탄산아파타이트로 된 인공골과 소뼈에서 유래한 무기질 골의 초기 골전도에 대한 연구

김도균,조태형,송윤미,판휘,이수연,진임건,김인숙,홍국선,황순정,Kim, Do-Kyun,Cho, Tae-Hyung,Song, Yun-Mi,Pan, Hui,Lee, Su-Yeon,Jin, Im-Geon,Kim, In-Sook,Hong, Kug-Sun,Hwang, Soon-Jung 대한악안면성형재건외과학회 2007 Maxillofacial Plastic Reconstructive Surgery Vol.29 No.6

Introduction: Although several types of calcium-phosphate coumpound have been frequently applied to osseous defects at maxillofacial area for many years, there is a controversy about its efficiency on bone conductivity comprared to xenograft bone substitute. Alloplastic carbonapatite has been introduced to improve disadvantages of hydroxyapatite and to mimic natural bone containing carbon elements. However, a preclinical study about its efficiency of osteoconductivity has not been reported. This study was performed to evaluate the early osteoconductive potential of synthetic carbonapatite with multiple pores relative to anorganic bovine xenograft. Materials and methods: Total 5 beagle dogs were used for maxillary augmentation model. The control (anorganic bovine xenograft) and experimental groups (synthetic carbonapatite) were randomly distributed in the mouth split design. After bone graft, all animals were sacrificed 4 weeks after surgery. Histological specimens with Masson Trichrome staining were made and histomorphometrically analysed with image analyser. The statistical analysis was performed using paired t-test. Results: In both groups, all animals had no complications. The experimental group showed relatively much new bone formation around and along the bone substitutes, whereas it was clearly reduced in the control group. The ratios of new bone area to total area, to material area and to the residual area excluding materials were higher in the experimental group ($0.13{\pm}0.03,\;0.40{\pm}0.13,\;0.20{\pm}0.06$ respectively) than in the control group ($0.01{\pm}0.01,\;0.03{\pm}0.02,\;0.03{\pm}0.03$, respectively). And the differences between both groups were statistically significant (p<0.001, <0.01, <0.01, respectively), while the ratio of material area to total area in two groups was not significant. Conclusion: Carbonapatite showed a high osteoconductivity in the early stage of bone healing compared to bovine derived anorganic bone substitute. This study suggests that this bone materials can be applied as a reliable bone substitute in the clinical treatment.

부착면 표면물질에 의한 성능 왜곡을 최소화한 이중 선로의 비대칭 다이폴 형태 태그 안테나 설계

김도균,추호성,Kim, Do-Kyun,Choo, Ho-Sung 한국전자파학회 2007 한국전자파학회논문지 Vol.18 No.4

본 논문에서는 부착될 물질이 가지는 전기적 특성에 의한 성능 변화가 적은 이중 선로의 비대칭 다이폴 형태 RFID 용도 태그 안테나(Asymmetric Dual-arm Dipole Antenna: ADDA)를 제안하였다. 제안된 태그 안테나는 상용 의료 폐기물 수거용 플라스틱 밀폐 용기(${\varepsilon}_r=1.7,\;tan\;{\delta}=0.002$)에 부착하여도 안테나의 동작 특성 변화가 적도록 설계되었다. 안테나의 세부적인 설계변수는 자유공간과 인식 대상 물체에 부착시 우수한 인식거리 성능을 나타내도록 Pareto 유전자 알고리즘을 사용하여 최적화하였다. 최적화 태그 안테나는 $100\;mm{\times}50\;mm$의 크기를 가지며, 3.7 %의 반사 손실 대역폭($S_{11}$< -10 dB)을 가지고 80 %의 복사효율을 나타내었다. 인식 거리 측정 결과, 자유공간에서 정면 방향(broadside) 5.3 m, 의료 폐기물 수거용 플라스틱 밀폐 용기에 부착시 최대 5.5 m의 인식거리 성능을 가지는 것을 확인하였다. In this paper we proposed the tag antenna with a low performance distortion from an attached surface material using the asymmetric dual-arm dipole antenna(ADDA) structure. The tag is designed to exhibit low performance changes when the tag is attached on a target object(the medical litter receptacle, ${\varepsilon}_r=1.7,\;tan\;{\delta}=0.002$). Detail design parameters for the proposed antenna are optimized to maintain a good readable range in free-space as well as on a target object. The size of the optimized antenna is $100\;mm{\times}50\;mm$. The antenna shows the matching bandwidth($S_{11}$< -10 dB) of 3.7 % and the radiation efficiency of 80 % at the operating frequency. Finally we confirmed the readable range of the tag antenna by measurement and it shows about 5.3 m in free space and 5.5 m on the target object.

