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Thi Phuong Diu TRAN(Thi Phuong Diu TRAN ),Thi Van Khanh NGUYEN(Thi Van Khanh NGUYEN ),Thanh Quang DO3(Thanh Quang DO3 ),Cong Nghiep NGUYEN(Cong Nghiep NGUYEN ),Thu Thuy LUONG(Thu Thuy LUONG ) 한국유통과학회 2022 유통과학연구 Vol.20 No.10
Purpose: This article focuses on exploring the associations between job satisfaction, organizational commitment, and turnover intention. Specifically, this study estimates the impacts of Vietnamese employees’ job satisfaction on their organizational commitment and turnover intention in FDI enterprises. Research design, data and methodology: The measures are adapted from previous studies to develop a questionnaire with a seven-point Likert scale. The dataset is directly collected from 227 respondents who are employees at FDI enterprises situated in the North of Vietnam. The dataset is analyzed by quantitative approaches using SPSS 24.0 and AMOS 24.0. Results: The results show that while turnover intention is positively correlated with monthly income, it is negatively correlated with job satisfaction and organizational commitment. Also, organizational commitment is positively associated with job satisfaction among employees at FDI enterprises in Vietnam. Conclusions: The findings of this study will serve as useful references for administrators of FDI enterprises and policymakers to promote employees’ job satisfaction and retain skilled employees.
Nguyen, Khanh Hoang Viet,Dao, Trong Khoa,Nguyen, Hong Duong,Nguyen, Khanh Hai,Nguyen, Thi Quy,Nguyen, Thuy Tien,Nguyen, Thi Mai Phuong,Truong, Nam Hai,Do, Thi Huyen Asian Australasian Association of Animal Productio 2021 Animal Bioscience Vol.34 No.5
Objective: Fibronectin 3 (FN3) and immunoglobulin like modules (Ig) are usually collocated beside modular cellulase catalytic domains. However, very few researches have investigated the role of these modules. In a previous study, we have sequenced and analyzed bacterial metagenomic DNA in Vietnamese goats' rumen and found that cellulase-producing bacteria and cellulase families were dominant. In this study, the properties of modular cellulases and the role of a FN3 in unique endoglucanase belonging to glycosyl hydorlase (GH) family 5 were determined. Methods: Based on Pfam analysis, the cellulases sequences containing FN3, Ig modules were extracted from 297 complete open reading frames (ORFs). The alkaline, thermostability, tertiary structure of deduced enzymes were predicted by AcalPred, TBI software, Phyre2 and Swiss models. Then, whole and truncated forms of a selected gene were expressed in Escherichia coli and purified by His-tag affinity column for assessment of FN3 ability to enhance enzyme activity, solubility and conformation. Results: From 297 complete ORFs coding for cellulases, 148 sequences containing FN3, Ig were identified. Mostly FN3 appeared in 90.9% beta-glucosidases belonging to glycosyl hydrolase family 3 (GH3) and situated downstream of catalytic domains. The Ig was found upstream of 100% endoglucanase GH9. Rarely FN3 was seen to be situated downstream of X domain and upstream of catalytic domain endoglucanase GH5. Whole enzyme (called XFN3GH5 based on modular structure) and truncate forms FN3, XFN3, FN3GH5, GH5 were cloned in pET22b (+) and pET22SUMO to be expressed in single and fusion forms with a small ubiquitin-related modifier partner (S). The FN3, SFN3 increased GH5 solubility in FN3GH5, SFN3GH5. The SFN3 partly served for GH5 conformation in SFN3GH5, increased modules interaction and enzyme-soluble substrate affinity to enhance SXFN3GH5, SFN3GH5 activities in mixtures. Both SFN3 and SXFN3 did not anchor enzyme on filter paper but exfoliate and separate cellulose chains on filter paper for enzyme hydrolysis. Conclusion: Based on these findings, the presence of FN3 module in certain cellulases was confirmed and it assisted for enzyme conformation and activity in both soluble and insoluble substrate.
Trinh Thi Thanh THUY,Nguyen Thi BINH,Trinh Thi Thu HUONG,Nguyen Thu THUY,Dang Thanh PHUONG,Tran Thi Bao KHANH,Nguyen Thi YEN 한국유통과학회 2021 The Journal of Asian Finance, Economics and Busine Vol.8 No.11
The development of the ethnic minorities and mountainous areas (EMMA) is currently receiving the attention of countries around the world. This is demonstrated through a large number of studies, in many respects, in many different countries. The objective of the study is to find out the current situation of the commodity market in the ethnic minorities and mountainous areas (EMMA) of Vietnam. In particular, the authors will study whether there is a link between the ability to access governmental policies and the characteristics of this commodity market. To achieve the goal, the authors employed the secondary data collection method to gather the relevant information on government policies for EMMA and conducted an interview of seventy (70) enterprises in the Northern midlands and mountainous regions and the Central Coast to clarify the characteristics of commodity market. By Levene’s test, the results showed that the accessibility to governmental policies has a certain influence on the development of the commodity market patterns in the EMMA in terms of diversification of distribution forms and sales method of the business. These findings brought some basic solutions to further enhance the role of the government in developing commodity markets in the EMMA of Vietnam.
