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김경원,윤정구 대한미생물학회 1988 大韓微生物學會誌 Vol.23 No.1
Non-specific cellular immunity may play an important role in the immune defense mechanism against tumors and has recently become of great interest to many researchers. Among the effector cells involved in non-specific cellular immune reactions, natural killer(NK) cells and antibody dependent cell-mediated cytotoxicity(ADCC) effector cells are the principal targets in many of the investigations studying the hosts immune defense aginst tumors. In general most chemotherapeutic agents are known to depress host immune functions. However, such an effect in non-specific cellular immunity particulary on NK cell and ADCC activities has not been fully determined. In this report, the effects of 5-fluorouracil(5-FU) and adriamycin(ADM), which are widely used for the chemotherapy of human cancer, on mouse NK and ADCC activities were studied. Adult ICR mice were injected with either one of the drugs or a combination of them and then at given interval, splenocytes were collected. NK and ADCC activities were measured in vitro using a 4hr ^(51)Cr release assay employing YAC-1 and L1210 target cells respectively. The following results were obtained. 1, The administration of different doses of 5-FU or ADM either alone or in combination resulted in a dose-dependent inhibition of NK activity 48 hours post injection. In these experiments, the doses which showed the most significant inhibition were 12.0mg/ml and 1.2mg/ml or greater for 5-FU and ADM respectively. No difference in NK activity was observed between mice treated with the drugs in combination. In contrast, assays of AD- CC activity in splenocytes from the same mice showed no appreciable change in the level of cytotoxicity. 2. Kinetic studies revealed t4at splenocytes from mice treated with a single dose of 5-FU (12mg/kg) or ADM(1.2mg/kg) alone or in combination showed significantly decreased levels of NK activity 48 72 hours after treatment. Thereafter NK activity progressively increased and reacked the level of the controls at 7 days. Again, no significant changes in ADCC activity were observed in these experiments. 3. Splenocytes from mice treated 48 hours previously with the drugs significantly suppressed the NK activity of normal mice. 4. Futhermore, these splenacytes had an impaired in-vitro production of interleukin-2 as compared to those from normal controls. In conclusion, mice treated with 5-FU or ADM either alone or in combination, exhibited significantly depressed NK activities 2 3 days after treatment, but the level of ADCC activity was not effected. This suggest that NK-suppressing mechanisms which involve the appearance and activation of suppressor cells and which impair the production of interleukin-2, may de- velope following chemotherapy.
Isolation and Characterization of a Bacterial Isolate for Polyhydroxyalkanoates Production
김경원,박제권 한국키틴키토산학회 2014 한국키틴키토산학회지 Vol.19 No.1
Microorganism accumulating polyhydroxyalkanoates (PHA) in its cytosol was isolated from water obtained from InCheonarea. This strain was determined to be Bacillus species that was examined by 16S rDNA sequences and phylogenetic treeanalysis. The bacteria accumulated up to 20.6% of PHA within 48 hours at 37oC in the presence of 2.0% glucose substrate underaerobic condition. The present work also investigates the influence of substrate on PHA production to find a clue trigger. ThePHA accumulation increased to 23.5 and 23.3% containing 2.0% salicylic acid and lactose, respectively. In contrast both glucosamineand xylose have negative effect on PHA production for this bacterial strain. To the best of our knowledge, this reportfirstly demonstrates the effects of various sugars on PHA production.
김경원,이준영,최상현,허지미,박성호 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.6
In the field of diagnostic test accuracy (DTA), the use of systematic review and meta-analyses is steadily increasing. By means of objective evaluation of all available primary studies, these two processes generate an evidence-based systematic summary regarding a specific research topic. The methodology for systematic review and meta-analysis in DTA studies differs from that in therapeutic/interventional studies, and its content is still evolving. Here we review the overall process from a practical standpoint, which may serve as a reference for those who implement these methods.
김경원,Atul B. Shinagare,Katherine M. Krajewski,Junhee Pyo,Sree Harsha Tirumani,Jyothi P. Jagannathan,Nikhil H. Ramaiya 대한영상의학회 2015 Korean Journal of Radiology Vol.16 No.2
We aimed to describe radiologic signs and time-course of imatinib-associated fluid retention (FR) in patients with gastrointestinal stromal tumor (GIST), and its implications for management. In this Institutional Review Board-approved, retrospective study of 403 patients with GIST treated with imatinib, 15 patients with imaging findings of FR were identified by screening radiology reports, followed by manual confirmation. Subcutaneous edema, ascites, pleural effusion, and pericardial effusion were graded on a four-point scale on CT scans; total score was the sum of these four scores. The most common radiologic sign of FR was subcutaneous edema (15/15, 100%), followed by ascites (12/15, 80%), pleural effusion (11/15, 73%), and pericardial effusion (6/15, 40%) at the time of maximum FR. Two distinct types of FR were observed: 1) acute/progressive FR, characterized by acute aggravation of FR and rapid improvement aftermanagement, 2) intermittent/steady FR, characterized by occasional or persistent mild FR. Acute/progressive FR always occurred early after drug initiation/dose escalation (median 1.9 month, range 0.3–4.0 months), while intermittent/steady FR occurred at any time. Compared to intermittent/steady FR, acute/progressive FR was severe (median score, 5 vs. 2.5, p = 0.002), and often required drug-cessation/dose-reduction. Two distinct types (acute/progressive and intermittent/steady FR) of imatinib-associated FR are observed and each type requires different management.
No Significance of the Free Cortisol Index Compared to Total Cortisol in Critically Ill Patients
김경원,김상완,김희정,신찬수,박성재,서길준,김성연 대한내분비학회 2011 Endocrinology and metabolism Vol.26 No.2
Background: Some patients exhibit an inadequate response of cortisol to stressful conditions; this state is known as critical illnessrelated corticosteroid insufficiency. These patients have low serum binding protein concentrations, thereby suggesting that total serum cortisol may not be reflective of circulating cortisol activity. As the free cortisol index (FCI = total cortisol/corticosteroid-binding globulin) has been correlated with serum free cortisol, we measured FCI in Korean patients for the first time. In this study, we attempted to determine whether FCI was superior to total cortisol in predicting 30-day mortality. Methods: We recruited 65 critically ill patients with relatively high Acute Physiology, Age and Chronic Health Evaluation (APACHE III) scores. Fourteen patients with pituitary disease but normal pituitary function were recruited from outpatient clinics. Total cortisol and corticosteroid-binding globulin were measured in patients and controls during the short Synacthen test. Results: The basal cortisol level and basal FCI level were higher in patients (n = 65) than in healthy controls (P < 0.001, respectively). We found that total cortisol was strongly correlated with FCI (P < 0.001) in critically ill patients; however, neither total cortisol nor FCI were associated with 30-day mortality among patients. Only severe clinical criteria (such as APACHE-III scores and low albumin)were associated with 30-day mortality. Conclusion: Our results do not suggest that FCI is more accurate than total cortisol in predicting clinical outcomes in critically ill patients.