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      • KCI등재

        Sweet Bee Venom의 rat를 이용한 4주 반복 근육시술 독성시험

        권혜연,권기록,Kwon, Hae-Yon,Kwon, Ki-Rok 대한약침학회 2011 Journal of pharmacopuncture Vol.14 No.1

        Objective: This study was performed to analyse four weeks repeated -dose toxicity of Sweet Bee Venom (SBV-pure melittin, the major component of honey bee venom) in rats. Methods: All experiments were conducted under the regulations of Good Laboratory Practice (GLP) at Biotoxtech Company, a non-clinical study authorized institution. Male and female rats of 5 weeks old were chosen for the pilot study of four weeks repeated-dose toxicity and was injected at the level of 0.56 mg/kg body weight (eighty times higher than the clinical application dosage as the high dosage), followed by 0.28 and 0.14 mg/kg as midium and low dosage, respectively. Equal amount of normal saline was injected as the control group every day for four weeks. Results: 1. No mortality was witnessed in all of the experiment groups. 2. All experiment groups appealed pain sense in the treating time compared to the control group, and side effects such as hyperemia and movement disorder were observed around the area of injection in all experiment groups, and the higher dosage in treatment, the higher occurrence in side effects. 3. Concerning weight measurement, neither male nor female groups showed significant changes compared to the control group. 4. Concerning to the CBC and biochemistry, all experiment groups didn't show any significant changes compared to the control group. 5. Concerning weight measurement of organs, experiment groups didn't show any significant changes compared to the control group. 6. To verify abnormalities of organs and tissues, those such as cerebellum, cerebrum, liver, lung, kidney, and spinal cords were removed and we conducted histologocal observation with H-E staining. Concerning the histologocal observation of liver tissues, some fatty changes were observed around portal vein in 0.56 mg/kg experiment group. But another organs were not detected in any abnormalities. 7. The proper high dosage of SBV for the thirteen weeks repeated test in rats may be 0.28 mg/kg in one time. Conclusion: Above findings suggest that SBV is relatively safe treatment medium. Further studies on the subject should be conducted to yield more concrete evidences.

      • KCI등재후보

        Outcomes of Laparoscopic Gastrectomy after Endoscopic Treatment for Gastric Cancer: A Comparison with Open Gastrectomy

        권혜연,형우진,이중호,이상길,노성훈 대한위암학회 2013 Journal of gastric cancer Vol.13 No.1

        Purpose: Additional gastrectomy is needed after endoscopic resection for early gastric cancer when pathology confirms any possibility of lymph node metastasis or margin involvement. No studies depicted the optimal type of surgery to apply in these patients. We compared the short-term and long-term outcomes of laparoscopic gastrectomy with those of open gastrectomy after endoscopic resection to identify the optimal type of surgery. Materials and Methods: From 2003 to 2010, 110 consecutive patients who underwent gastrectomy with lymphadenectomy either by laparoscopic (n=74) or by open (n=36) for gastric cancer after endoscopic resection were retrospectively analyzed. Postoperative and oncological outcomes were compared according to types of surgical approach. Results: Clinicopathological characteristics were comparable between the two groups. Laparoscopic group showed significantly shorter time to gas passing and soft diet and hospital day than open group while operation time and rate of postoperative complications were comparable between the two groups. All specimens had negative margins regardless of types of approach. Mean number of retrieved lymph nodes did not differ significantly between the two groups. During the median follow-up of 47 months, there were no statistical differences in recurrence rate (1.4% for laparoscopic and 5.6% for open, P=0.25) and in overall (P=0.22) and disease-free survival (P=0.19) between the two groups. Type of approach was not an independent risk factor for recurrence and survival. Conclusions: Laparoscopic gastrectomy after endoscopic resection showed comparable oncologic outcomes to open approach while maintaining benefits of minimally invasive surgery. Thus, laparoscopic gastrectomy can be a treatment of choice for patients previously treated by endoscopic resection.

