마두영약침(馬兜鈴藥鍼)의 천식억제(喘息抑制) 및 면역조절효과(免疫調節效果)에 대(對)한 실험적(實驗的) 연구(硏究)

박정준,김영일,이현,Park, Jung-Jun,Kim, Young-Il,Lee, Hyun 경락경혈학회 2005 대한침구의학회지 Vol.21 No.1

Objectives : The aim of this study was to investigate the Asthma-suppressive and Immune-regulatory effect of AF-HA(Aristolochiae Fructus Herbal-acupuncture) at Joksamni(St36) in OVA(ovalbumin) induced asthma mouse model. Methods : C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). The mice in the OVA-AF-HA group were treated with AF-HA at St36 for the later 8weeks(3times/week). The mice in the OVA-Needle-prick group were treated with single prick with an injection needle at St36 for the later 8 weeks(3times/week). Results : 1. The lung weight and the total cells in lung of the mice treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 2. Total leukocytes and eosinophils in BALF of the mice group treated with AF-HA at St36 decreased remarkably compared with those of the OVA-control group. 3. The collagen accumulation in lung of OVA-AF-HA group decreased significantly compared with that of the OVA-control group, 4. The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 5. The numbers of $Gr-1^+/CD11b^+\;and\;CD11b^+$ cells in lung of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 6. The numbers of $CCR3^+,\;CD4^+,\;CD8^+\;and \;CD3e^+/CD69^+$ cells in lung of the mice group treated with AF-HA at 5136 decreased significantly compared with those of the OVA-control group. 7. The mRNA expressions of $TNF-{\alpha}$, IL-4, IL-5, IL13 in lung of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. Conclusion : These results suggest that Aristolochiae Fructus Herbal-acupuncture at Joksamni(St36) may be an effictive therapeutic method to treat asthma.

마두령약침(馬兜領약鍼)의 천식억제(喘息抑制) 및 면역조절효과(免疫調節效果)에 대(對)한 실험적(實驗的) 연구(硏究)

박정준 ( Jung Jun Park ),김영일 ( Young Il Kim ),이현 ( Hyun Lee ) 대한경락경혈학회 2005 Korean Journal of Acupuncture Vol.22 No.3

Objectives: The aim of this study was to investigate the Asthma-suppressive and Immuno-regulatory effect of AF-HA(Aristolochiae Fructus Herbal-acupuncture) at Joksamni(St36) in OVA(ovalbumin)-induced asthma mouse model. Methods: C57BL/6 mice were sensitized and challenged with OVA(ovalbumin) for 12 weeks(once a week). The mice in the OVA-AF-HA group were treated with AF-HA at St36 for the later 8 weeks(3times/week). The mice in the OVA-Needle-Prick group were treated with single prick with an injection needle at St36 for the later 8 weeks(3times/week). Results: 1. The lung weight and the total cells in lung of the mice treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 2. Total Leukocytes and eosinophils in BALF of the mice group treated with AF-HA at St36 decreased remarkably compared with those of the OVA-control group. 3. The collagen accumulation in lung of OVA-AF-HA group decreased significantly compared with that of the OVA-control group. 4. The concentrations of IL-4, IL-5, IgE in BALF, and IL-4, IL-5, IL-13 in serum of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 5. The numbers of Gr-1+/CD11b+ and CD11b+ cells in lung of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 6. The numbers of CCR3+, CD4+, CD8+ and CD3e+/CD69+ cells in lung of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. 7. The mRNA expressions of TNF-α, IL-4, IL-5, IL-13 in lung of the mice group treated with AF-HA at St36 decreased significantly compared with those of the OVA-control group. Conclusion: These results suggest that Aristolochiae Fructus Herbal-acupuncture at Joksamni(St36) may be an effictive therapeutic method to treat asthma.

