Triterpenoids from aerial parts of Glochidion eriocarpum.

Thu, Vu Kim,Kiem, Phan Van,Yen, Pham Hai,Nhiem, Nguyen Xuan,Tung, Nguyen Huu,Cuong, Nguyen Xuan,Minh, Chau Van,Huong, Hoang Thanh,Lau, Trinh Van,Thuan, Ngo Thi,Kim, Young Ho Natural Product Communications 2010 Natural product communications Vol.5 No.3

<P>From the aerial parts of Glochidion eriocarpum, a new triterpene, glochieriol (1), three new triterpenoid saponins, glochieriosides C - E (2 - 4), together with four known triterpenes (glochidonol, glochidiol, lupeol, and 3-epi-lupeol) were isolated by using combined chromatographic separations. The structures of the new compounds were elucidated on the basis of spectroscopic data, including FTICR-MS, 1D and 2D NMR.</P>

Discovery of cycloartane-<i>type</i> triterpene saponins from <i>Mussaenda glabra</i>

Thu, Vu Kim,Bach, Nguyen Xuan,Anh, Luu The,Trang, Do Thi,Nhiem, Nguyen Xuan,Tai, Bui Huu,Van Kiem, Phan,Van Minh, Chau,Park, SeonJu,Seo, Yohan,Namkung, Wan,Kim, Seung Hyun Elsevier 2019 PHYTOCHEMISTRY LETTERS Vol.33 No.-

<P><B>Abstract</B></P> <P>Five new cycloartane saponins, mussaglaosides A–E (<B>1</B>–<B>5</B>) together with five known saponins, mussaendoside O, mussaendoside, G mussaendoside U, mussaendoside P, and mussaendoside Q (<B>6</B>–<B>10</B>) were isolated from the leaves of <I>Mussaenda glabra.</I> Their structures were determined on the basis of extensive spectroscopic methods, including 1D-, 2D-NMR, and MS data. All compounds were evaluated for ANO1 inhibitory activity using calcium-activated chloride channel and YFP expressing HT29 cells. Among the tested compounds, compound <B>6</B> strongly inhibited chloride channel activity with IC<SUB>50</SUB> value of 22.0 ± 1.7 μM without any cytotoxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Five new cycloartane saponins, mussaglaosides A–E (<B>1</B>–<B>5</B>) were isolated from <I>Mussaenda glabra</I>. </LI> <LI> The structures were successfully determined by spectroscopic evidence. </LI> <LI> Compound <B>6</B> strongly inhibited chloride channel activity (IC<SUB>50</SUB> value of 22.0 ± 1.7 μM). </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Factors Affecting Sustainable Tourism Development in Ba Ria-Vung Tau, Vietnam

VU, Dong Van,TRAN, Ghi Nha,NGUYEN, Hien Thi Thu,NGUYEN, Cong Van Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.9

Sustainable development - including tourism development - is the general trend of all economies. With the orientation to build and develop the tourism industry into a key economic sector and become a tourist center of the Southeast region, Vietnam, Ba Ria-Vung Tau Province is demanding a proper, rational, development policy, while ensuring the development and exploitation of immediate natural advantages, and ensuring long-term sustainable development. The objective of this study is to examine the factors and their trends in sustainable tourism development in Ba Ria-Vung Tau Province, Vietnam. Methods used include descriptive statistical analysis, exploratory factor analysis and regression analysis. Data was collected from the results of a survey of 550 domestic and foreign tourists visiting Ba Ria-Vung Tau. With the help of SPSS statistical software, 12 groups of factors affecting sustainable development were identified including: economy, society, environment, humanistic tourism resources, natural tourism resources, tourism human resources, tourism products and service, tourism quality, infrastructure, technical facilities, governmental management and group of criteria to evaluate sustainable tourism development. The research results show that there are four groups of factors that significantly affect sustainable tourism development in Ba Ria-Vung Tau. These are groups of factors: Society, Environment, Tourism products and service, and Technical facilities.

Rapid and label-free detection of H5N1 virus using carbon nanotube network field effect transistor

Vu Van Thu,Phuong Dinh Tam,Phuong Trung Dung 한국물리학회 2013 Current Applied Physics Vol.13 No.7

DNA hybridization-based detection techniques are widely used in genetics, medicine, and drug discovery. However, the current techniques are usually based on labels and reagents that are time consuming and complex to implement. In this study, we report a label-free DNA sensor based on single-walled carbon nanotube field effect transistor (SWCNTFET) for selective DNA hybridization detection of H5N1 virus. A network of single-walled carbon nanotubes (SWCNTs) acts as the conductor channel. ProbeDNA sequences were adsorbed onto SWCNTs. The developed DNA sensor can effectively detect full-complementary DNA with concentration as low as 1.25 pM. The sensitivity of the DNA sensor reached approximately 0.28 nM/nA. The effect of the parameters, including DNA probe concentration, its complementary concentration,mismatched sequence, and hybridization time, on the sensor response was also studied. The results showed the potential application of the DNA sensor for medical, environmental, and epidemic detection.

