鼻茸(Nasal Polyp)에 對한 文獻的 考察

김현아,Kim, Hyun-Ah 대한한방안이비인후피부과학회 1999 한방안이비인후피부과학회지 Vol.12 No.1

In the treatment of Nasal Polyps. which are produced with allergic rhinitis, chronic paranasal sinusitis at clinic. Herb-med., acupuncture and some medicine for external application have been used. The symptoms, however, has taken a turn for the better in temporary, the nasal polyps was not removed in completely. So the origin treatment was impossible by the use of herb-med.. acupuncture and medicine. Although a surgical operation (excision) of western-medicine is effective for a specified period of time (about 6 months), the nasal polyps tend to recur. Because of that the second and third operation might be needed, so we cannot consider the operation as the treatment of nasal polyps. The study was observed to investigate the nasal polyps treatment, and to search practical attempt for the clinic application through a literature study on Bisikyuk and Bithch which are similar with nasal polyps. As results, the practical application of external treatment for the nasal polyps treatment in clinic might be more necessary, and internal use of the Herb-med. with the external treatment might be treated as supplementary treatment.

알레르기性 鼻炎에 對한 文獻的 考察

김현아,정지천,Kim, Hyun-Ah,Jung, Ji-Chun 대한한방안이비인후피부과학회 1994 한방안이비인후피부과학회지 Vol.7 No.1

The study has been carried out to investigate of the Allergic Rhinitis by referring to 87 literatures. The results were as follows; 1. In oriental medical science, Allergic Rhinitis is belong to the category of the 'BiGu'(鼻구) 'GuChe'(구체). The 'Gu'(구) of the BiGu means watery rhinorrhea, the 'Che'(체) of the GuChe means sneezing. 2. The cause of a disease summarize the weak of Lung, Spleen and Kidney, and invasion into the nasal cavity of PoongHan etc a wrong air. Sometimes the pathologial change appear PoongHan changeHwa(風寒化火), HwaYeol is hidden in the inside(火熱內伏). The contributing factors are found a season(spring, winter), an abnormal weather(運氣 : 少陰 少陽 陽明 司天, 歲金不及), an emotional stress, an external wound of the harmful air, a food allergens and fatigue, a contact of substances, a sunlight etc. 3. Predominant symptoms are watery rhinorrhea, sneezing and nasal obstruction. Sometimes accompanic symptoms are nasal bleeding, mucopurulent rhinorrhea, olfactory disturbance, nasal polyp, rhinolalia clausa, respiratory disfunction etc. 4. The treatment-methodes is as follows, OnBoPaeJang GeoPoongSanHan(溫補肺臟 祛風散寒), GeonBilkGi(健脾益氣), BoSinNabGi (補腎納氣). The treatmentherbs is as follows, OnBoJiLuDan GaGam(溫補止流丹 加減), OkByeongPoongSan plus ChangIJaSan GaGam(玉屛風散合 蒼耳子散 加減), BoJungIkGiTang GaGam plus SoCheongLyongTang(補中益氣湯加減 配合 小靑龍湯), SinGiHwan GaGam(腎氣丸加減), GaeJiTang(桂枝湯) etc. 5. The external treatment is as follows, JeokBi(滴鼻), ChuiBi(吹鼻), SaekBi(塞鼻), stick and herbs-injection on the acupuncture-point, pressure ear acupuncture-point, herbs-pillow etc. 6. The acupuncture-moxa treatment is as follows, the methodes of cure apply TongJoGyeongGi(通調經氣), SanTongBiGui(宣通鼻竅) etc. Predominent acupuncture-points are YoungHyang(迎香), InDang(印堂), BiTong(鼻通), SangSeong(上星), HabGok(合谷) and so on. As mentioned above, from now on, it's need to the oriental medical scientific study of the Immunity and Allergy and to the external treatment's application for the ascent of the treatment-effect of the allergic disease.