계작지모가우슬탕(桂芍知母加牛膝湯) 약침이 류마티스 관절염 생쥐에 미치는 영향

정순현 ( Soon Hyun Jung ),조종관 ( Chong Kwan Cho ),김소연 ( So Yun Kim ),김영일 ( Young Il Kim ) 대전대학교 한의학연구소 2016 혜화의학회지 Vol.24 No.2

Objectives : The purpose of this study is to prove the effect and mechanism of Gamikyejakjimogawusul-tang(GKHA) herbal acupuncture on induced rheumatoid arthritis model of DBA/1 mice. Methods : We check effect of GKHA extract on the AST, ALT, Creatinine, BUN of serum and cell viability of GK extract in RAW 264.7 cells to test the stability of this study. In vitro, we measure total phenol contents, total flavonoid contents, DPPH free radical scavenging activity, ABTS cation radical scavenging activity of Gamikyejakjimogawusul-tang, effect of GK extract on ROS(Reactive Ooxygen Species) production to estimate a anti-oxidant capacity, and we also measure effect of GK extract on NO (Nitric Oxid), IL-1β, IL-6, IL-17, IL-21, TNF-α, MCP-1, GM-CSF production in RAW 264.7 cells to estimate a anti-inflammatory efficacy. In vivo, we compare a rheumatoid arthritis manifestation between control and experimental group and estimate a AI. Then we check effect of GKHA on the level of WBC, neutrophil, lympocyte, monocyte in the blood to see the effect of immune cells in blood. In addition we measure effect of GKHA on the level of hs-CRP, IgM, IgG, IL-1β, IL-6, IL-17, IL-21, TNF-α, MCP-1, GM-CSF in serum. We observe effects of GKHA on imaging of cartilage degeneration using micro CT-arthrography in paw hind. And we calculate effects of GKHA that reduced BV ratio, BS/BV ratio using 3D Micro-CT. Lastly we observe effects of GKHA histopathologic examination analysis. Results : 1. The toxicity on liver and kidney was disregardable and the cytotoxicity against RAW 264.7 cells was also disregardable. < In vitro > 1. Total phenol contents and total flavonoid contents in GK extract were in high level. 2. DPPH free radical scavenging activity and ABTS cation radical scavenging activity were increased according to concentration of GK extract 3. ROS production was significantly decreased in GK extract (at 10, 100 ㎍/ml). 4. NO, IL-6, TNF-α, MCP-1 production were significantly decreased in GK extract(at 10, 100 ㎍/ml). IL-17, GM-CSF production were significantly decreased in GK extract(at 1, 10, 100 ㎍/ml). IL-1β, IL-21 production were also decreased but there was no statistical significance. 5. 25x observation after H&E and M-T staining, infiltration of immune cells and subsidence of the cartilage and damage to the synovial cells were decreased. Conclusions : This study showed that GKHA extract had anti-oxidant capacity, anti-inflammatory efficacy. GKHA extract also had inhibiting effect on the process of rheumatoid arthritis and can protect joint and cartilage. So we expect that GKHA extract can be a meaningful treatment to rheumatoid arthritis patients.

금은화, 연교, 포공영 혼합물의 항염증 작용에 관한 연구

최강민 ( Kang Min Choi ),전주현 ( Ju Hyun Jeon ),김은석 ( Eun Seok Kim ),성기정 ( Ki Jung Sung ),김영일 ( Young Il Kim ) 대전대학교 한의학연구소 2021 혜화의학회지 Vol.30 No.1

