흰쥐에 Xylene 반복 투여가 Xylene의 대사에 미치는 영향

전태원,이혜자,윤종국,이상일,조현국 THE KOREAN SOCIETY FOR BIOMEDICAL LABORATORY SCIEN 1999 Journal of biomedical laboratory sciences Vol.5 No.1

실험동물에 xylene의 반복 투여가 이물질의 대사에 어떠한 영향을 미치는지를 알아보기 위하여 흰쥐에 m-xylene과 olive oil의 동량혼합액을 체중 100g당 0.25ml씩 2일 간격으로 1, 4, 8, 12 및 16회 복강으로 투여한 다음 마지막 투여 24시간 후에 처치하여 다음과 같은 결과를 얻었다. 요 중 m-methylhippuric acid 함량은 m-xylene 4회 투여군의 경우 1회 투여군에 비하여 약 56%의 유의한 증가를 보였으며 이후 12회 투여까지 유사한 결과를 나타내었으나 m-xylene 16회 투여시에는 xylene 1회 투여군 치와 유사한 치로 감소되었다. 그리고 간조직의 microsomal aniline hydroxylase와 alcohol dehydrogenase 활성은 m-xylene 12회 투여시 까지는 대체적으로 점진적인 증가를 보였으나 이후 16회 투여시에는 12회 투여군에 비하여 유의한 감소를 보였다. 또한 aldehyde dehydrogenase 활성은 m-xylene 투여 회수에 비례해서 전 실험기간 동안 감소되었으며 특히 16회 투여군에서 본 효소활성의 현저한 감소를 보였다. 한편 본 실험조건에서 투여기간에 따른 진자현미경적 미세구조의 변화는 초기에 활면소포체의 증식이 보이다가 16회 투여군에서는 활면소포체가 감소되고 조면소포체가 증가되었다. 이상 실험결과는 흰쥐에 있어서 xylene 투여 회수에 따라서 요 중 m-methylhippuric acid의 농도 변동이 초래되며 이는 효소단백 유도에 따른 xylene 대사효소 활성 변동에 기인된 결과로 생각된다. To evaluate the effect of repeated treatment of xylene on its metabolism, m-xylene (0.25ml of 50% in olive oil/100 g body weight) has been intraperitoneally given to the rats 1, 4, 8, 12 and 16 times every other day. m-Xylene was once more administered to the animals after 24 hrs since last injection of it. And then the animals were sacrificed after 24 hrs. Four times xylene treated rats showed the significantly elevated urinary m-methylhippuric acid, compared to those treated with the singe dose of m-xylene with the continued similiar high levels of urinary m-methylhippuric acid up to the animals pretreated 12 times and then those treated 16 times defined the significantly decreased urinary m-methylhippuric acid compared to those treated 12 times. On the other hand, hepatic aniline hydroxylase and alcohol dehydrogenase activities demonstrated a gradual increase from the first group to the 12 times xylene-treated animals, but those treated 16 times showed the significantly decreased value compared with the 12 times treated-group. And aldehyde dehydrogenase activities in rats treated with m-xylene 8, 12 or 16 times were significantly decreased compared to those pretreated one or four times. In the early stage of xylene administration, proliferation of SERs were seen whereas SERs were decreased and RERs were clearly increased in xylene-treated rats 16 times. These results indicate that the frequency of xylene injection may influence upon the changes in xylene metabolite, m-methylhippuric acid and it may be due to induction of xylene metabolizing enzymes.

