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Kang, Kyo-Hwa,Park, Sang-Yoon,Rho, Seung Bae,Lee, Je-Ho Oxford University Press 2008 Cardiovascular research Vol.79 No.1
<P>AIM: The tissue inhibitors of metalloproteinases (TIMPs) are complex molecules with both pro- and anti-tumour effects. Thus, their diverse expression could be because of their multifunctional properties with respect to tumour growth, angiogenesis, apoptosis, and other biological functions. Previous data have shown that TIMPs bind tightly to most matrix metalloproteinases, although the pathway that mediates angiostatic activity has not been fully established. METHODS AND RESULTS: As an initial step to elucidate the mechanism that regulates TIMP-3, we used a yeast two-hybrid system to screen a human ovary cDNA library for a novel TIMP-3-interacting partner. Here, we identified human angiotensin II type 2 receptor (AGTR2) as such a partner, which is well known to be a regulator of cardiovascular homoeostasis. In this present study, we investigated whether AGTR2-mediated apoptotic activity can inhibit the growth of ovarian cancer in an experimental model system. AGTR2 treatment was found to be more effective in inhibiting ovarian cancer growth than the treatment with TIMP-3 in parallel experiments. Subsequently, the efficacy of the combined treatment with TIMP-3 and AGTR2 was investigated. In the presence of both of these proteins, vascular endothelial growth factor-induced human umbilical vein endothelial cell proliferation was additively inhibited, and the inhibition of Akt and endothelial NO synthase phosphorylation was blocked. CONCLUSION: These combined results suggest that two angiostatic molecules may have an important biological role in regulating potent anti-angiogenic effects and possibly may have a role in anti-tumour therapy.</P>
관상동맥 전산화단층촬영 조영검사에서 생리식염수 투여를 통한 임상 유용성 평가
정강교(Kang-Kyo Jung),이미화(Mi-Hwa Lee),조평곤(Pyong-Kon Cho) 대한방사선과학회 2014 방사선기술과학 Vol.37 No.4
본 연구는 bolus tracking method을 이용한 관상동맥전산화단층조영검사(coronary artery CT angiography, 이하 coronary CTA)에서 조영제 주입 전 생리식염수(normal saline) 투여를 통해 변화되는 심박동수(heart rate) 특성을 고려한 촬영방법 변환으로 영상의 질과 선량에 미치는 관계를 보고자 하였다. 연구대상자는 건 강검진을 목적으로 건강검진센터에 내원하여 coronary CTA을 시행한 200명의 사람을 대상으로 평가하였다. 그 결과 선량평가에서는 전향적 동조화가 후향적 동조화보다 유효선량이 6.0±1.0 mSv(54.1%) 감소되었다. 평균 심박동수는 심장혈관확장제 니트로글리세린(nitroglycerin, 이하 NTG) 섭취 후 변화된 평균 심박동수와 생리식염수 투여 후 변화된 평균 심박동수 비교에서 4.8±0.3 bpm의 유의한 차이의 감소를 보였고 심박동수 변화의 폭(heart rate area)에서는 평균 4.7±2.0 bpm의 감소를 보였다. 영상평가에서는 SNR과 CNR, 그리고 blurring 정도의 평가에서 모두 심박동수가 감소됨에 따라 유의한 차이를 보였다. 임상에서 coronary CTA에서 피폭선량 감소와 영상의 질 향상을 위해 조영제 주입 전에 생리식염수 투여를 통한 심박동수 특성관찰이 요구된다. The purpose of this study is that in coronary artery angiography computed tomography (coronary CTA), to gain high quality of image and to use low dose radiation by administrating normal saline and convert-ing the mode of scanning heart rate (HR) characteristics before infusing contrast media. All patients data (total specimens: 200, male: 108, female: 92) were measured by using appropriate mode of scanning the heart rate (HR) after injection of saline. in addition we measured radiation dose (CTDIvol, effective dose) in all examinations. CT number and noise, and blurring of coronary artery (proximal RCA, middle RCA, proximal LCA) were measured and compared. The result of this study after injection of saline, mean heart rate was decreased about 4.8±0.3 bpm (beats per minute). 33 patients (13%) got converting scan mode due to reducing heart rate (HR). In pro-spective gating mode, radiation dose were measured less 6.0±1.0 mSv (54.1%) than retrospective gating mode. Also showed a significant difference in heart rate decrease in image evaluation.
