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전기경련충격시 경쟁적 역전사 중합효소연쇄반응(CRT-PCR)을 이용한 흰쥐 뇌 c-fos 유전자의 발현 양식 분석
양병환,이제욱,박응철,유재학,조광원,양보기,채영규,Yang, Byung-Hwan,Lee, Jei-Wook,Park, Eung-Chul,Yu, Jae-Hak,Cho, Goang-Won,Yang, Bo-Gee,Chai, Young-Gyu 대한생물정신의학회 1996 생물정신의학 Vol.3 No.2
To clarify the mechanism of action of electroconvulsive shack(ECS) in respect to molecular biology, and to detect the quantitative amount of change of c-fos gene expression after ECS in the rat's brain, the authors obtained brain specimens from the striatum, cerebral cortex, hippocampus, and cerebellum. Each brain was removed within 30min. after ECS(130V, 0.5sec) and ECS-sham. Then we performed RT-PCR. The results are 1) ECS was found to affect the expression of immediate early genes. 2) the cerebral cortex and hippocampus was more influenced by ECS thon in the cerebellum and striatum. From these results, we can suggest that ECS is related to the mechanism of cognition, mood, memory which is correlated to cerebral cortex and hippocampus.
Benztropine Mesylate가 Haloperidol 타액농도에 미치는 영향에 대한 연구
이승탁,사승언,양병환 大韓神經精神醫學會 1992 신경정신의학 Vol.31 No.3
Nineteen patients with schizophrenia by the DSM-III-R were administrated with only haloperidol in the first period. And the second period began after extrapyramidal symptoms developed, in this period they were administrated with haloperidol and benztropine concomittantly. At the third period, after withdrawal of benztropine, they were administrated with only haloperidol. For the purpose of evaluating the effect of benztropine mesylate on the haloperidol saliva level, the authors measured the haloperidol saliva level, the reduced haloperidol saliva level and the ratio of the reduced haloperidol saliva level/the haloperidol saliva level at the seperated administration period. The results are as follows : 1) Though the haloperidol saliva level of the single administration period of haloperidol was higher than that of other two periods, there was no statistically significant change. 2) The reduced haloperidol saliva level had no statistically significant change among three periods. 3) The reduced haloperidol saliva level/the haloperidol saliva level ratio had no statistically signifiant change among three periods. The authors concluded that the benztropine mesylate had no significant effect on the haloperidol saliva level in this study.
Haloperidol이 stress에 의한 흰쥐 선조체의 monoamine neurotransmitter 대사변화에 미치는 영향
이용성,김우일,고재경,양병환 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1
Haloperidol has been widely used as an antipsychotic drug and is thought to exert its effect by blocking dopamine receptors. In this study, changes in monoamine neurotransmitter metabolism induced by immobilization stress were investigated in corpus striata of the rats pretreated with haloperidol. Concerntrations of dopamine, norepinephrine, serotonin and their metabolites were determined by a single run of HPLC using electrochemical detector within 30 minutes. Concerntration of dopamine (DA) in corpus striatum (54.8 nmole/g wet tissue) was unchanged by haloperidol treatment, but concentrations of its metabolites including 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid(HVA) with their metabolic turnover rates were significantly increased. No changes in norepinephrine and serotonin metabolism were observed after haloperidol treatment. Immobilization stress did not make any changes in norepinephrine metabolism whereas it did make the dopamine and serotonin(HT) metabolism changed. Dopamine concentration was increased by 25% and DOPAC/DA and HVA/DA ratios were decreased by 37% and 25%, respectively, to those of normal control by immobilization stress. Hydroxyin-doleacetic acid(HIAA) content was increased by 73% and HIAA/HT ratio were increased by 44% to those of normal control. No significant differences in the pattern of serotonin metabolism were observed between normal and halopericol pretreated rats. But a significant modification of dopamine metabolism changes which had been induced by immobilization stress was observed following haloperidol pretreatment. The decreasing tendency of dopamine metabolism observed in the rats received immobilization stress was not observed in corpus striata of haloperidol pretreated rats. These results indicate that physiological responses of nigrostriatal tract to stresses are modified by a long-term treatment of haloperidol.
정신분열증환자에서 Haloperidol과 Reduced Haloperidol 사이의 상호변환에 있어 Haloperidol Reductase에 관한 연구
김민정,정은기,오동열,김이영,양병환 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.5
Haloperidol is metabolized through reductation by the enzyme haloperidol reductase at the benzylic ketone to form an alcohol metabolite, known as reduced haloperidol. The basic and clinical pharmacology of reduced haloperidol and also haloperidol reductase is the main subject of haloperidol study, as the reduced metabolite can be converted back to the parent drug which has some neuroleptic effect. This study was undertaken to investigate correlations between haloperiol reductase activity in RBC and reduced haloperidol formation, also the difference of haloperidol reductase activity between responding and nonresponding schizophrenic patient. The results were as follows : 1) The haloperidol reductase activity of schizophrenic patients in RBC at 2 weeks was 12.8±4.3ng/30 min/200ul RBC, 16.0±11.9 at 4 weeks and 22.3±71 in control group. There was statistically significant difference of haloperidol reductase activity in RBC between schizophrenic patient and control group at 2 weeks but no difference at 4 weeks. 2) We divided the patient into responding and nonresponding group by the percentage of improvement in total BPRS score as more or less than 31% respectively and there was no significant difference of haloperidol reductase activity in RBC among two groups. 3)) There was no significant relationship between haloperidol dose of administration and haloperidol reductase activity in RBC. Considering the above results, haloperidol reductase activity in schizophrenic patients showed different results according to the duration of drug administration, so the study which deal with the factors, influencing the activity of haloperidol reductase, should be undertaken in the future.
양병환,김석현,이영호 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2
About 150 years have passed since genetics introduced into the psychiatric fields. Nowadays, due to the development of biological psychiatry, psychiatric genetics become a very important section of the psychiatry, contributing to the research for genetic components of psychiatric disorders. But genetic studies of psychiatric disorders have many problems. One reason of the difficulty is that psychiatric disorders do not follow Mendelian inheritance. Instead, psychiatric disorders seems that they have polygenic and multifactorial inheritance characteristics. The authors reviewed the research methods of psychiatric genetics such as family study, twin and adoption study, segregation analysis, linkage and association studies. Also the problems and issues of the research methods were discussed.