비정부기구(NGO)의 탈북자 지원 경험 분석 및 개선 방향

전우택,윤덕룡,강성록,김형중,민성길 연세대학교 통일연구원 2001 통일연구 Vol.5 No.1

Objectives: Since 1994, the number of North Korean defectors, escaping North Korea and entering South Korea, has increased rapidly.As the number of defectors has increased the role of non-governmental organizations(NGOs) in assisting the defectors' adaptation to their new society has become more important.To increase the successfulness and effectiveness of NGO activities, their experiences were surveyed and analyzed. Methods: Representatives or acting staffs of 11 NGOs presently supporting North Korean defectors' adaptation to South Korean society were interviewed by researchers between June 21 and October 14, 2000.And one focus group discussion meeting with 26 NGO personnel from 13 NGOs was held on November 4, 2000. Results: As for their stated purpose of activity; to help defectors become good citizens (7), to transform defectors into mediate personnel between North and South Korea (5), to protect the human rights of the North Korean people (3), and th advocate their religions (3).Out of the 11 organizations, only 5 had their own educational program for volunteers.The contents of the NGO's support for volunteers were as follows; counseling (7), introduction of employment and job education (6), direct financial support (5), creation of one-to-one relationships (4), assistance for their religious life (2), assistance with English study and mathematics (1), and medical service (1).NGOs listed the following difficulties; financial (7), human relationship with defectors (6), lack of volunteers and management of them (4), problems in the relationship with the South Korean government (3).NGOs stated a need for close cooperation with other NGOs, involving the activation of NGOs Association (5), and co-operative joint actions (4).Conclusion: Firstly, NGOs need to specialize in their field of activity.Their lack of specialized areas and of ability is the man obstacles to NGOs intercooperation and a major impediment on their effective operation.Secondly, NGOs should be careful in their direct financial support to defectors, because such a form of support has many serious governmental cooperation.The government also needs to have a more open mind in its dealings with NGOs.Fourthly, NGOs should cooperate, especially in areas of joint concern such as volunteer education program.Fifthly, NGOs should pay attention to their volunteers' personnel management and development.Sixthly, NGOs need to increase the degree of activeness with which defectors seek support from NGOs.Usually, it is the NGOs, which play an active role in the support process, so that defectors become passive and dependent leading to many problems.

보호경찰관들의 탈북자 지원 경험 분석

전우택,윤덕용,민성길 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.2

본 연구는 남한에 들어와 살고 있는 탈북자들의 남한 사회 적응 지원 및 신변보호를 2년간 담당한 경찰관들을 대상으로 그들의 활동 속에서 경험한 지원상의 어려움, 인간 관계, 관계 개선을 위한 노력 등을 분석함으로써 향후 탈북자 지원 업무를 담당할 경찰관들과 자원봉사자들, 관련 공무원들을 활동을 더욱 효과적으로 하는데 목적이 있다. 방법: 과거 탈북자 보호 업무를 2년간 담당하였던 전국의 경찰관 전원을 대상으로 경찰청의 도움을 받아 설문조사를 실시하였다. 결과: 총 172명의 경찰관이 설문에 답하였다. 탈북자들의 성별, 연령, 학력에 따른 인간관계 평균점수에는 통계적으로 유의한 차이가 없었다. 그러나 인민학교 출신 탈북자들은 유일하게 시간이 지남에 따라 인간 관계가 더 나빠지는 것으로 나왔다. 또한 인간관계 유형도 연령대에 따라 다르게 나왔다. 탈북 경로에 있어 북한에서 직접 남한으로 들어온 사람들이 러시아, 중국 등을 경유하여 들어온 사람들보다 인간관계 평균점수가 통계적으로 유의하게 더 좋게 나왔다. 경찰관들의 연령대에 따른 인간관계 평균점수의 차이는 없었으나 관계 유형에는 차이가 있었다. 경찰관들이 탈북자들의 문제를 직접 해결을 하려고 나섰을 경우보다 교육행동적인 태도를 가지고 있었을 때 인간관계 평균점수가 통계적으로 더 유의하게 좋게 나왔다. 적응 초기에는 불안과 불신, 사회 부적응 등이 인간 관계에 문제가 되었으나 후기에는 자립의지 부족, 이기주의, 돌출행동 등이 문제가 되었다. 결론: 본 연구는 보호경찰관들과 탈북자들간의 인간관계가 그들의 인구학적 특징, 탈출 경로 등에 따라 다르게 나타남을 보여주었다. 또한 인간 관계를 좋게 하기 위한 노력의 방법이나 지원 방법에 따라 인간관계가 다르게 나타남을 보였다. 이것은 탈북자들을 지원함에 있어 과학적인 지침이 요구됨을 보여주는 것이었다. Objectives: The purpose of this study is to analyze the experience of South Korean police-men who are in charge of supporting the North Korean defectors' adaption to South Korean society for 2 years. Method: Written-form survey questionnaire were sent to all policemen who were in charge of defectors with the help of the National police bureau. Results: 172 policemen answered to survey questionnaire. There was no difference of human relationship score according to the defectors' sex, age, academic career. But defectors with low academic career showed bad human relationship as time went by. The type of human relationship change were different according to the defectors' age. Defectors who entered to South Korea directly from North Korea in short period had a better relationship in comparison with those who escaped to China or other third countries and stayed there for a long time to get a chance to enter to South Korea. As the policemen are younger, the relationship scores were better. But when some problem occurred in their relationship, younger policemen were less successful in solving the problem. There were many kind of efforts of policemen to improve the human relationship and it showed that the education-oriented effort is more effective and successful than direct problem-solving effort. Conclusions: This study showed that the human relationship of defectors and policemen in charge are affected by some demographic factors and defection routes and the types of efforts of policemen to improve the human relationship. It was suggested that the role of policemen in charge of defectors should be more well-defined, and NGO(Non Government Organization) need to have more continuos and specified program to help defectors' adaptation. Finally, the importance of continuing scientific researches about defectors' adaptation was emphasized.

