폐경후 증후군 환자에서 Estradiol Patch 치료의 임상 효과 : 제 1 보

김성완,장윤석,윤병구,조보연,이진용,이홍규,고창순,민헌기,박용수,이동수,김정구,김성연 대한내분비학회 1990 Endocrinology and metabolism Vol.5 No.2

We evaluated clinical efficacy and acceptability of transdermal estradiol patch treatment (beta estro, 1 mg/patch) in 30 patients with hot flushes and/or postmenopausal syndrome. 26 of 29 patients with hot flushes and 1 patient with postmenopausal syndrome were found to experience the improvement of symptoms. 1 of 3 patients who did not experience clinical improvement with patch treatment experienced the improvement of urinary symptoms and headaches. Among 3 of 26 patients who experienced improvement in hot flushes, 1 patient sufferes aggravation of headache and 2 patients complained generalized myalgia and dysphoria during treatment. 1 patient whose symptoms had not improved was the one who had the history of skin allergy against plasters and suffered the severe irritation symptoms at the sites of patch application and stopped the patch trement at 10th day of trial. The other 29 did not complain any side effects other than mild skin hyperemia at the site of plaster contact. 25 patients agreed that estradoil (beta estro 1 mg/patch) treatment for two weeks were "effective: in the amenlioration of their postmenpausal symptoms. The above findings showed that the trasdermal estradiol patch treatment improved severity scroes of hot flushes and symptoms of postmenopausal syndrome. Any significant side effect to stop the treament was not observed for 2 weeks of treament and the ratio (83%) of the subjective "effective" group with transdermal estradiol therapy suggessted that this modality might be an alternative of estrogen delivery for longterm treatment in patients with hot flushes and postmenopausal syndromes. (J Kor Soc Endocrinol 5: 131~140, 1990)

Artery Wall Binding Peptide-Poly(ethylene glycol)

김성완,장미경,나재운 한국고분자학회 2001 한국고분자학회 학술대회 연구논문 초록집 Vol.2001 No.10

무의 당(糖)과 질소(窒素) 함량에 관한 연구

김성완 啓明專門大學 産業開發硏究所 2002 啓明硏究論叢 Vol.20 No.1

무요리별 용도에 적합하고 품질이 우수한 품종을 육성하기 위한 기초자료를 얻기 위해 무의 당함량과 질소함량을 분석하였다. 이 시험에서 얻어진 결과를 요약하면 당 함량은 품종간 유의성을 보였으며 근피색에 따른 함량 차이는 근피가 녹색인 청장무가 47.3mg, 청피홍심무가 40.3mg. 청수궁중무가 32.0mg, 백색인 백수궁중무가 29.7mg, 진주대평무가 30.7mg, 알타리무가 28.6mg. 적색인 적장무가 19.7mg, 적환20일무가 11.0mg, 흑색인 흑피무가 24.1mg로 나타나 근피색에 따른 함량 차이는 녹색에서 가장 높게 나타났고 백색, 적색. 흑색간에는 차이를 인정할 수 없었다. F_(1)에서는 4조합이 양친의 평균보다 높게 나타났으며 1조합이 양친의 평균보다 낮게 나타났으며 평균 heterosis는 28%로 나타났다. 질소함량은 혹피무가 3.3mg, 적환20일무가 3.0mg. 진주대평무가 2.7mg. 청피홍심무가 2.3mg, 적장무가 2.1mg, 백수궁중무가 1.8mg로 나타나 흑색이 가장 높고 백색에 비해 흑색. 적색, 녹색이 높게 나타났다. 교배조합 성적에서 F_(1)이 양친의 평균보다 낮게 나타난 것은 F_(1)의 근색이 없어진 원인으로 판단된다. Concomitant with the higher standard of living and the increasing pressure for the opening of free international trade of agricultural products, the demand for cultivars having diverse characteristics and products having higher quality has been significantly increased in recent years, In order to establish theoretical as well as systemmatical information for the changing breeding objectives, 8 cultivars of radish having distinctive characteristics were collected and the expression as well as the inheritance of characteristics associated with quality was investigated among the cultivars and their progenies. Major results obtained can be summarized as follows. Total sugar contents in roots ranged from 40.4∼47.4mg in 'Chungjang' and 'Chungpi-HS' : 28.6∼32.3mg in 'Chungsu-GJ', 'Baeksu-GS', 'Jinju-DP', 'Jukjang' and 'Altari' : and 11.0∼24.2mg in 'Heukpi' and 'Jukhwan-20'. Roots with green skin showed the highest total sugar contents whereas no significant differences were found among the roots having other skin color. Total nitrogen contents was higher in black-skinned roots(3.0mg), lower in the white-skinned roots (1.8mg), and the roots having other skin color showed the total nitrogen contents in between. Total nitrogen contents in F_(1) plants were consistently higher than the values of parent.

