성견에서 교정적 고정원으로서의 티타늄 미니스크류에 대한 연구 : An experimental investigation in dogs

윤병수,최병호,이원유,김경남,심형보,박진형 대한치과교정학회 2001 대한치과교정학회지 Vol.31 No.5

교정치료에서 원하는 치아이동을 위해서는 안정된 고정원이 필요한데 티타늄 미니스크류가 매식과 제거가 쉽고, 구강 내 여러 부위에서 적용이 가능하고, 환자가 느끼는 불편감이나 비용적인 부담이 적고, 제거 후에 치유가 빠르게 진행될 수 있는 등의 장점이 있어 최근에 교정적 고정원으로 사용되기 시작하였다. 티타늄 미니스크류를 교정적 고정원으로 사용한 임상 예들이 여러 편 발표되었는데 미니스크류의 이완이 가장 큰 실패의 원인으로 보고되고 있다. 그러나 지금까지 보고된 논문들에서 교정적 고정원으로 안정성을 줄 수 있는 스크류의 식립 길이에 관한 연구가 없는 상태이다. 교정적 고정원으로 미니스크류를 효과적으로 사용하기 위해서는 식립 부위에 따른 골구조와 골밀도 차이를 고려한 식립 길이에 관한 기준이 필요하다. 이에 본 연구에서는 성견의 상악골과 하악골에서 직경 2mm 티타늄 미니스크류를 다양한 길이로 식립하고 교정력을 적용한 후 그 안정성을 평가하여 교정적 고정원으로 사용될 수 있는 미니스크류의 식립 길이를 결정하고자 하였다. 미니스크류가 상악에서는 6mm이상, 하악에서는 4mm 이상이 골 내에 식립될 때 8주 동안 200g의 교정력에 동요도나 위치변화를 보이지 않았다. 식립 부위로는 부착치은 부위 치근 사이에 식립될 때 구강청결이 유지되고 미니스크류 주변 치은조직에 자극을 주지 않아 정상적인 조직으로 유지 될 수 있었다. 또한 교정력 적용 8주 후 치근단 방사선 사진검사에서 스크류 주변 치근 흡수나 치조골 흡수, 치주 인대 손상이 관찰되지 않았다. 따라서 상 ㆍ 하악 골밀도와 골구조의 차이를 고려하여 미니스크류의 골내 식립 길이를 적절히 조절함으로써 교정적 고정원으로 티타늄 미니스크류가 효과적으로 사용될 수 있다고 생각된다. Titanium miniscrews are being used increasingly as an anchorage for tooth movement, because they are easy to place and to remove, increase the number of sites available, give minimum strain to patients regarding surgical procedures, and offer uneventful healing after removal. The use of titanium miniscrews as an orthodontic anchorage has been reported in clinical case reports, but clinicians hove experienced screw loosening when using such screws. To our knowledge, there are no published reports evaluating the stability of miniscrews. Information about the length of miniscrews used in relation to the location is of some importance, as stability will vary depending on bone quality. The purpose of this study was to evaluate a variety of lengths of miniscrews (diameter: 2mm) which were inserted in maxilla or mandible and to demonstrate in a dog moedl which miniscrew provides fundamental stability in the jaws. 10 mm long miniscrews in the maxilla and 8mm long miniscrews in the mandible showed no clinical mobility and retained their position throughout an 8 weeks force (200g) application. The mucosal condition around the screws was healthy in cases in which miniscrews were inserted in the alveolar bone between the roots and the head of the screws emerged into the attached gingiva. When the force application was terminated, radiographic analysis revealed neither root resorption nor periodontal pathology around the miniscrews that remained stable during the entire treatment period. This study suggests that if titanium miniscrews with adequate length are properly used depending on the location, they provide sufficient stability for orthodontic anchorage.

