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단기간의 저용량 Cytosine arabinoside 치료에 반응하였던 Down 증후군에 병발한 급성골수성백혈병 1례
김현수,이정호,이정찬,강정현,곽상혁,김철희,배광봉,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
The incidence of hematologic disorders in patients with Down's syndrome is significantly increased, about 14∼30 - fold higher than in general population and includes neonatal transient abnormal myelopoieis and acute leukemias. The age of onset of leukemia in Down's syndrome is peaking first in the newborn period and then under 4 years of age. Down's syndrome with acute leukemia above the age of 20 is very rare and it's treatment oucome is unclear. The treatment of Down's syndrome with leukemia has been controversial because of toxicity and associated congenital cardiac and other abnormalities. But if treated adequately, children with Down's syndrome show a favorable response to anti-leukemia therapy. A 24-year-old man with Down's syndrome was first seen for the evaluation of anemia and thrombocytopenia. The peripheral blood morphology and bone marrow study revealed acute myelogenous leukemia, cytogenetic study of bone marrow showed trisomy 21. Beacuse of his sicioeconomic condition and medical abnormalities including deafness, visual loss, he was treated with low dose subcutaneous cytosine arabinoside(Ara-C) for 11 days. Complete remission was obtained after 37 days. The complete remission lasted for 5 months. He subsequently relapsed, and died 6 months later.
Azathioprine에 반응을 보인 류마티양 관절염에 의한 경막염(Pachymeningitis)1예
배광봉,이정호,이정찬,곽상혁,강정현,김철희,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Rheumatoid arthritis frequently involves the cervical spine and may lead to neurologic impairement. However, direct involvement of CNS structures by inflammatory cells has been reported infrequently. The prevalence of this complication of rheumatoid arthritis is unknown. Inflammatory CNS involvement in rheumatoid arthritis reportedly occurs in the setting of longstanding, active, erosive articular disease and is accompanied by extracranial and extraspinal nodules and vasculitis. This is diagnosed by radiologic finding of CNS nodules or meningeal thickening and by biopsy or autopsy. Treatment with corticosteroid, cytotoxic agent or surgical decompression is helpful. But the majority of patients die within several months of onset of neurologic symptom. Recently, we experienced a case of pachymeningitis caused by rheumatoid arthritis, which resolved repeatedly with azathioprine treatment.
중증 재생불량성 빈혈 환자에서 신우신염에 대한 광범위항생제치료 중에 속발한 Saccharomyces cerevisiae 진균감염 1예
김철희,이정호,이정찬,강정현,곽상혁,배광봉,김현수,김종숙,조덕연,김삼용 충남대학교 의과대학 지역사회의학연구소 1999 충남의대잡지 Vol.26 No.1
Most patients with aplastic anemia who do not respond to immunosuppressive treatment or are not candidates for bone marrow transplantation die of infection or bleeding. The neutropenia in acute leukemia, aplastic anemia, or occurring subsequently to chemotherapy and bone marrow transplantation increases susceptibility to infection. In general, the number of infectious episodes correlate with the degree and duration of neutropenia. Global immunosuppression produced by conditioning for bone marrow transplantation or graft-versus-host disease, is associated with unusual bacterial and fungal pathogens, or serious viral and protozoan infections. In addition, repeated treatment with broad-spectrum antibiotics is associated with the emergence of resistant organisms and fungal diseases because of the altered microbial microenvironment of the host. The incidence of invasive fungal infection caused by Saccharomycetes eerevisiae in immunosuppressed patients is very rare, compared with that of infection by candida or aspcrgillus species. Cases of Saccharomycetes cerevisiae fungemia occurring in the course of treatment with broad-spectrum antibiotics are reported in patients with extensive burn or with prosthetic valve endocarditis. We experienced a case of urinary tract infection by Saccharomycetes cerevisiae in a 27-year old female patient with severe aplastic anemia. We report the case with a review of relevant literatures.
Jo Hyeong Ho,Kim Nayoung,Jang Jieun,Choi Yonghoon,Park Jaehyung,Park Young Mi,Ahn Soyeon,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Oh Hyeon Jeong,Lee Hye Seung,Park Young Suk,Ahn Sang-Hoon,S 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: The incidence and prognosis of gastric cancer (GC) shows sex difference. This study aimed to evaluate the effect of body mass index (BMI) on GC survival depending on sex. Methods: The sex, age, location, histology, TNM stages, BMI, and survival were analyzed in GC patients from May 2003 to February 2020 at the Seoul National University Bundang Hospital. Results: Among 14,688 patients, there were twice as many males (66.6%) as females (33.4%). However, under age 40 years, females (8.6%) were more prevalent than males (3.1%). Cardia GC in males showed a U-shaped distribution for underweight (9.6%), normal (6.4%), overweight (6.1%), obesity (5.6%), and severe obesity (9.3%) but not in females (p=0.003). Females showed decreased proportion of diffuse-type GC regarding BMI (underweight [59.9%], normal [56.8%], overweight [49.5%], obesity [44.8%], and severe obesity [41.7%]), but males did not (p<0.001). Both sexes had the worst prognosis in the underweight group (p<0.001), and the higher BMI, the better prognosis in males, but not females. Sex differences in prognosis according to BMI tended to be more prominent in males than in females in subgroup analysis of TNM stages I, II, and III and the operative treatment group. Conclusions: GC-specific survival was affected by BMI in a sex-dependent manner. These differences may be related to genetic, and environmental, hormonal factors; body composition; and muscle mass (Trial registration number: NCT04973631).
