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백상홍,이상원,진동찬 全北大學校 學徒護國團 1981 全國大學生學術硏究發表論文集 Vol.6 No.-
This study was made to isolate anaerobic bacteria from the rectal swabs of normal healthy persons and determine the normal flora of the intestine. Rectal swab specimens were obtaianed from normal healthy adults in Seoul. As the processes of bacteriological study, anaerobic bacteria were cultured in thioglycollate semisolid broth and isolated on brain heart infusion blood supplement agar plates, and biological properties were examined including the hemolysis on blood agar plated, gas production in the fluid media. Biochemical test was performed by Minitek Anaerobic Set (BBL^*) in anaerobic Gas Pak Jar (BBL^*) The result is as followings: 1. Among the 110 rectal swab specimens, 187 strains of anaerobic bacteria were isolated. The isolates included 88 straing (47.1%) of Gram positive bacilli, 74 strains (39.5%) of Gram negative bacilli and 25 strains (13.3%) of Gram positive cocci. 2. After preservation at-80 C in thioglycollate broth, only 134 strains (71.1%) of isolates survived. Theses survivors included 76 strains of Gram positive bacilli (survival rate 86.4%), 38 strains of Gram negative bacilli (survival rate 51.4%), and 20 strains of Gram positive cocci (survival rate 80.8%). 3. From these strains, 50 strains were randomly selected by the ratio of morphologic groups of isolates for the sugar fermentation and other biochemical tests. Among these selectes and tested straing, the determined were : Eubacterium aeroficiens 27 strains(54.0%) Bacteroiaes melaninogenicus 7 strains (14.0%) Peptostreptococcus produtus 6 strains (12.0%) Eubacterium limosum 1 strains (2.0%) and the undetermined strains were : Gram negative bacilli 7 strains (14.0%) Gram positive bacilli 1 strain (2.0%) Gram negative cocci 1 strain (2.0%)
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The Current Concept of Cell Therapy for Heart Failure
백상홍 대한심장학회 2005 Korean Circulation Journal Vol.35 No.6
Cardiac repair is a dream in the field of medical science. The biological limitations to human cardiac regenerative growth require the creation of new strategies for cardiac regeneration using cells, genes and protein. Recent experimental studies and early-phase clinical trials showed stem cells have the potential to enhance myocardial perfusion and contractile performance in patients with acute myocardial infarction, advanced coronary artery disease and chronic heart failure. Overall clinical experience also suggests that stem cell therapy can be safely performed if the right cell protocol is used within the correct clinical setting. Some experimental data have shown stable stem cell engraftment due to fusion or transdifferentiation into cardiomyocyte or vascular cell lineages, which could be likely explanations for these beneficial effects. Others have proposed that transient cell retention may be sufficient to promote functional effects, e.g., by release of paracrine mediators. We should proceed cautiously with carefully designed clinical trials, and concern for patient safety must remain the key issue. The translational basic research will be required to elucidate the mechanism of stem cell therapy.
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Beta Blockers in Heart Failure: More Evidence for an Old Friend
백상홍 대한의학회 2018 Journal of Korean medical science Vol.33 No.25
High resting heart rate (≥ 70 bpm) was common in heart failure with reduced ejection fraction (HFrEF; ejection fraction ≤ 35%) patients and is associated with adverse outcomes in a real-world analysis. For heart failure (HF) hospitalization, hazard appeared to be more closely associated with heart rate rather than β-blocker dose.1 Chronic β1-adrenergic receptor overactivation is well known to be an important component of pathologic ventricular remodeling, and evidence-based β-blockers are a clinically effective treatment of HFrEF owing in part to their reverse-remodeling effect. Current HF guidelines recommend the use of β-blockers based on many randomized controlled trials showing a reduced mortality rate > 35%. Although the beneficial effect of β-blocker seems undisputed, whether the target heart rate or target dose is more important in β-blocker therapy is the subject of debate. Meta-analysis showed that heart rate should be considered more important than the actual dose when tailoring β-blocker therapy. In particular, the target resting heart rate might be < 70 beats/min in HF patients. The reason why heart rate reduction is more important than β-blocker dose might be related to the large pharmacogenomic heterogeneity of β-blockers.2
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백상홍 ( Baeg Sang Hong ),양종목 ( Yang Jong Mog ),정욱성 ( Jeong Ug Seong ),전승석 ( Jeon Seung Seog ),노태호 ( No Tae Ho ),박인수 ( Park In Su ),김재형 ( Kim Jae Hyeong ),최규보 ( Choe Gyu Bo ),홍순조 ( Hong Sun Jo ) 대한내과학회 1992 대한내과학회지 Vol.42 No.4
In this study, the frequency of mechanisms of supraventricular tachycardia (SVT) were evaluated by analyzing the electrophysiologic findings of 26 patients with SVT without preexicitation between November 1987 and August 1990. The induction of tachycardia by programmed electrical stimulation and the determination of mechanism of SVT were performed by baseline electrophysiologic (EP) study in drug free status. The study group included 14 males and 12 females with ages rangiang from 16 to 54 years (mean±SD; 35.6±12.8). All patients had structurally normal heart except the 7 mitral value prolapse. We also compared the clinical findings, surface EKG during tachycardia and EP study findings according to the mechanism of SVT. The results were as follows: 1) In EP study, programmed stimulation induced sustained SVT was 20 of the 26 patients(induction rate 76 %). 2) Atrioventricular reentrant tachycardia (AVRT) using concealed bypass tract was the most common mechanism of SVT (80%), atrioventricular nodal reentrant tachycardia (AVNRT) was the second (15%) and the remainder was increased automaticity of the atrium (5%). 3) The age of the patients and their heart rates during tachycardia were not significantly different among the mechanism of SVT. 4) Functional bundle branch block during reciprocating tachycardia appeared in the AVRT group (4/16 cases). 5) The alternations of QRS during reciprocating tachycardia appeared in the AVRT group (3/16 cases). 6) The relationship between P wave and QRS complex (RP/RR) during tachycardia was useful in differentiating the mechanism of SVT (p<0.05). 7) The ventriculoatrial interval on His-bundle electrogram was more than 70 msec in the AVRT group, whereas this was less than 60 mesc in the AVNRT group. 8) In the AVRT group. P wave morphology and axis in the lead I was useful to determine the site of accessory pathway.
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