유한요소법에 의한 골강도와 micro-CT 지표 및 골밀도간의 상관관계

윤영남,이완,이병도 대한구강악안면방사선학회 2007 Imaging Science in Dentistry Vol.36 No.1

Purpose : Bone mineral density (BMD) and bone microarchitecture are important determinants for bone strength. Recently micro-CT have provided possibilities for measuring a variety of structural indices to characterize bone microarchitecture. The objective of this study was to compare the BMD and micro-CT parameters with Young's modulus calculated by finite element analysis(FEA) for the evaluation of bone strength. Materials and Methods : Bone specimens were obtained from the 18 female rabbits aged 16 weeks. Of those, 36 samples (right and left femur) were selected for 3D micro-CT analysis (ANT^(TM), SKYSCAN, Belgium) and BMD by PIXImus 2 (GE Lunar Co. USA). Five microstructural parameters of micro-CT, such as trabecular thickness (Tb.Th), bone specific surface (BS/BV), percent bone volume (BV/TV), structure model index (SMI) and degree of anisotropy (DOA) were studied. Young's modulus was obtained by software program (ANSYS 9.0, ANSYS Inc, Canonsburg, PA) based on micro-CT three dimensional images. Results : Young's modulus assessed by FEA correlated significantly with Tb.Th, BV/TV, BS/BV and SMI respectively. Young's modulus showed higher correlation with these microstructural parameters of micro-CT than BMD. Microstructural parameters except DOA showed significant correlations within the examined group. Conclusion : The microarchitectural parameters of micro-CT and BMD represented some informations in the evaluation of bone strength assessed by FEA. (Korean J Oral Maxillofac Radiol 2007; 37: 53-9)

Kodak Insight 구내필름의 치아우식증 진단능에 대한 연구

윤영남,이상래,이병도 大韓口腔顎顔面 放射線學會 2004 Imaging Science in Dentistry Vol.34 No.1

Purpose : To compare the diagnostic accuracy of Kodak Insight film with other intra-oral films in the detection of dental caries. Materials and Methods : Periapical radiographs of 99 extracted human teeth with sound proximal surfaces and interproximal artificial cavities were made on Kodak Ultra speed, Ektaspeed, Agfa Ektaspeed and Kodak Insight films and automatically processed. Six dentists examined the presence of dental caries using a five-point confidence rating scale and compared the diagnostic accuracy by ROC (Receiver Operating Characteristic) analysis and ANOVA test. Results : The sensitivity of Kodak Ultra speed, Ektaspeed, Agfa Ektaspeed and Insight film were 0.84, 0.77, 0.75 and 0.79 respectively. The specificity of Kodak Ultra speed, Ektaspeed, Agfa Ektaspeed and Insight film were 0.97, 0.95, 0.96 and 0.94 respectively. The mean ROC areas (Az) of Kodak Ultra speed, Ektaspeed, Agfa Ektaspeed and Insight film were 0.917, 0.910, 0.894, 0.909 respectively. There was no significant differences between Az of Insight film and other films (p = 0.178). Conclusion : Theses results suggested that Kodak Insight film have the comparative diagnostic accuracy of dental caries with Ultraspeed and Ektaspeed films.

Plus(+) Point Probe를 이용한 용접부 와전류검사

윤병식,남민우,김석곤,이희종,김용식 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.6

발전설비를 구성하는 주요 기기중 펌프, 발브, 배관 등의 용접부에 발생할 수 있는 균열 등의 결함을 검출하기 위한 plus-point 와전류검사탐촉자를 설계하여 결함을 검출하고 그 크기를 측정할 할 수 있는 검사기법을 연구하였다. 차동형 모드로 운전되는 plus-point 와전류탐촉자는 2개의 "I"자형 코일 이 십자형태로 교차되어 있으며, 탐촉자와 시험체 표면사이의 lift-off변화에 의한 영향이 재래식 표면 탐촉자에 비해서 작게 발생하는 특징이 있다. 결함에 대한 탐촉자 반응을 평가하기 위해서 304 스텐 인레스강 용접부에 인공결함인 균열성 노치를 방전가공하여 시험편을 제작하였으며, 이를 활용하여 plus-point 와전류탐촉자의 결함 검출, 종류 판별 및 크기를 측정할 수 있는 기법을 연구하였다. A plus-point eddy current test(ECT) probe was developed to examine the defects on the welds of pumps, valves, and pipings which are the major components of the electric power plants. non-destructive evaluation(NDE) techniques for detecting and sizing the flaws were studied adapting this probe. Differential plus-point ECT probe is consists of two "I"-type coils crossed each other and has an advantage having a small influence on the sensitivity by lift-off variation to the conventional types of probe. The specimens with crack-like electro dischrge machining(EDM) notches on the weld of type 304 stainless-steel were fabricated in order to evaluate the plus-point ECT probe response to the flaws. NDE techniques to detect and size the flaws and estimate the flaw type were established with this specimens.