객체 지향 方法을 이용한 멀티미디어 文書 편집기의 設計 및 具現

전은철,정혜윤,박성한 한양대학교 공학기술연구소 1992 공학기술논문집 Vol.1 No.1

This paper proposed a design technique of multimedia document editing system by using object-oriented methodology and its implementation using object-oriented language. The multimedia document editing system can generate a mixed document which consists of text, image, graphic and video, verifying the results by formatting document and process the information of position per page. The hierachical structured design of the class library is proposed where document processing methodolgy and object-oriented one are employed. The system is implemented with Turbo C++ package which provides object-oriented compiling function on a PC.

대학생의 무도 수련과 성격형성의 관계

전윤수,이성탁 한국스포츠리서치 2004 한국 스포츠 리서치 Vol.15 No.5

In this research, we survey the effects of martial art to character formation of university students statistically, and to collect data supporting them we ask questions to two groups of students who major in police administration in nation: one group have 350 holders of a rank in judo and fencing and the other have 100 students with no rank. For data analysis, mean and standard deviation of students are used, and T-test also analyzed for statistical significance test. The results are as follows: First, we study the effects of judo training with two group of students, more than one ranked group and no ranked group. In the case of rank one, male students with rank have more all the factors than students with no rank Female ranked students have more Dominance, Impulsiveness, and Maculinity than no ranked students. In contrast, no ranked students have more General activity, Reflectiveness, and Sociability then ranked students. In the case of rank two, male students with rank also have more all the factors than students with no rank. Female ranked students have more all the factor but impulsiveness than students with no rank. Second, we study the effects of Fencing training with two group of students, more than one ranked group and no ranked group. In the case of rank one, male students with rank have more General activity, Dominance, Reflectiveness and Sociality than students with no rank, and students with no rank more Impulsiveness and Masculinity. Female ranked students have more General activity, Maculinity and Sociality than others. Third, in comparison between students with rank in judo, more than one ranked male students have more all the factors but Masculinity than one ranked students. And more than one ranked Female students have more all the factors but impulsiveness. In the case of fencing, more than two ranked students have more all the factor but Reflectiveness than students with no rank.

분사처리 후 산부식 표면처리된 교정용 미니 임플랜트의 골유착능에 관한 연구

전미선,강윤구,모성서,이근혜,국윤아,김성훈 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.5

본 연구에서는 교정 치료 시 골내 고정원으로 사용되는 교정용 임플랜트의 표면처리 여부가 골유착능에 있어서 어떠한 효과를 보이는지 제거회전력의 측정을 통해 알아보고자 하였으며, 그에 따른 교정력 적용의 확장과 임상적 의의를 알아보고자 하였다. 실험군은 분사처리 후 산부식(Sand-blasted Large grit, and Acid etched, SLA) 표면 처리된 교정용 미니 임플랜트인 C-implant (Cimplant, Seoul, Korea)를 사용하였으며 대조군은 같은 디자인이지만 표면 처리를 하지 않은 평활면 C-implant를 사용하였다. 실험군과 대조군을 각각 2개씩 11마리의 가토 경골에 식립하였고 식립 후 6주에 가토를 희생시켜 제거회전력을 측정하여 t-test를 통하여 두 군의 제거회전력 차이의 통계적 유의성을 알아보았으며 조직표본을 만들어 조직소견을 관찰하였다. 실험결과 제거회전력은 SLA 처리한 C-implant 군이 평활면 C-implant 군보다 통계적으로 유의성 있게 높은 결과를 보였다 (p < 0.05). 평활면 C-implant 군의 평균 제거회전력 값은 4.614 Ncm이고, SLA C-implant 군의 평균 제거회전력 값은 6.286 Ncm로, SLA 군이 평활면 군보다 73% 더 높은 제거회전력에 대한 저항성을 나타내었다. 이상의 연구 결과에서 SLA 표면처리가 C-implant의 골유착능을 증가 시켰음을 알 수 있었다. 따라서 표면 처리된 교정용 미니 임플랜트는 기존의 임플랜트에 비해 좀 더 강한 힘에 저항할 수 있으며 탈락률을 낮출 수 있을 것으로 생각된다. Objective: The purpose of this study was to compare the torque resistance to removal of sandblasted large grit and acid etched (SLA) surface treated orthodontic mini-implants and smooth surface orthodontic mini-implants as well as performing histologic observations. Methods: Two groups of custom screw shaped orthodontic mini-implants (C-implant, 1.8 mm outer diameter × 9.5 mm length, Cimplant, Seoul, Korea) were designated. 22 SLA treated C-implants (SLA group) and 22 machined surface C-implants (machined group) were placed in the tibia metaphysis of 11 adult New Zealand white rabbits. Following a 6-week healing period, the rabbits were sacrificed. Subsequently, the C-implants were removed under reverse torque rotation with a digital torque measuring device and independent t-test was performed. Selected tissues were prepared for histologic observation. Results: The SLA group presented a higher mean removal torque value (6.286 Ncm) than the machined group (4.491 Ncm) which was statistically significant (p < 0.005). Histologic observation revealed a trend of more new bone formation in contact with the screw surface in the SLA group than the smooth group. Conclusions: The results of this study suggested that SLA surface treatment can enhance the osseintegration potential for C-orthodontic mini-implants.

