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- 저자 : 강세훈(Se Hun Kang) (검색결과 11 건)
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강세훈 ( Se Hun Kang ),이태훈 ( Tae Hoon Lee ),임현 ( Hyun Lim ),구본산 ( Bon San Koo ),이승범 ( Seung Bum Lee ),박영훈 ( Young Hoon Park ),나신 ( Shin Na ),박성준 ( Seong Joon Park ),나희경 ( Hee Kyong Na ),조유숙 ( You Sook Ch 대한천식알레르기학회 2011 천식 및 알레르기 Vol.31 No.1
Breast-feeding anaphylaxis is reported to be an extremely rare but potentially life-threatening condition. We report a 32-year-old woman who experienced recurrent anaphylaxis associated with breast-feeding. Generalized urticaria and angioedema accompanied by syncope were recurrent immediately after breast-feeding or milk letdown. Skin prick tests for the common food panel were all negative. UniCAP tests were performed to see if specific IgE to milk is present in her serum and the results was found to be negative. After weaning, the symptoms were completely resolved and never recurred. Based on her clinical course, it is believed that she had a breast-feeding anaphylaxis. (Korean J Asthma Allergy Clin Immunol 2011;31:55-58)
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강세훈 ( Se Hun Kang ),최종기 ( Jong Gi Choi ),권오성 ( O Sung Kwon ),최석원 ( Suk Won Choi ),박현우 ( Hyun Woo Park ),고영화 ( Young Wha Koh ),최창민 ( Chang-min Choi ) 대한내과학회 2011 대한내과학회지 Vol.81 No.1
Pyothorax-associated lymphoma is a distinct type of malignant lymphoma composed of lymphocytes, mostly of a B-cell nature.It occurs in patients with a long history of pyothorax and is strongly associated with Epstein-Barr virus infection. We experienced acase of pyothorax-associated lymphoma in a 66-year-old male. The patient had chronic pyothorax after tuberculous pleurisy was treated about 37 years earlier and was hospitalized for a recently occurring chest wall mass. A core needle biopsy of the chest wall mass led to a diagnosis of diffuse large B-cell lymphoma. Pyothorax-associated lymphoma is rare in Korea, but should be considered in patients with chronic pyothorax and a recently occurring pleural mass. (Korean J Med 2011;81:116-120)
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9-(4-[$^{18}F$] Fluoro-3-hydroxymethylbutyl) guanine 합성의 자동화와 최적화에 관한 연구
안재석,홍성탁,강세훈,원우재,An, Jae-Seok,Hong, Sung-Tack,Kang, Se-Hun,Won, Woo-Jae 대한핵의학기술학회 2011 핵의학 기술 Vol.15 No.2
단순 헤르페즈 제1형 티미딘 키나제(Herpes simplex virus type 1 thymidine kinase. HSV1-tk) 유전자는 보고 유전자(reporter gene)로서 필요한 조건뿐만 아니라 별도의 치료 유전자를 따로 이입할 필요가 없다는 장점을 가지고 있어 유전자 영상과 치료에서 가장 널리 사용되는 유전자 중 하나이다. 본 연구는 HSV1-tk 보고 유전자의 기질로서 많이 사용하고 있는 9-(4-[$^{18}F$] Fluoro-3-hydroxymethylbutyl) guanine ([$^{18}F$] FHBG) 합성의 자동화와 더불어 최적의 합성 조건을 구현하기 위하여 실행하게 되었다. [$^{18}F$] FHBG 합성의 자동화를 위해 Explora-RN (CTI, USA) module을 사용하였다. 최적의 합성수율 조건을 찾기 위하여 반응시간의 변화(3 min, 5 min, 10 min)와 반응온도의 변화($110^{\circ}C$, $120^{\circ}C$, $130^{\circ}C$)를 주었다. 또한 precursor 용량의 변화(5 mg, 7 mg, 10 mg)에도 합성수율이 어떻게 영향을 미치는지 알아보았다. [$^{18}F$] fluorination 단계에서 가장 높은 합성수율을 보인 반응온도는 $130^{\circ}C$였고, 반응시간은 5분이었다. 반면 precursor의 용량 변화 실험에서는 10 mg을 넣었을 때의 합성 수율($32{\pm}1.2%$)에 비하여 5 mg과 7 mg의 양에서는 안정된 값을 얻지 못하였다. [$^{18}F$] FHBG 합성의 Explora-RN 모듈에서의 자동화를 완성하였고 최적의 합성수율을 재현할 수 있는 반응시간과 반응온도, precursor의 농도를 찾았다. 하지만 감량 precursor 방법은 낮은 농도에서 비교적 큰 편차를 보여 안정된 값을 얻지는 못하였다. 이에 따라 임상에 직접 적용하기 위해서 더 많은 연구가 시행되어져야 할 것이다. Purpose: The HSV1-tk reporter gene system is the most widely used system because of its advantage is that it is possible to monitor directly without the introduction of a separate reporter gene in case of HSV1-tk suicide gene therapy. This study was performed to automate 9-(4-[$^{18}F$] Fluoro-3-hydroxymethylbutyl) guanine ([$^{18}F$] FHBG) that are widely used as substrate for the HSV1-tk reporter gene in living organisms with positron emission tomography (PET) and find the optimized conditions of synthesis. Materials and Methods: Fully automated synthesis of [$^{18}F$] FHBG was performed using Explora-RN (CTI, USA) module. We have changed of reaction time (3, 5, 10 min) and temperature (110, 120, $130^{\circ}C$) for the optimized conditions of synthesis. Also we experimented to find the optimal concentration of precursor (5, 7, 10 mg). Results: [$^{18}F$] FHBG