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김익용,조남천,윤광수,김대성,노병선,김수용 ( Ik Yong Kim,Nam Choen Cho,Kwang Soo Yoon,Dae Sung Kim,Byeong Sun Rhoe,Soo Yong Kim ) 대한소화기학회 1992 대한소화기학회지 Vol.24 No.6
To investigate the prognostic value of histologic and clinical factors in the primary gastrointestinal (GI) lymphoma, the clinicopathologic findings in 27 cases with GI lymphoma were reviewed. The lymphomas were reviewed. The lymphomas were located in stomach in 9 cases, small intestine in 7 cases, ileocecal area in 7 cases and large intestine in 4 cases. the mean age was 37.8 years (range 5 to 74 years), there were 18 men and 9 women. Common signs and/or symptoms at presentation were pain (N=27), palpable mass (N=13), bleeding (N=6) and weight loss (N=4). The clinical stage at time of operation was stage I, 29.6%, stage II, 37.0% stage III, 29.6 and the stage IV was 3.7% and resectability according to the location of the lesion were 88%, 42%, 85% and 75% respectively for stomach, small bowel, ileocecal area and large bowel tract. The histopathologic types according to the Working Formulation Classification were high grade (N=6), intermediate grade (N=19) and lower grade (N = 12). The most important factor for favorable prognosis was post-operative combined adjuvant therapy (p<0.05).
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Anaphase-Promoting Complex 7 is a Prognostic Factor in Human Colorectal Cancer
김익용,권혜연,박광화,김대성 대한대장항문학회 2017 Annals of Coloproctolgy Vol.33 No.4
Purpose: The anaphase-promoting complex (APC) is a multiprotein complex with E3 ubiquitin ligase activity and is required for ubiquitination of securin and cyclin-B. Several APC-targeting molecules are reported to be oncogenes. Dysregulation of APC may be associated with tumorigenesis. This study examines the relationship between APC expression and clinicopathological factors and evaluates the possibility of an aberrant APC function in colorectal carcinomas (CRCs). Methods: To determine whether the loss of APC7 expression is related to tumorigenesis, we used tissue micro-arrays in 114 resected CRCs to scrutinize the expressions of APC7 and Ki-67 immunohistochemistry and to find relations with clinocopathologic parameters. The expression of APC7 was defined as positive for summed scores of staining intensities from 0 to 3+. Results: Forty-four cases (67.7%) of colon cancer and 38 cases (77.6%) of rectal cancer showed immunopositive reactions to APC. The grade of APC expression was not statistically correlated with tumor location, age, T or TNM stage, or differentiation. However, the expression of APC did correlate with the expression of Ki-67 and to the tumor recurrent. Higher APC expression showed the better 5-year overall survival rate in 74% of grades 2, 3 groups (high expression) than 57% of grades 0, 1 groups (lower expression) respectively (P = 0.042). Conclusion: Positive APC expression may be a good prognostic factor for patients with CRC, and the loss of APC expression in tumor tissue may be related with the risk for recurrence and a poor survival rate compared to high APC expression. Further study of APC in controlling the cell cycle as aberrant function in CRC is needed.
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