식도암에서 외부방사선치료와 근접방사선치료의 병용요법

남택근,나병식,오윤경 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.2

Background and Objectives: To evaluate the role of brachytherapy following external radiotherapy by retrospective analysis in view of survival and prognostic factors in esophageal carcinoma. Materials and Methods: From Apr. 1999 to Dec. 2000, a total of 28 patients, who were diagnosed as esophageal carcinoma, were treated by curative external radiotherapy followed by brachytherapy with or without chemotherapy. Eligible primary tumors were located in the thoracic esophagus and lymphatic metastases were restricted to supraclavicular or mediastinal nodes. External radiotherapy was performed by 6 MV or 10 MV X-ray and the range of doses was 50.0 Gy - 59.4 Gy (median; 54.9) to primary tumors. One week later, the intraluminal brachtherapy (IB) was performed by high-dose rate remote controlled afterloader with radioisotope of ^192Ir. Fraction size of IB was 2~5 Gy, twice a week and delivered up to total doses of 3 Gy~ 20 Gy (median; 12). Twenty-one patients were treated by concurrent chemotherapy with the agents of cisplatin and 5-FU. Cisplatin, 75 ㎎/㎡, was given on the first day of weeks 1, 5, 8, 11 and 5-FU, 1,000 ㎎/㎡, was administered as a continuous infusion for the first 4 days of each course. Results: The estimated median survival time was 15 months and 1, 2, 3-year survival rates were 60.7%, 27.5%, 9.2%, respectively. The median survival time (MST) of the patients with stage II (n=9), III (n=17), IVA (n=2) were 20, 15, 5 months, respectively (p=0.68). The MST of the patients with complete response vs partial response were 21 vs 14 months, respectively (p=0.12). The MST of patients younger than 60 years vs older were 22 vs 12 months, respectively (p=0.07). The MST of patients with ECOG performance index 1 vs 2 were 16 vs 10 months, respectively (P=0.06) Tile Mn of patients treated by concurrent chemotherapy vs untreated were 20 vs 12 months, respectively (p=0.07). Four patients (14.3%) suffered massive hematemesis after brachytherapy and one patient with local recurrence salvaged by esophagectomy had mediastinal abscess. Of 21 patients treated by concurrent chemoradiothetapy, one patient had pancytopenia and other two patients had severe leukopenia. Conclusion: This study showed no better outcomes of brachytherapy boost after external radiotherapy than historical results of external radiotherapy alone. Concurrent chemotherapy might have more significant therapeutic role rather than brachytherapy boost and the employment of brachythelapy should be considered with great caution in the treatment of esophageal carcinoma.

