Hypertension Risk with Abacavir Use among HIV-Infected Individuals: A Nationwide Cohort Study

김정미,김정미,방지환,신주영,양보람,이중엽,박병주 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.10

Purpose: A high risk of cardiovascular disease (CVD) is reported for HIV-infected individuals. While a link between abacavir and CVD risk is suggested, an association between abacavir and hypertension remains unclear. This study evaluated hypertension risk with abacavir use in comparison to non-abacavir antiretroviral treatment (ART). Materials and Methods: From a nationwide cohort of HIV-infected individuals on their initial ART, 6493 who were free of hypertensionat baseline were analyzed. The use of ART was treated as a time-varying covariate measured as a daily unit. Incidence rate of hypertension was calculated, and Cox proportional hazard models were used to estimate adjusted hazard ratios (HRs) with 95% confidence interval (CI) of incident hypertension overall and among subgroups. Results: From the 6493 participants, 24072 person-years (PY) of follow-up were contributed during 2008–2016. The incidence rates of hypertension were 4.6 and 3.6 per 100 PY for abacavir and non-abacavir ART users, respectively. The population attributablefraction of abacavir use on hypertension was 12%. Abacavir exposure did not elevate the risk of hypertension among overall study population [HR, 1.2 (95% CI, 1.0–1.4), p=0.061]. However, those with poor ART adherence, defined as a medication possessionratio <50% [HR, 1.9 (95% CI, 1.5–2.4), p<0.0001] or requiring prophylactic antibiotics [HR, 1.2 (95% CI, 1.0–1.3), p=0.023], were at risk of hypertension induced by abacavir, as were men, individuals aged ≥40 years, and patients visiting tertiary hospitals in urban areas. Conclusion: When present, poor ART adherence, requiring prophylactic antibiotics, male sex, and older age may warrant additionalconcern for hypertension in patients treated with abacavir.

정규수술 스케줄 관리 및 개선활동을 통한 정규수술 취소율의 감소

김정미,박정옥,한경화,양경아,김정미,김영옥,이숙영,허지희,김주연,황미숙,박형주,김헌,이영길 한국의료QA학회 2008 가을학술대회 Vol.2008 No.3

『 고사기 』 에 있어서 천신강임신화고 : 韓國神話との比較硏究 한국신화와의 비교연구

김정미 한국일어일문학회 1988 日語日文學硏究 Vol.13 No.1

활성슬러지, 부분질산화 미생물, 혐기성 암모니아산화 미생물의 혼합비율에 따른 탈암모니아 활성 비교

김정미,최원영,박영현,정소연,Lucky Caesar Direstiyani,이태호 대한환경공학회 2017 대한환경공학회 학술발표논문집 Vol.2017 No.11

단일 탈암모니아 시스템의 효율적인 공정 개시

김정미,최원영,정소연,Lucky Caesar Direstiyani,권태원,박영현,유재철,이태호 대한환경공학회 2018 대한환경공학회 학술발표논문집 Vol.2018 No.11

아동중심 미술치료를 통한 새터민 아동의 자아개념과 학교생활 수행 향상 사례연구

김정미 한국미술치료학회 2008 美術治療硏究 Vol.15 No.2

The purpose of this study is that a child can study and hang out with other people in school amicably through child-centered art therapy and improving self-conception of North korean defector's child. A participant was a girl, 6th grade in primary school, and was a North Korean defector's child. A teacher in charge of her class requested social welfare manager to care of her to change her behaviors. The participant has had a lot of dissatisfactions and enmities regarding her friends. She curses them and can not hang out with them and even has a denial in class. Following these facts and her features, there have 17 total sessions of child-centered therapy program to improve a self-conception of child. For effect of therapy, used the pro and post measure of self-conception and checked a change of color following process about change of self-conception with explanation of a child. To show about change of school life, used the pro and post KSD projective test and understood about meaning of symbol with explanation of child. As a result, Not only the self-conception has been improved, but also the colors have been changed following change of the self-conception. Also, the school life has changed due to change of the self-conception through talking with a participant. Therefore, this study showed that child-centered art therapy can help a North Korean defector's child, to improve her self-conception so that hangs out with other people in school amicably. 본 연구는 새터민 아동을 대상으로 아동중심미술치료를 통해 자아개념을 긍정적으로 형성시켜 학교생활을 원만히 잘 수행할 수 있도록 도와주는 데 있다. 연구의 대상은 초등학교 6학년 새터민 여자아동으로서 사회복지사 선생님의 부탁으로 학교 담임선생님에 의해 의뢰되었다. 의뢰 내용에 의하면 새터민 아동은 친구들에 대한 불만과 미움이 많고 욕을 많이 하며 친구들과 잘 어울리지 않으며 학습에 대한 태도가 부정적이라고 하였다. 학교담임 선생님의 의뢰 내용과 새터민 아동의 특성을 감안하여 아동의 자아개념 향상을 치료의 목표로 두고 17회기에 걸쳐 아동중심 미술치료 프로그램을 실시하였다. 치료의 효과를 살펴보기 위해 사전 사후 자아개념척도를 사용하였으며 자아개념이 변해가는 과정을 아동의 설명과 함께 색으로도 확인해 보고자 하였다. 학교생활에 대한 변화를 보기 위해서는 KSD투사검사를 사전 사후 실시하여 아동의 대화를 통해 상징의 의미를 이해하였다. 그 결과 자아개념이 긍정적으로 형성되었으며, 자아개념의 변화에 따라 학교생활에도 변화가 있는 것을 아동의 설명을 통해 알 수 있었다. 또한 자아개념과 학교생활의 변화에 따라 색도 변화되는 것을 아동의 대화를 통해 알 수 있었다. 따라서 본 연구는 아동중심 미술치료가 새터민 아동의 자아개념을 향상시켜 학교생활을 원만히 수행하는데 도움이 되었음을 확인할 수 있었다.

