http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
노정우 ( Jung Woo Noh ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.1
Toll-like receptors (TLRs) are pattern-recognition receptors which identify pathogens or microorganisms associated molecular patterns (PAMP or MAMP) at the very early stage of their invasion to the host. So TLRs had been known to play a key role in the innate immune system only at first. However, a growing body of evidence that they participate in the adaptive immune system has accumulated as well. Though the primary role of TLRs is the surveillance of invading pathogens and evocation of the innate immune system against them. TLRs, unfortunately, are also found to be involved in pathogenetic processes of many diseases. So over- or under-activation of TLRs is regarded as being related with the course of many diseases. Many kidney diseases including urinary tract infection, sepsis, ischemiareperfusion injury, acute and chronic renal failure, glomerulonephritides either primary or secondary, and so forth are good examples where TLRs are working seriously. The author summarized the most recent evidences of the relationship between TLRs and the pathogenetic processes of many renal diseases.
만성신부전 환자에서 혈액투석이 혈장 Catecholamine 에 미치는 영향
노정우(Jung Woo Noh),김형건(Hyung Gun Kim),김형규(Hyung Kyu Kim) 대한내과학회 1989 대한내과학회지 Vol.36 No.1
N/A It is well known that the plasma catecholamine level indicates sympatho-adreno-medullary system activity. Using an advanced method of HPLC with ECD, the authars evaluated the syampatho-adrene-medullary system activity and the effect of hemodialysis on the plasma catecholamine level in 39 patients with ehronic renal failure accompanying hypertension, The results were as follows: 1. The base-line plasma concentrations of norepinephrine. epinephrine, dopamine, DOPA and DOPAC were significantly elevated in patients with chronic renal failure regardless of receiving hemodialysis 2. Intradialysis and single pass effects on plasma catecholamine levels showed that all catecholamines and their metabolites are dialyzable. 3. The intradialysis effect on the plasma catecholamine level was less in the group with dialysis induced hypotension than in the group without it, for all catecholamines except norepinephrine. 4. Norepinephrine was the most dialyzable but least responsive to dialysis induced hypotension among all the catecholamines. Epinephrine was the most responsive to dialysis induced hypotension of among all the catcholamines. 5. The difference in the intradialysis effect on the plama catecholamine level according to the type of dialyzer and vascular access was not significant. 6. There was no significant correlation between the intradialysis effect on the plama catecholamine level and blood flow rate or ultrafiltration rate. From the above findings, it is conclude4 that plasma catecholamine is responsible for the pathogenesis of dialysis induced hypotension and of hypertension in chronic renal failure.
혈액투석 중인 말기 신질환 환자에서 대사성 산증과 칼슘대사 장애의 연관성
한성우(Sung Woo Han),박우정(Woo Jung Park),현상훈(Sang Hoon Hyun),구자룡(Ja Ryoung Koo),전노원(Ro Won Chun),김형직(Hyung Jik Kim),채동완(Dong Wan Chae),노정우(Jung Woo Noh),김근호(Gheun Ho Kim) 대한내과학회 2000 대한내과학회지 Vol.58 No.4
Background: Mild metabolic acidosis is frequently found among the stable patients treated with maintenance hemodialysis. However, its clinical effects have yet to be clarified. This study was undertaken to estimate the prevalence of metabolic acidosis in the patients undergoing chronic hemodialysis and to evaluate the clinical significance of metabolic acidosis, especially in relation to calcium metabolism. Methods: In 124 patients undergoing maintenance hemodialysis, analysis of arterial blood gas and measurement of various biochemical markers and parathyroid hormone