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김용협,송상윤,심현정,정웅기,안성자,윤미선,정재욱,송주영,남택근 대한방사선종양학회 2015 Radiation Oncology Journal Vol.33 No.1
Purpose: To evaluate treatment outcomes and determine prognostic factors in patients with esophageal cancer treated with esophagectomy after neoadjuvant chemoradiotherapy (NCRT)Materials and Methods: We retrospectively evaluated 39 patients with esophageal cancer who underwent concurrent chemoradiotherapy followed by esophagectomy between 2002 and 2012. Initial clinical stages of patients were stage IB in 1 patient (2.6%), stage II in 5 patients (12.9%), and stage III in 33 patients (84.6%). Results: The median age of all the patients was 62 years, and the median follow-up period was 17 months. The 3-year overall survival (OS) rate was 33.6% in all the patients. The 3-year locoregional recurrence-free survival (LRFS) rate was 33.7%. In multivariate analysis with covariates of age, the Eastern Cooperative Oncology Group performance status, hypertension, diabetes mellitus, tumor length, clinical response, clinical stage, pathological response, pathological stage, lymphovascular invasion, surgical type, and radiotherapy to surgery interval, only pathological stage was an independent significant prognostic factor affecting both OS and LRFS. The complications in postoperative day 90 were pneumonia in 9 patients, anastomotic site leakage in 3 patients, and anastomotic site stricture in 2 patients. Postoperative 30-day mortality rate was 10.3% (4/39); the cause of death among these 4 patients was respiratory failure in 3 patients and myocardial infarction in one patient. Conclusion: Only pathological stage was an independent prognostic factor for both OS and LRFS in patients with esophageal cancer treated with esophagectomy after NCRT. We could confirm the significant role of NCRT in downstaging the initial tumor bulk and thus resulting in better survival of patients who gained earlier pathological stage after NCRT.
김용협,최유덕,안성자,김영철,오인재,남택근,정재욱,송주영 전남대학교 의과학연구소 2024 전남의대학술지 Vol.60 No.1
We aimed to identify blood lymphocytes as a prognostic factor for survival in patients with locally advanced stage III non-small cell lung cancer (NSCLC) treated with concurrent chemoradiotherapy (CCRT). This is a secondary study of 196 patients enrolled in the Korean Radiation Oncology Group 0903 phase III clinical trial to evaluate the prognostic significance of circulating blood lymphocyte levels. The median total lymphocyte count (TLC) reduction ratio during CCRT was 0.74 (range: 0.29-0.97). In multivariate analysis, patient age (p=0.014) and gross tumor volume (GTV, p=0.031) were significant factors associated with overall survival, while TLC reduction (p=0.018) and pretreatment neutrophil-to-lymphocyte ratio (NLR; p=0.010) were associated with progression-free survival (PFS). In multivariate logistic regression analysis, pretreatment NLR, GTV, and heart V20 were significantly associated with TLC reduction. Immunohistochemical analysis of programmed death ligand 1 and CD8 expression on T cells was performed on 84 patients. CD8 expression was not significantly associated with the pretreatment lymphocyte count (p=0.673), and PDL1 expression was not significantly associated with OS or PFS. Univariate analysis revealed that high CD8 expression in TILs was associated with favorable OS and was significantly associated with favorable PFS (p=0.032). TLC reduction during CCRT is a significant prognostic factor for PFS, and heart V20 is significantly associated with TLC reduction. Thus, in the era of immunotherapy, constraining the volume of the radiation dose to the whole heart must be prioritized for the better survival outcomes.
김용협,정웅기,정재욱,조익준,윤미선,송주영,남택균,안성자,이동훈,윤태미,이준규,임상철 대한이비인후과학회 2020 Clinical and Experimental Otorhinolaryngology Vol.13 No.1
Objectives. To investigate the prognostic factors and treatment outcomes of primary parotid carcinoma treated with surgery and postoperative radiotherapy (PORT). Methods. We reviewed retrospectively 57 patients with primary parotid carcinoma who were treated with surgery and PORT between 2005 and 2014. Superficial parotidectomy was performed in 19 patients, total parotidectomy in 10 patients, and total parotidectomy with lymph node dissection in 28 patients PORT on the tumor bed was performed in 41 patients, while PORT on tumor bed and ipsilateral cervical lymph nodes was performed in 16 patients. Results. With a median follow-up of 66 months, the 5-year overall survival, disease-free survival, locoregional control, and distant control rates were 77.0%, 60.2%, 77.6%, and 72.8%, respectively. The 5-year overall survival by stage was 100%, 100%, 80.0%, and 46.4% in stage I, II, III, and IV, respectively. Recurrences at primary lesions were found in seven patients, while at cervical nodes in six patients. Distant recurrences were developed in 12 patients. No patient with the low and intermediate histologic grade developed distant failure. As prognostic factors, the histologic grade for overall survival (P=0.005), pathological T-stage (P=0.009) and differentiation grade (P=0.009) for disease-free survival, pathological T-stage for locoregional control (P=0.007), and lympho-vascular invasion (P=0.023) for distant recurrence were significant on multivariate analysis. Conclusion. This study revealed that differentiation grade, histologic grade, pathological T-stage, and lympho-vascular invasion were significant independent prognostic factors on clinical outcomes.
신경회로망을 이용한 효율적인 뉴턴-랩손 반복계산기법에 관한연구
김용협,김종훈 서울대학교 항공우주신기술연구소 2000 항공우주신기술연구소 연구보고 Vol.1 No.1
An efficient Newton-Raphson method improved by neural network extrapolation is presented. The conventional Newton-Raphson scheme begins iteration at previously converged state for current load step. Instead, in the present method, an approximated converged solution for current load step is predicted by neural network extrapolation and the Newton-Raphson scheme starts iteration at the predicted point. The number of iterations required for convergence can be decreased because the distance between initial point and conversed point is effectively shorter than the conventional method. The present method saves computing cost, yielding converged solution identical to that of the conventional Newton-Raphson scheme. To validate the efficiency and accuracy of the present method numerical test is carried out for the structures undergoing geometrical nonlinear deformation. Numerical comparison with the conventional Newton-Raphson scheme demonstrates the present method saves 20~45 percent of CPU time.
김용협(Yong-hyeop Kim),현용섭(Yong-sub Hyun),류호중(Ho-joong Ryoo),김진수(Jin-su Kim) 한국철도학회 2007 한국철도학회 학술발표대회논문집 Vol.- No.-
Seoul Metro has been constructing the screen doors on the platforms to provide safe and comfort environments. The screen doors of each station are configured so that they can be operated in automatic mode in connection with ATC/ATO through the integrated control panel in the station control room and in manual mode through the control panel of the station control room and crew control panel. These systems have been implemented with different data communication protocols between systems, HMI configuration, and so on due to ordering processes, implementation time and diverse suppliers, and manufactured to be operated within single station. Seoul Metro has been planning to implement the integrated control system to secure seamless train operation and safety and to have a fast response system against emergency situations such as PSD failure and fire, by implementing the system that is able to collectively manage, monitor and control the operation status and equipment conditions of PSD on to the integrated control center. This paper has studied a scheme to reduce the budget for the future facility constructions by standardizing the data format for data communication with the integrated station control panel and using the open standard protocols, in order to secure consistency of operation, system expansion and maintenance with unified and standardized control items.