위식도접합부선암의 임상병리학적 특성

김한수,정오,박영규,김동의,류성엽,김영진,Kim, Han-Su,Jeong, Oh,Park, Young-Kyu,Kim, Dong-Yi,Ryu, Seong-Yeop,Kim, Young-Jin 대한위암학회 2008 대한위암학회지 Vol.8 No.4

목적: 위식도접합부선암의 임상병리학적 특성은 서구와 아시아 간의 많은 차이를 보인다고 알려져 있다. 그러나, 한국의 경우 위식도접합부선암의 유병율이 매우 낮고 이에 대한 연구 또한 부족하다. 따라서 저자들은 우식도접합부선암의 Siewert 분류에 따른 임상병리학적 특성을 조사하여 서구와 다른 국내 위식도접합부선암의 특성을 연구하고자 하였다. 대상 및 방법: 2004년 5월부터 2008년 2월까지 본원에서 위암으로 수술을 시행 받은 환자들을 대상으로 수술소견 및 병리 사진을 토대로 Siewert 분류법에 따라 위식도접합부선암을 분류하고, 의무기록을 바탕으로 환자들의 임상병리학적 특성들을 조사하였다. 결과: 위식도접합부선암은 전체 1,778예 중 70예(3.9%)였다. Siewert 1형은 3예(4.3%)로 매우 드물었으며, 2형과 3형이 각각 30예(42.8%) 37예(52.8%)였다. 2형이 3형에 비하여 평균연령이 높았으나(64세 vs 59세, P=0.049), 남녀비에는 차이가 없었다. 2형과 3형간에 Barrett 식도의 발현 정도나 Lauren 분류의 차이는 없었으나, 저분화암의 빈도는 3형에서 유의하게 높았다(P=0.045). 68예(97.1%)에서 근치적 절제가 시행되었으며, 각 아형간에 TNM 병기의 차이는 없었다. 결론: 국내의 위식도접합부선암은 매우 드물며 특히 1형의 유병율이 매우 낮다. 본 연구에서 서구의 보고와 부분적으로 일치하지 않는 병리학적 특성을 보였다. 향후 보다 많은 환자들을 대상으로 한국인의 위식도접합부선암의 특성을 연구할 필요가 있다. Purpose: Siewert's classification of adenocarcinoma of the esophagogastric junction (AEG) has been widely adopted, but there is a wide discrepancy of the clinicopathological features of AEG of the Asian patients as compared to that of the Western patients. The aim of this study was to investigate the clinicopathological characteristics of AEG according to the Siewert classification. Materials and Methods: Among the patients who underwent surgery for gastric carcinoma in our institution between May 2004 and February 2008, the AEG patients were selected based on their operation records and the photographs according to Siewert's classification. Results: There were 70 AEG patients (3.9%) among the total of 1,778 patients. There were 3 patients (4.3%) with type I, 30 patients (42.8%) with type II and 37 patients (52.8%) with type III. Curative resection (R0) was achieved in 68 cases (97.1%). No significant differences in gender, stage, Barrett's esophagus and the proximal margin were found between the patients with type II and type III AEG. The patients with type III were younger than the patients with type II (59 vs 64 years, respectively, P=0.049). Well differentiated histology (P=0.045) and the intestinal type (P=0.055) were significantly more frequent in the patients with type II as compared with that in the patients with type III. Conclusion: There was a striking difference of the Asian patients from the Western patients for the incidence of AEG (and especially type I). Some of the differences between type II and type III patients were similar to those of the previous Western studies. A large study is needed to investigate whether these features are typical in the Korean population.

