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기관지천식이 없는 일반인에서 메타콜린에 대한 기관지반응의 양상
김윤근,손지웅,이상록,김우경,조상헌,이명현,고영률,민경업,김유영 ( Yoon Keun Kim,Jee Wong Son,Sang Rok Lee,Woo Kyung Kim,Sang Heon Cho,Myung Hyeon Lee,Young Yull Koh,Kyung Up Min,You Young Kim ) 대한천식알레르기학회 1998 천식 및 알레르기 Vol.18 No.3
Backgrognd: Bronchial hbyperresponsiveness (BHR) is a key feature of asthma, and may precede the development of asthma. Genetically determined and acquired factors may contribute to development of BHR. Objective .' To evaluate expression of bronchial responsiveness to methacholine according to age, sex, smoking habit, and atopy in general population without bronchial asthma, a cross sectional study was performed. Method: A total of 1,190 general population who composed of 408 subjects with age less than 19 years (young age group), 621 subjects with age from 20 to 40 years (middle age group), and 161 subjects with age more than 41 years (old age group) were enrolled. Evaluations were made by a questionnaire, serum IgE level and skin prick test to common inhalant allergens, and methacholine bronchial provocation test (MBPT). Bronchial responsiveness were evaluated by positive rate of MBPT (PC,p-methacholine 4 25mg/ml), and slope of dose- response curve (slope, %fall of FEV, / log[last concentration of methacholine, mg/ml]). Result: Positive rate of MBPT was 11.0%, and slope (mean+SE) was 10.6+0.2 %/mg/ml. Postive rate of MBPT was more prevalent in the young age group than in middle and old age groups (19.6% vs. 6.6% vs. 6.2%, p<0.05), and slope was higher in young age group than in other groups (14.4+0.4 vs. 8.6+0.3 vs. 8.9+0.5 %/mg/ml, p<0.05). No significant differences in positive rate of MBPT and slope were noted according to sex in young and old age groups. However, in the middle age group, slope was higher in females than in males (9.5+0.4 vs. 7.9+ 0.3 %/mg/ml, p<0.05). No significant differences of slope was observed according to smoking habit in males of middle age group, but in males of old age group, the slope was higher in subjects with smoking habit than those without it (9.6+0.8 vs. 6.5+0.9 %/mg/ml, p<0.05). Sig- nificant relationship was observed between geometric value of serum IgE level and slope(r=0. 152, p=0.009). The postive rate of MBPT and slope were significantly higher in subjects with positive skin rea,ctivity to common inhalant allergens than those without it (14.3% vs. 8.6%, p ( 0.05; 11.8+0.4 vs. 9.8+0.3 %/mg/ml, p<0.05). The difference of bronchial responsiveness according to skin reactivity was observed in young and middle age groups, but not in old age group. Conclusion : Bronchial responsiveness to methacholine is significantly higher in children than in adults, in middle-aged females than in middle-aged males. Atopy and smoking may have a dif ferent role to determine the bronchial responsiveness depending upon age and sex.
