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Application of array comparative genomic hybridization in chronic myeloid leukemia.
Park, Seonyang,Koh, Youngil,Jung, Seung-Hyun,Chung, Yeun-Jun Humana Press 2013 Methods in molecular biology Vol.973 No.-
<P>Chromosomal alteration is one of the hallmarks of chronic myeloid leukemia (CML), and the Philadelphia chromosome is the most important and key example of the chromosomal changes in this disease. Indeed, the BCR-ABL1 fusion product is a target against which many tyrosine kinase inhibitors (TKIs) have been proven to be effective in the treatment of CML. However, the reality is that CML patients show resistance to TKIs both in an acquired and de novo manner, and the mechanism of TKI resistance is still largely unknown. This phenomenon suggests that in addition to the BCR-ABL mutation, further genetic alterations such as copy number aberration may be involved in unexplained TKI resistance. Although the recent array comparative genomic hybridization analyses (array-CGH) across the whole genome have detected multiple genetic aberrations in CML, the detailed feature of chromosomal alterations involved in different clinical phases of CML, such as chronic phase, accelerated phase, and blast crisis, remains unclear. Here we review the methodological aspects of array-CGH analysis for studying CML and its related data analysis.</P>
디아스포라의 불온한 주체성 - 수잔 최의 『외국인 학생』을 중심으로 -
박선양(Park, Seonyang) 국어문학회 2019 국어문학 Vol.71 No.-
이 논문은 디아스포라의 현재적 논의를 바탕으로 『외국인 학생』에 나타난 디아스포라의 불온한 주체성을 살폈다. 외국인 학생, 창은 한국전쟁에서 실존의 불안을 겪고 탈향하지만 사회·문화적 조건을 넘어서는 주체화를 수행하지 못하여 반복적 상황에 놓인다. 디아스포라로서 주체가 되려면 먼저 몸이 간직한 모국의 기억을 발설함으로써 부재했던 자아의 공간을 확보해야 한다. 그리고 조건부 환대를 넘는 우정을 맺고 경계에 자신의 자리를 마련해야 한다. 창은 캐더린과 우정을 나누며 차이를 인정받고 환대의 철회에 동의하는 소극적 주체가 된다. 그리고 백인과 흑인의 경계에서 이방인으로서 자유를 느끼며, 불온한 응전으로 저항하는 존재가 되어 자신만의 장소화에 성공한다. 『외국인 학생』에서 작가는 아버지의 전쟁이산 이유를 제시하고 디아스포라로서 주체화를 이루었다는 것을 보여준다. 작가의 혼종성이 수행하는 한민족 디아스포라의 서사적 정체성 역시 주체적 횡단 중이다. 이 수행은 한민족 문학이 갖는 보편성과 고유성의 접경에 기입되어 현재적 의의를 지닐 수 있을 것이다. Chang, left homeland after he suffered from the anxiety of existence during Korean War. But he couldn’t escape the repeated situations, unless he achieves the subjectiviation, which should be beyond the socio-cultural conditions making him anxious. He had to secure his own space, which was absent, through speaking out the memories of homeland, andspace by way of the friendship. Chang have become liberty existence at the in-between and therefore succeeded in his spatialization. Afterwards the disquieting potentiality will continue according as how Chang colours his space.
Clinical features of vascular events in patients with al amyloidosis
( Hyunkyung Park ),( Ji-won Kim ),( Youngil Koh ),( Jeong-ok Lee ),( Ki Hwan Kim ),( Soo-mee Bang ),( Inho Kim ),( Seonyang Park ),( Sung-soo Yoon ) 대한내과학회 2015 대한내과학회 추계학술발표논문집 Vol.2015 No.1
Background and Aims: AL amyloidosis can cause various vascular events, which are mainly related to vascular amyloid deposition or thromboembolism. Despite their clinical importance, only few reports have been published on the manifestations of vascular events in these patients. Methods: We retrospective reviewed medical records of patients including various imaging study results such as angiography, Doppler sonography, computed tomography, and magnetic resonance imaging to find out clinically significant vascular stenosis and thromboembolism. Results: Between January 2001 and March 2014, 106 patients (male/female=60/46) with biopsy-proven AL amyloidosis were included from 3 hospitals. The median age was 58 years (range, 23-79 years). During a median follow-up of 12.6 months (range, 0.1-156.8 months), 13 events of thromboembolism developed in 13 patients: 10 patients (9.4%) experienced cerebral infarction, 2 patients (1.9%) pulmonary embolism and 1 patient (0.9%) deep vein thrombosis. Patients with higher free light chain difference suffered significantly more from vascular events than the others in multivariable analysis. (20.2% vs. 8.9%, p=0.022). The median overall survival (OS) from pathologic diagnosis was 20.9 months (95% CI, 5.7-36.2). In multivariable analysis, higher BM plasma cell percentage and higher serum B2 microglobulin levels were poor prognostic factors. (p<0.05) Conclusions: The incidence of vascular events was substantial in patients with AL amyloidosis. Vascular events significantly occurred in patients with higher free light chain difference. Poor prognostic factor for overall survival was higher serum beta-2 microglobulin.
