1.8 Å resolution using synchrotron radiation. The crystal belongs tothe orthorhombic space group P212121, with unit cell dimensions of a = 73.2 Å, b = 100.0 Å, and c = 134.9 Å. A traceableelectron density map was calculated using anomalous diffraction data obtained from a crystal soaked in zinc ions.
Carbamazepine에 의해 발생된 것으로 사료되는 항경련제 과민성 증후군 1예
박석열,김주용,김창욱,김병천,이규석 대한피부과학회 2004 大韓皮膚科學會誌 Vol.42 No.4
Anticonvulsant hypersensitivity syndrome is a life threatening immunologic reaction of anticonvulsants therapy such as phenytoin, phenobarbital, or carbamazepine, characterized by multiple abnormalities ssuch as fever, rash, lymphadenopathy, acute hepatocellular injury, leukocytosis, and eosinophilia. We report a case of anticonvulsant hypersensitivity syndrome thought to be caused by the use of carbamazepine in a 65-year-old male. He developed erythematous skin eruption four weeks after beginning therapy with carbamazepine. The clinical, laboratory and histologic findings of this patient were compatible with anticonvulsant hypersensitivity syndrome.
A short guide to histone deacetylases including recent progress on class II enzymes
박석열,김정선 생화학분자생물학회 2020 Experimental and molecular medicine Vol.52 No.-
The interaction between histones and DNA is important for eukaryotic gene expression. A loose interaction caused, for example, by the neutralization of a positive charge on the histone surface by acetylation, induces a less compact chromatin structure, resulting in feasible accessibility of RNA polymerase and increased gene expression. In contrast, the formation of a tight chromatin structure due to the deacetylation of histone lysine residues on the surface by histone deacetylases enforces the interaction between the histones and DNA, which minimizes the chance of RNA polymerases contacting DNA, resulting in decreased gene expression. Therefore, the balance of the acetylation of histones mediated by histone acetylases (HATs) and histone deacetylases (HDACs) is an issue of transcription that has long been studied in relation to posttranslational modification. In this review, current knowledge of HDACs is briefly described with an emphasis on recent progress in research on HDACs, especially on class IIa HDACs.