The Clinical Significance of Serum Vascular Endothelial Growth Factor Levels Measured at Ovulation Triggering Day In Intrauterine Insemination Cycles

김현준,지병철,서창석,김석현,최영민,김정구,문신용,Kim, Hyun-Jun,Jee, Byung-Chul,Suh, Chang-Suk,Kim, Seok-Hyun,Choi, Young-Min,Kim, Jung-Gu,Moon, Shin-Yong The Korean Society for Reproductive Medicine 2007 Clinical and Experimental Reproductive Medicine Vol.34 No.1

Objective: The objective of this study was to investigate whether serum levels of vascular endothelial growth factor (VEGF) measured at ovulation triggering day reflect ovarian response in intrauterine insemination (IUI) cycles. Methods: Forty-nine fertile women who undergoing superovulation and IUI were included. Superovulation was performed using clomiphene citrate (100 mg/d on day 3$\sim$7) in combination with human menopausal gonadotropin (150 IU every other day starting on day 5). Serum samples were obtained on the day of hCG administration and the levels of VEGF-A and estradiol were measured. The numbers of mature follicle $\geq$17 mm in diameter were also counted. Results: Serum VEGF-A levels did not correlate with the numbers of mature follicle count nor serum estradiol levels. Serum estradiol level was positively associated with mature follicle count. Serum VEGF-A levels tended to be lower in women with mature follicle count less than three or women with more than five. Conclusion: Our results indicate that serum VEGF-A levels do not have an association with superovulation outcome in IUI cycles. However, a tendency of lower VEGF-A level in poor and high responder suggests that those with extreme response to superovulation may be related with abnormal angiogenesis. Further studies should be warranted in larger populations. 목 적: 자궁강 내 인공수정을 위한 과배란유도 시 혈청 vascular endothelial growth factor (VEGF) 농도가 과배란유도의 결과를 반영할 수 있는지를 확인해 보고자 하였다. 연구방법: 과배란유도 후 자궁강 내 인공수정을 시행 받은 49 명의 불임여성을 대상으로 hCG 투여 일에 혈청을 얻어 VEGF-A 및 estradiol 농도를 측정하였다. 과배란유도는 clomiphene citrate (100 mg/d on day 3$\sim$7) 와 human menopausal gonadotropin (150 IU every other day starting on day 5) 병합요법을 이용하였다. hCG 투여 일에 17mm 이상의 성숙난포 수와 자궁내막 두께를 동시에 측정하였다. 결 과: 혈청 VEGF-A 농도는 성숙난포 수, estradiol 농도 및 자궁내막 두께와는 무관하였던 반면 성숙난포 수와 estradiol 농도는 양의 비례관계를 보였다. 혈청 VEGF-A 농도는 성숙난포 수가 2 개 이하인 저 반응 군과 6 개 이상인 고 반응 군에서 통계적으로 유의하지는 않지만 낮은 수치를 보였다. 결 론: 혈청 VEGF-A 농도는 자궁강 내 인공수정 시술 시 과배란유도의 결과와 무관한 것으로 사료되지만 저 반응 군과 고 반응 군에서 낮은 농도를 보이는 것으로 보아 이들을 대상으로 한 추가 연구가 필요할 것으로 판단된다.

평균 연강수량 산출을 위한 최소기간에 대한 연구

김현준,김승,김형섭,정성원,Kim Hyeon-Jun,Kim Sung,Kim Hyeong-seop,Jung Sung-won 한국관개배수위원회 1995 한국관개배수논문집 Vol.2 No.1

Since precipitation is variable with time and space, a mean annual precipitation should be estimated with adequate consideration of their variations. In Korea, the thirty-year period has been widely used to estimate the mean annual precipitation. However,

Seminal Tumor Necrosis Factor-alpha Level and Sperm Nuclear DNA Integrity in Healthy Donors

김현준,지병철,문정희,이정렬,서창석,김석현,Kim, Hyun-Jun,Jee, Byung-Chul,Moon, Jeong-Hee,Lee, Jung-Ryeol,Suh, Chang-Suk,Kim, Seok-Hyun The Korean Society for Reproductive Medicine 2009 Clinical and Experimental Reproductive Medicine Vol.36 No.1

