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정재욱,박세연,강다현,박동일,문재영,이정은,정성수,박희선,김주옥 대한결핵 및 호흡기학회 2017 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.124 No.-
Immunotherapy is powerful option for lung cancer patients without drug targets and chemotherapy resistant patients. It also has changed the concept of conventional anti-cancer therapy in the point of regulating tumor microenvironment. Our previous study revealed that the Hippo pathway effector YAP confers EGFR-TKI resistance in lung adenocarcinoma, and inhibition of YAP restores sensitivity to EGFR-TKIs. In this study, we examined whether PD-L1 is relevant in terms of conferring EGFR-TKI resistance and whether YAP directly regulates the expression of PD-L1. First, we compared the expression levels of PD-L1 and YAP between EGFR-TKI-resistant PC9 cells and the parental PC9 adenocarcinoma cells. The expression levels of both YAP and PD-L1 were markedly higher in the EGFR-TKI-resistant cells compared to the parental cells. YAP knockdown significantly decreased the expression of PD-L1 in the EGFR-TKI-resistant cells, while YAP overexpression increased the expression of PD-L1 in the parental PC9 cells. Then, our results revealed that YAP regulates the transcription of PD-L1, and the YAP/TEAD complex binds to the PD-L1 promoter. Surprisingly, knockdown of PD-L1 was sufficient to decrease cell proliferation and wound healing in the EGFR-TKI-resistant PC9 cells. These data suggest a PD1-independent oncogenic function of PD-L1. The Hippo effector YAP plays a crucial role in linking the PD-L1 and EGFR-TKI resistance by directly regulating the expression of PD-L1 in lung cancer. Targeting PD-L1 directly or via YAP could provide an effective therapeutic strategy for lung adenocarcinoma.
Sulfonyl Hydrazide-Based Polymeric Foaming Agent Nanoparticles
정재욱,김구성,이소림,김건우,김동현,정일두 한국고분자학회 2017 Macromolecular Research Vol.25 No.2
Polymeric foaming agent (PFA), poly(methacryloyl toluenesulfonylhydrazide) (poly(MATSH)), was synthesized from p-toluenesulfonyl hydrazide (TSH) with methacryloyl chloride (MAC) and transformed into nanoscale material by using a method of emulsion-solvent evaporation with polyvinyl alcohol (PVA) as an emulsifier. Average particle size of poly(MATSH) nanoparticle was determined by dynamic light scattering (DLS) and transmission electron microscopy (TEM), in comparison with TSH and MATSH monomer nanoparticles. Thermal decomposition temperature of the prepared nanoparticles was measured by using thermogravimetric analysis (TGA). A fraction of PVA remained in poly(MATSH) nanoparticle in spite of repeated washing increased decomposition temperature of the nanoparticles. The exothermic temperature of poly(MATSH) nanoparticle was examined by using differential scanning calorimetry (DSC). Furthermore, the polymer incorporated with poly(MATSH) nanoparticle according to foaming formulation based on styrene butadiene rubber (SBR) by compression molding showed higher expansion ratio due to higher surface volume and also made finer and more uniform cell structure due to smaller particle size and better compatibility with polymer and other fillers than those of poly(MATSH) in the morphology study of scanning electron microscopy (SEM).
정재욱,최석환,김범수,정성광 대한비뇨의학회 2012 Investigative and Clinical Urology Vol.53 No.10
Purpose: The purpose of this study was to investigate the risk factors for urethrocutaneous fistula development after hypospadias repair. Materials and Methods: Between January 1990 and May 2010, 348 patients underwent hypospadias repair. This study included 294 patients who were followed up for more than 6 months. Potential risk factors for the development of fistula after operation included age, location of hypospadias, type of hypospadias repair, suture materials and methods, methods and duration of catheterization, combined congenital urologic disorders, timing of presentation and repair of fistula, and location of fistula. Data were analyzed retrospectively. Binary logistic regression analysis was used for univariate and multivariate analysis. Results: Out of 294 patients, 63 patients (21.4%, 63/294) developed urethrocutaneous fistulas after hypospadias repair. In the univariate analysis, fistula formation was statistically related with type of hypospadias and type of hypospadias repair. In the multivariate analysis with stratification by hypospadias site, however, only the location of hypospadias was a significant independent risk factor in urethrocutaneous fistula development after hypospadias repair (p<0.001). Conclusions: Our results suggest that the risk of developing urethrocutaneous fistula after hypospadias repair is associated with the location of hypospadias (more proximal-type hypospadias). Type of hypospadias repair, suture materials, suture techniques, and number of other combined urologic disorders were not related to the development of urethrocutaneous fistulas. Purpose: The purpose of this study was to investigate the risk factors for urethrocutaneous fistula development after hypospadias repair. Materials and Methods: Between January 1990 and May 2010, 348 patients underwent hypospadias repair. This study included 294 patients who were followed up for more than 6 months. Potential risk factors for the development of fistula after operation included age, location of hypospadias, type of hypospadias repair, suture materials and methods, methods and duration of catheterization, combined congenital urologic disorders, timing of presentation and repair of fistula, and location of fistula. Data were analyzed retrospectively. Binary logistic regression analysis was used for univariate and multivariate analysis. Results: Out of 294 patients, 63 patients (21.4%, 63/294) developed urethrocutaneous fistulas after hypospadias repair. In the univariate analysis, fistula formation was statistically related with type of hypospadias and type of hypospadias repair. In the multivariate analysis with stratification by hypospadias site, however, only the location of hypospadias was a significant independent risk factor in urethrocutaneous fistula development after hypospadias repair (p<0.001). Conclusions: Our results suggest that the risk of developing urethrocutaneous fistula after hypospadias repair is associated with the location of hypospadias (more proximal-type hypospadias). Type of hypospadias repair, suture materials, suture techniques, and number of other combined urologic disorders were not related to the development of urethrocutaneous fistulas.
정재욱,이상민,홍정욱 한국전산구조공학회 2016 한국전산구조공학회논문집 Vol.29 No.4
대규모 지진에 대한 원전의 안전성을 확보하는 방안으로 기존 원전 구조물에 면진장치를 설치하는 방안이 도입되고 있다. 면진장치를 설치함으로써 상부구조와 지반의 거동을 격리시킬 수 있고, 구조물 자체의 고유주기가 길어지게 되는데, 이를 통 해 지진하중에 대한 구조물의 응답을 감소시킬 수 있게 된다. 특히 원전구조물 설계 시 원전구조물 자체뿐만 아니라 원전 내 부 기기에 대한 안전성 확보가 필수적이다. 이를 위해 특정 층에 위치한 기기의 설계를 위해 각 층의 최대 요구 응답을 나타 내는 층응답스펙트럼이 일반적으로 사용된다. 본 논문에서는 원전 구조물의 지진해석을 통해 특정 층의 층응답스펙트럼을 평가하고, 면진 장치의 거동 특성중 하나인 2차 경화에 대한 영향 또한 평가하였다. In order to secure the stability against strong earthquakes, isolation devices on the existing nuclear power plant have been introduced. By applying the isolation device on structures, it is possible to isolate structures from the ground motion. Therefore, the natural frequencies of the structures become longer, and the responses of the structures due to the ground motion decrease. Especially, when designing the nuclear power plant, it is important to ensure the safety of internal devices as well as the nuclear power plant itself. The floor response spectrum is commonly used in designing the internal devices. In this research, floor response spectrum is evaluated and the effect of second hardening behavior is investigated by performing earthquake analysis.