포화지방산계 LB 막의 수평방향에 대한 전기적 특성 비교

김도균,최용성,장정수,권영수 ( Do Kyun Kim,Yong Sung Choi,Jeong Soo Chang,Young Soo Kwon ) 한국전기전자재료학회 1997 한국전기전자재료학회 춘계학술대회논문집 Vol.1997 No.0

적혈구 침강속도에 대한 Westergren tube 각도, 온도 및 NaCl 농도가 미치는 영향

김도균,김영홍,유창준,Kim, Do-kyun,Kim, Young-hong,Yu, Chang-jun 대한수의학회 1996 大韓獸醫學會誌 Vol.36 No.1

Erythrocyte sedimentation rate is influenced by plasma protein, red cell itself and physiological conditions and it is clear that the measurement of erythrocyte sedimentation rate varies with technique and various environmental factors. The effect of temperature, angle of test tube, and osmobility with different percent of NaCl solution on erythrocyte sedimentation rate on sheep was determined by modified Westergren method. In sheep, as the angle of Westergren tube was decreased from $90^{\circ}$ to $45^{\circ}$, erythrocyte sedimentation rate was increased in both diluted plasma and NaCl solutions. As temperature was increased from $4^{\circ}C$ to $20^{\circ}C$ at $45^{\circ}$ angle. erythrocyte sedimentation rate was increased. In ruminants, this modified Westergren methods, erythrocyte 1 : plasma 9 instead of erythrocyte 4 : plasma 6(whole blood), enable them to have meanings as dog therefor, using this method, clinical can determine the erythrocyte sedimentation rate of ruminants for diagnosis. Because erythrocyte sedimentation rate was changed according to the angle of Westergren tube, temperature as erythrocyte diluted with NaCl, this study detected that the change of temperature, the angle of Westergren tube could change erythrocyte sedimentation rate by effecting red cell itself. The increase of osmobility owing to change of NaCl percent resulted in the decrease of rapid erythrocyte sedimentation rate. So this fact indicate that deformibility and the change of red cell volume have meaning in the change of erythrocyte sedimentation rate.

드럼형 마찰대전장치를 이용한 혼합플라스틱의 정전선별

김도균,조희찬,전호석,Kim Do Kyun,Cho Hee Chan,Jeon Ho Seok 한국자원리싸이클링학회 2004 資源 리싸이클링 Vol.13 No.1

마찰대전을 이용한 정전분리는 서로 상이한 물질간의 마찰을 통해 서로 다른 극성으로 하전시켜 이를 전기장내에 통과시켜 분리하는 기술이며, 플라스틱과 같은 부도체입자들의 정전분리에 많이 사용된다. 본 연구에서는 연속식 드럼형 마찰대전장치를 개발하고 이를 폐건축 및 폐가전 플라스틱의분리에 적용시켰다 분리대상 플라스틱은 폐건축 자재의 경우 PE/PVC 혼합시료를 대상으로 하였으며, 폐가전의 경우 ABS/PS/PP의 혼합시료를 대상으로 하였다. 건축자재 혼합플라스틱 및 가전제품 혼합플라스틱 모두 드럼형 마찰대전장치를 이용할 경우 실험한 조건에서 무게기준으로 95%이상의 순도조건에서 95%이상의 회수율을 보였다. Triboelectrostatic separation process is a technology that different particles charged after contact and rubbing different materials are separated in a high electric field. This technology has an advantage in that it can be used for separating non-conducting materials such as plastics unlike other electrostatic separation processes. There are two objectives in this study. One is to develop an effective continuous tribo-electrostatic separation process. The other is to apply the developed device for the separation of mixed plastics. Results show that almost all tested plastics reaches over 95% in yield and grade after separation.