Jo Hyeong Ho,Kim Nayoung,Oh Hyeon Jeong,Song Du Hyun,Choi Yonghoon,Park Jaehyung,Lee Jongchan,Yoon Hyuk,Shin Cheol Min,Park Young Soo,Lee Dong Ho,Lee Hye Seung,Park Young Suk,Ahn Sang-Hoon,Suh Yun-Suh 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.5
Background/Aims: There are few reports regarding mixed carcinoma, defined as a mixture of glandular and poorly cohesive components, in patients with gastric cancer (GC). The aim of this study was to evaluate the proportion and characteristics of mixed carcinoma in GC patients. Methods: A total of 7,215 patients diagnosed with GC at Seoul National University Bundang Hospital were enrolled from March 2011 to February 2020. GC was divided into four groups (wellmoderately differentiated GC, poorly differentiated GC, poorly cohesive carcinoma, and mixed carcinoma). The proportion of each GC type and the clinicopathological features were analyzed and divided into early GC and advanced GC. Results: The proportion of mixed carcinoma was 10.9% (n=787). In early GC, submucosal invasion was the most common in poorly differentiated (53.7%), and mixed carcinoma ranked second (41.1%). Mixed carcinoma showed the highest proportion of lymph node metastasis in early GC (23.0%) and advanced GC (78.3%). In advanced GC, the rate of distant metastasis was 3.6% and 3.9% in well-moderately differentiated GC and mixed carcinoma, respectively, lower than that in poorly differentiated GC (6.4%) and poorly cohesive carcinoma (5.7%), without statistical significance. Conclusions: Mixed carcinoma was associated with lymph node metastasis compared to other histological GC subtypes. And it showed relatively common submucosal invasion in early GC, but the rates of venous invasion and distant metastasis were lower in advanced GC. Further research is needed to uncover the mechanism underlying these characteristics of mixed carcinoma (Trial registration number: NCT04973631).
조호현(Ho Hyeon Jo),남지희(Jihee Nam),김성은(Sungeun Kim),신비경(Bigyeong Kim),김수민(Sumin Kim) 대한설비공학회 2022 대한설비공학회 학술발표대회논문집 Vol.2022 No.6
As the global warming problem has recently emerged, many countries are implementing carbon energy-related policies to reduce carbon dioxide. However, most cases are limited to new buildings. Therefore, in this study, PCM was applied to an aging educational building, but the effect was evaluated by applying it to the passive element of the building, the envelope, and the active element, Photovoltaic (PV). As a result of the study, when PCM was applied in the form of a building material to the roof surface, a reduction rate of 14521.6 kWh/year was shown for the cooling load, and the value for the heating load was slightly increased due to the shading caused by the PV panel installation. Considering the amount of PV power generation, the application of PCM in the form of a building material to the roof surface resulted in a total energy saving rate of 22.55%. Through this, it was concluded that it is possible to reduce the load on building energy through the application of PCM and contribute to national energy saving.
조현동(Hyeon-Dong Jo),황윤건(Yun-Geon Hwang),박태조(Tae-Jo Park),손자덕(Ja-Deok Sohn),정호경(Ho-Gyeong Chung) 한국트라이볼로지학회 2008 한국트라이볼로지학회 학술대회 Vol.2008 No.11
In tins paper, a deformation analysis is conducted for coaxial elastomeric seals which is adopted in the power-by-actuator for aircraft. An axisymmetric finite element contact model is developed and analyzed using MARC. The deformed seal shapes, contact stress and von-Mises stress distributions for various operating pressures, rod and cylinder clearances. The results presented an optimum design data of coaxial seals for power-by-actuator.
교육시설 실내 공기질 향상을 위한 기밀성능 개선 및 평가
조호현(Ho Hyeon Jo),양성웅(Sungwoong Yang),육현성(Hyunseong Yuk),최지용(Ji Yong Choi),김영욱(Young Uk Kim),김수민(Sumin Kim) 대한설비공학회 2021 대한설비공학회 학술발표대회논문집 Vol.2021 No.6
Fine dust is known to cause various Respiratory disease and affects human health. Modern people spend 80% of the day living indoors, which means that indoor air quality has a great influence on humans. In particular, infants and children are very vulnerable to the environment. In this study, under the assumption that the fine dust of the outside air is higher than that of the indoor, the inflow of external fine dust is to be prevented through architectural improvement of the school building. As a method of reducing fine dust, an experiment was conducted by adopting a strategy to improve airtightness. The building is a five-story school building, and experiments are conducted in a special classroom. Airtightness performance is measured according to the standard of ISO 9972. In addition, thermal imaging cameras are taken for each construction part and wind speed is measured. To improve the airtight performance, the frame is changed from a single window to a double window. In addition to changing the frame, subsidiary materials for construction were installed to improve airtightness. As a result of architectural improvement, ACH was reduced by 19 to 37%. Wind speed is also reduced by up to 1.2m/s after window improvement. The concentration of fine dust was decreased the most from 0.3 to 0.5 μm. This means that the influence of fine dust introduced from the outside is reduced by improving the airtightness in the fine dust particle size of 0.3 to 1.0. Based on the result of the reduced fine dust concentration, the appropriateness of the indoor fine dust concentration in school facilities was evaluated. Through this research, it is effective to block the inflow of external fine dust through trench replacement and airtight performance improvement technology.