      • KCI등재

        R&D Spillovers for Public R&D Productivity

        권혜연,권일웅 연세대학교 동서문제연구원 2019 Global economic review Vol.48 No.3

        This paper empirically investigates whether the productivity of a public (government-funded) R&D project improves when the aggregate R&D investment in the same technology field increases. Based on the unique project level data that cover almost entire public R&D projects in Korea, this paper shows that aggregate investment in other public R&D projects in the same technology field increases a public R&D project’s outputs both independent of its project expenditure (additive spillover effects) and interactive with its project expenditure (multiplicative spillover effects). The spillover effects from the aggregate private R&D investment in the same technology field also exist, but to a much lesser extent.

      • KCI등재후보

        혈역학 감시의 일반적 원칙

        권혜연,장지영,배금석,심홍진 대한외상중환자외과학회 2017 Journal of Acute Care Surgery Vol.7 No.1

        Hemodynamic monitoring continuously checks hemodynamic variables for problems so that the clinician can treat them when a patient’s vital signs are unstable. There are many different monitoring systems, and many new technologies were developed over the past three decades. It is challenging to understand the many monitoring system in the intensive care units, for example. However, all such monitoring systems are based on the general principle of moni-toring oxygen transport to a peripheral organ. In this review, from conventional to recent principles, general concepts and paradigm shifts of hemodynamic monitoring will be discussed. (J Acute Care Surg 2017;7:2-8)

      • 이동 Ad Hoc 네트워크 기술 동향

        권혜연,신재욱,이병복,최지혁,남상우,임선배,Kwon, H.Y.,Sin, J.U.,Lee, B.B,Choi, J.H.,Nam, S.W.,Lim, S.B. 한국전자통신연구원 2003 전자통신동향분석 Vol.18 No.2

        이동 Ad Hoc 네트워크는 고정적이고 계층적인 인프라스트럭처 네트워크와는 비교되는, 이동 노드만으로 구성된 자율적이고 수평적인 네트워크이다. 이동 Ad Hoc 네트워크의 이동 노드는 중재자의 도움 없이 능동적인 연결 설정이 가능하고 네트워크의 참여 또는 이탈이 자유로우며 에너지원의 공급이 제한되어 빈번하게 네트워크의 토폴로지를 변화시킨다. 이러한 망의 특성상 이동 Ad Hoc 네트워크 기술은 하위 계층의 전파 전파, 전파 간섭 및 전력 제어에서부터 링크 계층의 다중 접속 및 자원 할당, 네트워크 계층의 라우팅, 트랜스포트 계층의 연결 설정 및 유지, 그리고 보안 및 상위 계층 애플리케이션에 이르기까지 다양한 기술적 해결 요구사항을 갖는다. 본 고에서는 이러한 Ad Hoc 네트워크의 특징과 특성을 살펴보고 관련 주요 요소 기술과 과거부터 현재까지 이동 Ad Hoc 네트워크 기술 분야에서 진행되어온 연구동향을 살펴본다.