Objective : The purpose of this study is to investigate the inflammatory-control effects of Cheonghyeol-antidote complex(Lonicera japonica Thunberg, Forsythia viridissima Lindley, and Taraxacum platycarpum H. Dahlstedt complex, CHA) in LPS-induced RAW264.7 cell and mouse inflammation models. Method : For in vitro and in vivo experiment, Indicators such as cell viability, mRNA expression level(iNOS, IL-6, IL-1β, COX-2, TNF-a), Inflammatory factor production(NO, IL-6, IL-1β, TNF-a), and protein phosphorylation level(ERK, JNK, p38) were analyzed. For in vivo experiment, Indicators such as mRNA expression level(iNOS, IL-6, IL-1β, COX-2, TNF-a), Inflammatory factor production(IL-6, IL-1β, TNF-a), protein phosphorylation level(ERK, JNK, p38) and immune cell(white blood cell, lymphocyte) were analyzed. Results : 1. In vitro experiment In cell viability of CHA, CHA showed cell viability below 90% at concentrations of 400 μg / ml or more. In mRNA expression level, IL-6 and IL-1β showed a significant decrease at all concentrations except 25 μg / ml concentration, and iNOS, COX-2, and TNF-a showed a significant decrease at all concentrations of CHA compared to the control group. In inflammatory factor production, NO and TNF-a showed a significant decrease at all concentrations except 25 μg / ml concentration of CHA, and IL-1β showed a significant decrease at 100, 200 μg / ml concentration of CHA compared to the control group. IL-6 showed a significant decrease at all concentration of CHA compared to the control group. In protein phosphorylation level, ERK and p38 showed a significant decrease at all concentrations except 25 μg / ml concentration of CHA and JNK showed a significant decrease at all concentrations of CHA compared to control group. 2. In vivo experiment In mRNA expression level, iNOS, COX-2 and TNF-a showed a significant decrease in all administration groups of CHA compared to the control group. In Inflammatory factor production, IL-6, IL-1β and TNF-a showed a significant decrease in all the administration groups of CHA. In protein phosphorylation level, ERK, JNK, and p38 showed a significant decrease in all the administration groups of CHA. In the immune cells, leukocytes and lymphocytes showed a significant decrease in all the administration groups of CHA. Conclusions : This study shows that CHA has antioxidant and inflammatory-control effects on LPS-induced RAW264.7 cells. It is hoped that further research will be conducted on the individual mechanisms of Lonicera japonica Thunberg, Forsythia viridissima Lindley, and Taraxacum platycarpum H. Dahlstedt.

컨테이너 터미널 내 반출입 차량 대기시간 예측에 관한 연구

김영일,신재영,박형준,Kim, Yeong-Il,Shin, Jae-Young,Park, Hyoung-Jun 한국항해항만학회 2022 한국항해항만학회지 Vol.46 No.4

물동량의 증가로 인해 컨테이너 터미널의 혼잡도가 높아지고 있고 이에 따른 장치장 및 게이트에서의 반출입 차량의 대기시간이 큰 폭으로 길어지고 있어 차량 운용 및 항만 운영 비효율이 극심한 상태이다. 이러한 문제 해결을 위해 부산항의 경우, 항만 공사 및 터미널 측에서 반출입 차량 예약시스템(VBS), 터미널 차량 혼잡도 정보, 예상 작업 처리 시간 정보 등을 서비스하고 있지만 실제 대기시간과 상이한 경우가 있어 가시적인 효과는 여전히 미흡한 실정이다. 따라서 이러한 문제를 해결하기 위한 기초자료로써 본 연구에서는 부산 신항의 컨테이너반출입 정보를 활용하여 딥러닝 기반의 반출입 차량 평균 대기시간 예측 모형을 제시하였다. 실제 평균 대기시간과의 비교를 통해 예측률을 검증한 결과 제시한 예측 모형이 높은 예측률을 보이는 것을 확인하였다. Due to the increase in container cargo volume, the congestion of container terminals is increasing and the waiting time of gate in-out trucks has significantly lengthened at container yards and gates, resulting in severe inefficiency in gate in-out truck operations as well as port operations. To resolve this problem, the Busan Port Authority and terminal operator provide services such VBS, terminal congestion information, and expected operation processing time information. However, the visible effect remains insufficient, as it may differ from actual waiting time.. Thus, as basic data to resolve this problem, this study presents deep learning based average gate in-out truck waiting time prediction models, using container gate in-out information at Busan New Port. As a result of verifying the predictive rate through comparison with the actual average waiting time, it was confirmed that the proposed predictive models showed high predictive rate.