아그로박테리움을 이용한 Actinobacillus pleuropneumoniae ApxIIA (ApxII toxin) 유전자 발현 옥수수 형질전환체 개발

김현아,유한상,양문식,권석윤,김진석,최필선,Kim, Hyun-A,Yoo, Han-Sang,Yang, Moon-Sik,Kwon, Suk-Yoon,Kim, Jin-Seog,Choi, Pil-Son 한국식물생명공학회 2010 식물생명공학회지 Vol.37 No.3

To develop edible vaccines for swine, the embryogenic calli (type II) derived from HiII genotype were inoculated with A. tumefaciens strain C58C1 containing the binary vector pMYV611, 613, 616, and V621, 622 and 623 respectively. Six of those vectors carry nptII gene which confers resistance to paromomycin and apxIIA gene producing ApxII toxin which is generated in various serum types of A. pleuropneumoniae as a target gene. The 4,120 callus clones for pMYV611, 5,959 callus clones for pMYV613, 7,581 callus clones for pMYV616, 52,329 callus clones for V621, 48,948 callus clones for V622, and 56,188 callus clones for V623 were inoculated. The frequency of positive response clone was confirmed into range of 2.3% - 4.4% for each vectors by NPTII ELISA kit assay, and the selected callus clones of them were finally 3 callus clones from pMYV611 (0.07%), 4 callus clones from pMYV613 (0.07%), 2 callus clones from pMYV616 (0.03%), 51 callus clones from V621 (0.1%), 72 callus clones from V622 (0.15%), and 102 callus clones from V623 (0.18%) respectively. From the selected callus clones of each binary vector, the integration of the apxIIA gene into maize genome was detected from 2 plants of pMYV613 and 2 plants of V623 by Southern blot analysis. 돼지 흉막폐렴백신을 개발하기 위해 옥수수 HiII genotype 으로부터 유도한 type II형의 배발생캘러스를 식물발현벡터 pMYV611, pMYV613, pMYV616, V621, V622 및 V623로 형질전환시킨 Agrobacterium (C58C1)과 공동배양 하였다. 이들 식물발현벡터는 paromomycin 항생제 저항 유전자인 NPTII 선발마커와 표적 유전자로서 흉막폐렴균의 여러 가지 혈청을 생산하는 apxIIA유전자로 재조합하여 구축하였다. 식물발현벡터pMYV611, pMYV613, pMYV616, V621, V622 및V623의 경우 각각 4,120개, 5,959개, 7,581개, 52,329개, 48,948개 및 56,188개의 캘러스 클론을 Agrobacterium과 공동한 후 NPTII assay kit에 의해 nptII유전자의 발현빈도를 조사한 결과 각 벡터별로 2.3-4.4%의 캘러스 클론에서 항체결합 양성반응을 보였고, 이들 중 최종적으로 선발된 형질전환 캘러스 클론은 pMYV611에서 3개 (0.07%), pMYV613에서 4개 (0.07%), pMYV616에서 2개 (0.02%), V621에서 51개 (0.1%), V622에서 72개 (0.15%) 및 V623에서 102개 (0.18%)를 각각 얻었다. 형질전환된 캘러스 클론으로부터 재분화된 식물체에서 유전자 도입여부를 Southern 분석으로 통해 확인한 결과 pMYV613에서 2개 식물체 및 V623에서 얻은 2개 식물체에서 각각 확인되었다.

주택 거래 활성화를 위한 정책 방안

김현아,Kim, Hyeon-A 한국주택협회 2006 주택과 사람들 Vol.194 No.-

하반기 부동산 시장은 기반시설, 부담금 신설 등 부동산 시장의 발목을 잡는 각종 규제가 시작된다. 이에 따라 하반기에 집을 사고 팔 계획이 있는 사람들은 이러한 제도를 충분히 염두에 두고 움직여야 한다고 전문가들은 충고한다. 하반기 부동산 시장을 움직일 변수에 대해 알아보자.

아메드 방수유출장치 삽입수술과 병합수술의 효과

김현아,박가희,박태관,온영훈,Hyun A Kim,Ka Hee Park,Tae Kwann Park,Young Hoon Ohn 대한안과학회 2014 대한안과학회지 Vol.55 No.4

Purpose: To evaluate surgical results after combined operation associated with Ahmed glaucoma valve (AGV) implantation. Methods: A retrospective review was performed for 71 eyes of 67 patients who underwent combined operation associated with AGV implantation from June 2003 to August 2012. Results: Pars plana vitrectomy or phacoemulsification combined with AGV implantation were performed for 16 eyes and AGV implantation alone was performed in 55 eyes. Mean IOP (mm Hg) and the number of antigluacoma agents for both the combined and single groups showed a statistically significant decrease (combined/single; <em>p</em> = 0.008/0.000, 0.002/ 0.000). Visual acuity (log MAR) was improved, but these differences were not statistically significant (combined/single; <em>p</em> = 0.309/0.052). Conclusions: Combined vitrectomy or phacoemulsification and AGV implantation for intractable glaucoma with vitreoretinal disease or cataract is considered to be the primary procedure because of its equivalent efficacy in lowering IOP, improving visual acuity and decreasing the number of glaucoma agents. J Korean Ophthalmol Soc 2014;55(4):578-584