were carried out with predialysis blood obtained from arterial side of arteriovenous fistula. Results: Ninety two patients(74.2%) had metabolic acidosis. Their arterial pH was 7.32±0.01, arterial bicarbonate concentration 17.1±0.3 mEq/L, and PaCO2 33.1±0.5 mmHg. The patients with metabolic acidosis showed a lower calcium(7.90±0.16 vs. 8.68±0.17 mg/dL, p<0.05), and higher phosphorus(4.96±0.16 vs. 3.68±0.39 mg/dL, p<0.05), alkaline phosphatase(233.6±22.7 vs. 145.9±13.7 U/L, p<0.05) and parathyroid hormone(176.5±23.7 vs. 52.8±14.4 pg/mL, p<0.05) levels compared to those with normal acid-base balance. In the patients with metabolic acidosis, PaCO2 level showed a positive correlation with arterial bicarbonate concentration(r=0.62, p<0.001). The lower arterial bicarbonate was, the higher serum potassium(r=-0.24, p<0.05), phosphorus(r=-0.42, p<0.001) and anion gap(r=-0.28, p<0.01) were. When the patients were divided into two groups according to the dialysate buffer used, the lower calcium-acetate group showed lower total calcium(7.28±0.25 vs. 7.96±0.17 mg/dL, p<0.05) and ionized calcium(0.85±0.05 vs. 1.08±0.04 mmol/L, p<0.05) levels and higher alkaline phosphatase(457.1±170.2 vs. 209.4±15.9, p<0.05) and parathyroid hormone (364.4±83.7 vs. 155.4±23.6 pg/mL, p<0.05) levels compared to the higher calcium-bicarbonate group. Conclusion: Current hemodialytic practice is less than ideal, as evidenced by a high prevalence of metabolic acidosis. The metabolic acidosis in maintenance hemodialysis is associated with abnormal calcium metabolism, suggesting that a more aggressive correction of metabolic acidosis may be required by individualizing dialysis prescription.(Korean J Med 58:420-429, 2000)
만성신부전 환자에서 심근 troponin I와 T 및 CK-MB의 진단적 의의
윤정이(Jung E Yun),이형철(Hyung Cheol Lee),이준상(June Sang Lee),박규용(Kyu Yong Park),박대균(Dae Kyun Park),구자룡(Ja Ryong Goo),김형직(Hyung Jik Kim),김근호(Gheun Ho Kim),전노원(Rho Won Chun),채동완(Dong Wan Chae),노정우(Jung Woo N 대한내과학회 2000 대한내과학회지 Vol.58 No.2
Background : Nonspecific elevations of CK-MB, cTnT have been well known in patients with chronic renal failure(CRF) on maintenance hemodialysis. It has been suggested that recently developed cTnI seldom shows nonspecific elevations in these patients. Status of CRF patients can be divided into three groups: predialysis group, hemodialysis group and peritoneal dialysis group. Until now, most researchers have studied CK-MB, cTnT and cTnI only in CRF patients receiving maintenance hemodialysis. No previous studies have ever compared the differences of the nonspecific positivity of CK-MB, cTnT and cTnI according to the different status of CRF patients. Methods : Nonspecific positive ratios of cTnI, cTnT, & CK-MB in were evaluated 20 predialysis patients, 13 CAPD patients and 20 hemodialysis patients. No one had had any evidence of myocardial ischemia during the previous 3 months before the study entry. The predialysis group was again divided into two groups according to the cut off level of serum creatinine of 3.0 mg/dl. Authors also compared the nonspecific positive ratios of cTnI, cTnT, CK-MB between diabetic CRF group and non diabetic CRF group. The sensitivity, specificity and false positive ratios of each enzymes were examined on and 6 hours after arrival in 21 CRF patients who visited the emergency room with the complaint of chest pain. Results : 1) There were no nonspecific significant elevations of cTnI in CRF patients regardless of the status of CRF. But there were significant nonspecific elevations of CK-MB, cTnT in them. It was more marked in cTnT especially with the cut-off value of 0.1 ng/ml. 2) Nonspecific positive ratios of cTnT was significantly increased in diabetic CRF patients. 3) The sensitivity and specificity of cTnI were 100% and 93.3% each, which were significantly higher than those of CK-MB(83.3%, 66.7%) & cTnT(66.7%, 53.3%). Conclusion : In CRF patients, the nonspecific positive ratios of CK-MB, cTnT were higher than that of cTnI, and only cTnI did show significant specific elevations in all the CRF patients with acute myocardial infarction. It is likely that the status of CRF patients, dialysis mode, the sampling time point would not give significant changes in the nonspecific positive ratios of CK-MB, cTnT and cTnI.(Korean J Med 58:204-212, 2000)