Tobacco Control Policies in Vietnam: Review on MPOWER Implementation Progress and Challenges

Hoang, Van Minh,Tran, Thu Ngan,Vu, Quynh Mai,Nguyen, Thi Tuyet My,Le, Hong Chung,Vu, Duy Kien,Tran, Tuan Anh,Nguyen, Bao Ngoc,Vu, Van Giap,Nguyen, Manh Cuong,Pham, Duc Manh,Kim, Bao Giang Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.no.sup1

In Vietnam, the WHO Framework Convention on Tobacco Control (WHO FCTC) took effect in March 2005 while MPOWER has been implemented since 2008. This paper describes the progress and challenges of implementation of the MPOWER package in Vietnam. We can report that, in term of monitoring, Vietnam is very active in the Global Tobacco Surveillance System, completing two rounds of the Global Adult Tobacco Survey (GATS) and three rounds of the Global Youth Tobacco Survey (GYTS). To protect people from tobacco smoke, Vietnam has issued and enforced a law requiring comprehensive smoking bans at workplaces and public places since 2013. Tobacco advertising and promotion are also prohibited with the exception of points of sale displays of tobacco products. Violations come in the form of promotion girls, corporate social responsibility activities from tobacco manufacturers and packages displayed by retail vendors. Vietnam is one of the 77 countries that require pictorial health warnings to be printed on cigarette packages to warn about the danger of tobacco and the warnings have been implemented effectively. Cigarette tax is 70% of factory price which is equal to less than 45% of retail price and much lower than the recommendation of WHO. However, Vietnam is one of the very few countries that require manufacturers and importers to make "compulsory contributions" at 1-2% of the factory price of cigarettes sold in Vietnam for the establishment of a Tobacco Control Fund (TCF). The TCF is being operated well. In 2015, 67 units of 63 provinces/cities, 22 ministries and political-social organizations and 6 hospitals received funding from TCF to implement a wide range of tobacco control activities. Cessation services have been starting with a a toll-free quit-line but need to be further strengthened. In conclusion, Vietnam has constantly put efforts into the tobacco control field with high commitment from the government, scientists and activists. Though several remarkable achievements have been gained, many challenges remain. To overcome those challenges, implementation strategies that take into account the contextual factors and social determinants of tobacco use in Vietnam are needed.

High-performance nonenzymatic electrochemical glucose biosensor based on AgNP-decorated MoS2 microflowers

Dinh Van Tuan,Dang Thi Thuy Ngan,Dao Vu Phuong Thao,Nguyen Thi Nguyet,Nguyen Thi Thuy,Nguyen Phuong Thuy,Vu Van Thu,Vuong-Pham Hung,Phuong Dinh Tam 한국물리학회 2022 Current Applied Physics Vol.43 No.-

A facile hydrothermal route was used to synthesize silver nanoparticle (AgNP)-decorated microflower molybdenum disulfide (MoS2-MF) for bio-electrochemical platform fabrication to detect nonenzymatic glucose concentration. The morphologies of the materials were studied by scanning electron microscopy, and their structural characteristics were analyzed by X-ray diffractometry and energy-dispersive X-ray spectroscopy. The electrochemical characteristics of the AgNPs/MoS2-MF/PtE biosensor were studied by cyclic voltammetry. The obtained data indicated that the developed nonenzymatic glucose sensor has a large linear response between 1.0 and 15.0 mM, a limit of detection of as low as 1.0 mM, and a sensitivity of 46.5 μA nM-1 cm-2. The biosensor also displayed outstanding selectivity, stability, reproducibility, and repeatability. Additionally, the AgNPs/MoS2-MF/ PtE biosensor was utilized to detect glucose concentration in real sample and showed practical application potential for glucose detection.

Tracking the establishment of local endemic populations of an emergent enteric pathogen

Holt, Kathryn E.,Thieu Nga, Tran Vu,Thanh, Duy Pham,Vinh, Ha,Kim, Dong Wook,Vu Tra, My Phan,Campbell, James I.,Hoang, Nguyen Van Minh,Vinh, Nguyen Thanh,Minh, Pham Van,Thuy, Cao Thu,Nga, Tran Thi Thu National Academy of Sciences 2013 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.110 No.43

