급성 골수성 백혈병에서 고용량 Cytarabine 을 이용한 공고요법

김도하(Do Ha Kim),이규형(Kyoo Hyung Lee),조재근(Jae Kun Cho),김선희(Seon Hee Kim),이제환(Je Hwan Lee),김성배(Sung Bae Kim),김상위(Sang We Kim),서철원(Chul Won Suh),이정신(Jung Shin Lee),김우건(Woo Kun Kim),김상희(Sang Hee Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.4

Objectives: This study was designed to evaluate the therapeutic efficacy of postremission therapy utilizing high-dose cytarabine in patients with newly diagnosed acute myelogenous leukemia and to assess the toxicities of the therapy. Acute promyelocytic leukemia (FAB M3) is excluded because it has very unique clinicopathologic characteristics. Methods: Those patients who achieved complete remission had first consolidation therapy with conventional dose cytarabine and daunorubicin but second and third consolidation was done with high-dose cytarabine (cytarabine 1gm/㎡ i.v. over 1 hour every 12 hours daily for 5 days) and daunorubicin. Overall survival and disease free survival were compared with previous conventional dose cytarabine and daunorubicin postremission therapy. Results: 1) Complete remission occurred in 62% (28 of 45 patients) and control group 48% (14 of 29 patients) (p=0.15). 2) The median survival of all 45 patients was not different significantly compared with control group (10 months vs 7 months, p=0.08). 3) The median disease free survival of 21 complete responders receiving at least one course of consolidation was 10 months and there was no significant difference compared with control group 7 months (p=0.47). 4) The toxicity including treatment-related motility, neutropenia duration was similar in both groups. Conclusion: Although our high-dose cytarabine consolidation therapy regimen appeared to have acceptable toxicity, its results did not show the superiority to previous conventional dose cytarabine consolidation regimen.

수위강하곡선을 이용한 함양량 추정기법의 국가 지하수 관측소 지하수위 자료에의 적용성 평가

김규범 ( Gyoo Bum Kim ),이명재 ( Myeong Jae Yi ),김정우 ( Jeong Woo Kim ),이진용 ( Jin Yong Lee ),이강근 ( Kang Kun Lee ) 대한지질공학회 2004 지질공학 Vol.14 No.3

ADSL 시스템의 Crosstalk 영향에 따른 전송속도 분석 및 시뮬레이터 개발

김찬문(Chan-moon Kim),나용욱(Yong-Wook Na),송상섭(Sagn-Seob Song),이재진(Jae-Jin Lee),진근하(Kun-ha Jin),김형배 한국통신학회 2000 한국통신학회 학술대회논문집 Vol.2000 No.11

급성 심근 경색 환자에서 좌심실 기능 , 좌심방 기능 및 폐정맥 혈류 양상의 변화

김복근(Bok Kun Kim),주승재(Seung Jae Joo),배영환(Young Hwan Bae),박선미(Sun Mi Park),최진(Jin Choi),최휘(Hwi Choi),윤병철(Byung Chul Yoon),오원섭(Won Sub Oh),구양훈(Yang Hwun Koo),홍성준(Sung Jun Hong),김진(Jin Kim),박능화(Neung Hwa 대한내과학회 1997 대한내과학회지 Vol.53 No.6