Dinh Van Tuan,Dang Thi Thuy Ngan,Dao Vu Phuong Thao,Nguyen Thi Nguyet,Nguyen Thi Thuy,Nguyen Phuong Thuy,Vu Van Thu,Vuong-Pham Hung,Phuong Dinh Tam 한국물리학회 2022 Current Applied Physics Vol.43 No.-
A facile hydrothermal route was used to synthesize silver nanoparticle (AgNP)-decorated microflower molybdenum disulfide (MoS2-MF) for bio-electrochemical platform fabrication to detect nonenzymatic glucose concentration. The morphologies of the materials were studied by scanning electron microscopy, and their structural characteristics were analyzed by X-ray diffractometry and energy-dispersive X-ray spectroscopy. The electrochemical characteristics of the AgNPs/MoS2-MF/PtE biosensor were studied by cyclic voltammetry. The obtained data indicated that the developed nonenzymatic glucose sensor has a large linear response between 1.0 and 15.0 mM, a limit of detection of as low as 1.0 mM, and a sensitivity of 46.5 μA nM-1 cm-2. The biosensor also displayed outstanding selectivity, stability, reproducibility, and repeatability. Additionally, the AgNPs/MoS2-MF/ PtE biosensor was utilized to detect glucose concentration in real sample and showed practical application potential for glucose detection.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,김은지,강정일,강희경,Nguyen Xuan Cuong,Nguyen Hoai Nam,Phan Van Kiem,Chau Van Minh,김영호 한국식품영양과학회 2015 Journal of medicinal food Vol.18 No.1
Bioassay-directed fractionation and purification were used to isolate 12 steroids (1–12) from a CH2Cl2 extract of the edible Vietnamese sea urchin Diadema savignyi Michelin. The cytotoxic activity of the CH2Cl2 extract and 12 steroids was evaluated in three human cancer cell lines (HL-60, PC-3, and SNU-C5). Relative to the effects of the positive control, mitoxantrone, the CH2Cl2 extract (with an inhibitory concentration of 50% [IC50] values ranging from 1.37 ± 0.15 to 3.11 ± 0.15 μg/mL) and compounds 2 (with IC50 values ranging from 5.29 ± 0.11 to 6.80 ± 0.67 μM) and 11 (with IC50 values ranging from 4.95 ± 0.07 to 6.99 ± 0.28 μM) exhibited potent cytotoxic effects against all three tested human cancer cell lines. In addition, the CH2Cl2 extract and compounds 2 and 11 were found to induce apoptosis. The induction of apoptosis was accompanied by alterations of the apoptosis-related protein expression, inactivation of ERK1/2 mitogen-activated protein kinase signaling, and decreased c-Myc expression. These data suggest that compounds 2 and 11 from the edible sea urchin D. savignyi may have potential for the treatment of colon cancer, leukemia, and prostate cancer as complementary cancer remedies.
Nguyen Phuong Thao,Bui Thi Thuy Luyen,Chau Ngoc Diep,Bui Huu Tai,김은지,강희경,이상현,장해동,Nguyen The Cuong,Nguyen Van Thanh,Nguyen Xuan Cuong,Nguyen Hoai Nam,Chau Van Minh,김영호 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.4
This study performed phytochemical and bioactiveassessments of the mangrove Lumnitzera racemosaWilld. leaves. Bioassay-guided fractionation of the methanolicextracts led to the identification of thirty-six compounds(1–36), their structures were elucidated using detailed NMRspectroscopic and MS analysis. The extracts, fractions, andthe isolated compounds were screened for potential antioxidantand cytotoxic activities. Antioxidant assays wereperformed using peroxyl radical-scavenging and reducingassays, whereas cytotoxicity was measured using MTTassays in HL-60 and Hel-299 cell lines. The methanolicextract, CH2Cl2 and n-BuOH fractions (10.0 lg/mL)exhibited potent antioxidant activity, with Trolox equivalent(TE) values of 24.94 ± 0.59, 28.34 ± 0.20, and27.09 ± 0.37 (lM), respectively. In addition, the isolatedcompounds exerted cytotoxic effects in a dose-dependentmanner; compounds 1 and 14 exhibited the most potentcytotoxicity in HL-60 cells, with IC50 values of 0.15 ± 0.29and 0.60 ± 0.16 lM, respectively. To clarify the mechanism(s) behind these cytotoxic effects, we measured thetime-dependent changes in apoptotic markers including thecondensation and fragmentation of nuclear chromatin, andthe downregulation of p-ERK1/2, p-AKT, and c-Myc levels.
