염증성 장질환에서 생물학적 치료의 임상적 응용

진윤태 ( Yoon Tae Jeen ) 대한소화기학회 2002 대한소화기학회지 Vol.40 No.4

Crohn's disease and ulcerative colitis known as inflammatory bowel diseases, are chronic inflammatory disorders involving the gastrointestinal tract. Because the cause of both disease remains unknown, a curative therapy has been lacking. Until recently, conventional treatments have focused on nonspecific suppression of the inflammatory process and are often effective in achieving symptomatic control, but frequently fail to prevent relapse when administered over time. Recent advances in basic research have provided new insights into the role of specific immune cells and their mediators in intestinal inflammation. Such understanding has led to the development of biologic treatments directed at altering specific pathogenic mechanisms that have the potential to modifiy the natural course of these disorders. The compounds directed against important regulatory cytokines such as tumor necrosis factor-alpha ( TNF-α ) have demonstrated the greatest clinical efficacy to date. These clinical findings are consistent with scientific observations that have suggested a central role of TNF-α in chronic intestinal inflammation. It is probable that biologic therapy will play an important role in the future treatment of inflammatory bowel diseases. ( Korean J Gastroenterol 2002; 40: 219-227)

한국인의 염증성 장질환 진단의 문제점

진윤태 ( Yoon Tae Jeen ),권용대 ( Yong Dae Kwon ) 대한장연구학회 2006 Intestinal Research Vol.4 No.2

Inflammatory bowel disease (IBD) is defined as chronic inflammatory intestinal disorder of unknown origin. Not only Crohn`s disease (CD) and ulcerative colitis (UC) are widely known as such IBD, but Behcet`s colitis and intestinal tuberculosis also belong to IBD. Particularly because intestinal tuberculosis is common disorder in Korea; Crohn`s disease (CD) is on the increase, the differentiation of intestinal tuberculosis from CD is very important. Even though theses diseases have similar clinical feature, their eventual course is quite different. However diagnosis of IBD is intricate because of no pathognomonic feature. Recently introduction of CARD15/NOD2 gene polymorphism which causes increasing of incidence of CD intensifies genetic diagnostic tool research, and new diagnostic approach as systematic analysis of endoscopic findings is suggested. Therefore more advanced and more convenient method to diagnose IBD will be developed in near future. (Intestinal Research 2006;4:75-78)

특집-궤양성 대장염 : 궤양성 대장염의 최신치료

진윤태 ( Yoon Tae Jeen ),김주형 ( Ju Hyung Kim ) 대한내과학회 2009 대한내과학회지 Vol.76 No.6

Ulcerative colitis is an idiopathic inflammatory bowel disease characterized by colonic mucosal inflammation and chronic relapsing episodes. The initial therapeutic approach depends on both the extent of colonic involvement and the severity of the disease process at presentation. The mainstay of ulcerative colitis therapy is the administration of 5-aminosalicylic acid (5-ASA) or steroid. Additional medical therapy or colectomy should be considered if the patient remains symptomatic despite conventional therapy, regardless of the extent of colonic involvement. Cyclosporins are effective as a short-term rescue therapy for steroid-refractory ulcerative colitis. Recently, new 5-ASA and steroid formulations with altered delivery, dosing regimens, and less frequent administration have been introduced and demonstrated to be efficacious in active mild to moderate colitis. Infliximab is given to try to avoid the need for colectomy and has proven efficacious in ulcerative colitis. This review outlines the standard therapy for ulcerative colitis and discusses new insights into the recent trend focusing on new therapies, including biological agents and leukocytapheresis. (Korean J Med 76:654-660, 2009)

스테로이드 불응 중증 궤양성 대장염의 치료

진윤태 ( Yoon Tae Jeen ),금보라 ( Bo Ra Keum ) 대한소화기학회 2006 대한소화기학회지 Vol.48 No.4

원발성 윤상인두근 기능장애

진윤태(Yoon Tae Jeen),송치욱(Chi Wook song),엄순호(Soon Ho Um),김창덕(Chang Duck Kim),류호상(Ho Sang Ryu),현진해(Jin Hae Hyun) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.4

Priary cricopharyngeal dysfunction is a rare motility disease of the esophagus having a prominent cricopharyngeal bar on barium study in patient with oropharyngeal dysphagia. Abnormal findings of esophageal manometry such as hypertensive upper esophageal sphincter, or failure of relaxation are detectable in only minority of patients suggestive of cricopharyngeal dysfunction. We used radionuclide oropharyngeal transit study which has been proposed as a diagnostic tool for esophageal motility disorder recently. Drug therapy or cricopharyngeal myotomy has been used to treat primary cricopharyngeal dysfunction, We report a case of a 61-year-old woman who presented with oropharyngeal dysphagia and prominent cricopharyngeal bar on barium study. Manometric finding shows a markedly increased pressure of upper esophageal sphinter in the anterior and posterior direction. Radionuclide oropharyngeal transit study shows delayed transit of radioisotope in the oropharynx(Korean J Gastroenterol 1996; 28:602-604.