Objectives: Acute myocardial infarction decreases left ventricular systolic and diastolic function. Left ventricular diastolic function is usually assessed with the left ventricular filling patterns. Abnormal left ventricular tilling patterns after acute myocardial infarction can be classified as relaxation abnormality, pseudonormalization, and restriction, but sometimes the differentiation between pseudonormalization and the normal pattern is difficult. To assess left ventricular systolic and diastolic function, and left atrial function after acute myocardial infarction, M-mode, two-dimensional, pulsed Doppler, and automated border detection echocardiography were performed. To complement the information obtainable from the mitral flow patterns, pulmonary venous flow patterns were also analysed to assess the left ventricular filling patterns. Methods: Twenty six patients (mean age 60 ±10) underwent echocardiographic examination 7 to 14 days after acute myocardial infarction. Twenty healthy persons(mean age 57±12) were served as a control group. Various indexes were obtained with M-mode, two-dimensional, pulsed Doppler, and automated border detection echocardiography Results: 1) Mean age, sex ratio, heart rate, body mass index were not different between patient and control groups. There were five patients with hypertension in patient group. Left ventricular mass index of patient group was greater than that of control group (163±43g/㎡ vs. 109±22g/㎡, P<0.0D1). 2) Patients had decreased cardiac index(2.35±0.53L/min/㎡ vs. 3.02±0.70L/min/㎡, P<0.05) and left ventricular ejection fraction(55±12% vs. 62± 0.4%). There was a negative correlation between left ventricular regional wall motion score and ejection fraction(r=-0.71; P<0.001). 3) In patients, peak mitral flow velocity at atrial contraction(A) was higher(73±11cm/sec vs. 63±13 cm/sec; P<0.01), E/A ratio was lower(0.77±0.28 vs. 1.01±0.25; P<0.01), and left ventricular isovolumic relaxation time was longer(126±34msec vs. 97±21msec; P<0.005). 4) Patients had smaller systolic time-velocity integral(13.0±3.30cm vs. 14.8±2.83cm, P=0.056) and diastolic time--velocity integral(9.18±2.21cm vs. 11.2±2.77cm, P<0.01). 5) Relaxation abnormality of left ventricular filling patterns, which was classified by E/A ratio of less than 1, was more frequently founded in patients than in controls(45%). Four patients had E/A ratio of greater than 1; SV/DV ratio was greater than 1 in two and less than 1 in others. 6) End-diastolic area of left atrium(minimal area) was larger in patients(11±1.9㎠ vs. 9.6+1.4㎠, P<0.01). Therefore, patients showed decreased atrial emptying index and expansion index. Patients had a greater extent of left atrial area decrease resulting from atrial contraction. Conclusion: Patients with acute myocardial infarction showed a decreased left ventricular systolic function and a relaxation abnormality 7 to 14 days after attack, Minimal area of left atrium increased and left atrial function decreased.

복부 초음파 검사 보편화 시대의 소아 장중첩증의 임상적 고찰 - 소장형과 대장형의 비교 -

김완성,정진호,이종훈,박재균,문현종,신혁재,이종인,Kim, Wan-Sung,Jeong, Jin-Ho,Lee, Jong-Hoon,Park, Jae-Kun,Moon, Hyoun-Jong,Shin, Hyuk-Jai,Lee, Jong-In 대한소아외과학회 2011 소아외과 Vol.17 No.1

We analyzed the clinical characteristics and outcome of ileocecal and small bowel intussusceptions (ICI and SBI) in the pediatric patients. From August 2003 to July 2010, 144 children with intussusception were included in this study. We retrospectively reviewed the clinical records and Imaging study findings. A total of 86 children with ICI and 58 children with SBI were diagnosed. Children with SBI were older than ICI ($36.6{\pm}24.6$ months vs. $24.2{\pm}21.6$ months, p=0.002). Typical symptoms such as irritability, abdominal mass, bloody stool were more frequent in ICI than SBI (p<0.05) patients. In the ICI group, intussusceptums were reduced with air reduction (84.5%), surgery (17.4%), and spontaneity (1.2%). All patients in the SBI group were reduced spontaneously. SBI occurred in older age and was reduced spontaneously more frequently than ICI. Conservative management with close observation with follow-up by ultrasonography is recommended for SBI.

땅콩의 근류형성(根瘤形成)과 질소고정(窒素固定)에 대한 근류균(根瘤菌) 접종방법(接種方法)의 영향(影響)

김무기,소재돈,박건호,최대웅,Kim, Moo-Key,So, Jae-Don,Park, Kun-Ho,Choi, Dae-Ung 한국토양비료학회 1992 한국토양비료학회지 Vol.25 No.1

