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A Bacterial Metabolite, Compound K, Induces Programmed Necrosis in MCF-7 Cells via GSK3β
( Chae Won Kwak ),( Young Min Son ),( Min Jeong Gu ),( Girak Kim ),( In Kyu Lee ),( Yoon Chul Kye ),( Han Wool Kim ),( Ki Duk Song ),( Hyuk Chu ),( Byung Chul Park ),( Hak Kyo Lee ),( Deok Chun Yang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.7
Ginsenosides, the major active component of ginseng, are traditionally used to treat various diseases, including cancer, inflammation, and obesity. Among these, compound K (CK), an intestinal bacterial metabolite of the ginsenosides Rb1, Rb2, and Rc from Bacteroides JY-6, is reported to inhibit cancer cell growth by inducing cell-cycle arrest or cell death, including apoptosis and necrosis. However, the precise effect of CK on breast cancer cells remains unclear. MCF-7 cells were treated with CK (0-70 μM) for 24 or 48 h. Cell proliferation and death were evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and flow cytometry assays, respectively. Changes in downstream signaling molecules involved in cell death, including glycogen synthase kinase 3β (GSK3β), GSK3β, β-catenin, and cyclin D1, were analyzed by western blot assay. To block GSK3β signaling, MCF-7 cells were pretreated with GSK3β inhibitors 1 h prior to CK treatment. Cell death and the expression of β-catenin and cyclin D1 were then examined. CK dose- and time-dependently inhibited MCF-7 cell proliferation. Interestingly, CK induced programmed necrosis, but not apoptosis, via the GSK3β signaling pathway in MCF-7 cells. CK inhibited GSK3β phosphorylation, thereby suppressing the expression of β-catenin and cyclin D1. Our results suggest that CK induces programmed necrosis in MCF-7 breast cancer cells via the GSK3β signaling pathway.
백서에서 진통과 금단증상에 미치는 Enkephalinase Inhibitor의 영향
곽기철,조문환,김기원,채수완,조규박 의과학연구소 1991 全北醫大論文集 Vol.15 No.3
Analgesic effect and influence of 2 enkephalinase inhibitors, thiorphan and N-carboxyl-Phe Leu(CMPL) on the analgesia induced by centrally administered Leu-enkephalin, B-endorphin or morphine, and their influences on the withdrawal signs in chronic morphine-dependent rats were examined. Intracerebroventricular administration of thiorphan and CMPL induced short-lasting analgesia in a dose dependent manner, whereas CMPL was 3.5 time more potent than phiorphan. these analgesic effects were attrnuated by preteatment with naloxone. Subanalgesic doses of yhese inhibitors significantly enhanced the analgesic effect of :eu-enkephalin or B-endorphine However, neither of these inhibitors affecyed the analgrsic effect morphine. In chronic morphine-dependent rats, intraventricular thiorphan or CMPL significantly attenuated naxone-precipitated jumping, diarrhea, ptosis and teeth chattering, while wet-dog shaking sign was unaltered and penile licking sign was increased. These results showed that enkephalinase inhibitors can produce analgesia by themselves and that they can enchance the analgesic effects of ensogenous opioids. these data also suggest that enkephalinase inhibitors might be useful in attenuating opiate withdrawal symptoms.
채석래,박언섭,이종민,곽승민,강문원,양철우,신완식,방병기 대한감염학회 1992 감염 Vol.24 No.3
Benign hemophagocytic syndrome is usually associated with systemic viral infection and occasionally occurs with bacterial, fungal and protozoal infections. In our knowlege, hemophagocytic syndrome associated with scrub typhus has not been prevously reported. We experienced a case of rickttsia-asssociated pancytopenia and hemophagocytosis in a 22-year old man who admitted to our hospital for high fever, chill, myalgia, and abdominal pain. It was speculated that scrub typhus may be one of the causes of benign hemophagocytic syndrome.