Cyclohexane에 의한 흰쥐의 폐독성

전태원,이상일,윤종국 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.4

Cyclohexane에 의한 생체장기의 독성을 검토할 목적으로 휜쥐에 체중 kg당 1.56 g의cyclohexane을 복강으로 1일 1회 2일 간격으로 4회 투여한 다음 24시간 후에 처치하여 각 장기 (간,신장, 비장, 심장, 소장, 위 및 폐)의 체중 당 장기무게 (%)와 조직세포중 glucose-6-phosphatase (G6Pase) 활성변동을 측정한 결과, 실험군의 체중 당 폐무게가 대조군에 비하여 현저하게 증가 (p<0,001)하였고 이와는 반대로 G6pase 활성은 유의한 (p<0.001) 감소를 나타내었다. 그러나 폐를 제의한 장기에서는 별다른 차이를 볼 수 없었다. 이러한 결과는 cyclohexane이 주로 폐조직에 독작용을 야기시킨다는 것을 시사해 주고 있으며, 폐조직에서 malondialdehyde 함량이 대조군에 비하여 유의하게 (p<0.05) 증가된 것이 이를 뒷받침 해 주고 있다. 한편, cytochrome P450에 의해 나타나는 aniline hydroxylase활성은 폐조직이 간조직에 비하여 대단히 낮았으며, alcohol dehydrogenase (ADH) 활성 역시 간조직 보다 현저하게 낮게 나타났다. 그리고 cyclohexane투여로 인하여 ADH 활성은 간 및 폐조직 모두에서 증가하였으나 간조직에서 더욱민감한 반응을 나타내었다. 이상 실험결과를 종합해 볼 때, cyclohexane은 폐조직에 주로 독성을 나타 내며 이는 간조직에서 대사된 cyclohexane의 독성 중간대사산물인 cyclohexanone이 혈류를 통해 폐조직에 분포되어 나타난 결과로 사료된다. In order to search the target organ of cylclohexane toxicity, the rats were intraperitoneally treated with cyclohexane (1.56 g/kg of body wt.) four times every other day. In the increasing rate of organ weight per body weight (%) in cyclohexane-treated animals, the lung was highest among the liver, spleen small intestine, stomach, heart and kidney. And in the decreasing rate of glucose-6-phosphatase (G-6-Pase) activity in each organ that of lung was also highest among all organs. Lung MDA content was significantly increased (p<0.05) by the cyclohexane treatment. On the other hand, microsomal aniline hydroxylase activity in lung tissue both of control and cyclohexane-treated rats was greatly low as could be scarcely measured, but that in liver possessing high activity was significantly increased (p<0.05) in cyclohexane-treated rat compared with control. Alcohol dehydrogenase activity in lung was markedly higher than that of liver and the latter was significantly (p<0.05) increased by the cyclohexane treatment. In conclusion, cyclohexane treatment to the rats showed mainly lung toxicity and it may be responsible far cyclohexanon, cyclohexane metabolite, distributed from liver.