Objectives: Seminal concentration of tumor necrosis factor-alpha (TNF-${\alpha}$) relevant to sperm nuclear DNA integrity has not been studied. The present study aimed to evaluate seminal concentration of TNF-${\alpha}$ in correlation with sperm parameters and nuclear DNA integrity in asymptomatic healthy donors. Methods: Semen samples were obtained by masturbation from forty-five healthy donors. Results: Sperm quality was assessed by computer-assisted semen analysis and nuclear DNA integrity measured by the TUNEL assay in raw semen. TNF-${\alpha}$ concentrations were measured by ELISA in frozen-thawed seminal plasmas. Sperm DNA fragmentation rates were ranged between 1.9% and 53.0% (mean${\pm}$SD, 12.4${\pm}$9.6%). Univariate analysis revealed that DNA fragmentation rate was not associated with sperm concentration or motility but had a correlation with linearity negatively (r=-0.325, p=0.03) and age positively (r=0.484, p=0.001). The mean seminal concentration of TNF-${\alpha}$ was 4.9 pg/mL with a range from 1.1 to 22.6 pg/mL. The TNF-${\alpha}$ concentration had no correlation with clinically relevant parameters of sperm quality or nuclear DNA fragmentation rate. Conclusion: Our results indicate that sperm nuclear DNA fragmentation may be not associated with seminal TNF-${\alpha}$ level or sperm quality in asymptomatic healthy donors. 목 적: 정액 내 tumor necrosis factor-alpha (TNF-${\alpha}$) 농도와 정자 DNA 손상 및 정액 검사 소견과의 관련성을 평가하고자 하였다. 연구방법: 정액 표본은 45명의 건강한 남성에서 자위에 의하여 획득하였다. 정자의 상태는 컴퓨터 정액 분석기를 이용하여 판정하였으며, 두부의 DNA 손상은 TUNEL 분석방법에 의해 측정하였다. TNF-${\alpha}$ 농도는 동결-융해된 정장액에서 ELISA법으로 측정하였다. 결 과: 정자 DNA 손상율은 1.9%에서 53% (mean ${\pm}$ SD, 12.4${\pm}$9.6%)로 매우 광범위하게 나타났다. 단변량분석에 의하면 DNA 손상 정도와 정자의 농도, 운동성과는 관련이 없었으나, 직진운동성 (linearity)과는 음의 상관 관계를 나타내었으며 (r=-0.325, p=0.03) 연구 대상 남성의 연령과는 양의 상관 관계를 나타내었다 (r=0.484, p=0.001). 정액내에 존재하는 TNF-${\alpha}$ (>1 pg/mL)는 연구 대상 남성의 73.3% (33/45)에서 검출되었으며 평균 농도는 4.9 pg/mL, 범위는 1.1에서 22.6 pg/mL이었다. 정액 검사 상의 정자 상태와 정자 DNA 손상과는 유의한 관련성이 나타나지 않았다. 결 론: 본 연구에서는 정자 DNA의 손상이 남성의 연령과 관련성이 있음을 확인하였으나, TNF-${\alpha}$와의 관련성은 확인할 수 없었다.

Implicit와 explicit 방법의 결합에 의한 3차원 유한차분 빔전파 방법의 개선

김현준,오범환,박세근,이일항,이승걸,Kim, Hyun-Jun,O, Beom-Hoan,Park, Se-Geun,Lee, El-Hang,Lee, Seung-Gol 한국광학회 2004 한국광학회지 Vol.15 No.6

3차원 유한 차분 빔전파 방법의 계산시간 및 수렴성 문제를 해결하기 위해서 implicit와 explicit 방법을 결합하는 복합 방법(hybrid method)을 제안하였다. 방향성 결합기의 결합길이를 결정하는 문제를 대상으로 제안된 방법과 implicit 방정식의 해를 직접 구하는 방법의 계산 시간을 비교하였다. 그 결과 직접 풀이법에 비해 제안된 방식의 계산 속도가 최소 10배 이상 빠름을 확인하였다. We propose a hybrid method combining the implicit with the explicit methods in order to reduce the calculation time and improve the convergence problem of the 3-dimensional finite-difference beam propagation method. The numerical simulation of a directional coupler is carried out by the proposed method. It is found from the simulation results that the calculation speed of our method is 10 times faster than that of direct solving techniques.