동복호 (同福湖) 유입하천의 조류증식능에 (藻類增植能) 관한 연구

김현아,이나나,유춘만,위성욱,주현수,이종빈,위인선 ( Hyun Ah Kim,Na Na Lee,Chun Man Yu,Seong Uk Wui,Hyun Soo Joo,Jong Bin Lee,In Sun Wui ) 한국환경생물학회 1995 환경생물 : 환경생물학회지 Vol.13 No.1

On filtered and autoclaved water samples from the upper stream of Lake Tong-Bok, physico-chemical analysis and algal growth potential (AGP) test using Selenastrum capricornutum Printz were performed from October, 1991 to July, 1992 in order to assess fertility potential of the lake and to identify possible limiting nutrients. Water temperature of the lake was fluctuated from 3.8℃ to 30.7℃, the range of pH was 6.0 to 8.0, the level of dissolved oxygen ranged from 5.5㎎/ℓ to 14.4㎎/ℓ, biochemical oxygen demand varied from 0.3㎎/ℓ to 7.6㎎/ℓ, and suspended solides was fluctuated from 0.7 ㎎/ℓ to 24.5㎎/ℓ. Results of nutrient analysis were as followings. The level ammonia was from ND(<0.01㎎/ℓ) to 0.74㎎/ℓ, nitrite and nitrate were ND(<0.01㎎/ℓ) - 0.06 ㎎/ℓ, 0.09㎎/ℓ - 1.33㎎/ℓ respectively. The range of phosphate level varied from ND(<0. 01㎎/ℓ) -0.24㎎/ℓ, and total phosphorus was fluctuated 0.04㎎/ℓ - 0.63㎎/ℓ. Algal growth potentials of the filtered and filtered after autoclaved samples were 0.1 ㎎/ℓ - 21.0㎎/ℓ and 2.9㎎/ℓ - 13.9㎎/ℓ respectively during surveyed period. AGP of the filtered after autoclaved were higer than those of the filtered only except some specific sites. The points of maximum growth were measured after addition of N, P, Fe and EDTA each in comparison with unenriched (control) samples. Phosphate appeared to be the major limiting element in AGP test for a tested organism throuhgout the year, especially during spring and summer. According to trophic level by Sudo(1980), it was estimated that Tong-Bok stream was eutrophic, Nae-Puk stream was oligo-mesotrophic, and all other streams of Lake Tong-Bok were mesotropic.

투습도 측정방법에 따른 스포츠웨어용 투습직물의 투습특성

김현아,김승진,Kim, Hyun-Ah,Kim, Seung-Jin 한국의류산업학회 2017 한국의류산업학회지 Vol.19 No.4

This study investigated water vapor permeability of the 73 breathable fabrics for sports-wear according to the materials, finishing methods and fabric structural parameters. The water vapor permeability by KS K 0594 method of PET breathable fabric was superior than that of nylon one, in addition, water vapor permeability of coated or laminated breathable fabrics were higher than those of hot melt or dot laminated fabrics. The water vapor permeability of breathable fabric was dependent on the thickness, weight and density, which was consistent with measuring method. However, water vapor permeability according to materials and finishing method showed different results according to measuring method. The correlation coefficient of WVP of PET breathable fabrics between ISO and KS K measuring methods was -0.83 and the correlation coefficient of WVP of coated breathable fabrics was -0.72 and -0.71 for KS K and ASTM and -0.72 for KS K and ISO in hot melt laminated breathable fabrics. According to regression analysis, WVP of PET breathable fabric by both KSK and ISO measuring methods was highly dependent upon on the density and weight. In addition, WVP of hot melt laminated breathable fabric was highly dependent upon thickness, weight and density. Therefore, relevant measuring method for WVP of breathable fabrics has to be adopted to measure precise breathability.

미분양으로 인한 건설사들의 경영난-빠른 대책없으면 심각한 내수 침체 가능성

김현아,Kim, Hyeon-A 한국주택협회 2008 주택과 사람들 Vol.219 No.-

건설사들이 미분양과 원자재 가격 상승이라는 '이중고'에 시달리고 있다. 지방에서 시작된 미분양이 수도권까지 확산되면서 1995년의 역대 최대 미분양 사태와 비교되며 장기화될 조짐을 보이고 있다. 대외 경제 여건 악화와 원가 상승, 금리 인상까지 겹쳐 더욱더 어려워질 것으로 보이는 건설사들의 경영난을 들여다봤다.