Effective strains of cowpea bradyrhizobia JB7 $nal^rspe^r$ and CB756 $str^rrif^r$, antibiotic-resistant variants of JB7 and CB756, respectively, were used to examine changes of rhizosphere populations and nodule occupancy. Populations of each strain increased gradually in the rhizosphere, reaching a maximum of about $10^8$ cells per root system. Nodule number increased as the density of inoculum increased from $10^2$ cells to $10^8$ cells per seed. Inoculation with liquid suspension resulted in the formation of more nodules than the peat slurry or granule inoculation. When JB7 $nal^rspe^r$ and CB756 $str^rrif^r$ were introduced in equal numbers in inoculum mixtures the former consistantly occupied the majority of nodules with all three groundnut cultivars used. There was no difference in yield between nitrogen treatments and inocultation treatments. 항생제 내성 변이균주 JB7 $nal^rspe^r$와 CB756 $str^rrif^r$을 이용하여 살균하지 않은 밭토양에서 접종방법이 근류균의 증식과 근류형성 및 질소고정에 미치는 영향을 조사하였다. JB7 $nal^rspe^r$균주(菌株)를 종자당 $10^2$에서 $10^8$세포수준으로 접종(接種)했을때 접종농도(接種濃度)의 증가와 함께 근류형성(根瘤形成)이 증가하였다. 접종방법별(接種方法別)로는 YMB배양 액체접종(液體接種)이 Peat slurry나 Peat입자(粒子) 접종(接種)보다 더 많은 근류(根瘤)를 형성(形成)했고, Peat slurry와 입자(粒子) 접종간(接種間)에는 차이가 없었다. 토양(土壤) g당 $10^3$ 세포(細胞)의 근류균(根瘤菌)을 함유(含有)하는 토양(土壤)에 JB7 $nal^rspe^r$와 CB756 $str^rrif^r$을 혼합(混合)하여 접종(接種)했을때 모든 근류(根瘤)가 접종균(接種菌)에 의하여 형성되었으며, JB7 $nal^rspe^r$균주(菌株)에 의한 근류점유율이 월등히 높았다. 품종간에 근류점유율의 차이는 없었다. 접종균류(接種菌株)는 근권에서 점진적으로 증식되었으며, JB7 $nal^rspe^r$가 더 큰 폭으로 증가되었다. 땅콩의 수량은 무접종구보다 접종구가 높았으나 질소처리구(窒素處理區)와 접종구간에는 차이가 없었다.

3차원 인텐시티 프로브의 근거리 음장 측정에서의 오차 수치해석

김석재,지석근,김천덕,Kim, Suk-Jae,Jee, Suk-Kun,Suzuki, Hideo,Kim, Chun-Duck 한국음향학회 1994 韓國音響學會誌 Vol.13 No.3

이 연구에서는 3차원 음향 인텐시티를 동시에 측정할 수 있는 프로브를 이용하여 음향 인텐시티를 측정할 때 필연적으로 발생하는 오차를 컴퓨터의 수치계산으로 검토하였다. 이 3차원 음향 인텐시티 프로브는 Suzuki등에 의해 제안된 4개의 마이크로폰으로 구성된 것이고, 수치계산에서는 이상적인 점음원과 유한 크기를 가지는 면음원에 대해서 프로브의 각 축방향 및 임의의 방향에 대한 측정오차를 근거리 음장에서 분석하였다. 그 결과, 점음원의 경우 측정거리가 프로브를 구성하는 마이크로폰 사이의 간격보다 약 2.5배 이상 떨어진 거리에서 오차 1dB 이하의 정밀한 측정을 할 수 있었고, 유한 크기의 면음원의 경우, 면음원의 한 변의 길이가 0.02m이상일 때 근거리 음장의 측정오차가 크게 감소하기 시작하여, 한 변의 길이가 0.2m일 때 측정거리가 마이크로폰 사이의 간격보다 0.67배로 근접하여 측정하여도 1dB 이하의 정밀한 측정이 가능한 것으로 평가되어 이 프로브의 근거리 음장 측정의 유효성이 확인되었다. We studied an inherent error be caused by a measuring acoustic intensity using probe which can measure simultaneously the three-dimensional acoustic intensity. This three-dimensional intensity probe was constructed with four microphones, proposed by Suzuki et al. . In the computer simulation, we analyzed the nearfield measurement error with arbitary direction and each of axis direction on the ideal point source and the plate sound source which have finite size. From the results, in case of point source, we obtained accurate measurement below about 1dB when the distance of measurement was about 2.5 times with the distance among microphones in this probe. And in the case of plate sound source, the nearfield measurement error was decreased as the length of one side became above 0.02m, we obtained accurate measurement below about 1dB when the length of one side is 0.2m. The nearfield measurement error of finite size sound is small to ignore. Therefore this probe is useful to measure nearfield intensity.

