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- 저자 : 정순현 ( Soon Hyun Jung ) (검색결과 5 건)
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계작지모가우슬탕(桂芍知母加牛膝湯) 약침이 류마티스 관절염 생쥐에 미치는 영향
정순현 ( Soon Hyun Jung ),조종관 ( Chong Kwan Cho ),김소연 ( So Yun Kim ),김영일 ( Young Il Kim ) 대전대학교 한의학연구소 2016 혜화의학회지 Vol.24 No.2
Objectives : The purpose of this study is to prove the effect and mechanism of Gamikyejakjimogawusul-tang(GKHA) herbal acupuncture on induced rheumatoid arthritis model of DBA/1 mice. Methods : We check effect of GKHA extract on the AST, ALT, Creatinine, BUN of serum and cell viability of GK extract in RAW 264.7 cells to test the stability of this study. In vitro, we measure total phenol contents, total flavonoid contents, DPPH free radical scavenging activity, ABTS cation radical scavenging activity of Gamikyejakjimogawusul-tang, effect of GK extract on ROS(Reactive Ooxygen Species) production to estimate a anti-oxidant capacity, and we also measure effect of GK extract on NO (Nitric Oxid), IL-1β, IL-6, IL-17, IL-21, TNF-α, MCP-1, GM-CSF production in RAW 264.7 cells to estimate a anti-inflammatory efficacy. In vivo, we compare a rheumatoid arthritis manifestation between control and experimental group and estimate a AI. Then we check effect of GKHA on the level of WBC, neutrophil, lympocyte, monocyte in the blood to see the effect of immune cells in blood. In addition we measure effect of GKHA on the level of hs-CRP, IgM, IgG, IL-1β, IL-6, IL-17, IL-21, TNF-α, MCP-1, GM-CSF in serum. We observe effects of GKHA on imaging of cartilage degeneration using micro CT-arthrography in paw hind. And we calculate effects of GKHA that reduced BV ratio, BS/BV ratio using 3D Micro-CT. Lastly we observe effects of GKHA histopathologic examination analysis. Results : 1. The toxicity on liver and kidney was disregardable and the cytotoxicity against RAW 264.7 cells was also disregardable. < In vitro > 1. Total phenol contents and total flavonoid contents in GK extract were in high level. 2. DPPH free radical scavenging activity and ABTS cation radical scavenging activity were increased according to concentration of GK extract 3. ROS production was significantly decreased in GK extract (at 10, 100 ㎍/ml). 4. NO, IL-6, TNF-α, MCP-1 production were significantly decreased in GK extract(at 10, 100 ㎍/ml). IL-17, GM-CSF production were significantly decreased in GK extract(at 1, 10, 100 ㎍/ml). IL-1β, IL-21 production were also decreased but there was no statistical significance. 5. 25x observation after H&E and M-T staining, infiltration of immune cells and subsidence of the cartilage and damage to the synovial cells were decreased. Conclusions : This study showed that GKHA extract had anti-oxidant capacity, anti-inflammatory efficacy. GKHA extract also had inhibiting effect on the process of rheumatoid arthritis and can protect joint and cartilage. So we expect that GKHA extract can be a meaningful treatment to rheumatoid arthritis patients.
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정순현 ( Soon Hyun Chung ),이승민 ( Seung Min Lee ),전주현 ( Ju Hyun Jeon ),김정호 ( Jung Ho Kim ),김영일 ( Young Il Kim ) 대전대학교 한의학연구소 2013 혜화의학회지 Vol.22 No.1
Object: Recently, demend for Korean Medicine have been rapidly increasing in Korea. However, there are still a few studies for recognition, satisfaction and satisfaction factors of Korean Medicine to increase competitiveness of Korean-Medical service. Thus, the purpose of this study is to grope ways to strengthen the competitiveness of Korean-Medical service by investigating recognition and satisfaction factors on Korean medicine. Method: People who have been experienced Korean Medicine were targets of investigation. Questionnaire was consisted of questions about awareness for the Korean Medicine, awareness of Korean-Medical treatment, satisfaction level for Korean Medicine, satisfaction and dissatisfaction factors. This questionnaires were conducted through personal interviews. Result: Total 315 members responded to the survey and the results of the analysis were as follows. 1. Korean Medicine treatment was recognized as the scientific medical act to protect human body wellness. 2. Korean-Medical service can be represented by acupuncture and moxibustion therapy, physical therapy, Korean medicine. And care for diseases such as pain disorders, chronic fatigue, anti-aging, and geriatric disease were wanted. 3. The factors that influence on satisfaction of the Medical Services was the perception that Korean Medicine is scientific and safe. Conclusion: To strengthen the competitiveness of Korean-Medical service, first, efforts to enhance the effectiveness of the basic treatment such as acupuncture and moxibustion, herbal medicine are required. Second, scientific development of Korean Medicine is necessary. Finally, the effort to offer various services of Korean Medicine are needed.
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정순현(Jung Soon-Hyun) 한국현상학회 2006 철학과 현상학 연구 Vol.29 No.-
탈 근대적 사유의 선구자로 지목되는 베르그손은 자신의 저서들을 통해 칸트의 선험철학과 그의 주체개념을 꾸준히 비판하면서 지속과 생명을 기초로 형이상학을 재건하고자 하였다. 칸트의 선험적 주체는 근대의 합리적 사유체계를 설명하는 핵심 개념이다. 사유주체의 종합적 통일능력을 바탕으로 하는 칸트의 선험적 주체는 공간을 통해 인식의 객관성을 확립한다. 베르그손에 따르면 칸트의 선험적 주체는 과학적 인식의 토대를 제공해주는 가능한 경험의 일반 조건이 되지만 그렇게 됨으로써 진정한 시간성을 잃어버린 피상적이고 상징적이며 관념적인 주체이다. 칸트와는 달리 베르그손 철학에 있어 주체는 인식의 가능한 조건을 넘어선 확장된 의식에서 포착되며 실재의 경험을 주도하는 자유롭고 구체적인 모습을 보여준다. 베르그손은 의식과 오성, 지성의 역할을 분석하고 공간의 방식이 아닌 시간의 방식으로 주체를 기술한다. 즉 주체의 실재 경험은 새롭게 정의된 신체주관과 기억의 상호작용을 통해 역동적으로 이루어진다. 공간이 아닌 시간 속에서, 시간적으로 체험하는 실재의 자아가 바로 베르그손 형이상학이 기초하는 주체개념이다.
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