<P><I>Shigella sonnei</I> is a human-adapted pathogen that is emerging globally as the dominant agent of bacterial dysentery. To investigate local establishment, we sequenced the genomes of 263 Vietnamese <I>S. sonnei</I> isolated over 15 y. Our data show that <I>S. sonnei</I> was introduced into Vietnam in the 1980s and has undergone localized clonal expansion, punctuated by genomic fixation events through periodic selective sweeps. We uncover geographical spread, spatially restricted frontier populations, and convergent evolution through local gene pool sampling. This work provides a unique, high-resolution insight into the microevolution of a pioneering human pathogen during its establishment in a new host population.</P>

Determinants of Liquidity in Manufacturing Firms

VU, Thu Minh Thi,TRUONG, Tu Van,DINH, Dung Thuy Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.12

This study examines the factors that affect firm's liquidity in manufacturing companies listed in Vietnam. Factors studied include the board size, the board independence, the firm size, the firm age, and its return. We use different metrics to measure firm's solvency status, including the cash ratio, the quick ratio, and the cash conversion cycle. Accordingly, three econometric models are built to test hypotheses proposed by researchers in order to explain the relationship between the five factors above and liquidity's measures. The study used the data set of manufacturing companies listed on the Ho Chi Minh City Stock Exchange in the period from 2015 to 2019. The final sample group comprises 139 firms with 633 observations. The results show that in manufacturing firms, while the cash ratio and the quick ratio are positively associated to the board size, the board independence, and the firm's profitability, the net operating cycle is negatively correlated to the board size, the firm size, the board independence, and the profitability. Therefore, larger firms with larger board size and more independent members can help to improve capital management efficiency.There is no evidence for the relationship between the firm age and solvency measurements, between cash conversion cycle and firm's profitability.

Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart

Vu Thi Thu,Dang Van Cuong,김나리,염재범,Mohamad Warda,박원선,고재홍,김의용,한진 대한약리학회 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.2

Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or survival of viable and infarcted cardiac tissues under oxidative stress. To date, however, the interplay between the mitochondrial antioxidant enzyme system and the level of reactive oxygen species (ROS) in the body has not yet been resolved. In the present study, we examined the effects of IR- and IPC-induced oxidative stresses on mitochondrial function in viable and infarcted cardiac tissues. Our results showed that the mitochondria from viable areas in the IR-induced group were swollen and fused, whereas those in the infarcted area were heavily damaged. IPC protected the mitochondria, thus reducing cardiac injury. We also found that the activity of the mitochondrial antioxidant enzyme system, which includes manganese superoxide dismutase (Mn-SOD), was enhanced in the viable areas compared to the infarcted areas in proportion with decreasing levels of ROS and mitochondrial DNA (mtDNA) damage. These changes were also present between the IPC and IR groups. Regional differences in Mn-SOD expression were shown to be related to a reduction in mtDNA damage as well as to the release of mitochondrial cytochrome c (Cyt c). To the best of our knowledge, this might be the first study to explore the regional mitochondrial changes during IPC. The present findings are expected to help elucidate the molecular mechanism involved in IPC and helpful in the development of new clinical strategies against ischemic heart disease.

Regional Differences in Mitochondrial Anti-oxidant State during Ischemic Preconditioning in Rat Heart

Thu, Vu Thi,Cuong, Dang Van,Kim, Na-Ri,Youm, Jae-Boum,Warda, Mohamad,Park, Won-Sun,Ko, Jae-Hong,Kim, Eui-Yong,Han, Jin The Korean Society of Pharmacology 2007 The Korean Journal of Physiology & Pharmacology Vol.11 No.2

Ischemic preconditioning (IPC) is known to protect the heart against ischemia/reperfusion (IR)-induced injuries, and regional differences in the mitochondrial antioxidant state during IR or IPC may promote the death or survival of viable and infarcted cardiac tissues under oxidative stress. To date, however, the interplay between the mitochondrial antioxidant enzyme system and the level of reactive oxygen species (ROS) in the body has not yet been resolved. In the present study, we examined the effects of IR- and IPC-induced oxidative stresses on mitochondrial function in viable and infarcted cardiac tissues. Our results showed that the mitochondria from viable areas in the IR-induced group were swollen and fused, whereas those in the infarcted area were heavily damaged. IPC protected the mitochondria, thus reducing cardiac injury. We also found that the activity of the mitochondrial antioxidant enzyme system, which includes manganese superoxide dismutase (Mn-SOD), was enhanced in the viable areas compared to the infarcted areas in proportion with decreasing levels of ROS and mitochondrial DNA (mtDNA) damage. These changes were also present between the IPC and IR groups. Regional differences in Mn-SOD expression were shown to be related to a reduction in mtDNA damage as well as to the release of mitochondrial cytochrome c (Cyt c). To the best of our knowledge, this might be the first study to explore the regional mitochondrial changes during IPC. The present findings are expected to help elucidate the molecular mechanism involved in IPC and helpful in the development of new clinical strategies against ischemic heart disease.