한국 법질서와 정의론: 공정과 공평, 그리고 운의 평등 -시론(試論)-

김도균 ( Do Kyun Kim ) 서울대학교 법학연구소 2012 서울대학교 法學 Vol.53 No.1

The chief social problems in Korea can be characterized as unfairness and inequity (i.e. unjustified equal and unequal treatment), which are insufficiently rectified by the Korean legal system. As an effort to find a way out, this paper attempts to articulate and to make explicit those notions and principles of justice thought to be already latent in the Korean legal system, and to work out a public conception of justice which can explain and justify them systematically. By way of doing so, this paper first analyzes considered justice-judgments found in Korean legal discourses, especially in courts` decisions, and proceeds to propose a desert-based conception and principles of social justice by examining three existing theories of justice in the light of that proposal. A libertarian theory of justice emphasizes individual performances as the core distributive criterion but does not provide grounds for justifying the criterion per se. In contrast, an egalitarian theory of justice successfully satisfies the fairness requirement and the principle of desert by neutralizing and eliminating unfair effects of natural and social luck, which are not the product of individual efforts and choices. Lastly, a theory of justice based on the idea of common good takes the principle of desert seriously into account but fails to tackle the matter of socioeconomic justice in a satisfactorily manner. This paper draws on an empirical study and related normative considerations, thus leading to a proposal that if a theory of justice is to serve as a reasonable public conception of justice aspiring to be an ideal standard by which law is to be judged, it must achieve two things: first, to incorporate the principles of fairness and desert as essential part of justice-judgements; second, to deal properly with the problem of inequality in life chances which results from the arbitrary effects of natural and social luck.

제도병치를 통한 한국 공적연금제도의 다층구조화 과정 연구

김도균(Kim, Do Kyun) 한국사회정책학회 2015 한국사회정책 Vol.22 No.1

본 논문의 목적은 한국 공적연금제도의 다층구조화 과정의 제도적 메커니즘을 분석하는 것이다. 한국의 국민연금제도는 1988년 도입 이후 평균소득 대비 소득대체율이 70%에서 40%로 급격히 축소되고, 기초노령연금·기초연금 제도가 도입되는 등 중요한 변화를 겪었다. 하지만 국민연금 중심의 일원적 공적연금체계가 근본적으로 변경되지는 않았다. 본 논문은 이러한 제도변화를 설명하기 위해 제도와 환경, 행위자의 상호작용을 강조하고, 행위자의 전략이 제도변화에 미치는 영향에 주목한다. 또한 행위자의 전략에 영향을 미치는 변수로 ‘비토포인트의 강약’과 ‘제도의 자유재량적 해석 가능성’을 강조한다. 결론적으로 본 논문은 한국 공적연금제도의 변화를 다층구조화 과정으로 규정하고, 이러한 제도변화를 ‘제도전용’이 아니라 ‘제도병치’의 결과로 설명한다. This paper aims at analysing the institutional mechanism of the multi-pillar restructuring in the Korean pension system. Since the national pension system was introduced in 1988, its replacement rate was sharply retrenched from 70% to 40% of the average income level. Also, adding to the national pension, the basic old-age pension and the basic pension were introduced in 2007 and 2014 respectively. Despite of these crucial changes, however, the unitary public pension system mainly based on the national pension was not fundamentally changed. This paper put an emphasis on the interaction between environment, institution, and actors and focuses on the effect of actor’s strategy on the institutional change. In addition, it also focuses on the role of ‘veto point’ and ‘discretion in interpretation/enforcement’ as variables affecting actors’ strategy. As s result, this paper argues that the institutional change in the Korean pension system is explained not by ‘policy conversion’, but by ‘policy layering’.

순환잔골재 혼입 모르타르의 건조수축 및 내흡수성

김도균 ( Kim Do-kyun ),김진섭 ( Kim Jin-seop ),임건우 ( Im Geon-woo ),이건철 ( Lee Gun-cheol ) 한국건축시공학회 2024 한국건축시공학회 학술발표대회 논문집 Vol.24 No.1

대기 중 PM<SUB>2.5</SUB>의 오염기여도 추정 및 PAHs 농도비를 이용한 연소 오염원 확인

김도균(Do-Kyun Kim),이태정(Tae-Jung Lee),김성천(Seong-Cheon Kim),김동술(Dong-Sool Kim) 한국대기환경학회 2012 한국대기환경학회지 Vol.28 No.5

Mechanism Underlying NaF-induced Apoptosis and Cell Cycle Arrest on G361 Human Melanoma Cell Line

김도균(Do-Kyun Kim),손현진(Hyeon-Jin Sohn),김인령(In-Ryoung Kim),김규천(Gyoo-Cheon Kim),박봉수(Bong-Soo Park),곽현호(Hyun-Ho Kwak) 대한체질인류학회 2011 해부·생물인류학 (Anat Biol Anthropol) Vol.24 No.4

