http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
현경희,오유경,김정애,공경환,김지현,양준호,배명수,김호동,이종달,장현욱,용철순,최한곤 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
( Young Ae Yang ),( Gyu Yeun Kim ),( Jae Hee Kim ),( Sun Hee Park ),( Se Yong Jang ),( Myung Hwan Bae ),( Jang Hoon Lee ),( Dong Heon Yang ),( Hun Sik Park ),( Yong Keun Cho ),( Shung Chull Chae ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Despite prognostic value of anemia, there have been few effective risk models incorporating anemia to predict major adverse cardiac events (MACEs). We aimed to assess whether modifi ed clinical SYNTAX score (mCSS) would improve the ability of the SYNTAX score (SS) and the Clinical SYNTAX score (CSS) to predict MACEs of patients undergoing primary percutaneous coronary intervention (PCI) after ST-elevation myocardial infarction (STEMI). Methods: The CSS was calculated in 642 patients by multiplying the SS to an ACEF score (age/left ventricular ejection fraction + 1 if estimated glomerular fi ltration rate >60ml/min). The mCSS was calculated by adding anemia to ACEF score (ACEF score + 1 if hemoglobin levels < 12. 0g/dL in women and Results: During the follow-up, rate of MACE was signifi cantly higher in the highest tertile group compared with patients in the lower 2 tertiles (1. 4% versus 4. 2% versus 14. 7%; log-rank p Conclusions: Novel mCSS incorporating anemia improves the discrimination accuracy of SS and CSS to predict MACEs of patients underwent primary PCI after STEMI.
양영애(Young Ae Yang),조은주(Eun Ju Jo),박수희(Soo Hee Park),박수정(Su Jong Park),김혜린(Hye Rin Kim),이명화(Myung Hwa Lee),양미연(Mi Yeon Yang) 대한인간공학회 2008 大韓人間工學會誌 Vol.27 No.4
Objective: This study is to analyze the factor affecting elderly's speed of mobile phone ability. Method: Sixty healthy senior citizens who live in Kim-hye participated in Cognition, Visual perception, Speed of mobile phone ability and the collected data was analyzed by an independent multiple regression analysis. Result: The findings can be summarized as follows; 1. Although men were faster than women while using mobile phone, there was little satisfical significance(p<0.05). 2. Although people in their sixties were faster than people in their seventies while using mobile phone, there was minial difference(p<0.05). 3. The primary factor which affect mobile phone using speed is figure ground, visual memory, visual processing and the most beneficial discovery in the entire project is figure ground(p<0.05). Conclusion: The result of study showed that in order to enhance figure ground, visual memory, visual processing in mobile phone using speed. These results will be consider useful for elderly's mobile phone ability.
Secondary renal amyloidosis in a 13-year-old girl with bronchiectasis
Yang, Eun-Ae,Lee, Dong-Won,Hyun, Myung-Chul,Cho, Min-Hyun The Korean Pediatric Society 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.7
A 13-year-old girl was diagnosed with non-cystic fibrosis (CF)-related multifocal bronchiectasis accompanied by nephrotic-range proteinuria of unknown cause. On renal biopsy, there were many segmental homogeneous deposits of amyloid tissue with positive Congo red staining in the glomeruli and interstitium. On electron microscopy, relatively straight, non-branching, randomly arranged amyloid fibrils were showed in the mesangium of the glomeruli. These fibrils were approximately 10 nm in diameter, compatible with secondary amyloidosis. Her level of serum amyloid A was remarkably elevated. To our knowledge, this girl is the first case of secondary renal amyloidosis induced by bronchiectasis in Korean children.