피부화상에 의한 피부 및 간의 조직학적 변화에 관한 연구

김한수,김상수,김용권,Kim, Han-Soo,Kim, Sang-Soo,Kim, Yong-Kwon 대한물리치료과학회 2001 대한물리치료과학회지 Vol.8 No.1

In order to investigate a pathogenesis of liver damage induced by skin burn, thermal injury was induced by scald burn on entirely dorsal surface in rats (total body surface area 30%) except for inhalated injury. At 5 and 24 h after scald bum, biochemical assay and morphological changes in skin tissue, serum and liver tissue were examined. The effects of bum injury on the levels of glutathione, lipid peroxide and on the activities of oxygen free radical generating and scavenging enzymes have been determined in association with observing of histologic and ultrastructural changes, measuring the protein concentration in plasma, and counting the number of intravascular polymorphonuclear leukocytes. The activity of xanthine oxidase, an enzyme of oxygen free radical generating system. was elevated (p<0.01) in serum, but not in skin and in liver tissue. Futhermore, thermal injury decreased not only the protein concentration in plasma but also the number of leukocytes, that indicates induction of edema formation with protein exudation and inflammation by neutrophil infiltration into the internal organs. These data suggest that acute dermal scald burn injury leads to liver damage, that is related to elevation of xanthine oxidase activity in serum. Xanthine oxidase may be a key role in the pathogenesis of liver damage induced by skin burn.

몰로키아 분말을 첨가한 밀·보리 혼합 식빵의 제조 및 생리활성 평가

김한수,김영호,김애정,Kim, Han soo,Kim, Young Ho,Kim, Ae Jung 한국식품영양학회 2015 韓國食品營養學會誌 Vol.28 No.4

This study was performed to produce WBM (wheat and barley mixture) bread containing molokhia powder with quality characteristics and antioxidant activities. Analysis of the chromaticity of WBM prepared with molokhia powder showed that; the lightness and redness were decreased, but yellowness was increased. In mechanical properties, hardness, gumminess, and chewiness were significantly increased as the amount of molokhia powder was increased. However, cohesiveness was significantly decreased. In sensory evaluation, WBM bread containing 1.5% of molokhia powder (MB1.5) showed an overall high preference level. The total polyphenol content of molokhia powder EtOH extract and MB1.5 were 29.19 and 58.18 mg TAE/g, respectively. The total flavonoid contents of molokhia powder EtOH extract and MB1.5 were 20.62 mg and 33.25 mg RE/g, respectively. The radical scavenging ability ($IC_{50}$) of DPPH ($IC_{50}$) for molokhia powder EtOH extract and MB1.5 was 31.04 and $58.18{\mu}g/mL$, respectively while that of ABTS was 33.25 and $54.15{\mu}g/mL$, respectively. The ${\alpha}-glucosidase$ inhibitory effects of molokhia powder EtOH extract and MB1.5 were 494.88 and $814.88{\mu}g/mL$, respectively. MB bread containing 1.5% molokhia powder showed antioxidative effects and ${\alpha}-glucosidase$ inhibitory activity, meaning that not only molokhia but also MB1.5 bread has the potential to prevent chronic degenerative diseases such as diabetes.

경추견인: 문헌고찰과 치료지침

김한수,이용덕,권원안,Kim Han-Soo,Lee Yong-Deok,Kwon Won-An 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.3

Traction has been used since ancient times in the treatment of painfull spinal conditions, but the literature on traction and its clinical effectiveness Is limited. Traction can be defined as a drawing or pulling tension applied to a body segment. Cervical traction is a technique that applies a longitudinal force of the cervical spine and associated structures. Goals of traction include reduction of radicular signs and symptoms associated with conditions such as disk protrusion, degenerative disk disease, lateral stenosis, muscle spasm, and subluxations. The various mechanical factors most relevant to cervical traction are organized and discussed. The factors presented are 1) angle of pull, 2) Traction force, 3) duration of traction, 4) neck position and clinical application, and 5) frequency of treatment. It should allow physical therapists to adjust traction protocol to match the patient's symptoms and diagnosis. The purpose of this study is to provide a comprehensive overview of the cervical traction and treatment guidelines.