불화나트륨(sodium fluoride, NaF)은 치아우식증을 예방하기 위한 치과용 물질로 널리 사용되어 왔다. 치아우식증 예방을 위한 불소의 장기간 섭취가 인체에 미치는 영향에 대해 알려진 것이 거의 없고, 과복용 시 심각하고 치명적인 독성을 일으킬 수 있다는 보고가 있으나 불소의 안전성은 여전히 논쟁요소로 남아 있다. 그러나 불소는 구강건강을 위한 주요 물질로서 인정받고 있는 것이 사실이다. NaF은 몇 가지의 정상세포들에서 세포자멸사를 유도하고, 얼마간의 암세포에서 세포주기 정지와 세포자멸사를 유도한다고 알려져 있다. 이 연구의 목표는 사람구강편평상피세포암종세포(G361 세포)에 NaF 적용 후, 세포자멸사의 유도와 세포자멸사에 대한 분자생물학적 기전을 밝히는 것이다. 사람흑색종세포의 생존율은 MTT법으로, G36l 세포의 성장억제능의 측정은 clonogenic assay를 사용하였다. NaF 적용시, G361 세포에서 세포자멸사가 유도되는 것을 확인하기 위해서 Hemacolor 염색법, Hoechst 염색법, DNA 전기영동법 및 TUNEL법을 사용하였다. 그리고 G361 세포에 NaF을 적용한 후, Western blot 분석, 세포면역화학염색, 공초점레이져주사현미경 검경, FACScan flow cytometry, 사립체막 전위변화, proteasome 활성도 측정 등을 시행하였다. NaF로 처리된 G361 세포는 시간 및 용량의존적인 세포생존율 감소, 용량의존적인 성장억제 및 세포자멸사에 의한 세포죽음을 보였다. 그리고 NaF가 적용된 G361 세포에서 핵농축, DNA 조각남, 사립체막전위와 proteasome 활성도의 감소, DNA양의 감소, cytochrome c의 사립체에서의 세포질로의 유리, AIF와 DFF40(CAD)의 핵으로의 이동, Bax와 Bcl-2의 분율 변화, 그리고 caspase-9, caspase-7, caspase-6, caspase-3, PARP, Lamin A/C, DFF45(ICAD)의 활성화와 같은 다양한 세포자멸사 증거를 보였다. 더 나아가서 NaF에 처리된 G361 세포에서 G1 세포주기에 관계하는 Cyclin D1, Cyclin D3, Cdk2 그리고 Cdk4의 발현의 감소와 p53의 탁월한 발현의 증가를 보였다. 이 연구를 통하여 NaF가 G1 세포주기정지 단백질의 변형 그리고 proteasome, 사립체 및 caspase 경로의 연속 반응을 통해 G361 세포의 세포자멸사를 유도함을 명확하게 증명하였다. Fluoride is widely used in dentistry to prevent dental caries, even though the safety of fluoride is a controversial issue. There are no known adverse effects of long-term fluoride ingestion for caries prevention, but an overdose can cause serious acute toxicity. Nevertheless it is accepted that fluoride is an important material for oral health. This study was undertaken to investigate the modulation of cell cycle-related proteins and apoptosis induction underlying mechanism by NaF treatment on G361 human melanoma cell line. The viability of G361 cells and the growth inhibition of G361 cells were assessed by MTT assay and clonogenic assay respectively. Hoechst staining, DNA electrophoresis and TUNEL staining were conducted to observe G361 cells undergoing apoptosis. G361 cells were treated with NaF, and Western blotting, immunocytochemistry, con-focal microscopy, FACScan flow cytometry, MMP activity and proteasome activity were performed. NaF treatment in G361 cells resulted in a time- and does-dependent decrease of cell viability and a does-dependent inhibition of cell growth, and induced apoptotic cell death. And tested G361 cells showed several lines of apoptotic manifestation such as nuclear condensation, DNA fragmentation, the reduction of MMP and proteasome activity, the decrease of DNA contents, the release of cytochrome c into cytosol, the translocation of AIF and DFF40 (CAD) onto nuclei, a significant shift of Bax/Bcl-2 ratio, and the activation of caspase-9, caspase-7, caspase-6, caspase-3, PARP, Lamin A/C and DFF45 (ICAD). Furthermore, NaF resulted in down-regulation of the G1 cell cycle-related proteins, and up-regulation of p53. Taken collectively, our present findings demonstrate that NaF strongly inhibits cell proliferation by modulating the expression of the G1 cell cycle-related proteins and induces apoptosis via proteasome, mitochondria and cas-pase cascades in G361 cells.