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1995년 서울지역 거주자에서 발생한 Plasmodium Vivax에 의한 Malaria 1예
김영선,박기령,어은경,최진혁,이정수,정화순 梨花女子大學校 醫科大學 醫科學硏究所 1996 EMJ (Ewha medical journal) Vol.19 No.2
Malaria has a wordwide incidence of more than one thousand to three thousand million clinical cases and results in approximately 200 to 300 million deaths per year. Although Korea was an endemic area of Malaria, it was nearly eradicated from the country. However, indigenous cases of malaria have been reported since 1994. Recently, we experienced a case of Plasmodium vivax infection in a resident of Seoul. A 25-year old young man who had no history of being abroad, blood transfusion nor parenteral use of drug visited our hospital due to fever and chill for 4 days. A peripheral blood smear demonstrated Plasmodium vivax infection. He was treated with hydroxychoroquine and premaquine without relapse.
진영선(Youngsun Jin),김현옥(Hyunok Kim) 한국인지과학회 2017 인지과학 Vol.28 No.4
최근 인지적 통제에 대한 연구들은 최적의 통제 수준이 보상과 비용에 의해 결정된다는 것을 밝혀냈다. 보상이 가지는 가치는 주관적이며 이에 따라 최적의 신호 강도도 달라진다. 우리는 인지적 통제에 대한 노화의 영향에 대한 연구 결과들이 비일관적인 이유가 노인이 탄력적으로 통제 신호를 조절한 결과일 수 있다고 보았다. 다시 말해, 노인은 최적의 통제 수준을 결정하는 능력을 잘 유지하고 있을 수 있는데, 이는 전대상회의 역할로 알려져 있다. 반면 인지적 통제에서 노화에 따른 기능의 감퇴는 주로 규칙 표상의 유지와 억제에서 나타나는데, 이는 주로 외측전전두피질이 담당하고 있다. 본 연구는 청년과 노인에게 보상의 유형을 조절한 Go-Nogo 과제를 수행하게 하여 각 보상 조건에서 행동결과와 ERN(Error-Related Negativity) 크기를 비교하였다. 두 집단 모두는 각 연령에게 가장 중요하다고 여겨지는 조건에서 가장 뛰어난 행동 수행과 가장 큰 ERN 크기를 나타내었다. 또한 노인은 d’과 정확률에서는 연령차를 나타내었으나 ERN의 크기에서는 연령차를 나타내지 않았다. 이와 같은 결과는 인지적 통제의 각 과정에 대한 노화의 영향이 상이할 수 있을 가능성을 보여준다. Recently, studies on cognitive control revealed that the optimal level of control is determined on the basis of reward and cost. The value of reward can be subjective and therefore, the optimal control strength can vary accordingly. The inconsistent effect of aging on cognitive control can be the result of flexible adjustment of control signal strength made by the older subjects. In other words, the elderly people maintains the ability to set the optimal level of control, which is known as the function of the dorsal anterior cingulate cortex. On the other hand, the age-related decline in cognitive control is obvious in rule maintenance and inhibition, which has to do with the function of lateral prefrontal cortex. In this study, we had young and old adults perform go-no go task and compared the behavioral and neural results for different reward conditions. Both age groups showed the best performance and the largest ERN amplitude when the reward was most appealing to them. And there was no age effect in ERN amplitude even though older adults’ d’ and accuracy was inferior to younger participants. These findings suggest that the effect aging on different cognitive control processes can be asymmetric.
What factors make portal sites perform well in Korea?
Kyung Jin Nam,Youngsun Kwon 한국정보사회학회 2013 정보사회와 미디어 Vol.- No.27
As the market size of portal business increases, the competition among portal sites has also increased in terms of both service quality and diversity. Google is the most powerful portal site in the world, whose market share is 65.2% of the world market, but this is not the case in Korea. The purpose of this study is to find the order of importance among hierarchical-factors which affect users in their choice of portal sites. Using an AHP analysis based on survey data, the order of importance of primary factors, first, information offering, followed by, in order, entertainment & additional services, interactivity, and usability. Including sub-factors of the primary factors, the order of importance is accuracy and quickness of information offering, diversity of entertainment & additional services and an understanding of usability. The results also show that Naver and Daum are preferred to Google, implying that the main role of portal site has evolved from gateway to access to the internet for searching information to total brand sites of diverse activity, which is consistent with the ranking of the market shares noted above.
Distribution and occurrence of microplastics in fish of the Han River
Tae-Jin Park(박태진),Seunghyun Lee(이승현),Youngsun Lee(이영선),Mun Ju Park(김문주),Ji Hyung Park(박지형) 환경독성보건학회 2021 한국독성학회 심포지움 및 학술발표회 Vol.2021 No.5
We investigated the distribution of microplastic in fish inhabiting in the Han River with 5 species. Sampling sites were deliberately selected, where the degree of pollution from microplasic and habitats of fish were taken into account. According to the sites, the highest abundance was the North Han River (28.2±14.9 particle/fish), followed by the downstream of the Han River (19.9±9.9 particle/fish) and the South Han River (16.8±13.4 particle/fish). According to the species, the highest abundance was carp, followed by Crucian carp, skygager, catfish and sky carp. There is a significant correlation between the abundance and eating habit. Omnivore fish such as Carp and Crucian carp showed the highest abundance and insectivore like skin carp was the least abundance. Micropalstic abundance in fish was positively related to an increasing fish body and weight although the model explained a small portion of the variation in the data. Additionally the abundance in water did not affect the abundance in fish. Polypropylene was the most abundant polymer type, followed by polyethylene and polytetrafluoroethylene in fish. Consequently, this study will make a contribution to better understanding of microplastic exposure to the aquatic life and provide the information to manage and reduce microplastic in freshwater.
Hye Jin Yun,조영화,Youngsun Moon,박영우,윤혜경,Yeun-Ju Kim,Sung-Ha Cho,이영일,Bong-Su Kang,김원재,박기랑,설원기 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.3
For cancer gene therapy, cancer-specific overexpression of a therapeutic gene is required to reduce side effects derived from expression of the gene in normal cells. To develop such an expression vector, we searched for genes over-expressed and/or specifically expressed in cancer cells using bioinformatics and have selected genes coding for protein regulator of cytokinesis 1 (PRC1) and ribonuclease reductase 2 (RRM2) as candidates. Their cancer-specific expressions were confirmed in both breast cancer cell lines and patient tissues. We compared each promoter’s cancer-specific activity in the breast normal and cancer cell lines using the luciferase gene as a reporter and confirmed cancer-specific expression of both PRC1 and RRM2 promoters. To test activities of these promoters in viral vectors, the promoters were also cloned into an adeno-associated viral (AAV) vector containing green fluorescence protein (GFP) as the reporter. The GFP expression levels by these promoters were various depending on cell lines tested and, in MDA-MB-231 cells, GFP activities derived from the PRC1 and RRM2 promoters were as strong as that from the cytomegalovirus (CMV) promoter. Our result showed that a vector containing the PRC1 or RRM2 promoter could be used for breast cancer specific overexpression in gene therapy.