was purified by HPLC system and collected at around 10-12 min. Synthesis using Explora-RN module showed a $32.0{\pm}1.2%$ yield of radiochemical (decay corrected), the purity was greater than 98%. And the entire synthesis time was less than 48 min. Temperature of the highest synthesis yield was $130^{\circ}C$, reaction time was 5 minutes and concentration of precursor was 10 mg (recommended volume in manual) (n=36). In contrast to radiochemical yield of precursor 10 mg ($32{\pm}1.2%$), yield of 5 and 7 mg precursor was unstable. Conclusion: Automation of [$^{18}F$] FHBG synthesis at Explora-RN module has been completed. In addition, we were able to obtain optimized reaction time, temperature and concentration of precursor. Therefore this study would be provided more rapid synthesis and higher radiochemical yield.
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성인 천식 환자에서 흡연에 따른 폐기능 및 임상적 특성
최종기 ( Jong-Ki Choi ),강세훈 ( Se-Hun Kang ),박영훈 ( Young-Hoon Park ),배윤정 ( Yun-Jeong Bae ),김태범 ( Tae-Bum Kim ),이태훈 ( Tae-Hoon Lee ),박찬선 ( Chan-Sun Park ),문희범 ( Hee-Bom Moon ),조상헌 ( Sang-Heon Cho ),박흥우 ( H 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.4
Background: Cigarette smoking is common in adult asthmatic patients and the smoking rates in these patients are similar to those in the general population. However, adult asthmatics who are current smokers or ex-smokers have been excluded in many clinical studies. Objective: We investigated the impacts of smoking on pulmonary functions and clinical features of asthmatics by using a data from a recently established adult asthma cohort: COREA (Cohort for Reality and Evolution of Adult Asthma). Method: COREA is a Korean adult asthma cohort established since 2005. 1,283 asthma patients were enrolled in this COREA. The patients in this cohort were divided into 3 groups; the current smoker group, the ex-smoker group and the non-smoker group according to the status of smoking. We analyzed and compared the clinical and laboratory parameters of these 3 groups using clinical data, symptom score, pulmonary functions, and quality of life score. Result: Among 1,283 asthmatic patients, 16% were current smokers, 38% were ex-smokers, and 46% were non-smokers. The current smoker and ex-smoker groups were male dominant. Ex-smokers were older and had a longer history of asthma symptoms, mean treatment duration and smoking. Currently smoking asthmatics coughed more frequently in past 3 months. Current smokers and ex-smokers presented significantly lower FEV1, FVC, FEV1/FVC than nons-mokers (P<0.05). Elevated total serum IgE levels were observed in the current smoking and ex-smoking asthmatics groups. In an induced sputum analysis, eosinophil counts were observed to be reduce in the current smoking asthmatic group. Conclusion: The results of this study indicated that smoking has deteriorating effects on pulmonary functions and clinical respiratory symptoms in asthmatic patients. Education for quitting smoking in asthmatics should be stressed for a better control of asthma. (Korean J Asthma Allergy Clin Immunol 2008;28:263-270)
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간세포암 환자에서 간동맥화학색전술 후 발생한 간십이지장 누공
박윤혜 ( Yoon Hea Park ),강세훈 ( Se Hun Kang ),김승업 ( Seung Up Kim ),김도영 ( Do Young Kim ),박준용 ( Jun Yong Park ),안상훈 ( Sang Hoon Ahn ),한광협 ( Kwang Hyub Han ),전재윤 ( Chae Yoon Chon ) 대한소화기학회 2011 대한소화기학회지 Vol.58 No.3
Transarterial chemoembolization (TACE) is recommended as one of the first line therapy for unresectable hepatocellular carcinoma (HCC). Rupture of HCC following TACE is a rare and potentially fatal complication. We report a case of hepaticoduodenal fistula with ruptured HCC and liver abscess complicated by TACE. A 52-year-old male was treated by TACE three times, followed by radiation therapy and systemic chemotherapy. 30 days after the last TACE, right upper quadrant pain of abdomen was developed. About 1 month later, computed tomography of abdomen showed ruptured HCC with debris containing liver abscess and hepaticoduodenal fistula. Esophagogastroduodenoscopy revealed hepaticoduodenal fistula and hepatic parenchyme covered with exudate. The patient was managed with supportive care, but the hepaticoduodenal fistula persisted. (Korean J Gastroenterol 2011;58:149-152)