도토리 우유식빵의 품질 특성

김정미,주정임 한국식생활문화학회 2019 韓國食生活文化學會誌 Vol.34 No.3

The aim of this study was to optimize the best recipe to make acorn bread containing milk as a functional food. The color value, textural, and sensory properties of the acorn bread added with 10%~40% ratio of milk were measured to develop the best recipe. As a result, the L-value of color increased with the amount of milk added, but the a- and b-values decreased. As the textural measurement, the hardness increased with increasing milk added. Cohesiveness and springiness decreased, but the gumminess and brittleness increased with the addition of 20% milk, and decreased with further addition. The sensory evaluation revealed color, taste, and overall acceptances to have high scores at 20% addition of milk. Softness and chewiness were good at 10% addition. During the storage periods at room temperature, the L- and b-values increased with increasing milk addition, whereas a-value decreased. In freezer storage, the L-value increased with increasing milk content, but the a- and b-values decreased during the storage periods. The textural properties increased during the storage at room temperature. The addition of milk decreased the cohesiveness and springiness, but the gumminess and brittleness increased significantly after one day storage. In freezer storage, all textural properties increased significantly during thestorage periods, but the hardness decreased after two days storage. With the increasing amount of milk added increased the cohesiveness, springiness, and the gumminess except for four days, but decreased hardness and brittleness after two days two days storage. Therefore the addition of milk in acorn bread improved the textural properties significantly.

동적 다엽콜리메이터의 Leaf gap이 전산화 치료계획에 미치는 영향

김정미,윤인하,홍동기,백금문,Kim, Chong Mi,Yun, In Ha,Hong, Dong Gi,Back, Geum Mun 대한방사선치료학회 2014 대한방사선치료학회지 Vol.26 No.2

목 적 : 최근 사용이 급증하고 있는 미국 베리안사의 이클립스 치료계획 시스템은 치료기에 설치되어 있는 다엽콜리메이터의 충돌 보호를 위해 존재하는 하드웨어적 제한성을 립 갭이라는 설정을 통하여 소프트웨어적으로 극복함으로써 정확한 치료계획을 구현 할 수 있도록 한다. 본 연구에서는 이클립스 치료계획 시스템에 설정되어 있는 립 갭이 치료계획에 미치는 영향을 분석하고 정확한 임상적용에 이용할 수 있도록 하고자 한다. 대상 및 방법 : 연구에 사용되어진 이클립스 치료계획 시스템의 버전은 11.0이다. 시스템에 설정되어 있는 립 갭은 각 치료기와 광자 에너지별로 측정되었다. 일반적으로 0.05~0.30 mm의 값을 가지고 있고, 다엽콜리메이터의 교정상태에 따라 다르므로 일괄되게 적용하지 않고 측정를 통하여 적용한다. 본 연구에서는 세기변조와 용적변조 치료계획을 측정된 각각의 립 갭을 적용하고, 립 갭이 달라질 때마다 치료계획의 영향을 Dmax, CI 등을 이용하여 평가하였다. 결 과 : 동일한 치료계획을 각각의 치료기에서 립 갭을 변화하며 평가하였을 때, 립 갭이 0.05 mm ~ 0.50 mm로 증가할수록 Dmax, CI 의 값이 2~5% 이상 증가하였다. 세기변조방사선치료계획과 용적변조방사선치료계획 모두 동일한 경향을 나타내었고 각 치료계획 간의 유의성은 찾아 볼 수 없었다. 결 론 : 치료기의 다엽콜리메이터의 립 갭 설정은 일반적으로 고유한 측정값을 가지고 있다. 하지만, 다엽콜리메이터의 노후, 교정, 수리 및 점검 후에 립 갭은 변할 수 있고, 이러한 값은 결국 치료계획에 영향을 미치기 때문에 반드시 확인 후 치료에 적용해야 한다. 경우에 따라선 립 갭을 초기 설정값을 유지하는 할 수 있는데, 이는 치료계획에 미치는 영향을 무시할 수 있기 때문에 바람직하지 않다. Purpose : The Varian's Eclipse radiation treatment planning system is able to correct radiation treatment thought leaf gap which is limitation MLC movement for collision with both MLC. In this study, I'm try to analyze dosimetric effect about the leaf gap in treatment planning system. And then apply to clinical implement. Materials and Methods : The Elclipse version is 10.0. In general, the leaf gap set to 0.05~0.3 mm and must measurement each leaf gap. The leaf gap measured by each LINACs and photons. We applied to measured each leaf gap in IMRT and VMAT. Changing the leaf gap, we evaluated treatment plans by Dmax, CI, etc. Results : When the same plan was evaluated with changing the leaf gap, an increase of 2-5% over the value Dmax, CI increases mm to 0.0~0.50 mm leaf gap. Volumetric modulated and intensity modulated radiation therapy plans all showed the same trend was not found significant between each radiation treatment planning. Conclusion : Generally, the leaf gap setting has a unique measure of the Multileaf collimator. However, the aging of the Multileaf collimator, calibration, and can be changed, after inspection and repair of the lip gap should eventually because these values affect the treatment plan must be applied to the treatment after confirmation. In some cases, may be to maintain the initial setting value of the lip gap, which is undesirable because it can override the influence on the treatment plan.