IgE 매개성 호흡기 알레르기 질환에서 유세포 분석법 및 림프아구 형성능 측정을 통한 T 림프구의 병리기전적 역할에 관한 연구
김유영(You Young Kim),조상헌(Sang Heon Cho),최동철(Dong Chull Choi),윤호주(Ho Joo Yoon),민경업(Kyung Up Min),조영주(Young Joo Cho),문희범(Hee Bum Moon) 대한내과학회 1993 대한내과학회지 Vol.45 No.6
Background: Allergic inflammation may be the basis of bronchial hyperresponsiveness that is a characteristic of bronchial asthma. Lymphocytes are prominent among the inflammatory cells infiltrating asthmatic airways and express low affinity IgE receptor. We performed this study to evaluate the role of T- lymphocyte in the development of bronchial asthma. Methods: We measured delayed skin responsiveness to multiple recall antigens, lymphocyte blastogenesis to mitogens and allergen and surface markers of Tl-ymphocyte such as CD3, CD4, CD8, IL-2R, HLA-DR, VLA-1 by flowcytometric technique in 30 allergic asthmatics, 12 patients who showed improvement with immunotherapy and 11 healthy subjects. Results: 1) IL-2R(+) cells and HLA-DR(+) cells were in- creased significantly compared to those of controls (IL-2R(+) cells were 9.9±4.9%, 3.7±1.8%; HLA-DR(+) cells were 9.9±5.2%, 3.7±3% respectively). And IL-2R(+) cells showed inverse relationship with bronchial hyperresponsiveness. CD8(+) cells were increased in asthmatics, but CD3(+) cells and CD4(+) cells were not different from those of controls. Cell surface markers were not changed with immunotherapy. 2) Lymphoproliferative responses to PHA(10-100 ug/ml), Con A(1-10 ug/m1) and D.farinae (10-6-10-2 w/v%) showed no significant differences among D.farinae sensitive asthmatics, immunotherapy patients and healthy controls. 3) Delayed skin responses to multiple recall antigens were similar among groups. 4) None of lymphoproliferative responses, cell surface markers and delayed skin responses of allergic asthmatics showed significant correlation with parameters of type 1 hypersensitivity reaction. Conclusion: CD8(+) cells are increased in allergic asthmatics, and the lymphoproliferative responses to allergens and mitogens are not changed compared to healthy controls. And activated Tlymphocytes play an important role in the development of allergic asthma.
한국에서 이소사이아네이트에 의한 직업성 천식의 현황과 조기 진단에 관한 연구
김유영(You Young Kim),조상헌(Sang Heon Cho),윤호주(Ho Joo Yoon),민경업(Kyung Up Min),백도명(Do Myung Paik),정규철(Kyu Chull Chung) 대한내과학회 1994 대한내과학회지 Vol.47 No.4
Objectives: To evaluate the prevalence of isocyanate -induced asthma in Korea and to develop strategies for early diagnosis and prevention of occupational asthma, we performed this study. Methods: Medical questionaire, prick skin tests with isocyanate and common inhalant allergens, measurements of serum total IgE and isocyanate specific IgE, serial measurements of peak expiratory flow rate and methacholine bronchial challenge test were per- formed in 140 workers from three factories using isocyanate. The medical questionaire included symptoms and their relation to works. Bronchial provocation test using isocyanate was performed in workers who were sus- pected to be occupational asthmatics. Isocyanate concentration of work place was also measured. Results: 1) 32 among 140 workers complained of asthmatic symptoms greater than grade 2.16 among 32 symptomatic workers told that their symptoms had improved during holidays on questionaire. 2) 66 among 140 workers were atopics, The most common allergen was house dust mite. Only one worker showed positive skin prick test to isocyanate, whereas two workers showed papular skin responses a day later. 3) 5 workers showed positive responses to methacholine bronchial provocation. 2 of them were proved to be isocyanate-induced asthmatics. And another one who were confirmed as an isocyanate-induced asthmatic had shown negative response to metacholine, but he con- verted to positive response to metacholine provocation test after provocation test with isocyanate. 4) 7 workers showed weekly variation greater than 20% on serial peak expiratory flow rate measurements. Among them, 2 workers were proved to be isocyanate-induced asthmatics. 5) Isocyanate-specific IgE antibodies were detected in 21 workers. 6) Isocyanate bronchial provocation tests were performed in 21 workers who were suspected to be occupational asthmatics. 3 workers showed early asthmatic responses. 7) The isocyanate concentrations in the air of workplaces were less than 0.005 ppm, mean exposure limit for 8 hours. Conclusion: The prevalence of isocyanate-induced asthma was 2.14%. It is recommended that the workers who are going to be employees of isocyanate using factories should be nonatopic and not have bronchial hyperresponsiveness nor asthma symptom. For early diagnosis of occupational asthma, medical questionaire, serum IgE, and methacholine bronchial provocation test should be performed at the time of regular health examination, and then serial measurements of peak expiratory flow late is needed in whom are sespected to be occupational asthmatics, And bronchial provocation test with isocyanate should be performed for definite diagnosis.