Generalized Primary Amyloid Lymphadenopathy
Jin Hyun Park,Ji Won Kim,김기환,Doo Hyun Chung,김인호,Seonyang Park,Byoung Kook Kim,윤성수,Hyeon Jin Cho,Ji Hyun Kwon 대한혈액학회 2009 Blood Research Vol.44 No.4
Generalized Primary Amyloid Lymphadenopathy
이창섭,송진수,최평균,조재현,방지환,박경화,박완범,김홍빈,김남중,윤성수,박선양,김병국,오명돈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.5
혈액질환 가운데 결핵 발생이 증가한다고 알려진 것은 호지킨 림프종을 포함한 림프증식성질환 그리고 모양세포성 백혈병 등이 있다. 또한 동종 골수이식을 받은 환자에서도 결핵은 증가한다고 알려져있다. Kaplan 등은 골수구성 백혈병 환자에서 결핵 발생이 증가한다고 보고하였다. 그러나 골수구성 백혈병 환자에서 결핵의 발생이 증가하는 이유에 대해서는 아직까지 정확하게 밝혀지지 않았다. 저자들이 2년 동안 후향적으로 조사한 180명의 성인 골수구성 백혈병 환자들 가운데 결핵이 발생한 환자는 4명이었고, 발생 부위는 모두 림프절이었다. 결핵은 골수구성 백혈병의 특정 아형에만 국한되어 발생하지 않았지만, 50%에서 FAB 분류에 의한 M4였다. 림프절이 종대된 골수구성 백혈병 환자에서 특히, 결핵의 유병율이 높은 나라에서는 결핵성 림프절염도 감별진단에 포함시켜야 한다. During the neutropenic phase, leukemia patients receiving chemotherapy are prone to bacterial and, fungal infections; occasionally mycobacterial, viral and protozoal organisms may also cause infections. Mycobacterium tuberculosis infection was reported very rarely in these patients. This report describes four patients with M. tuberculosis infection identified from 185 adult patients who were diagnosed myelogenous leukemia between January 2003, and December 2004. There was no patient with M. tuberculosis infection from 44 lymphoid leukemia and 11 acute biphenotypic leukemia patients. Sites of infection were all lymph nodes. Three among four patients were presented with lymphadenopathy at initial diagnosis of leukemia, and the other one presented with lymphadenopathy after induction chemotherapy. There was no patient presented with lymphadenopathy during the neutropenic phase. Tuberculous lymphadenitis was presented in a patient with three acute myelogenous leukemia (FAB class 2 M4, 1 M2) and a chronic myelogenous leukemia, accelerated phase. An acute myelogenous leukemia patient had a leukemic cell and tubercle bacilli in the same lymph node. Tuberculosis should also be included as a differential diagnosis in myelogenous leukemia patient with lymphadenopathy, especially in the countries in which the disease is endemic.
Clinical course of non-severe aplastic anemia in adults
Kwon, Ji Hyun,Kim, Inho,Lee, Yun Gyoo,Koh, Youngil,Park, Hayne Cho,Song, Eun Young,Kim, Hyun Kyung,Yoon, Sung Soo,Lee, Dong Soon,Park, Sung Sup,Shin, Hee Young,Park, Seonyang,Park, Myoung Hee,Ahn, Hyo Springer-Verlag 2010 INTERNATIONAL JOURNAL OF HEMATOLOGY Vol.91 No.5
말초조혈모세포이식 환자에서 발생한 지역사회발생 Respiratory Syncytial Virus 폐렴 1예
박선양,이환종,박영주,최강원,양재석,김병국,송호준,최희정,김홍빈,오명돈 대한감염학회 1997 감염 Vol.29 No.5
말초조혈모세포이식 환자에서 기관지 폐포세척액의 항원검출법과 배양으로 확진된 RSV에 의한 지역사회 발생 폐렴을 경험하였기에, 문헌 고찰과 함께 보고한다. Pneumonia is a fatal disease in immunocompromised patients including bone marrow transplantation recipients. Etiological agents include fungi, cytomegalovirus, Pneumocystis carinii, influenzavirus and parainfluenzavirus. We describe a community-acquired RSV pneumonia in a patient who received intense chemotherapy followed by peripheral stem cell transplantation for acute leukemia. The patient was treated with intravenous immunoglobulim and ribavirin aerosol. About 1 month later, she was recovered.