토끼 태아에서 표피성장인자 투여가 코티졸 , 티록신 , 프로락틴의 생성에 미치는 영향

김수평(Soo Pyung Kim),신종철(Jong Chul Shin),이종건(Jong Kun Lee),김용욱(Yong Wook Kim),변태섭(Tae Sup Byun),신재인(Jae In Shin),이종승(Chong Seong Yi),나종구(Jong Gu Rha) 대한산부인과학회 1998 Obstetrics & Gynecology Science Vol.41 No.12

Respiratory distress syndrome (RDS) is a major cause of death in premature neonates, and it is caused by the failure of morphological and biochemical lung maturation (synthesis and secretion of lung surfactant). It is known that cortisol, thyroxine, prolactin, epidermal growth factor (EGF), and estrogen accelerate the lung maturation. Cortisol and thyroxine are currently used in the antenatal treatment for the prevention of RDS in premature neonates. In order to evaluate the effect of EGF on the levels of cortsol, thyroxine, and prolactin, this study was undertaken. Phosphate buffered saline (PBS) with and without EGF was directly injected into the 25 days gestational fetus in uterus. Blood was collected for the measurement of cortisol, thyroxine, and prolactin one day or two days after the injection. Body weights and lung weights were also measured. The results were as follows: 1. There was no significant difference in body weights and lung weights between PBS-treated group(control group) and EGF-treated poup(experimental group), 24 hours and 48 hours after the injection. 2. 24 hours after the injection, the levels of cortisol were significantly inaeased in the EGF-treated group compared with those in the PBS-treated group. However 48 hours after the injection, there was no significant difference in the levels of cortisol between the two groups. The levels of thyroxine and prolactin in the EGF-treated group did not significantly differ from those in the PBS-treated group 24 hours and 48 hours after the injection. In conclusion, in vivo, the synthesis of cortisol may be affected by EGF treatment, which suggests that the action of EGF for lung maturation may be partially mediated by the increased endogenous levels of cortisol.

FMM에 의한 프랙탈 안테나 고속 해석

김요식(Yo-Sik Kim),이광재(Kwang-Jae Lee),김건우(Kun-Woo Kim),오경현(Kyung-Hyun Oh),이택경(Taek-Kyung Lee),이재욱(Jae-Wook Lee) 한국전자파학회 2008 한국전자파학회논문지 Vol.19 No.2

본 논문에서는 FMM(Fast Multipole Method)을 적용하여 평면형 다층 구조인 마이크로스트립 프랙탈 안테나 구조에 대한 고속 해석을 구현하였다. 우선 FMM 알고리즘에 이용되는 적분식인 MPIE(Mixed Potential Integral Equation)을 풀기 위해서 실수축 적분 방법(RAIM: Real-Axis Integration Method)으로부터 정확한 공간 영역 그린 함수를 구한다. 구해진 그린함수를 MoM(Method of Moment)을 이용하여 계산할 경우, 연산과 메모리 요구량 O(N²)이 소요되는데, 이를 거대 구조의 해석에 대해 적용할 때나 높은 정확성을 위한 셀(미지수 N) 수의 증가하는 경우 계산량이 기하급수적으로 증가하여 구조 해석에 문제가 된다. FMM은 이와 같은 연산과 메모리 요구량의 문제점을 해결하기 위하여 개발되었다. FMM은 그린함수의 가법 정리(addition theorem)를 이용하여 행렬-벡터 곱의 복잡성을 줄여 연산과 메모리 요구량을 O(N<SUP>1.5</SUP>)으로 줄인다. 시어핀스키(sierpinski) 프랙탈 안테나의 구조에 대해 MoM과 FMM를 적용, 상용 툴과 계산 결과의 정확성, 계산 시 메모리 크기, 해석 시간 등을 비교하여 효율성을 보여주었다. In this paper, we present a fast analysis of multilayer microstrip fractal structure by using the fast multipole method (FMM). In the analysis, accurate spatial green’s functions from the real-axis integration method(RAIM) are employed to solve the mixed potential integral equation(MPIE) with FMM algorithm. MoM's iteration and memory requirement is O(N²) in case of calculation using the green function. the problem is the unknown number N can be extremely large for calculation of large scale objects and high accuracy. To improve these problem is fast algorithm FMM. FMM use the addition theorem of green function. So, it reduce the complexity of a matrix-vector multiplication and reduce the cost of calculation to the order of O(N<SUP>1.5</SUP>). The efficiency is proved from comparing calculation results of the moment method and Fast algorithm.

뇌졸중환자의 상,하지 근활성도에 대한 탄력밴드 운동의 효과

김남정 ( Nam Jung Kim ),김현수 ( Hyun Soo Kim ),오재근 ( Jae Kun Oh ),이복환 ( Bock Hwan Lee ) 한국운동생리학회(구-한국운동과학회) 2006 운동과학 Vol.15 No.4