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박인숙 배화여자대학 1999 培花論叢 Vol.18 No.-
We studied about propolis' effect on the prolongation of acidification of kimchi during its fermentation at 10℃. In the result of inhibitory effect of propolis on the growth of Lactobacillus plantarum in MRS broth, propolis didn't show the ability of the complet inhibition in growth but, showed the ability of bacteriostatic effect. All experimental groups such as 1.0, 1.5, and 2.0 % propolis-added kimchi produced propolis-specific and non-acceptible odors. In the experiment of 0.05, 0.1, and 0.5 % propolis-added kimchi fermentation, all experimental groups prolonged the acidification and showed better taste than that of control kimchi. Especially, 0.05 propolis-added kimchi showed the best taste among all of things. Microbial changes in propolis-added kimchi fermentation didn't show the strain-specific inhibitory effects of propolis, but showed that it caused the prolongation of acidification of kimchi by inhibition of lactic acid bacteria in the prior stages of kimchi fermentation. And the growth of yeast in kimchi fermentation was delayed by addition of propolis.
신생아의 신체적 성장과 어머니 정체감에 대한 마사지요법의 효과
박인숙,김달숙 한국아동간호학회 2006 Child Health Nursing Research Vol.12 No.3
=The Effect of Massage Therapy on Physical Growthof the Newborn and Identity as Mothers*
박인숙,안미령,서수경,이선우,최흥석,안은주,진숙,손수정,구효정,양지선,유태무 식품의약품안전청 2000 식품의약품안전청 연보 Vol.4 No.-
약물에 대한 약동학(PK) 및 약력학(PD) 연구는 최적의 약물효과를 얻기 위한 약물툰여계획수립에 대한 기본데이타를 제공하띠 현대 약물요법에서 그 중요성이 더욱 강조되고 있다. PK-PD 모델링은 투여용량-혈중농도-약효간의 관계를 수학적으로 묘사하여 약동학 및 약력학 사이의 정량적이고 구체적인 상관성을 규명하고 이를 이용하여.투여용량으로부터 시간에 따른 약물의 동태 및 효력을 예측할 수 있다. 따라사 신약개발시에도 전임상단계 및 임상시험단계에서 PK-PD에 관한 정보가 제공되면 의다 적절한 약물요법을 결정하여 약물의 효과를 극대화할 수 있으므로 치료률 및 신약개발의 가능성을 높이는데 기여한다. 본 시험에서는 PK-PD 모델링에 대한 기본개념 및 방법을 연구하고자, 국내예서 개발된 캄토테신계 항암제인 CKD-6OB를 이용하여 약물의 약동학 및 약력학적 특성을 HT-29 cell에서 측정하였다. 항암제의 치료는 암세포로의 약물침투 및 효력발현 시점에 따라 투약을 조절함으로써 부작용을 최소화할 수 있다. 따라서 효력검색을 위하여 MTT 측정법을 사용하여 암세포의 증식정도를 측정하였으며, 투여시간에 판른 세포내외의 약물농도 측정을 통하여 약물동태를 연구하였다. 실험결과 CKD-602의 HT-29 cell에 대한 ICD는 250nbt로 나타났으며, 약물투여 24시간 후부터 세포로의 유입이 나타났파. 그러나 CKD-602의 쎄포내외의 농도비율이 거의 변화가 없으며 CKD-602의 려T-29 cell 에 대한 지연효과가 나폭나는 것으로 미루어 CKD-602의 항암효력이 약물농도 주입속도와 상관성이 있을 것으로 사료된다. Pharmacokinetic(PK) and pbarrnacodynamic(PD) information get from the scientific basis of modern iharrnacotheraDy PharrnacoEnetics describes ·the drug concentration- time courfes in body Huids resulting from administration of a cnfain drug dost and pharmacodynamics describes the observed effect resulting from a crrtain drug concentration. A Pf(/PD model is amathematical descfption of these relationships. The rationale for PK#PD-rnodelfng is to linkpharmacokinetics arid pharrnacofynamics In order to establish and evaluate dose-concentration-response relationships and subseauently describe and predict the effect-time courses resultingfrorrl a drug dose. The expanded use cf PK/PD-modeITing is assumed to be highly beneficialfor drug development as well as applied pharrnacotherfpy and will most likely improve thecurrent state of applied therapeutics. The anticancer drug therapy depends on the ability of the drug to penetrate on the solidtumor for the time-and concentraton-dependent drug. The present study examined thedeterminants of Pft/PD modeling of CKD-602 in HT-29 cel.Is. Anticancer effects of CKD-602by MTT assay was dependent on the time and the concentration. The concentration ofCKD-602 in both the cell and the medium was correlated with time and drug concentration.But pharmacodynamics of CKD-602 was not drug uptake limited and the relative importance ofdrug was exposure time. The knowledge of relative importance of a drug. in pbarrnacodynamicstudies will heTp to idendify the optimal dose resimens.
박인숙,강경아,김신정,김태희 한국아동간호학회 2004 Child Health Nursing Research Vol.10 No.1
Purpose: The purpose of this study was to explore the fatigue of the mothers of the hospitalized children's mothers in descriptive study. Method: Two hundred eighty three mothers who take care of the hospitalized children in three University hospitals were enrolled from June, 1 to October, 30, 2003. Data were collected using a questionnaire titled "Symptom Table on Fatigue Perception" designed by the Fatigue Research Committee of Japan, consisted of a total 30 items categorized into three sub-dimensions: the physical, the psychological and the neuro-sensory. SPSS was used for the analysis of data with 0.05 of significance. Result: 1) The mean average fatigue score of subjects was 1.94(SD:.48): the physical fatigue revealed the highest value with a mean of 2.19(SD:.57), followed by psychological fatigue with a mean score of 1.85(SD:.52), neuro-sensory fatigue with a mean of 1.79(SD:.51). 2) With the respect to the general characteristics of hospitalized children and mothers, there were statistically significant differences in the mothers' fatigue perception by the child sex(t=-2.697, p=.008), the character of child(F=9.032, p=.000), the child condition compared to pre-hospitalization(F=3.523, p=.031), with or without support in domestic households(t=-1.981, p=.049), the amount of sleeping time(t=2.704, p=.007), and with or without of night-time sleep disturbance because of the child hospitalization(t=2.082, p=.038). Conclusion: These results suggest that health care professional need to be aware of the persistent presence of the maternal fatigue related to the child hospitalization and the factors worsen the degree of the fatigue.
박인숙,이남형 한국아동간호학회 2002 Child Health Nursing Research Vol.8 No.3
-Key concept : Stress, Pediatric patient's Parent, Emergency department