      • KCI등재

        성인에서의 직장후방종양의 임상적 고찰: 증례 보고 및 문헌 고찰

        권혜연,허혁,민병소,김남규,손승국,조장환 대한대장항문학회 2008 Annals of Coloproctolgy Vol.24 No.4

        Retrorectal tumors are particularly rare among the adult population, occurring in 1 of 40,000 hospital admissions. Clinical diagnosis is difficult and is often delayed because of vague symptoms. This study aimed to investigate the clinicopathological features of retrorectal tumors. Between January 1999 and March 2005, 10 patients were diagnosed with retrorectal tumors at the Department of Surgery, Yonsei University Medical Center, and their medical records were reviewed. We analyzed chief complaints, imaging studies, surgical approaches and pathologic examinations. Out of 10 patients, 8 were female and 2 were male. The mean age was 42.8 years. Four patients had no symptoms. Perianal and abdominal pain were the most common presentations. CT and MRI were the most frequently performed imaging studies. Surgery was performed in 9 patients. Postoperative pathologic diagnosis was possible in 9 patients. An epidermal cyst was the most common tumor (4 patients); others included a mature teratoma, an adenocarcinoma from a tail gut cyst, a duplication cyst, a neurogenic tumor, and a smooth muscle cell tumor. Imaging techniques like CT scans, MRI and TRUS are helpful to determine the size and the extent of a tumor and its relationship to the surrounding anatomical structures for the operative approach. A surgical resection is the standard of treatment and demonstrates good results and a good prognosis.

      • 設問調査에 의한 高1 女學生의 月經에 관한 調査分析

        권혜연,이인선 동의대학교 한의학연구소 2000 동의한의연구 Vol.4 No.-

        1. 목적 : 본 연구는 성숙과정에 있는 여고생들의 月經痛을 검토, 月經異常의 정도 및 이에 대한 인식과 치료패턴에 대해 조사하여 한의학적 예방과 치료적 접근의 기초자료로 활용하고자 설문조사를 실시하였다. 2. 방법 : 2000년 5월 부산광역시에 소재하는 J여상 1년 399명과 J여고 1년인 498명, 총 897명에게 月經痛 및 月經異常의 치료에 대한 내용의 설문지를 작성하여 자료를 수집하였으며, 百分率은 인원 혹은 건수를 중심으로 하였고 나이는 한국나이로 산출하였다. 3. 결과 : 대조군은 월경력 및 장애정도에 큰 차이를 나타내지 않았다. 본 조사에서 여고생 중 적지 않은 수가 月經異常을 자각하고 있었으나 마땅한 치료수단의 부재로 대부분 그냥 참거나 鎭痛劑를 복용하는 경우가 대부분인 것을 알 수 있었다. 또한 韓醫院 진료의 경우 月經病에 대한 전문기관이란 인식이 病院(산부인과)보다 낮은 것으로 나타났으나, 韓醫院 을 선택한 응답 중 17.1%가 病院(산부인과)이 여학생의 月經病 치료에 부적합하기 때문으로 응답하였고, 특히 月經痛이 심하여 醫療機關 진료를 받은 경험이 있는 학생 중 75%가 韓醫院 진료를 받았다고 달하였다. 4. 결론 : 이러한 결과로 볼 때 미혼의 10代 여고생의 月經異常에 대해 한방 부인과 치료가 적절한 수단으로서의 가능성을 가진다고 할 수 있으며, 이에 대해 국민보건향상의 관점에서 좀 더 근본적인 해결책과 적극적인 관심 침 치료대책이 필요할 것으로 생각된다. 1. The prupose of study ; In the study, we investigated the menstrual history, the degree of dysmenorrhea, the recognition of coping mode with questionnaires in order to use it as basic materials for orient-medical prevention and treatment. 2. The method of study ; For the study, 897 girl students of J Girls' High School and J Girls' commercial School students in Pusan were sampled. Data were collected through questionnaires of 14 questions in March, 2000 and were analyzed using the Korean age, the percentage of persons and cases. 3. The result of study ; As the result of this reserch, there was no significant differences of menstrual history and dysmenorrhea disorder in control group. The most of girls recorgnized their own dysmenorrhea, but endured pains or depended on drugs by the absence of an appropriate method of medical treatment. Also it shows that orintal clinic is not recognized as a menorrhea disorders' field of specialization better than Gynecology clinic, that is, western medicine, but 17% out of girls selecting oriental clinic said that western clinic is not proper for care, 75% out of the girls who experienced medical treatment as severe pain replied that they visited oriental clinic for care. According to the above results, we found that orient-Gynecology clinic is an appropriate means with some potentialities and suggested that it is necessary to a fundamental solution and anxiety for national health.

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