아로마테라피용 배초향(Agastache rugosa) 줄기의 방향성 정유 성분

김정미,Kim, Jeong-Mee 한국식생활문화학회 2021 韓國食生活文化學會誌 Vol.36 No.3

This study was carried out to investigate the flavoral essential oil components in the stems of Agastache rugosa. These components were analyzed using gas chromatography-mass selective detector (GC-MSD). The stems of Agastache rugosa were contained alcohols, aldehydes, ketones, fatty acid esters, and terpenoids. The peak area (%) of estragole was highest among its oil components and the next were pulegone and menthone. The terpenoid alcohols found were 1-octen-3-ol, chavicol, spatulenol, 3-hexen-1-ol, 2-cyclohexen-1-ol, methyl eugenol, and octaethyllene glycol. The stems also contained ketones such as pulegone, menthone, cis-isopulegone, 2-cyclohexene-1-one, 3-octanone, 1-cyclohexanone, isoindole-1-one, t-ionone, inden-2-one, as well as the aldehydes of 4-methoxycinnam and benzaldehyde. The following esters were also detected 1-isopulegone-3-yl acetate, caryophyllene oxide, acetate and benzendicarboxylic acid ester. The terpenoids in the stems were identified as caryophyllene, limonene, cyclohexasiloxane-D, germacrene-D, anethole, cadinene, muurolene, and bourbonene. Overall Agastache rugosa contained several functional oil components including phenylpropanoids and terpenoids as flavoral essential oil components for natural aromatherapy.

보육교사의 일상적 스트레스가 심리상태 및 삶의 만족도에 미치는 영향 -어린이집 보육교사 중심으로-

김정미 사단법인 인문사회과학기술융합학회 2015 예술인문사회융합멀티미디어논문지 Vol.5 No.4

본 연구의 목적은 어린이집 보육교사의 일상생활 스트레스가 심리상태에 미치는 영향과 삶의 만족도에 관한 주제를 분석하고자 한다. 연구대상은 서울시 소재 어린이집 보육교사 215명을 대상으로 2014년 6월3일부터 12월15일까지 설문조사를 실시하였다. 분석방법은 SPSS 프로그램을 활용하여 상관분석, 요인분석, 빈도분석 등을 실시하였다. 분석결과 첫째, 보육교사의 일상생활 스트레스는 심리상태에 유의한 영향을 미치는 것으로 나타났다. 둘째, 보육교사의 심리상태는 삶의 만족도에 유의한 영향을 미치는 것으로 나타났다. 이러한 결과는 일상적 스트레스가 낮을수록 심리상태가 양호하다는 것을 의미하며 심리상태가 양호할수록 삶의 만족도가 높다는 것을 의미한다. 본 연구의 시사점은 보육교사의 일상적인 스트레스를 통하여 안정된 심리상태와 삶의 만족도 제고를 위한 효율적 프로그램 개발 및 처우개선의 기초자료가 될 것으로 사료된다. The purpose of this study is to analyze the influence that the everyday stress of day care center teachers has on their mental state and level of life satisfaction. For this study, a survey was conducted on 215 teachers of day care centers in Seoul from June 3 to December 5, 2014. The analysis was made using the SPSS program to conduct the correlation analysis, factorial analysis, frequency analysis, etc. The research results showed that, first, the everyday stress of day care center teachers has a significant effect on their mental state. Second, the mental state of day care center teachers has a significant effect on their level of life satisfaction. These results showed that their mental state was more favorable the lower their everyday stress, and their level of life satisfaction was higher the more favorable their mental state. The implications of this study are expected to become basic data for the development of an effective program to enhance the mental state and level of life satisfaction of day care center teachers through everyday stress and for the improvement of working conditions.