34 Human cDNA Microarray를 사용한 대장암의 유전자 발현 프로필

진윤태 ( Yoon Tae Jeen ),전훈재 ( Hoon Jai Chun ),조남영 ( Nam Young Jo ),정록선 ( Rok Son Choung ),김용식 ( Yong Sik Kim ),김영선 ( Young Sun Kim ),박철희 ( Chul Hee Park ),이홍식 ( Hong Sik Lee ),이상우 ( Sang Woo Lee ),엄순호 ( 대한소화기학회 2002 대한소화기학회 추계학술대회 Vol.2002 No.-

The Eects of Thermal Annealing of ZnO Ceramics

Tae-Bong Hur,Dae-Hwang Yoo,Gwang Soo Jeen,Yoon-Hwae Hwang,Hyung-Kook Kim,Younghun Hwang,Youngho Um 한국물리학회 2003 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.42 No.IV

We studied the eects of thermal annealing of ZnO ceramics by X-ray photoelectron spectroscopy, photoluminescence and X-ray scattering methods. The ZnO ceramics fabricated from the high purity ZnO powder (99.999 %) were annealed at 950 C in air and in N2 atmosphere. The ZnO ceramics annealed in N2 atmosphere have O-rich condition. The concentration of antisite oxide(OZn) increases when ZnO ceramics have the O-rich condition or N-compensation. As the concentration of antisite oxide(OZn) increases, the photoluminescence intensity of the green band emission increases.

Treatment and Prognosis of Advanced HCC with Metastasis

( Tae Hyung Kim ),( Soon Ho Um ),( Han Ah Lee ),( Jung Mi Chang ),( Dae Hoe Gu ),( Jem Ma Ahn ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Yoon Tae Jeen ),( Hong Sik Lee ),( Hoon Jai Chun ),( Chang Duck K 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: As hepatocellular carcinoma (HCC) progresses, it is accompanied by deterioration of liver function, which makes treatment difficult. In particular, advanced HCC involves not only impairment in liver function and general condition but also vascular invasion and other organ metastasis. It is very heterogeneous stage and needs to be further subdivided. In the present study, we investigated treatment outcomes and the factors associated with prognosis in HCC patients with distant metastasis. Methods: We analyzed data of 103 patients with advanced HCC with distant metastasis at initial diagnosis from June 2004 to June 2015. The patients received the first treatment for HCC in our hospital. Results: Mean age of patients was 57.3 ± 11.6 years and men were predominant (80.6%). The median observation period was 3.2 (0.3-39.1) months, and 99 (96.1%) of these patients died. There were no significant association with survival in sex, age, etiology and the number of liver tumors (p = 0.274, 0.094, 0.854 and 0.280, respectively). In univariate analysis, bilobar tumor distribution, invasion of main portal vein or IVC, Child-Pugh class, and treatment modality showed significant association with shorter survival. (p = 0.033, <0.001, 0.015, <0.001, and <0.001, respectively). In multivariate analysis, Child-Pugh class (p<0.001) and initial treatment modality (p=0.001) were significantly independent factors for survival. In Kaplan-Meier curve, systemic chemotherapy-alone or combination of locoregional treatment (LRT) and cytotoxic chemotherapy has no significant difference on survival compared with best supportive care as initial treatment. (median survival time, MST, 2.3 vs. 1.6 months) However, LRT alone (MST) or combination of sorafenib and LRT (MST 4.8, 4.3 months) showed significant survival benefit. (p = 0.001, 0.002). Conclusions: The Child-Pugh score and treatment modality in HCC patients with metastasis showed significant prognostic relevance. We also found that locoregional control for primary liver mass therapy is important in the treatment of sorafenib.

십이지장궤양으로 위공장물합술(胃空腸物合術)후 발생한 조기위암 1예

진윤태,현진해,문정섭,유호상,김경수,추현광 대한소화기내시경학회 1990 Clinical Endoscopy Vol.10 No.2

Cancer of the gastric stump, first described by Balfour in 1922, is defined as the cancer detected more than 5 years after surgery for a benign disease. We experienced a case of cancer found at the gastric stump after gastrojejunostomy in a 53 years old male patients, proven pathologically as a early cancer. He visited to our hospital with the chief complaint of epigastric pain and indigestion for 1 Months. On past history, he has been received gastrojejunostomy due to duodenal ulcer obstruction, 23 years ago, Gastrofiberscopy was done, and we could find the early gastric cancer lesions at the anterior wall of gastric angle as type Ilc+III and antrum as type IIa. The microscopic finding of the multiple endoscopic biopsies at the gastic angle and antrum revealed the adenocarcinoma of signet ring cell type infiltrated to the level of submucosa. And so, we could diagnose these lesions as a early gastric cancer in the gastric stump after gastrojejunostomy. He was treated with subtotal gastrectomy and discharged with cured condition. Therefore, we report this case with a literature review.

완전 관해된 급성 골수성 백혈병 환자의 신장에 발생한 과립성 육종 1예

진윤태,김재선,박종재,최윤상,김준석,채양석 대한내과학회 1992 대한내과학회지 Vol.42 No.2

저자들은 완전 관해된 급성골수성 백혈병 환자에서 콩팥에 발생한 과립성 육종 1예를 경험하였기에 문헌 고찰과 함께 보고하는 바이다. Granulocytic sarcoma is an extramedullary tumor composed of granulocytic precursor cells such as myeloblast or monoblast. These tumor were originally celled "Chloroma" because of the green color imparted by the heavy concentration of the enzyme myeloperoxidase present in myelogenous leukemic cells. The tumor usually develops during the course of myelogenous leukemia or myeloproliferative disorders and may represent the inital manifestation of leukemia. Rarely, granulocytic sarcoma is recognized as an isolated tumor without any evidence of leukemia. However, in such cases, leukemia generally develops within 1 to 2 years of the diagnosis of granulocytic sarcoma. Accurate inital diagnosis of granulocytic sarcoma in a nonleukemic patient may reduce the risk of subsequent acte myelocytic leukemia if appropriate chemotherapy is begun in time. We are reporting a case of a 21-year-old man who was diagnosed as having an isolated granulocytic sarcoma of the right kidney. Eight months ago, he was treated with induction chemotherapy due to acute myelocytic leukemia and complete remission was occurred.