체내 납부담의 지표로서 누적 혈중 납량과 누적 혈중 ZPP가 납 관련 신기능에 미치는 영향

윤강호,김남수,김진호,김화성,이병국 대한산업의학회 2006 대한직업환경의학회지 Vol.18 No.4

목적: 체내 납부담의 지표로서 누적 혈중 납량과 누적 혈중 ZPP가 납관련 신기능에 미치는 영향을 알아보기 위하여 678명의 납 작업자들을 대상으로 본 연구를 시도하였다. 방법: 누적 혈중 납량과 누적 혈중 ZPP는 입사시부터 매 1년간의 혈중 납량과 혈중 ZPP를 누적하여 구하였다. 입사시기가 1983년 이전인 납 작업자의 경우는 최초 혈중 납량과 최초 혈중 ZPP를 그 이전의 값으로 추정하여 구하였다. 체내 납부담의 지표로서 골중 납량과 DMSA착화납량을 측정하였으며, 최근의 납 노출 지표로서는 혈중 납량과 혈중 ZPP를 측정하였다. 신기능을 평가하는 지표로서는 임상 신기능 지표로서 BUN과 혈청 creatinine을 측정하였고, 신기능 조기지표로는 NAG (N-acetyl-D- glucosamide)와 RBP (Retinol binding protein)를 측정하였다. 결과: 혈중 납량과 혈중 ZPP의 누적지수와 골중 납량과는 결정계수(r²)는 각각 0.72와 0.567로서 유의한 상관이 있었으며 이들 누적지수와 골중 납량은 곡선형적 모델이 더 적합하였다. 신기능 지표들을 종속변수로 하고 성, 연령, 직력 및 음주와 흡연을 통제한 후 혈중 납량과 혈중 ZPP를 독립변수로 한 중회귀분석에서 혈중 납량은 4개의 신기능 지표들 중 지수 변환한 NAG와만 유의한 관련이 있는 반면, 혈중 ZPP는 지수변환한 NAG를 제외한 신기능 지표들과 유의한 관련이 있었다. 한편 신기능 지표들을 종속변수로 하고 연령 및 직력과 음주와 흡연을 통제한 후 체내 납 부담노출지표들을 독립변수로 한 중회귀분석에서 골중 납량과 혈중 ZPP 누적지수는 4개의 신기능 지표들과 유의한 관련이 있는 반면, DMSA 착화납량과 혈중 납량 누적지수는 BUN을 제외한 신기능 지표들과 유의한 관련이 있었다. 결론: 상기한 결과로 보아 혈중 납량과 혈중 ZPP의 누적지수는 체내 납부담의 지표로서 효용성이 입증되었으며, 특히 혈중 ZPP의 누적지수가 혈중 납량의 누적지수보다 체내 납부담의 대리지표로서 더 좋은 것으로 나타났다. Objective: To evaluate the possibility of cumulative blood lead and blood ZPP as surrogates of lead body burden and to investigate their association with renal function as an index of lead body burden. Methods: The study subjects comprised 678 lead workers with past blood lead and blood ZPP data from their employment. Cumulative blood and ZPP were calculated by accumulating the every year mean value of both indices from the new employment since 1983. To assess the cumulative data of lead workers who started their lead work before 1983, the years before 1983 were simulated with the first available data from 1983. Study variables for lead body burden were tibia bone lead and DMSA chelatable lead, whereas those for current lead biomarkers were blood lead and blood ZPP. BUN and serum creatinine were selected as clinical renal biomarkers, while NAG (N-acetyl-D-glucosamine) and RBP (Retinol binding protein) were selected as early renal biomarkers. Results: The association between cumulative blood lead and blood ZPP with tibia bone lead was statistically significant with determinant coefficients (r²) of 0.72 and 0.567, respectively, and their relationships were better explained by the curvilinear regression model. In multiple regression analysis of current lead biomarkers on the renal biomarkers after controlling for possible confounders (age, sex, job duration, smoking and drinking status), blood lead was associated only with log-transformed NAG, whereas blood ZPP was associated with 3 other renal biomarkers. On the other hand, in multiple regression analysis of biomarkers of lead body burden on renal biomarkers after controlling for possible confounders (age, sex, job duration, smoking and drinking status), cumulative blood ZPP and tibia bone lead were associated with all 4 renal function biomarkers, whereas cumulative blood lead and DMSA chelatable lead were associated with 3 renal biomarkers except BUN. Conclusion: Cumulative blood and ZPP were demonstrated to be good surrogates of lead burden. Furthermore, the cumulative blood ZPP was confirmed to have a better association than the cumulative blood lead.

