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c-$\phi$ 지반에서의 아칭현상을 고려한 원형수직터널 토압 : II. 실내 모형실험
김도훈,차민혁,이대수,김경렬,이인모,Kim, Do-Hoon,Cha, Min-Hyuck,Lee, Dea-Su,Kim, Kyung-Ryeol,Lee, In-Mo 한국터널지하공간학회 2010 한국터널지하공간학회논문집 Vol.12 No.2
원형수직터널에 작용하는 토압은 아칭효과로 인해 2차원 일반 흙막이벽에 작용하는 토압보다 작으므로 원형수직터널 설계 시 벽체에 작용하는 실질적인 토압의 예측이 필요하다. 본 논문은 두 개의 연속된 논문(Companion papers)의 두번째로서 원형수직터널 설계 시 건조한 사질토뿐만 아니라 c-$\phi$ 지반과 다층지반에서 적용 가능하도록 새롭게 제안된 토압식(김도훈 등, 2009)을 증명하기 위해 대형 모형실험을 수행하였다. 고안된 모형실험 장비는 단계별 굴착이 가능하도록 제작 벽체의 반경을 변화시켜가며 실험을 수행하였다. 또한 강사 방법으로 지반을 조성하기 전 건조한 시료에 물을 첨가하고 불포화사질토를 형성시켜 겉보기 점착력을 발현시킴으로써 c-$\phi$ 지반과 다층지반에서 실험을 진행하였다. 실험 결과로서, 단계별 굴착을 모사하였을 때, 아칭효과에 의해 굴착된 지반에서 굴착되지 않은 지반으로 하중이 전이가 일어나는 확인할 수 있었다. 또한, 동시에 굴착했을 때의 토압은 예측한 값에 비해 상당히 작게 나타났지만, 단계별로 굴착했을 때의 최종 토압은 동시 굴착 시의 토압에 비해 크게 나타나며 새롭게 제안된 토압식과 잘 일치하였고 c-$\phi$ 지반과 다층지반에서 수행한 실험의 결과도 겉보기 점착력의 효과로 인해 토압의 감소를 보이며 이론적인 값과 잘 일치하는 것으로 나타났다. The earth pressure acting on the vertical shaft is less than that acting on the retaining wall due to three dimensional arching effect. Thus, it might be essential to estimate the earth pressure actually acting on the shaft when designing the vertical shaft. In this paper, large-sized model tests were conducted as Part II of companion papers to verify the newly suggested earth pressure equation proposed by Kim et al. (2009: Part I of companion papers) that can be used when designing the vertical shaft in cohesionless soils as well as in c-$\phi$ soils and multi-layered soils. The newly developed model test apparatus was designed to be able to simulate staged shaft excavation. Model tests were performed by varying the radius of vertical shaft in dry soil. Moreover, tests on c-$\phi$ soils and on multi-layered soils were also performed; in order to induce apparent cohesion to the cohesionless soil, we add some water to the dry soil to make the soil partially-saturated before depositing by raining method. Experimental results showed a load transfer from excavated ground to non-excavated zone below dredging level due to arching effect when simulating staged excavation. It was also found that measured earth pressure was far smaller than estimated if excavation is done at once; the final earth pressure measured after performing staged excavation was larger and matched with that estimated from the newly proposed equation. Measured results in c-$\phi$ soils and in multi-layered soils showed reduction in earth pressures due to apparent cohesion effect and showed good matches with analytical results.
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김도훈,조치흠,권선영,류남희,전동석,이원목,하정숙 대한부인종양학회 2018 Journal of Gynecologic Oncology Vol.29 No.6
Objective: We performed small-scale mutation and large genomic rearrangement (LGR) analysis of BRCA1/2 in ovarian cancer patients to determine the prevalence and the characteristics of the mutations. Methods: All ovarian cancer patients who visited a single institution between September 2015 and April 2017 were included. Sanger sequencing, multiplex ligation-dependent probe amplification (MLPA), and long-range polymerase chain reaction (PCR) were performed to comprehensively study BRCA1/2. The genetic risk models BRCAPRO, Myriad, and BOADICEA were used to evaluate the mutation analysis. Results: In total, 131 patients were enrolled. Of the 131 patients, Sanger sequencing identified 16 different BRCA1/2 small-scale mutations in 20 patients (15.3%). Two novel nonsense mutations were detected in 2 patients with a serous borderline tumor and a large-cell neuroendocrine carcinoma. MLPA analysis of BRCA1/2 in Sanger-negative patients revealed 2 LGRs. The LGRs accounted for 14.3% of all identified BRCA1 mutations, and the prevalence of LGRs identified in this study was 1.8% in 111 Sanger-negative patients. The genetic risk models showed statistically significant differences between mutation carriers and non-carriers. The 2 patients with LGRs had at least one blood relative with breast or ovarian cancer. Conclusion: Twenty-two (16.8%) of the unselected ovarian cancer patients had BRCA1/2 mutations that were detected through comprehensive BRCA1/2 genetic testing. Ovarian cancer patients with Sanger-negative results should be considered for LGR detection if they have one blood relative with breast or ovarian cancer. The detection of more BRCA1/2 mutations in patients is important for efforts to provide targeted therapy to ovarian cancer patients.