Induction of methionine adenosyltransferase 2A in tamoxifen-resistant breast cancer cells
( Nguyen Thi Thuy Phuong ),( Sang Kyum Kim ),( Ji Hye Im ),( Jin Won Yang ),( Min Chang Choi ),( Sung Chul Lim ),( Kwang Yeol Lee ),( Young-mi Kim ),( Jeong Hoon Yoon ),( Keon Wook Kang ) 전남대학교 약품개발연구소 2016 약품개발연구지 Vol.25 No.-
We previously showed that-S-adenosylmethionine-mediated hypermethylation of the PTEN promoter was important for the growth of tamoxifen-resistant MCF-7 (TAMR-MCF-7) cancer cells. Here, we found that the basal expression level of methionine adenosyltransferase 2A (MAT2A), a critical enzyme for the biosynthesis of S-adenosylmethionine, was up-regulated in TAMR-MCF-7 cells compared with control MCF-7 cells. Moreover, the basal expression level of MAT2A in T47D cells, a TAM-resistant estrogen receptor-positive cell line was higher compared to MCF-7 cells. Immunohistochemistry confirmed that MAT2A expression in TAM-resistant human breast cancer tissues was higher than that in TAM-responsive cases. The promoter region of human MAT2A contains binding sites for nuclear factor-кB, activator protein-1 (AP-1), and NF-E2-related factor 2 (Nrf2), and the activities of these three transcription factors were enhanced in TAMR-MCF-7 cells. Both the protein expression and transcriptional activity of MAT2A in TAMR-MCF-7 cells were potently suppressed by NF-кB inhibition but not by c-Jun/AP-1 or Nrf2 Knock-down. Interestingly, the expression levels of microRNA (miR)-146a and-146b were diminished in TAMR-MCF-7 cells, and miR-146b transduction decreased Nf-кB-mediated MAT2A expression. miR-146b restored PTEN expression via the suppression of PTEN promoter methylation In TAMR-MCF-7 cells. Additionally, miR-146b overexpression inhibited cell proliferation and reversed chemoresistance to-hydroxyramoxifen in TAMR-MCF-7 cells.
Role of PTEN promoter methylation in tamoxifen-resistant breast cancer cells.
Phuong, Nguyen Thi Thuy,Kim, Sang Kyum,Lim, Sung Chul,Kim, Hyung Sik,Kim, Tae Hyung,Lee, Kwang Yeol,Ahn, Sang-Gun,Yoon, Jung-Hoon,Kang, Keon Wook M. Nijhoff ; Kluwer Academic Publishers 2011 Breast cancer research and treatment Vol.130 No.1
<P>Tamoxifen (TAM) resistance is a serious clinical problem in the treatment of breast cancer. Here, we found that S-adenosylmethionine (SAM) and DNA methyltransferase1 (DNMT1) expression are up-regulated in TAM-resistant breast cancer (TAMR-MCF-7) cells. We further focused on whether increased SAM with DNMT1 overexpression in TAMR-MCF-7 cells lead to aberrant methylation of the PTEN gene promoter and its therapeutic potential. Methylation-specific PCR analyses revealed that two sites within the PTEN promoters were methylated in TAMR-MCF-7 cells, which resulted in down-regulation of PTEN expression and increase in Akt phosphorylation. Both the loss of PTEN expression and the increased Akt phosphorylation in TAMR-MCF-7 cells were completely reversed by 5-aza-2'-deoxycytidine (5-Aza), a DNMT inhibitor. 5-Aza inhibited the basal cell proliferation rate of TAMR-MCF-7 cells and intraperitoneal injection of 5-Aza significantly suppressed TAMR-MCF-7 tumor growth in a xenograft study. Immunohistochemistry showed that PTEN expression in TAM-resistant human breast cancer tissues was lower than in TAM-responsive cases. These results suggest that methylation of the PTEN promoter related to both SAM increase and DNMT1 activation contributes to persistent Akt activation and are potential therapeutic targets for reversing TAM resistance in breast cancer.</P>
Triterpenoid saponins from the roots of Rosa rugosa Thunb. as rat intestinal sucrase inhibitors
Nguyen Phuong Thao,Bui Thi Thuy Luyen,주성호,Tran Manh Hung,Nguyen Xuan Cuong,Nguyen Hoai Nam,권영인,Chau Van Minh,김영호 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.10
Medicinal plants constitute an important sourceof potential therapeutic agents for diabetes. The purpose ofpresent study is to investigate the effect of root extract ofRosa rugosa Thunb. on inhibition of sucrase related todiabetes mellitus (DM). Bioassay-guided fractionation ofthe methanol extract led to the identification of 13 triterpenoidsaponins (1–13). Their structures were elucidatedon the basis of extensive spectroscopic analysis, including1D, 2D NMR, and MS. The n-butanol fraction showedpotent rat intestinal sucrase inhibitory activity with value of87.62 ± 5.84 % inhibition compared to the positive controlacarbose (50.96 ± 2.97 % inhibition at 0.02 mM). Subsequently, compounds 11–13 (1.0 mM) exhibited significantsucrase inhibitory activity, with inhibition percentagevalues of 41.17 ± 3.52, 46.80 ± 4.00, and39.39 ± 4.19 %, respectively. Whereas, compounds 2–6,8, and 10 showed moderate sucrase inhibitory activity(ranging from 13.26 ± 7.00 to 32.08 ± 6.04 % inhibition)at a same concentration. The data provide a starting pointfor creating new sucrase inhibitors, which may be usefulfor the development of effective therapies for the treatmentof DM.