음도 고정 시 강도 변화에 따른 일반인과 성악인 발성의 성대접촉률 변화 특성의 비교

김한수,전용선,정성민,조근경,박은희,Kim, Han-Su,Jeon, Yong-Sun,Chung, Sung-Min,Cho, Kun-Kyung,Park, Eun-Hee 대한후두음성언어의학회 2005 대한후두음성언어의학회지 Vol.16 No.1

Background and Objectives : The most important two factors of the voice production are the respiratory function which is the power source of voice and the glottic closure that transform the air flow into sound signals. The purpose of this study was to investigate the differences between trained singers and untrained controls under varying intensity at a constant vocal pitch by simulataneous using the airway interruption method and electroglottography(EGG). Materials and Methods : Under two different intensity condition at a constant vocal pitch(/G/), 20(Male 10, Female 10) trained singers were studied. Mean flow rate(MFR), subglottic pressure(Psub) and intensity were measured with aerodynamic test using the Phonatory function analyzer. Closed quotients(CQ), jitter and shimmer were also investigated by electroglottography using Lx speech studio. These data were compared with that of normal controls. Results : MFR and Psub were increased on high intensity condition in all subject groups but there was no statistically significance. Statistically significant increasing of CQ. were observed in male trained singers on high intensity condition (untrained male : 51.31${\pm}$3.70%, trained male :55.52${\pm}$6.07%, p=.039). Shimmer percent, one of the phonatory stability parameters, was also decreased statistically in all subject groups(p<.001). Conclusion : The trained singers' phonation was more efficient than untrained singers. The result means that the trained singers can increase the loudness with little changing of mean flow rate, subglottic pressure but more increasing of glottic closed quotients.

외래 시행 성대주입술을 위한 마취 방법

김한수,Kim, Han Su 대한후두음성언어의학회 2020 대한후두음성언어의학회지 Vol.31 No.2

Vocal fold injections are usually performed with a patient wake in an office under local anesthesia. For comfortable and safe office-based procedures, thorough anesthesia and premedication should be provided to the following three regions; nasal cavity, oropharynx, and larynx. Topical lidocaine is most widely used anesthetics on office based procedure. Lidocaine has a low to intermediate potency, 45 minutes to 60 minutes' duration of action, and onset of sufficient anesthesia within 90 seconds of topical administration. Tetracaine, prilocaine, ropivacaine, and bupivacaine also have been used in the office-based procedures. Nasal decongestant, oxymetazoline, is also used for widening nasal cavity by constriction of nasal mucosa. The amount of topical and local anesthetics used in vocal fold injection rarely exceeds toxic doses. The physician should know proper anesthesia techniques and must be familiar with the safe dose and complication of all anesthetics used.

다운제품의 선택과 취급

김한수,Kim, Han-Su 기술표준원 2005 기술표준 Vol.37 No.-

음성인식프로그램을 이용한 무후두 음성의 말 명료도와 병적 음성의 수술 전후 개선도 측정

김한수,최성희,김재인,임재열,최홍식,Kim, Han-Su,Choi, Seong-Hee,Kim, Jae-In,Lee, Jae-Yol,Choi, Hong-Shik 대한후두음성언어의학회 2004 대한후두음성언어의학회지 Vol.15 No.2

Background and Objectives : The purpose of this study was to examine objectively pre and post operative voice quality evaluation and intelligibility of alaryngeal voice using speech recognition program, HUVOIS. Materials and Methods : 2 laryngologists and 1 speech pathologist were evaluated 'G', 'R', 'B' in the GRBAS sclae and speech intelligibility using NTID rating scale from standard paragraph. And also acoustic estimates such as jitter, shimmer, HNR were obtained from Lx Speech Studio. Results : Speech recognition rate was not significantly different between pre and post operation for pathological vocie samples though voice quality(G, B) and acoustic values(Jitter, HNR) were significantly improved after post operation. In Alaryngeal voices, reed type electrolarynx 'Moksori' was the highest both speech intelligibility and speech recognition rate, whereas esophageal speech was the lowest. Coefficient correlation of speech intelligibility and speech recognition rate was found in alaryngeal voices, but not in pathological voices. Conclusion : Current study was not proved speech recognition program, HUVOIS during telephone program was not objective and efficient method for assisting subjective GRBAS scale.