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김도훈,이재희,하정숙,류남희,전동석,김재룡 대한진단검사의학회 2010 Annals of Laboratory Medicine Vol.30 No.6
Background : Accurate and early detection of vancomycin-resistant enterococci (VRE) is critical for controlling nosocomial infection. In this study, we evaluated the usefulness of a selective chromogenic agar medium and of multiplex PCR for detection of VRE, and both these techniques were compared with the conventional culture method for VRE detection. Methods : We performed the following 3 methods for detecting VRE infection in stool specimens: the routine culture method, culturing in selective chromogenic agar medium (chromID VRE, bioMérieux, France), and multiplex PCR using the Seeplex VRE ACE Detection kit (Seegene Inc.,Korea) with additional PCR for vanC genes. Results : We isolated 109 VRE strains from 100 stool specimens by the routine culture method. In chromID VRE, all the isolates showed purple colonies, including Enterococcus gallinarum and E. raffinosus, which were later identified using the Vitek card. All VRE isolates were identified by the multiplex PCR method; 100 were vanA-positive E. faecium, 8 were vanA- and vanC-1-positive E. gallinarum, and 1 was vanA-positive E. raffinosus. Conclusions : For VRE surveillance, culturing the isolates in chromID VRE after broth enrichment appears to be an accurate, rapid, and easy method for routine screening test. Multiplex PCR is relatively expensive and needs skilled techniques for detecting VRE, but it can be an auxiliary tool for rapid detection of genotype during a VRE outbreak. (Korean J Lab Med 2010;30:631-6)
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김도훈,최종열 한국산업경제학회 2011 산업경제연구 Vol.24 No.3
본 연구에서는 우리나라 제조업을 산업유형으로 나누어 제품혁신의 성과 효율성을 추정하고, 성과 효율성에 영향을 미치는 기업의 특성요인들을 분석해 보았다. 그리고 제품혁신 성과 효율성과 경영성과 간의 관계를 분석하여 향후 기업의 성과 및 경쟁력 향상을 위한 생산전략 수립에 시사점을 제공하고자 하였다. 제품혁신 성과 효율성 분석에 있어서는 성과 산출변수로 혁신제품의 매출액을 기준으로 하였으며, 투입변수로는 제품혁신 활동과 직접적인 관련이 있는 제품혁신 관련 연구인력과 연구비용, 그리고 특허건수를 사용하였다. 또한 제품혁신 성과 효율성에 영향을 미치는 기업특성요인 분석에 있어서는 기업규모, 회사형태, 상장여부, 정부지원, 그리고 외부협력 공동개발 여부 등을 고려하였다. 분석 결과, 제품혁신 성과 효율성이 증가할수록 경영성과가 개선되는 것으로 평가되어 제품혁신의 성과 효율성 개선을 위한 효과적인 생산전략의 수립이 필요한 것으로 파악되었다. This study estimated the outcome efficiency of product innovation by sectoral types in the Korean manufacturing industry and investigated firm's characteristics that would determine the outcome efficiency of product innovation. In addition, by estimating the relationship between the outcome efficiency of product innovation and management performances, it is aimed to provide management implications to firms in establishing production strategies. In the analysis of outcome efficiencies of product innovation, the revenue of innovated products was used as an output variable, while input variables included the number of researchers and costs related to product innovation and the number of patents. Furthermore, firm's size, type of company, government supports, and external collaboration on product innovation were considered in the analysis of firm's characteristics that would affect to the outcome efficiency of product innovation. Analytical results indicated that the management conditions could be improved as the level of the outcome efficiency would be increased. It implies that the production strategy by firm should be mainly concentrated on improving the efficiency of product innovation.
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