신증후군으로 나타난 전신성 홍반성 낭창 환자에서 확인된 IgA 신병증
한권우 ( Kweon Woo Han ),이영기 ( Young Ki Lee ),이해리 ( Hae Ri Lee ),황상익 ( Sang Ik Hwang ),김성균 ( Seong Gyun Kim ),오지은 ( Ji Eun Oh ),서장원 ( Jang Won Seo ),구자룡 ( Ja Ryong Koo ),김형직 ( Hyung Jik Kim ),노정우 ( Jung 대한신장학회 2005 Kidney Research and Clinical Practice Vol.24 No.2
알코올성 간경변에 동반된 반월상을 보이는 IgA 신병증 1예
정다혜 ( Da Hye Jung ),이영기 ( Young Ki Lee ),손승연 ( Seung Yeon Son ),황상익 ( Sang Ik Hwang ),이승민 ( Seung Min Lee ),이동훈 ( Dong Hun Lee ),노정우 ( Jung Woo Noh ),오국환 ( Kook Hwan Oh ),문경철 ( Kyung Chl Moon ) 대한신장학회 2011 Kidney Research and Clinical Practice Vol.30 No.6
It has been reported that IgA nephropathy is associated with alcoholic liver cirrhosis. However, crescentic glomerulonephritis or nephrotic syndrome are relatively rare. We experienced a patient with IgA nephropathy complicated with alcoholic liver cirrhosis who showed favorable clinical outcomes through steroid treatment. A 54-year-old man with alcoholic liver cirrhosis was hospitalized for generalized edema, nephrotic-range proteinuria and azotemia. We performed a renal biopsy and crescentic formations were found in half of the glomeruli. After use of steroid, azotemia and proteinuria improved gradually.
급성망막괴사증후군 의심 환자에서 항바이러스제 정맥주사 후 발생한 급성신부전 1 예
조준희,장주현,이동훈,이영기,노정우,배지현,김하경,Joon Hee Cho,Joo Hyun Jang,Dong Hun Lee,Young Ki Lee,Jung Woo Noh,Ji Hyun Bae,Ha Kyoung Kim 대한안과학회 2010 대한안과학회지 Vol.51 No.11
Purpose: To report a case of acyclovir-induced acute renal failure (ARF) suspected as acute retinal necrosis syndrome. Case summary: The authors report a 55-year-old male patient who presented with left eye visual disturbance due to suspected acute retinal necrosis syndrome. Non-oliguric ARF developed after the infusion of intravenous acyclovir (850 mg every 8 hours). The patient did not show any uremic symptoms or signs. The crystal was not discovered in the urine. After stopping the acyclovir infusion and hydration, acyclovir-induced ARF was reversed. Conclusions: Although possessing critical nephrotoxicity, acyclovir is a useful antiviral drug. Therefore, when using acyclovir, the importance of hydration and preventing acyclovir-induced ARF should be considered. J Korean Ophthalmol Soc 2010;51(11):1528-1531
임규성(Kyu Sung Rim),김우중(Woo Joong Kim),노정우(Jung Woo Noh),서정은(Jung Eun suh),박충기(choong Ki Park) 대한소화기학회 1987 대한소화기학회지 Vol.19 No.2
Benign tumors of esophagus are rare pathologic conditions. Among them, squamous cell papilloma of esophagus is a distinctly rare disorder which is reported with increasing frequency recently. Usually it is found by accident as a small mass without developing symptoms during gastrofibers- copic examination. Squamous cell papillorna of esophagus is small polypoid tumor with benign nature. Pathologically surface epithelium composed of finger like projections is lined by increased numbers of squamous cells and there are fibrovascular cores. Squamus cell papilloma of esophagus is known to be found more in frequency in men than in women and in lower esophagus than in upper esophagus but our cases revealed reversed pattern. More cases should be examined for evaluation in detail. Recently we had the opportunity to observe 3 cases of pathologically demonstrated squamous cell papilloma of esophagus. Our purpose here is to report these cases and to review the literatures.