후두암의 보존적 수술에 대한 임상적 고찰

김성완,김영기,홍기환 의과학연구소 1991 全北醫大論文集 Vol.15 No.3

Most laryngeal or laryngopharyngeal carcinomas are amenable to laryngeal sparing Procedures. Laryngeal conser-vation surgery stirives to maintain the laryngeal functions of respiration, deglutition, and voice production withadequate resection of the tumor. These techniques are neccessarily based on the precise staging of the tumor and the knowledge of tumor be-havior as related to the histologic type and the various barriers of the larynx. The unique embryology, compart-mentalization of the larynx and growth patterns of laryngeal cancer are the foundation for principle of conservation surgery of the larynx. This report is for the results of 13 cases of conservation laryngeal surgery from 1985 to 1990, which were 3cases of endoscopic CO2 laser cordectomy, 3 cases of vertical hemilaryngectomy, 5 cases of subtotal supraglottic laryngectomy, and 2 cases of near total laryngectomy.

석회혼합토의 압축강도에 관한 연구 (제1보) -석회함량 및 갱생이 강도에 미치는 영향-

김성완 한국농공학회 1972 한국농공학회논문집 Vol.14 No.4

The following results were obtained by the compression test of 3, 7, 14 and 28 days cured lime soil mixtures. The soil used in this test was clayey soil(sand : 20% silt : 45%, clay : 35%) and the rates of hydrated lime mixture for the dry weight of soil were 4, 8, 12, 19 and 20 percents. 1. The optimum moisture content increases and the maximum dry density decreases with the increase of the lime content. 2. The compacted moisture for the maximum strength in lime soil mixture increases with the increase of the lime content and the increase of curing periods. 3. The compressive strength increase of curing periods and its increasing ratio is largest at the 8 percent lime content. 4. The line content for the maximum strength decreases with increase of curing period and the largest strength shows at the 8 percent lime content when the curing period is over two weeks. 5. It seems to depend on the temperature effect that the compressive strength of lime soil mixtures cured in soil shows the lowest value. Accordingly, the effect of curing moisture does not influence to the strength of lime soil mixtures as much as the variation of curing temperature.

뽈랴꼬프(Ю. Поляков)의 언어 개성 (접미사 활용 조어를 중심으로)

김성완 세계문학비교학회 2023 世界文學比較硏究 Vol.82 No.-

Polyakov occupies a unique position in contemporary Russian literature and has many readers to date. His works project all situations of morality, ethics, society, and history in national and individual lives after the dissolution of the Soviet Union. So he is evaluated as “a writer who satirizes post-Soviet life.” The main content of this paper is an intensive analysis of vocabulary formed based on his linguistic intuition. By doing so, the purpose of this thesis is to examine how the style of Ironiya, including criticism, satire, and ridicule, is being realized. Specifically, it is to reveal the practical contents of the “suggestive evaluation” shown by the derivative of the suffix utilization. In Chapter 2, the types of individual random words were considered, and in Chapter 3, vocabulary by means using subjective evaluation suffixes was examined in detail. As a result, it was considered that Plyakov’s derivative words using exaggeration, emphasis, and diminutive suffixes imply satire and criticism of the absurd reality of materialism, consumption orientation, and absence of ethics and morality. In other words, it was revealed that the derivative of the use of suffixes guarantees the main characteristics of the individuality of Polyakov’s language, commonly referred to as ‘irony’. 뽈랴꼬프는 현대 러시아 문학에서 독특한 위치를 차지하고 있으며 현재까지 많은 독자를 보유하고 있다. 그의 작품은 소련 해체 이후 국가와 개인의 삶에서 도덕, 윤리, 사회, 역사의 모든 상황을 투영한다. 이런 이유로 그는 “소비에트 이후의 삶을 풍자한 작가”라는 평가를 받는다. 이 논문의 주요 내용은 그의 언어적 직관을 바탕으로 형성된 어휘를 집중적으로 분석 한 것이다. 이를 통해 비평, 풍자, 조롱 등 아이러니의 양식이 어떻게 구현되고 있는지 고찰하 였다. 2장에서는 개별 임의 단어의 종류를 고찰하였고, 3장에서는 주관적 평가 접미사를 이용한 수단별 어휘에 대해 자세히 살펴보았다. 그 결과 과장, 강조, 지소형 접미사를 사용하는 뽈랴 꼬프의 파생어는 물질만능주의의 부조리한 현실과 소비지향, 윤리와 도덕의 부재에 대한 풍 자와 비판을 내포하고 있음을 밝히고 있다.

Respiratory Syncytial Virus에 의한 호흡상피세포 감염 시 Polymeric Immunoglobulin Receptor가 호산구의 탈과립에 미치는 영향