BDNF Enhancement of Neuronal Differentiation with Adipose-Derived Stem Cells(ADSCs)
( Chae Yoon Lim ),( Kwon Il Keun ),( Jeong June Choi ),( Hee Jin Lee ),( Sang Hee Park ),( Weon Sun Lee ),( Dong Hoon Kwak ),( Ji Youl Lee ),( Young Joon Jun ),( Won Bae Lee ),( Sung Eun Kim ),( Dai J 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
Adipose-derived stem cells(ADSCs) are multipotent cells that can be manipulated to differentiate into different cell lines and are considered a potential cell source for regenerative medicine and tissue engineering. The brain derived neurotrophic factor (BDNF) is known to stimulate stem cells to differentiate into neuronal cells as well as promote plasticity. The purpose of this study was to evaluate the effects of BDNF on the neuronal differentiation of ADSCs. The proliferation of the ADSCs was increased by BDNF in a dose-dependent manner. The expression of neuronal markers including Nestin and microtubule-associated protein(MAP2) were highly upregulated by BDNF. In addition, BDNF considerably suppressed the expression of glial fibrillary acidic protein(GFAP), a preventative glial cell or astrocyte marker. Using immunocytochemistry, we confirmed the results by real time-PCR. An increased production of Nestin and MAP2 by BDNF, but not GFAP was observed. These data show that supplementation of the ADSCs with BDNF effectively maintained cell survival, proliferation and differentiation of these cells into neuronal precursor cells. In conclusion, specific neuronal differentiation of ADSCs after treatment with BDNF increased the generation of a mature neuronal phenotype.
Chae, Jey Sook,Kang, Ryungwoo,Kwak, Jung Hyun,Paik, Jean Kyung,Kim, Oh Yoen,Kim, Minjoo,Park, Ji Won,Jeon, Justin Y.,Lee, Jong Ho American Diabetes Association 2012 Diabetes Care Vol.35 No.8
<P><B>OBJECTIVE</B></P><P>To determine the association of regular exercise, BMI, and fasting glucose with the risk of type 2 diabetes and to predict the risk.</P><P><B>RESEARCH DESIGN AND METHODS</B></P><P>Korean subjects (<I>n</I> = 7,233; 40–79 years old) who were not diagnosed with diabetes at baseline were enrolled through the National Health Insurance Corporation. All participants underwent biennial examinations, and 1,947 of 7,233 subjects also underwent a 6-month program of moderate-intensity exercise (300 min/week) without dietary advice.</P><P><B>RESULTS</B></P><P>During follow-up (mean = 2 years), there were 303 incidents of type 2 diabetes in the nonexercise program group (<I>n</I> = 5,286) and 83 in the exercise program group (<I>n</I> = 1,947). After adjusting for confounders, the risk of type 2 diabetes was positively associated with BMI and inversely with regular exercise, especially among overweight/obese subjects. After further adjustment for BMI, the odds ratios for risk of diabetes associated without and with regular exercise were 1.00 and 0.77, respectively. Among subjects with normal fasting glucose, exercise reduced the diabetes risk; however, among those with impaired fasting glucose (IFG), the protective effect of exercise was found only among overweight/obese subjects. The overweight/obese subjects in the exercise program group exhibited improved fasting glucose compared with the nonexercise program group and showed 1.5 kg of weight loss and a 3-cm decrease in waist circumference. Among overweight/obese subjects with unchanged fasting glucose, weight loss was greater in the exercise program group.</P><P><B>CONCLUSIONS</B></P><P>Regular exercise reduces the risk of type 2 diabetes in overweight/obese individuals. Particularly, regular exercise and weight or waist circumference control are critical factors for preventing diabetes in overweight/obese individuals with IFG.</P>
A biocompatible implant electrode capable of operating in body fluids for energy storage devices
Chae, Ji Su,Heo, Nam-Su,Kwak, Cheol Hwan,Cho, Wan-Seob,Seol, Geun Hee,Yoon, Won-Sub,Kim, Hyun-Kyung,Fray, Derek John,Vilian, A.T. Ezhil,Han, Young-Kyu,Huh, Yun Suk,Roh, Kwang Chul Elsevier 2017 Nano energy Vol.34 No.-