다항회귀모형에서의 추가받힘점 선택

김영일,장대흥,Kim, Young-Il,Jang, Dae-Heung 한국데이터정보과학회 2014 한국데이터정보과학회지 Vol.25 No.6

최적실험의 제일 큰 약점은 실험기준이 지나치게 모형과 그에 수반되는 가정에 의존한다는 점이다. 이는 종종 모형의 모수의 개수와 받힘점의 개수가 일치를 하는 경우로 이루어지는데 이는 가정된 모형이 참이 아닌 경우를 대비한 실험이 될 수 없다. 이런 경우 문헌에서는 가정된 다항회귀모형의 차수보다 큰 차수를 가진 다항회귀모형을 가정하고 최적실험을 제안하나 이는 D-효율에 근거한 관행적인 방법일 뿐이다. 본 연구에서는 O'Brien (1995)이 제안한 가정된 모형의 일반적인 이탈을 염두에 둔 추가받힘점 생성에 관하여 알아보고 단순회귀모형과 2차 회귀모형에 대한 실험들을 D-효율로 카타로그화 하여 실험자로 하여금 선택을 할 수 있게 하였다. O'Brien은 비선형모형에 대해 추가받힘점의 선택 방법을 제시하였지만 방법을 구현하는 데 있어 명확치 않은 기준이 있어 모수에 의존하는 비선형모형에 대한 최적실험보다는 다항회귀모형을 중심으로 심층적으로 사용방법을 알아보았다. The major criticism of optimal experimental design is that it depends heavily on the model and its accompanying assumption that often leads the number of support points equal to the number of parameters in the model. Often in the past, a polynomial model of higher degree is assumed to handle the experimental design for the polynomial regression of lower degree. In this paper we searched the possible set of designs which are robust to the departure of the assumed model. The designs are categorized with respect to D-efficiency. The approach by O'Brien (1995) was discussed in univariate polynomial regression model setting.

신경회로망을 이용한 가열로 감독제어

김영일,문기철,장근수 ( Young Il Kim,Ki Cheol Moon,Kun Soo Chang ) 한국화학공학회 1996 화학공학의이론과응용 Vol.2 No.1

빅데이터 분석 기법을 활용한 모바일 CRM 설계 및 구현

김영일,양승수,이상순,박석천,Kim, Young-Il,Yang, Seung-Su,Lee, Sang-Soon,Park, Seok-Cheon 한국인터넷방송통신학회 2014 한국인터넷방송통신학회 논문지 Vol.14 No.6

최근 기업에서 데이터 마이닝 기법을 이용한 CRM을 마케팅이나 새로운 기획에 활용하고 있다. 그러나 데이터 마이닝 기술은 전문지식이 필요하여 일반인의 접근이 어렵고 시간과 공간의 제약을 받게 된다. 본 논문에서는 이를 해결하기 위해 데이터 마이닝 기법을 적용한 Mobile CRM을 제안하였다. 이를 위해 기존 CRM 시스템의 구조를 분석하고 데이터 흐름과 형식을 정의 하였다. 또한 시스템 프로세스를 정의하여 데이터 마이닝 기법을 이용한 판매동향분석 알고리즘과 고객판매추천 알고리즘을 설계하였다. 제안 시스템에 대한 평가는 시나리오 테스트를 통해 정상 동작을 확인하였으며 기존 시스템과의 비교 검증을 실시하였다. 테스트 결과 기존 프로그램과 데이터 값이 일치하여 신뢰성을 확인하고 제안한 통계 테이블 조회를 통해 데이터 분석 시간을 감소시켜 신속성을 검증하였다. In the recent enterprises and are utilizing the CRM using data mining techniques and new marketing plan. However, data mining techniques are necessary expertise, general public access is difficult, it will be subject to constraints of time and space. in this paper, in order to solve this problem, we have proposed a Mobile CRM applying the data mining method. Thus, to analyze the structure of an existing CRM system, and defines the data flow and format. Also, define the process of the system, was designed sales trend analysis algorithm and customer sales recommendation algorithm using data mining techniques. Evaluation of the proposed system, through the test scenario to ensure proper operation, it was carried out the comparison and verification with the existing system. Results of the test, the value of existing programs and data matches to verify the reliability and use queries the proposed statistical tables to reduce the analysis time of data, it was verified rapidity.