Kyoungrim Kang,Sang-Hwa Lee,Dong-Hee Kim,Kyo-Yeon Park 국제문화기술진흥원 2022 International Journal of Advanced Culture Technolo Vol.10 No.4
Objectives: The objective of this study was to explore the effects of the simulation-based learning program on stress, problem-solving ability, self-efficacy, and resilience of final-year nursing students in a college in South Korea. Methods: The design of the study was a one-group pretest-posttest. The participants of this study were final-year nursing students in 2018. A total of 105 students completed it. The intervention was an 8-week simulation-based practice course. The primary and secondary outcome measures were baseline and follow-up questionnaires regarding demographic factors, stress, problem-solving ability, self-efficacy, and resilience. Results: Problem-solving ability (t=6.567, p<.001), self-efficacy in four situations (p<.001) and resilience (t=2.352, p=.021) increased after simulation-based learning than before learning. Stress also increased after simulation-based learning compared to before learning (t=5.960, p<.001). The level of stress, self-efficacy, and resilience were mainly related to participants’ satisfaction with their clinical placement, and interpersonal relationships (p<.05). Conclusions: Simulation-based learning is expected to improve nursing students’ problem-solving ability, self-efficacy, and resilience. This can lead to induce learning motivation of nursing students, improve their coping strategies for solving problems, and ultimately provide high-quality care.
3-D Simulation of T-Shaped Electrode and Comparison of Results with Experiments
Shin, Yeong-Kyo,Hwang, Tae-Su,Kang, Seok-Dong,Park, Hun-Gun,Ryu, Jae-Hwa,Kim, Hyun-Chul,Shin, Seong-Won,Lee, Jae-Koo The Korean Infomation Display Society 2002 Journal of information display Vol.3 No.2
Numerical simulation is one of the most useful tools to study gas discharge phenomena that occur in alternating current plasma display panel (AC-PDP) cell. Most PDP cell simulations have been performed for two-dimensional cell, is cross-section along the address electrode. We developed a three-dimensional PDP simulator and applied it to a T-shaped electrode cell in order to show the effects of sustain electrode shape that cannot be included in two-dimensional simulation. The dependence of power consumption on electrode shape and area in the simulation showed the same trend as experiment.
감의 脫澁處理中 Pectin 含量과 Texture의 變化
崔鍾旭,孫泰華,鄭信敎,李吉雨,姜峻洙 慶北大學校 1989 論文集 Vol.47 No.-
This experiment was made to investigate the changes of the contents of acetaldehyde, alcohol, tannin, and to study the texture changes of persimmon in relation to the contents of pection during the removal of astringency by CO_2. 1. During the removal of astringency of persimmon fruits, the contents of soluble tannin showed the rapid decrease in high concentration of CO_2, but the contents of ethanol and acetaldehyde showed the rapid increase in all treatments. 2. The contents of W.S.P. increased, but H.S.P. decreased in all treatments. 3. All texture paramenters of persimmon fruits except springness and adhesiveness were decreased druing the removal of astringency. 4. The contents of W.S.P. were good correlated with the changes of hardness in all treatments.
Pyoeng Gyun Choe,Eun Kyo Kang,Sun Young Lee,Boram Oh,Dahae Im,Hyo Yeon Lee,Hyemin Jung,Chang Kyung Kang,Min Sun Kim,Wan Beom Park,Eun Hwa Choi,Be Long Cho,Myoung-don Oh,Nam Joong Kim 대한내과학회 2020 The Korean Journal of Internal Medicine Vol.35 No.4
Background/Aims: As the novel coronavirus (coronavirus disease 2019 [COVID-19]) outbreak progresses rapidly, staying home is recommended for suspected patients; however, the safety of this recommendation is uncertain. In Korea, non-hospital facilities called “living and treatment centers (LTCs)” have been established since 5 March 2020. The LTCs provided a unique opportunity to evaluate the safety of selection criteria for low-risk groups. Methods: Between 5 March and 9 April 2020, patients with COVID-19 who met the following criteria were admitted to the LTC; alert, age below 65 years old, no underlying disease or well-controlled underlying disease, body temperature below 38.0°C, whether taking antipyretics or not, and no dyspnea. Patients were closely observed by doctors or nurses’ interviews twice a day and transferred to hospitals when symptoms worsened. Results: A total of 113 patients were admitted to the LTC; 52.2% were female, with a median age of 25 years (interquartile range, 21.5 to 39.5). Of 113 patients, 54 (47.8%) were asymptomatic at diagnosis, and 15 (13.3%) had no symptoms until they were released from isolation. During the follow-up period, two (1.8%) patients were transferred to a hospital but did not progress to severe status during hospitalization. Conclusions: The risk of progression was negligible in COVID-19 patients who met the admission criteria for LTC at the time of diagnosis. LTCs could be a safe alternative considering shortage of hospital beds.