교재중심 강의와 문제중심학습 방식이 기초의학에서 과학적 추론에 미치는 효과 비교

김현아,김각균,이승우,Kim, Hyeon-A,Kim, Kack-Kyun,Lee, Sung-Woo 대한안면통증구강내과학회 2005 Journal of Oral Medicine and Pain Vol.30 No.1

Purpose: The aim of this preliminary study was to evaluate the effect of Problem-Based Learning (PBL) curriculum on development of comprehension of basic medical knowledge and quality of semi-structured problem solving including scientific reasoning skill. This scientific reasoning contained five components including: size of simple, design of research cause-effect, construction of risk factor, analysis statistic of data, interpretation of result. Materials and Methods: Seoul National University Dental students (100) participated in this experience during two weeks, 2004. Forty eight multiple-choice questions (MCQ) concerned "Infection Control and Prevention" were asked before and after two sections of Lecture-Based Learning (LBL) and PBL (pretest-posttest control group design). A semi-structured problem in epidemiological research was asked to these students after two sections (posttest-only control group design). Data (mean and SD) were analysed using the t Test for two independent samples (p<.05), comparing PBL versus LBL. Results: Our analyse of scores show no difference between LBL and PBL in the development of comprehension of "Infection Control and Prevention". The quality problem solving (epidemiological research) was significantly different between the two groups (p=.029); specially, two components' scores of reflection on scientific reasoning cause-effect (p=.000) and interpretation of result (p=.001) were significantly better for PBL than for LBL. Conclusion: Theses results indicate that comparing LBL and PBL, PBL curriculum have not been disadvantaged in comprehension of basic knowledge, and have contributed to develop the scientific reasoning in problem solving.

미세정자주입술로 임신이 된 남자태아의 Y 염색체 미세결실의 Vertical Transmission, de novo, 그리고 Expansion의 연구

김현아,이숙환,조성원,정혜진,손수민,강수진,배성근,김수희,윤태기,Kim, Huyn-Ah,Lee, Sook-Hwan,Cho, Sung-Won,Jeong, Hye-Jin,Son, Soo-Min,Kang, Soo-Jin,Bae, Seong-Keun,Kim, Soo-Hee,Yoon, Tae-Ki 대한생식의학회 2004 Clinical and Experimental Reproductive Medicine Vol.31 No.2

Objectives: Despite severe oligospermia, males with Y chromosome microdeletion can achieve conception through ICSI (Intracytoplasmic Sperm Injection). However, ICSI may not only result in the transmission of microdeletions but also the expansion of deletion to the offspring. The purpose of this study was to screen vertical transmission, expansion of microdeletions and de novo deletion in male fetuses conceived by ICSI. Materials and Methods: A total of 32 ICSI treated patients with their 33 (a case of twin) male fetuses conceived by ICSI were used to make this study group. Sequence-tagged sites (STSs)-based PCR analyses were performed on genomic DNA isolated from peripheral blood of fathers and from the amniocytes of male fetuses. Ten primer pairs namely, sY134, sY138, MK5, sY152, sY147, sY254, sY255, SPGY1, sY269 and sY158 were used. The samples with deletions were verified at least three times. Results: We detected a frequency of 12.5% (4 of the 32 patients) of microdeletions in ICSI patients. In 4 patients with detected deletions, two patients have proven deletions on single STS marker and their male fetuses have the identical deletion in this region. Another two patients have two and three deletions, but their male fetuses have more than 3 deletions which include deletions to their father's. Meanwhile, seven male fetuses, whose fathers were analyzed to have all 10 STS markers present, have deletions present in at least one or more of the markers. Conclusions: Although the majority of deletions on the Y chromosome are believed to arise de novo, in some cases a deletion has been transmitted from the fertile father to the infertile patient. In other cases the deletion was transmitted through ICSI treatment, it is likely that one sperm cell is injected through the oocyte's cytoplasm and fertilization can be obtained from spermatozoa. Our tests for deletion were determined by PCR and our results show that the ICSI treatment may lead to vertical transmission, expansion and de novo Y chromosome microdeletions in male fetuses. Because the sample group was relatively small, one should be cautious in analyzing these data. However, it is important to counsel infertile couples contemplating ICSI if the male carries Y chromosomal microdeletions.