족삼리(足三里)(St36)의 전침자극(電鍼刺戟)이 fMRI상 뇌활성(腦活性) 변화(變化)에 미치는 영향(影響)

김영일,김영화,임윤경,이현,이병렬,김연진,Kim, Young-il,Kim, Young-hwa,Lim, Yun-kyoung,Lee, Hyen,Lee, Byung-ryul,Kim, Yeon-jin 대한침구의학회 2003 대한침구의학회지 Vol.20 No.5

Objective: Recently. many studies have showed the evidences of the effect of the Electro-acupuncture treatment through scientific. Methods : One of these methods is functional MRI. We performed electro-acupuncture on Zusanli(St36) and observed the change of brain activation using fMRI. Zusanli(St36) is located on the lateral side of the lower leg. 3 cun(寸) inferior to the Patella of the lower border. Theoretically and clinically. this point has been considered very important for gynecological disorders. spleen and stomach disorders. and psychological disorders. To see the effects of electro-acupuncture stimulation on Zusanli(St36). the experiment was carried out on twelve healthy volunteers. using the gradient echo sequence with the 3.0T whole-body fMRI system(ISOL). After the needle insertion on right Zusanli(St36). 2 Hz of electric stimulation was given for 30 seconds. repeated five times. with 30 seconds' intervals. The Image analysis including motion correction. talairach transformation, and smoothing was done with SPM99. Results ad conclusion : The electro-acupuncture stimulation on Zusanli(St36) activates Brodmann Area 6, 13, 2, 19, 21, 22, 39, 40, 38, 3which indicates the pathways of the electro-acupuncture stimulation on Zusanli(St36) and the possibility of the relationship of the electro-acupuncture stimulation on Zusanli(St36) with autonomic nervous system, internal organic system.

원격검침 설비의 네트워크 상태감시를 위한 SNMP 기반의 저압 AMI 망관리시스템 개발

김영일,박소정,김영준,정남준,최문석,박병석,Kim, Young-Il,Park, So-Jeong,Kim, Young-Jun,Jung, Nam-Jun,Choi, Moon-Suk,Park, Byung-Seok 한국전력공사 2016 KEPCO Journal on electric power and energy Vol.2 No.2

KEPCO installed AMI (Advanced Metering Infrastructure) metering system for low-voltage customers from 2008. AMI metering system of KEPCO has operated 2.55 million customers and will plan to operate 22 million customers until 2020. KEPCO developed AMI NMS (Network Management System) to operate the meter reading network efficiently. NMS monitors the network status of DCUs (Data Concentration Unit) and modems. NMS provides functionalities of data collection and analysis. It collects property data of network device, network topology information, communication performance information, fault information, and etc. It analyzes collected data and controls network devices by remote access. AMI NMS collects about 370 MIBs (Mangement Information Bases) using SNMP (Simple Network Management Protocol). This paper introduces main functionalities, designed context, and implemented service screen. 한국전력공사는 200년부터 저압 고객에 대한 AMI (Advanced Metering Infrastructure) 기반의 검침시스템을 구축하여 운영하고 있다. 한전의 AMI 검침시스템은 현재 255만호에 설치되어 운영되고 있으며 2020년까지 2200만호를 설치하여 운영할 예정이다. 본 연구에서는 원활한 AMI 검침망 운영을 위해 DCU (Data Concentration Unit) 및 모뎀에 대한 네트워크 동작상태를 감시할 수 있는 AMI 망관리시스템을 개발하였다. AMI 망관리시스템은 네트워크 장비에 대한 속성 데이터 및 네트워크 토플로지 정보, 통신성능 정보, 장애정보 등을 수집하고, 데이터 분석을 통해 장애내역을 생성하며, 원격에서 장비를 제어하는 등의 기능을 제공하고 있다. AMI 망관리시스템은 전력선 통신망에서 네트워크 장비에 대한 약 370여개의 MIB (Management Information Base) 정보를 SNMP (Simple Network Management Protocol)를 이용하여 수집과 제어를 수행하고 있다. 본 논문에서는 AMI 망관리시스템에 대한 주요 기능과 설계내용, 구현된 서비스 화면을 소개하고자 한다.