Dy₂O₃-TiO₂ 산화물의 소결성 및 소결체 특성에 관한 연구

김한수,정창용,김시형,이병호,이영우,손동성,이상현,Kim, Han-Soo,Joung, Chang-Yong,Kim, Si-Hyung,Lee, Byoung-Ho,Lee, Young-Woo,Sohn, Dong-Seong,Lee, Sang-Hyun 한국세라믹학회 2002 한국세라믹학회지 Vol.39 No.11

산화물 제어봉 물질로서 $Dy_xTi_yO_z$ 소결체를 powder process에 의해 제조하였다. $Dy_2O_3+TiO_2$ 혼합분말의 소결성과 고용체의 상을 TMA와 XRD로써 각각 분석하였으며, 소결체의 비열과 열확산계수를 측정하여 열전도도를 구하였다. $Dy_xTi_yO_z$에서 Dy의 함량에 따라 소결성과 밀도가 변하였고 $3\;g\;Dy/cm^3\;Dy_xTi_yO_z$의 경우 $1580{\circ}C$의 소결온도에서 용융이 일어났다. $4.00\;g\;Dy/cm^3$ 소결체에는 $Dy_2TiO_5+Dy_2Ti_2O_7$의 두 상이 존재하며 $4.54\;g\;Dy/cm^3$의 경우 $Dy_2TiO_5$의 단일 상만이 존재하는 결과를 보였다. $Dy_xTi_yO_z$의 열전도도는 $25~600{\circ}C$ 범위에서 온도에 따라 큰 변화가 없으며 $1600{\circ}C$ 소결체가 1.69∼1.78 W/mK, 1550$^{\circ}C$ 소결체의 경우에는 1.49~1.55 W/mK이었다. .$Dy_xTi_yO_z$ pellets were fabricated as a reactor control material by the powder process. Sinterability of $Dy_2O_3+TiO_2$ mixtures and phases of solid solutions were analyzed by using TMA and XRD, respectively. The thermal conductivity of .$Dy_xTi_yO_z$ pellet was determined from the measurement data of the specific heat and the thermal diffusivity of the pellet. The sinterability and the sintered density varied as a function of Dy content in $Dy_xTi_yO_z$. The pellet of $3\;g\;Dy/cm^3\;Dy_xTi_yO_z$ melted in the sintering temperature of $1580{\circ}C$. There were two phases of $Dy_2TiO_5+Dy_2Ti_2O_7$ and a single phase of $Dy_2TiO_5$ for the pellet that has the Dy content of .$4.00\;g\;Dy/cm^3$ and .$4.54\;g\;Dy/cm^3$, respectively. The thermal conductivity of $Dy_xTi_yO_z$ was nearly constant in the temperature range of $25~600{\circ}$. It was 1.69~1.78 W/mK for the pellet sintered in .$1600{\circ}$ and 1.49~1.55 W/mK for the pellet sintered in $1550{\circ}$.

근력강화 운동프로그램이 노인의 균형증진에 미치는 영향

김한수,김상수,이동호,Kim Han-Soo,Kim Sang-Soo,Lee Dong-Ho 대한물리치료학회 2002 대한물리치료학회지 Vol.14 No.3

The purpose of this study was to investigate the effects of strengthening exercise program on the improvement of balance in the elderly Subjects were forty members living in Daegu (20 males, 20 females), between 65 and 81 years of age. The subjects were divided into two groups; an experimental group and a control group, and each group included 10 males and 10 females. The subjects for the experimental group were participated in the strengthening exercise program for 8 weeks, between April 2001 and June 2001 The results of this study were as follows: 1. General characteristics statistically significantly affecting for CTSIB were mental status; weight, height, vision, systolic blood pressure, diastolic blood pressure, pulse rate, mental status, obesity and thigh BMD were BBT; age, weight, height, vision, blood pressure systolic, blood pressure diastolic, blood pulse rate, mental status, obesity, spine BMD and thigh BMD were for OLST. 2. After the exercise program, there was no significant difference in the balance ability between the experimental group and the control group in CTSIB. However, there was a significant difference in OLSTR on the hard (p<0.05) and soft (p<0.05) surface with open eyes condition between the experimental group and the control group. In the case of OLSTL, there was a significant difference on the hard surface with open eyes condition (p<0.05), and on the soft surface with open eyes condition (p<0.05) and closed eyes condition (p<0.05) between the experimental group and the control group. There was no significant difference in the balance ability between the experimental group and the control group in BBT.