<P><B>Abstract</B></P> <P>Implantable electronic medical devices (IEMDs) can potentially be used to solve various clinical problems including the monitoring of chronic diseases and electro-organ transplantation. Several recently introduced techniques based on implantable devices that exploit novel metal- or carbon-based hybrid materials are biocompatible owing to their encapsulation in nontoxic polymers. However, such techniques limit the correct functioning of implantable devices, resulting in frequent replacement, difficult miniaturization, and inflammatory side effects in the body. Here, we describe a new technique for application to IEMDs that is capable of providing energy storage using the natural ions of body fluids as electrolytes in a supercapacitor (or ultracapacitor). The system is constructed with a solar cell for energy harvesting and a supercapacitor for energy storage. We assembled IEMDs with two biocompatible electrodes, specifically, MnO<SUB>2</SUB> nanoparticles affixed to multi-walled carbon nanotubes as the positive electrodes and phosphidated activated carbon as the negative electrodes. From the obtained result, this work can be further extended to the use of rats. This technique avoids the problems of performance degradation and toxicity that normally limits the reaction that is permissible in extracellular fluid. We present this concept schematically. The two biocompatible electrodes were successfully implanted into the subcutaneous layer of a rat's skin with both electrodes showing stable performance in use as parts of a supercapacitor. These findings establish a platform for potential biocompatible materials for implantable energy storage devices.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Kwak, Soo Heon,Chae, Jeesoo,Lee, Seungbok,Choi, Sungkyoung,Koo, Bo Kyung,Yoon, Ji Won,Park, Jin-Ho,Cho, Belong,Moon, Min Kyong,Lim, Soo,Cho, Young Min,Moon, Sanghoon,Kim, Young Jin,Han, Sohee,Hwang, M American Diabetes Association 2018 Diabetes Vol.67 No.9
<P>We investigated ethnicity-specific exonic variants of type 2 diabetes (T2D) and its related clinical phenotypes in an East Asian population. We performed whole-exome sequencing in 917 T2D case and control subjects, and the findings were validated by exome array genotyping in 3,026 participants. In silico replication was conducted for seven nonsynonymous variants in an additional 13,122 participants. Single-variant and gene-based association tests for T2D were analyzed. A total of 728,838 variants were identified by whole-exome sequencing. Among nonsynonymous variants, PAX4 Arg192His increased risk of T2D and GLP1R Arg131Gln decreased risk of T2D in genome-wide significance (odds ratio [OR] 1.48, P = 4.47 x 10(-16) and OR 0.84, P = 3.55 x 10(-8), respectively). Another variant at PAX4 192 codon Arg192Ser was nominally associated with T2D (OR 1.62, P = 5.18 x 10(-4)). In T2D patients, PAX4 Arg192His was associated with earlier age at diagnosis, and GLP1R Arg131Gln was associated with decreased risk of cardiovascular disease. In control subjects without diabetes, the PAX4 Arg192His was associated with higher fasting glucose and GLP1R Arg131Gln was associated with lower fasting glucose and HbA(1c) level. Gene-based analysis revealed that SLC30A8 was most significantly associated with decreased risk of T2D (P = 1.0 x 10(-4)). In summary, we have identified nonsynonymous variants associated with risk of T2D and related phenotypes in Koreans.</P>
( Ganghee Chae ),( Eun Jae Ko ),( Sei Won Lee ),( Sang Gyu Kwak ),( Donghwi Park ),( Jin Hyoung Kim ),( Byung Ju Kang ),( Taehoon Lee ),( Yangjin Jegal ),( Seung Won Ra ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Background To assess functional capacity of COPD patients, 6-minute walk test (6MWT) and incremental shuttle walk test (ISWT) have been used. These field tests have a good correlation between walking distance and peak oxygen uptake (peak VO2) in cardiopulmonary exercise testing (CPET). Our aim was to investigate the correlation between peak VO2 and distance of 6MWT and ISWT in COPD patients via meta-analysis. Methods We searched PubMed, SCOPUS, Embase, and the Cochrane Library published up to June 30, 2020. Studies comparing the correlation of 6MWT, ISWT and peak VO2 measured by CPET in COPD patients were included. A meta-analysis was performed using the fixed- and random-effects model, and publication bias was evaluated by funnel plot and Egger's test. Results Our findings included data from 12 studies involving 746 patients. A meta-analysis showed that there was a significant predictor between ISWT and peak VO2 (correlation coefficient = 0.81; 95% CI: 0.74 to 0.85, p-value <0.0001). Also, 6MWT was a significant predictor of peak VO2 (correlation coefficient = 0.65; 95% CI: 0.57 to 0.72, p-value <0.0001) (Figure 1). These Results may suggest that ISWT reflects a stronger correlation with peak VO2 level than 6MWT. Conclusions This meta-analysis provided further evidence that 6MWT and ISWT were correlated significantly with peak VO2 measured by CPET in COPD patients and ISWT had a stronger correlation than 6MWT. These Results may suggest that ISWT can be considered a valid and reliable test to assess maximal functional capacity in COPD patients.