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Lymphoscintigraphy에 이용되는 방사성의약품의 사용제한으로 인한 대체 방사성의약품의 성능평가
서영덕,정재훈,문종운,윤상혁,김영석,강세훈,원우재,김석기,Seo, Young-Deok,Jeong, Jae-Hun,Moon, Jong-Woon,Yun, Sang-Hyeok,Kim, Yeong-Seok,Kang, Se-Hun,Won, Woo-Jae,Kim, Seok-Ki 대한핵의학기술학회 2009 핵의학 기술 Vol.13 No.1
Purpose: Several radioactive agents were used for lymphoscintigraphy in breast cancer. But recently, due to the change of local radiopharmaceutical licensing policy and discontinuation of supplies from manufacturer, we could not use many radiocolloids such as $^{99m}Tc$-Antimony Trisulfide Colloid, $^{99m}Tc$-Tin Colloid, $^{99m}Tc$-Human Serum Albumin. So it is necessary to use the substitution radiopharmaceutical. Therefore, this study aims to evaluate the performance of substitution radiopharmaceutical ($^{99m}Tc$-Phytate) including the existing radiocolloids and to set up of the appropriate protocol in lymphoscintigraphy. Materials and Methods: For each radiocolloids ($^{99m}Tc$-Antimony Trisulfide Colloid (ASC), $^{99m}Tc$-Tin Colloid (TC), $^{99m}Tc$-Human Serum Albumin (HSA), $^{99m}Tc$-Phytate) were performed the particle size by Zeta Sizer (Nano-ZS) and we compared the radiolabeling time, procedure and acquisition time for each of the radiocolloids (total 200 patients). For the last time, we made an analysis of image for each of the radiocolloids with our previous report (SJ Jang et al, Korean Nucl Med Mol imaging Vol.41, No.6, Dec 2007). Results: The particle size of each radiocolloids showed A.S.C (50 nm), T.C (310 nm), H.S.A (10.8 nm), $^{99m}Tc$-Phytate (499 nm). The labeling and acquisition time for each of the radiocolloids showed no substantial difference. But there is difference of the labeling time for the A.S.C. because the ASC procedure need to boiling process. There were no significant differences among those radiocolloids (p>0.005) in the identification rate (IR), false negative rate (FNR), and negative predictive value (NPV). Conclusions: $^{99m}Tc$-labeled radiocolloids showed equivalent results in lymphoscintigraphy. Therefore, in this exam of each radiocolloids could be applied appropriate protocol in lymphoscintigraphy.
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H1N1 Influenza 폐렴 환자에서 발생한 Mycobacterium abscessus 감염
정경원 ( Kyoung Won Jung ),유훈 ( Hoon Yu ),이태훈 ( Tae Hoon Lee ),권오성 ( O Sung Kwon ),최석원 ( Suk Won Choi ),강세훈 ( Se Hun Kang ),심태선 ( Tae Sun Shim ),김동순 ( Dong Soon Kim ),송진우 ( Jin Woo Song ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.69 No.3
Novel influenza A (H1N1) virus is a common pathogen of febrile respiratory infection recently. Here, we report the case of a 63-year-old male patient who presented with 3 days` ongoing cough and fever. He was diagnosed with novel influenza A (H1N1) pneumonia by real-time reverse-transcriptase-polymerase-chain-reaction (rRT-PCR). During treatment for novel influenza A (H1N1), his symptoms and radiologic findings improved initially, but multiple lung nodules developed subsequently and found on chest x-ray (on the 5th hospital day). Mycobacterium abscessus was isolated repeatedly from sputum and bronchoalveolar lavage fluid. To our knowledge, this is the first reported case of Mycobacterium abscessus lung disease in a patient with H1N1 influenza pneumonia.
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김청택(Cheong Taek Kim),정민환(Min Han Jung),김현식(Hyun Sik Kim),김호정(Ho Jeong Kim),강상진(Sang Jin Kang),강세훈(Se Hun Kang) 한국생약학회 2000 생약학회지 Vol.31 No.2
Two diterpenes and one new sucrose isovaleryl ester having inhibitory effects on melanogenesis in B16 mouse melanoma were isolated from Euphorbiae Lathyridis Semen which has been used in traditional medicine for cancer, tumors and warts. New sucrose isovaleryl ester was identified as α-D-giucopyranoside, 3,4,6-tris-O-(3-methyl-l-oxobutyl)-β-D-fructofuranosyl,2,6-bis(3-methylbutanoate) and two diterpenes were identified as ingenol-20-palmitate and 5,10-diacetyl-3-benzoyllathyrol(Euphorbia factor L₃) from their spectral data.
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