김성완,조중생,김재명,황준연,RobertoGarofalo 대한이비인후과학회 2003 대한이비인후과학회지 두경부외과학 Vol.46 No.6

Background and Objectives:The presence of eosinophil-specific cytotoxic mediators in nasopharyngeal secretions of infants induced airway inflammation and the associated epithelial damage. A recent report demonstrated that RSV-infected respiratory cells induce eosinophil degranulation by a CD11b/CD18-dependent, ICAM-1-independent mechanism. However, the molecule on the epithelial cell membrane involved in the receptor-mediated degranulation of eosinophils after RSV infection has not been clearly identified. Materials and Method:We investigated the efect of RSV infection on the expresion of pIgR on A549 cells and blocking of the RSV-infected cell induced eosinophil degranulation with monoclonal antibodies of the pIgR. Results:After 24h of RSV infection, A549 cells expressed pIgR remarkably whereas pIgR was hardly expressed by the uninfected cels in flow cytometry and in the semi-quantitative RT-PCR. CD11b/CD18 on eosinophils was highly expresed by the RSV con-ditioned media. Purified eosinophils cocultured with the RSV-infected A549 cells showed approximately eightfold increase in ECP in the isotype control, compared with the control and that was blocked by treatment of anti-pIgR monoclonal antibody. Conclusion:It is strongly sugested that pIgR expression in the epithelial cells may be a key factor for eosinophil degranula-(Korean J Otolaryngol 2003 ;46 :481-7)

비용종 상피세포와 섬유아세포 동시배양 모델에서 시토카인의 발현

김성완,조중생,박재경,이건희,차창일 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2007 東西醫學硏究所 論文集 Vol.2007 No.-

Background and Objectives: Nasal polyposis is a chronic inflammatory disease characterized histologically by edematous fluid with sparse fibrous cells, few mucous glands and proliferation of stromal and epithelial cells. There have been many studies done separately about epithelial cells, fibroblasts, and other inflammatory cells in nasal polyps. However, there is no usable study model for the cell-to-cell interaction. Therefore, we tried to make a new model for the study of nasal polyp by coculture of epithelial cells and fibroblasts. Subjects and Method: Nasal polyp was collected during endoscopic sinus surgery. Almost half of them were used for epithelial cell culture and the remaining portion was used for fibroblast culture in the same polyp. Using a transwell insert fibroblasts were placed in the bottom and epithelial cells were placed on the insert respectively. RNA were isolated both from cpithelial cells and fibroblasts of 12,24, and 48 hours' coculture. The expressions of IL-8,IL-6, and eotaxin from coculturcd cells were compared with cells that were cultured alone by semiquantitative RT-PCR. Results: IL-8 was highly expressed in fibroblasts than in epithelial cells, especially in cocultured cells. The expression of IL-6 in fibroblasts was much higher than in epithelial cells, especially in cocultured fibroblasts. Eotaxin is weakly expressed in fibroblasts but not in epithelial cells. Conclusion : These findings indicate that cocultured cells show different expression of the mRNA of various cytokines compared with cultured cells alone. And this coculture system may be more ideal than the mono-cell culture system for the study of cell-to-cell interactions and to reveal the pathogenesis of oasal polyposis.

마이크로파 가열에 의하여 합성된 알루미나 임자의 특성

김성완 부경대학교 산업과학기술연구소 2003 産業科學技術硏究論文集 Vol.5 No.-

養生條件이 人工輕量骨材콘크리트의 알카리-실리카 反應에 미치는 影響

金成完,成瓚鏞 충남대학교 농업과학연구소 1991 농업과학연구 Vol.18 No.2

This paper was performed to obtain the data applied to use of synthetic lightweight aggregate concrete affected by alkali silica reaction. The results obtained were summarized as follows : 1. The expansion of each type concrete was increased with increase of curing age, respectively. Also, at the curing age 90 days, the rate of expansion of type A, B, C and I) concrete was increased 0.173%, 0.575%, 0.230% and 0.680%, respectively. Specially, the rate of expansion of type D concrete was shown 3.93 times higher than the type A concrete. The cracks width were increased with increase of expansion and at the 0.680% expansion, the maximum width was shown 0.5㎜. 2. The dynamic modulus of elasticity of each type concrete was increased with increase of curing age, respectively. At the curing age 30 days, the highest dynamic modulus of elasticity was showed at each type concrete, respectively. But, it was gradually decreased with increase of curing age at those concrete, respectively. Also, at the curing age A, B. C and D concrete was increased 24.3%. 33.7%, 28.1% and 37.0%, respectively. The rate of loss in type D concrete was shown 1.52 times higher than the type A concrete. 3. The ultrasonic pulse velocity of each type concrete was increased with increase of curing age, respectively. At the curing age 30 days, the highest ultrasonic pulse velocity was showed at each type concrete, respectively. But, it was gradually decreased with increase of curing age at those concrete, respectively. Also, at the curing age 90 days, the percentage loss of ultrasonic pulse velocity of type A, B, C and D concrete was increased 6.4%, 8.7%, 8.5% and 1.4.2%. respectively. The rate of loss in type D concrete was shown 2.21. times higher than the type A concrete. 4. The relation between dynamic modulus of elasticity and ultrasonic pulse velocity was highly significant. The dynamic modulus of elasticity was increased with increase and decreased with decrease of ultrasonic pulse velocity. Also, the decreasing rate of the dynamic modulus of elasticity was shown 2-7 times higher than the ultrasonic pulse velocity at each age, respectively. 5. The dynamic. modulus of elasticity and ultrasonic pulse velocity were decreased with increase of expansion, and the decreasing rates were increased with increase of curing age. The increasing rate of expansion was shown higher than the decreasing rate of dynamic mod ti)us and ultrasonic pulse velocity..