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돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향
최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 형질전환복제돼지연구센터 2004 논문집 Vol. No.8
Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-r, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18, It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PKl5 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.
崔尙丁,李孝眞,吳明淑 弘益大學校 科學技術硏究所 2001 科學技術硏究論文集 Vol.12 No.-
As the number of coal fired power plants in the domestic power industry continues to increases, the amount of fly ash produced is also increasing, making the reutilization of fly ash a vital issue. Various methods to reutilize the fly ash from coal power plants have been investigated, and one of such areas with the potential to grow is the usage as light weight sintered construction materials. Sintered fly ash aggregates are produced in two steps; the first is the pellet formation step, during which the fly ash particles containing unburnt carbons were made into a pellet using caking components, and the second the pellet sintering by the combustion heat of the carbons. During the sintering process, the combustion rate of the carbon affects the characteristics of sintered pellets. The combustion of carbon occurs via adsorption of O₂ on the active sites, and desorption of CO/CO₂. The parameters which affect the rate of adsorption, desorption, and transfer of O₂ and CO/CO₂ include the O₂ partial pressure and flow rate, the pellet size, the porosity, the pore tortuosity, the pore size distribution, the carbon content and distribution. This study investigated the combustion of carbon during the production of sintered fly ash through modeling. A simple combustion model using Langmuir isotherm is used to calculate the pellet temperature. The oxygen diffusion through the pores is ignored. At the temperatures of sintering, the desoption process is a rate limiting process, making the overall rate sensitive to the desoption kinetic parameters. In addition, it was found that the carbon content and the heat capacity of the pellet affected both the rate of the reaction and the final pellet temperature, while the area of active sites only affect the reaction rate. The future work will include the combustion modeling with external and internal diffusion of O₂, and the model confirmation through experimentation.
피더부하 균등화지수를 이용한 배전계통의 긴급정전복구 및 부하균등화
崔相烈,鄭澔聖,申明澈 성균관대학교 2003 학술회의지원논문목록집 Vol.2003 No.-
This paper presents an algorithm to obtain an approximate optimal solution for the service restoration and load balancing of large scale radial distribution system in a real-time operation environment. Since the problem is formulated as a combinatorial optimization problem, it is difficult to solve a large-scale combinatorial optimization problem accurately within the reasonable computation time. Therefore, in order to find an approximate optimal solution quickly, the authors proposed an algorithm which combines optimization technique called cyclic best-first search with heuristic based feeder loadings balance index for computational efficiency and robust performance. To demonstrate the validity of the proposed algorithm. numerical calculations are carried out the KEPCO's 108 bus distribution system.
호텔기업의 로열티 프로그램이 몰입과 고객 애호도에 미치는 영향에 관한 연구
최우성,황명호 한국문화관광학회 2003 문화관광연구 Vol.5 No.2
In the hotel industry, the royalty (membership) program is very important because the profit or loss in their hotels income depends on it. The revenue from VIP membership takes 30~40% of total profits in the total hotel revenue. The utility value of the membership system is very powerful and hotels use this system to gain dominance over others. The hotels royalty program is a very important method in managing customers examining how to activate customer relationships, and analyzing how to affect customer loyalty. In the hotels royalty program, I researched how to influence level of commitment and loyalty.
예방적 lamivudine 투여로 성공적인 동종골수이식술을 시행한 HBV 양성 중증 재생불량빈혈 환자 1예
성윤경,안명주,오호석,최정혜,이영열,김인순,최일영 대한내과학회 2004 대한내과학회지 Vol.66 No.1
저자들은 만성 B형 감염을 동반한 중증 재생불량빈혈 환자에게 lamivudine을 예방적으로 투여하여 HBV의 재활성 없이 성공적으로 동종골수이식술을 시행하였기에 문헌고찰과 함께 보고하는 바이다. Reactivation of hepatitis B virus (HBV) infection has been known to be a serious complication of immunosuppressive or cytotoxic chemotherapy in HBV carriers or chronic hepatitis B patients. We report here a 25-year-old woman who has severe aplastic anemia and chronic hepatitis B underwent successful allogeneic bone marrow transplantation (BMT) with prophylactic lamivudine treatment and showed no evidence of reactivation of hepatitis B, HBV DNA elevation, or liver dysfunction. This result suggests that prophylactic administration of lamivudine to a BMT recipient of chronic hepatitis B might be a safe and promising measure to prevent fatal liver dysfunction.
돼지 신장세포(PK15)의 이종이식 거부반응에 대한 재조합 IL-18의 영향
최연실,김은미,김영관,박상연,심정현,윤도영,강형식,명평근 충남대학교 생물공학연구소 2004 생물공학연구지 Vol.10 No.1
Various cytokines including IL-1β, IL-2, IL-4, IL-10, IL-12p40, IFN-γ, and TNF-α have been recently reported to play important roles in both host and donor cell activations during xenotransplantation. Interleukin (IL)-18, a proinflammatory cytokine, can induce IL-4 and IL-13 production in T cells, NK cells, B cells, mast cells, and basophils. IL-18 has the capacity to stimulate innate immunity and both Th1-and Th2- mediated responses, but little is known to involve in the xenograft rejection. In order to investigate the role of IL-18 in xenograft rejection, we transplanted the pig kidney (PK15) cells to C57BL/6 mouse with or without intraperitoneal injection of mouse recombinatant IL-18. It was analyzed the population of T cell, B cell and NK cell in the mice transplanted with PK 15 cells and recombinant IL-18 by flow cytometry. We found that splenic CD3+ T cells were increased in mice injected PK15 cells with recombinant IL-18. These results suggest that recombinant IL-18 is critical in the xenograft rejection by increasing T cell population of the recipients.