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강진형(Jin Hyoung Kang),문찬수(Chan Soo Moon),김훈교(Hoon Kyo Kim),이경식(Kyung Shik Lee),김동집(Dong Jip Kim),윤세철(Sei Chul Yoon),조승호(Seung Ho Cho),서병도(Byung Do Suh) 대한두경부종양학회 1992 대한두경부 종양학회지 Vol.8 No.1
The causes of treatment failure in head and neck cancer are locoregional recurrence, distant metastasis and second primary cancer. The favorite sites of second primary cancer are head and neck, lung and esophagus. But, the incidence of stomach cancer in Korea is the highest of all, high incidence of stomach cancer is expected in head and neck cancer patients. We experienced 2 cases of stomach cancer after successful treatment of primary head and neck cancer at Kang Nam St. Mary's hospital. The first case was a 60-year-old male with nasopharyngeal non-keratinizing carcinoma(stage III, T1N1M0). He received three cycles of induction chemotherapy including cisplatin and 5-fluorouracil followed by radiotherapy which resulted in complete response. Five months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. He received one cycle of FAM chemotherapy and died 4 months after diagnosis of stomach cancer. The second case was a 50-year-old male with pyriform sinus squamous cell carcinoma(stage II, T2N0M0). He received curative partial pharyngolaryngectomy followed by radiotherapy which result in free of disease. Four months after completion of radiotherapy. stomach adenocarcinoma(stage IV, T4N2M1) was diagnosed. Bypass gastrojejunostomy was performed. The screening test for stomach cancer including upper gastrointestinal X-xay series and/or endoscope of the stomach should be performed periodically for the patients with head and neck cancer in Korea.
한국인에서 혈청 페리틴 농도와 흡연 및 폐기능과의 관계
김서윤 ( Seo Yun Kim ),이수환 ( Su Hwan Lee ),이인선 ( In Seon Lee ),김샛별 ( Sae Byol Kim ),문찬수 ( Chan Soo Moon ),정성모 ( Sung Mo Jung ),김세규 ( Se Kyu Kim ),김영삼 ( Young Sam Kim ) 대한결핵 및 호흡기학회 2012 Tuberculosis and Respiratory Diseases Vol.72 No.2
Background: Cigarette smoke induced release of iron could alter iron metabolism in the lungs of chronic smokers and contribute to the increase in the total oxidative burden on the lungs of smokers. In previous studies, ferritin levels of bronchoalveolar lavage fluid in smokers were elevated. The aim of the present study was to investigate the relationship between serum ferritin concentration, smoking and lung function in Korean people. Methods: This study was based on the data acquired in the second year (2008) of the Forth National Health and Nutrition Examination Survey that was conducted from 2007 to 2009. The analysis included 2,244 subjects who were older than 20 years and had complete data from both lung function test and serum ferritin concentration. Among participants, 1,076 were male and 1,168 were female. Results: Mean serum ferritin concentrations in males were 120.3±80.1μg/L and 47.9±39.8μg/L in females. There were no differences in serum ferritin concentrations between non-smokers and smokers after adjusting for age, body mass index, and amounts of alcohol. Serum ferritin concentrations were associated with smoking amounts by simple linear regression but not associated with smoking amounts after adjustment with age, body mass index, and amounts of alcohol in both males and females. Lung function was not associated with serum ferritin concentrations. Conclusion: Our data suggested that serum ferritin concentrations are not related with smoking and lung function.
구인두 칸디다증 치료에 대한 Fluconazole의 효과
신완식,강문원,이상헌,윤임중,진종률,임영,김동집,김춘추,박종원,문찬수 대한감염학회 1991 감염 Vol.23 No.2
The efficacy analysis of oral or intravenous fluconazole in the treatment of oropharyngeal candidiasis of 20 patients. In the pretreatment clinical assessment, 11 cases were grade Ⅱ, and 9 cases were grade Ⅲ. In the pretreatment oropharyngeal culture, 3 cases were 1 positive, 15 cases were 2 positive, and 2 cases were 3 positive. Oral or intravenous fluconazole 100㎎ once daily were administered. In the posttreatment efficacy assessment, the clinical improvement time was 1-3 days, the clinical cure time was 3-11 days, the mean clinical effectiveness time was 5.6 days, and the mean clinical effectiveness time was 8.1 days. Fluconazole had a few and short-term side effects that included nausea, headache, and transient liver function abnormalities.
다량의 Interleukin-6 를 분비하는 심장점액종 1 예
박준철,변광호,강형식,홍순조,최재경,최인표,윤호중,문찬수,정욱성,윤광무,김재형,최규보 대한내과학회 1993 대한내과학회지 Vol.45 No.4
Cardiac myxoma is known to show clinical manifestations such as constitutional disturbance, embolization, valvular stenosis and regurgitation, congestive heart failure and arrhythmia. Constitutional disturbance with myxoma includes fever, anemia, weight loss, arthralgia, Raynaud phenomenon, increased ESR, increased immunoglobulin G and fibrinogen, positive antinuclear Ab, and positive indirect Coombs's test. We presented a case of left atrial myxoma with increased IL-6 level. M-mode echocardiography revealed the tumor echoes behind the anterior leaflet of the mitral valve during diastole. Transesophageal echocardiography revealed a large left atrial myxoma inserting at the interatrial septum. Complete tumor resection was performed, and the resected tumor was 4×4×3 cm in size. The serum and myxoma ce11 IL-6 level, detected by means of the ELISA method with antihuman IL-6 monoclonal antibody, were 256 u/ml and 8,343 u/ml.