대학생을 위한 예비 부모 교육 프로그램 개발을 위한 연구

윤기영,전효숙,박상임,이미숙,이석란,박수옥 서원대학교 학생생활연구소 1998 학생생활연구 Vol.16 No.-

The purpose of this study are to examine reference materials, existing lecture analysis, investigate how student response about new lecture model and to project the basic direction of pre-parent education program. The result of this study are as follows ; <Lecture Model : Parent and Child> Sequence Theme 1 Introduction, Positive Self-Concept 2 Love and Sex 3 Friends versus Lovers 4 Marriage 5 Parenting and Parent's Role 6 Pregnancy and Embriology 7 Brith 8 Middle Term Exam 9 Parent's Role for Infant and Toddler 10 Parent's Role for Child 11 Parent's Role for Youth 12 Society and Environment for Child Care 13 Communication for Parent-Child 14 Problem solving method for Child Care 15 Parent in Future 16 Final Exam

Vision System을 이용한 음성인식 자동 영상 추적기 구현에 관한 연구

전윤식,최성률 호남대학교 1999 호남대학교 학술논문집 Vol.20 No.2

In this paper, I made Speech Recognition Auto Image Tracker with using Vision System. There are several senses in human body. If you should choose the most correct sense to realize the outside circumstances, you may not hesitate to pick up the sight. Meanwhile, Voice is the most convenient means to order without moving. Therefor, I realized that system with the merits of these two senses. Speech Recognition was done by seeking Linear Prediction coefficients and comparing each other. In Image Recognition, Object Recognitions were done by calculating the field of them in the space, and Motion extraction was done by inputing two images during a constant time and calculating the difference between them. In conclusion, when you choose a object, you want with voice order, Main PC realizes it and judges, if the object coming into the Vision System is what you want and tracks it.

Bromobenzene의 투여 횟수에 따른 간독성의 차이

이상희,전태원,윤종국 대한의생명과학회 2000 Journal of biomedical laboratory sciences Vol.6 No.1

실험동물에 있어서 간조직의 손상 정도에 미치는 xenobiotics의 투여기간에 의한 영향을 검토할 목적으로 hepatotoxin의 일종인 bromobenzene의 투여 횟수에 의한 간손상 정도와 이의 기전을 구명 한 결과는 다음과 같다. 횐쥐에 1일 간격으로 bromobenzene (400 mg/kg)을 복강으로 1회, 3회 및 6회 투여 한 실험군을 대상으로 하여 실시한 실험에서 혈청 alanine aminotransferase (ALT)의 확성 및 체중 당 간 무게는 bromobenzene을 1회 투여 한 1일째에는 대조군과 별다른 변동을 볼 수 없었으나 3회 투여 한 3일째에는 유의하게 증가되었으며, 이후 6일째 6회 투여한 실험군에서는 체중 당 간 무게 및 혈청 ALT활성이 3일째 보다 현저히 감소되어 오히려 대조군과 유사하였다. 이와 같이 투여 횟수의 증가에 따른 간손상의 정도가 투여 횟수와 비례하지 않은 것이 어떠한 기전에 의해서 나타나는지를 구명하기 위해 bromobenzene 대사에 관여 하는 간조직 중 aniline hydroxylase 및 glutathione S-transferase 활성과 glutathione (GSH) 함량을 측정한 결과, 이들 대사효소 및 GSH이용률이 bromobenzene 6회 투여 군에서 1회 및 3회 투여군보다 높게 나타났다. 이상 실험 결과를 종합해 볼 때 어떤 독성물질이 생체에 계속 폭로 시 어느 시점에서 중독현상이 경감되는 것은 이 독성물질의 대사율을 증가시켜 해독하려는 생리적응현상이 일어 날 수 있다는 가설을 제시 할 수 있다. A Study on the Effect of Injection Frequency on the Liver Damage in Rats To investigate the effect of injection frequency of bromobenzene on the liver damage, bromobenzene (400 mg/kg, i.p.) was given daily to rats for six days. All experimental animals were sacrificed at 24 hours after the last injection. Morphological changes of the liver were observed under a light microscopic examination. Functional changes of the liver were evaluated by the measurement of alanine aminotransferase activity. To clarify the cause of discrepancy in liver damage, hepatic glutathione (GSH) content, glutathione S-transferase (GSI) and aniline hydroxylase (AH) activities were determined. In the experiments of daily bromobenzene treatments, the sacrificed animals at six day (6 time-injected animals) showed slighter liver damage than those sacrificed at 3 day (3 time-injected ones), based on the liver morphological or functional findings; the decreasing ratio of GSH content and increasing ratio of liver GST and AH activities in the 6 time-injected group were higher than those in the 3 time-injected one.