전장축소형 무화염 소염기 형상설계 연구

김현준,이준호,채제욱,이성배,김인우,Kim, Hyun-Jun,Lee, Joon-Ho,Chae, Je-Wook,Lee, Sung-Bae,Kim, In-Woo 한국군사과학기술학회 2011 한국군사과학기술학회지 Vol.14 No.6

This paper includes that there are results of designing the flash hider and analyzing fluid dynamics of a front area of the barrel to shorten the length of small arms. Generally, the muzzle flash can be generated out of the barrel by the reaction between the oxygen in the air and unburned gunpowder contained in the propellant gas if a barrel is not long enough to burn gunpowder fully inside of the barrel. Though, the hugh muzzle flash, which is a characteristic of small arms with short barrel length, caused a soldier to aim at the target at night by making the soldier blind for a while and endangers his life by revealing firing position to enemies. Besides, the heat of muzzle flash can weaken the performance of thermal sights, which are attached to small arms for night battlefield. In this paper, flash hiders with several different shapes were designed for a newly developed 5.56mm caliber rifle with short barrel length. The performance of each flash hider to reduce the muzzle flash was compared theoretically and experimentally. Through the authorized test procedure, a highly efficient design of flash hider for reducing the muzzle flash was identified. The result of the paper can be helpful when designing flash hiders for small arms with short barrel length.

인간과 하천 5 - 고대 수리시설의 과거와 현재, 그리고 미래 - 김제 벽골제(碧骨堤) -

김현준,장철희,Kim, Hyeon-Jun,Jang, Cheol-Hui 한국하천협회 2013 하천과 문화 Vol.9 No.4

석유류에 대한 조세제도

김현준,Kim, Hyeon-Jun 대한석유협회 1997 석유와 에너지 Vol.1997 No.1

조선왕조실록에 수록된 홍수기록 조사

김현준,Kim, Hyeon-Jun 한국수자원학회 2000 한국수자원학회논문집 Vol.33 No.1

Maxwell 방정식의 효율적인 풀이를 위한 경계요소법과 웨이브렛의 결합

김현준,이승걸,오범환,이일항,Kim, Hyun-Jun,Lee, Seung-Gol,O, Beom-Hoan,Lee, El-Hang 대한전자공학회 2002 電子工學會論文誌-CI (Computer and Information) Vol.39 No.6

Maxwell 방정식을 효율적으로 풀기 위해 웨이브렛 행렬 변환(wavelet matrix transformation)과 경계요소법(Boundary Element Method)을 결합하는 방법을 제안하였으며, 2차원 위상변이 마스크(phase- shifting mask) 문제에 적용하였다. 계산 결과를 해석적인 해 및 참고문헌의 결과와 비교함으로써 구현된 모듈의 정확도를 검증하였으며, 제안된 방법이 경계요소법만을 적용한 경우에 비해 연산 시간과 메모리 사용 측면에서 효율적임을 확인하였다. The wavelet transform is combined with the boundary element method (BEM), to solve efficiently the Maxwell's equation and the proposed method is applied to the electromagnetic problem for the analysis of topological effects of phase-shifting masks. The accuracy of the module developed was verified by comparison with both analytic solutions and published results. In addition, it was found that the boundary element method in combination with the wavelet matrix transform would be more efficient than the conventional methods based on the BEM in views of the calculation speed and the usage of computer memory.

한국의 조경수 생산과 유통현황 및 수요분석

김현준,이태영,권영휴,Kim, H.J.,Lee, T.Y.,Kwon, Y.H. 국립한국농수산대학교 교육개발센터 2011 현장농업연구지 = Journal of practical agricultural resear Vol.13 No.1

The purpose of this study carried out to analyze production status, pricing trend and distribution status of landscape plants, so that it could predict the demand of landscape plants for the balance of supply and demand. The production amount of landscape plants made constantly increased. The annual output of shrubs increased more higher than that of trees. The prices of trees have raised consistently, but shrubs were susceptible to price fluctuations. And there were still many problems in the distribution structure. The landscaping work has focused on the metropolitan area. And large-scale nationwide projects were scheduled for coming years, so the demand of landscape plants was expected to expend. However, the lack of increase in production amounts of landscape plants, it is cause to supply problems. So, demand forecast was necessary to control the production of landscape plants.