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키토산 함유 주사형 지지체가 성체 줄기세포 분화 중 골 형성 유전자 변화에 미치는 영향
정창호 ( Chang Ho Jeong ),위찬우 ( Chanwoo Wee ),고성균 ( Sung Kyun Ko ),정병훈 ( Byunghoon Jeong ),장철원 ( Cheolwon Jang ),임원봉 ( Wonbong Lim ) 한국키틴키토산학회 2024 한국키틴키토산학회지 Vol.29 No.1
Several injectable materials have been applied for bone substitute in bone defect however, nothing has achieved acceptance in clinic. This study was carried out to investigate whether chitosan-alginate gel/mesenchymal stem cell composites are potentially injectable substitute materials for bone remodeling. The chitosan-alginate gel/mesenchymal stem cell composites were implanted in the bone defect lesion of rat calvaria to investigate the mRNA expressions of implanted mesenchymal stem cells. The implantation of chitosan-alginate gel/mesenchymal stem cell promoted the expression of collagen type 1 in bone defect lesion and induced the growth of osteoblast cells, thereby promoting new bone formation. In addition, the new bone formation process was improved by increasing the expression of Col13a1, Tnn, Fignl1, and Chad, which are related to the growth and differentiation of osteoblasts, and decreasing the expression of MMP13, which is related to the differentiation of osteoclasts. The present study suggests that chitosan-alginate gel/mesenchymal stem cell composites could be a useful tool for treatment of bone defect as a bone substitute.
최영길(Young Gil Choi),김승룡(Seung Ryong Kim),고성균(Sung Kyun Ko),정태영(Tai Young Chung),이근영(Keun Young Lee),김기경(Ki Kyong Kim),강성원(Sung Won Kang) 대한산부인과학회 2000 Obstetrics & Gynecology Science Vol.43 No.2
Placenta percreta with bladder invasion is an extremely rare complication causing life-threatening hemorrhage, up to 17 liters.1 Most reported cases have been diagnosed after 30 weeks of pregnancy and few have presented before 20 weeks.2 Only 20 cases of placenta percreta with invasion of the bladder have been reported during last decade. In this condition, chorionic villi attach directly to the myometrium without intervening decidua. The exact etiology of impaired decidualization is unknown; however, a previous endometrial insult, such as previous cesarian section or endometrial curettage may be a contributing factor. To avoid massive bleeding, uterine body incision, hypogastric artery ligation before hysterectomy and uterine cervical removal have been attempted.1 Chorionic villi may attach to the myometrium (accreta), invade the myometrium(increta), or in its severe form (percreta) the trophoblastic tissue penetrates the whole myometrium and invades adjacent structures. We experienced a case of placenta previa percreta with bladder invasion and review the literatures.
직류전동기 위치제어용 Neuro-Fuzzy 제어기 설계
고성균,이택종 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1
This paper describes a scheme that the fuzzy logic controller(FLC) compensates for variable load while a neural controller holds the control of the DC motor using pre-learned information without relearning. FLC can be used effectively to minimize the variable loading effects in the positon control of DC motor. The proposed controller consists of FLC, which is added in parallel to neural controller. The proposed controller has implemented with low cost DSP processor (ADSP-2105) in order to be directly applicable in the industrial field and the results show the proposed scheme is very effective to attain good cntrol characteristics under the variable load condition.
강성원,이근영,조현진,최영길,김승용,정태범,고성균,전현아,김홍배 대한부인종양 콜포스코피학회 2000 Journal of Gynecologic Oncology Vol.11 No.1
Extramammary Paget's disease(EMPD) of the vulva is an uncommon neoplasm which accounting for 2.5% of all vulvar malignancies and 0.02% of all female cancer. Several hundred cases have been reported worldwide since the first description by sir James Paget in 1874, It generally affects postmenopausal age group and presents high rate of recurrence but the precise incidence remines unclear, Although Paget's disease of the breast and the vulva are histologically similar, their histogenesis and biological behavior are considered to be significantly different and EMPD has gcnerally perceived more benign compared to that of the breast. Four histologic forms of vulvar EMPD have been recognized and treated vulvar EMPD in according to the 4 histologic classification. The high rate of recurrence disease remains a challenge for optimal management. Recently we experienced a case of Paget's disease of the vulva, diagnosed as an intraepithelial Paget's disease preoperatively and underwent radical vulvectomy and superiomedial thigh(SMT) flap, and present with a brief review of literature.