인터넷비즈니스 기업의 성공사례와 시사점

허남수,윤병섭 慶南大學校 産業經營硏究所 2001 産業經營 Vol.28 No.-

등록주선인의 명성이 코스닥 IPO에 미치는 영향

허남수,윤병섭 慶南大學校 産業經營硏究所 2002 産業經營 Vol.31 No.-

酸化反應을 利用한 芳香族 Amine化合物의 分析硏究

白南勳,李允中,崔秉箕 同德女子大學校 1985 同大論叢 Vol.15 No.1

There were many reports relating to a process for assaying the amount of organo-phosphorous compounds which was prosecuted by the steps of 1) oxidizing organo phosphorous compounds to organic phosphorous-peroxides (peroxyphosphonates), and 2) measuring the color-intensity of the compounds formed by the oxidation of aromatic amines with the organic phosphorous-peroxides. According to this procedure, the author assayed the amount of amines by measuring the color-intensity which changes depending upon their concentration. The amines used in this experiment can be classified into three categories according to the different coloring methods described as in the following: 1) diect oxidation(azotization) with organic phosphorous-peroxides, 2) oxidation(diazotization) with organic phosphorous-peroxides followed by coupling reaction, and 3) diazotization with sodium nitrite followed by coupling reaction to azo compounds. Results from the above experiment are summarized as below. 1. Benzidine, phenylenediamine, and hydrazine derivatives were analyzed with good reproducibility and precision in the sample ragne of 4.1×10??∼1.29×10?? mol by direct azotization with organic phosphorous-peroxides. 2. Hydrazide derivatives were quantitized with good reproducibility and precision in the sample range of 1.19×10??∼7.29×10?? mol by diazotization with organic phosphorous-peroxides followed by coupling reaction. 3. Sulfanilamide derivatives were tested with good reproducibility and precision in the sample range of 1.61×10??∼2.87×10?? mol by diazotization with nitrou sacid followed by coupling reaction. In conclusion, the prsent method complements the conventional quantitization procedures which are liable to oxidative deradation and lack of precision due to the use of external indicators.

CASE 프로그램에 의한 중학생들의 인지가속 효과

최병순,한효순,강성주,이상권,강순희,박종윤,남정희 한국과학교육학회 2002 한국과학교육학회지 Vol.22 No.4

학생들의 인지발달을 촉진시켜 학습효과를 높이려고 개발된 CASE 프로그램의 효과를 조사했다. 중학교 1학년(841명) 학생들이 연구에 참가하였으며, 같은 분량의 시간동안 실험반에서는 교육과정에 따른 과학 교과 수업과 '생각하는 과학' 활동을 병행하였고, 통제반에서는 과학교과 수업만을 수행하였다. 연구 초기에 논리적 사고력 검사(SRT II)를 이용하여 집단의 동질성을 비교하고, 2년 동안 실험반에 CASE프로그램을 처치한 후 이질동형겸사도구인 SRT VII을 이용하여 처치별, 성별, 인지수준별 인지가속에 대한 효과를 조사했다. CASE 프로그램에 의한 중학생들의 인지발달 가속효과는 중간검사에서는 보이지 않았으나, 사후검사에서 상당히 큰 것으로 확인되었다. 성별에 따라 CASE 프로그램의 효과를 비교한 결과 남??여 중학생들 모두에게 유의미한 인지가속이 이루어진 것으로 나타났다. 남학생들 보다 여학생들의 인지수준이 더 발달된 것으로 밝혀졌으며, 처치와 성별간 상호작용 효과는 나타나지 않았다. 학생들의 사전 인지수준에 따라 CASE 프로그램의 효과를 분석한 결과, 모든 인지수준에서 처치효과가 뚜렷하게 있었으나 특별한 경향성은 나타나지 않았다. 특히 초기 구체적 조작기(ES=1.1.)와 전조작기(ES=1.07), 그리고 구체적조작 후기(ES=1.01) 학생들에게 상당히 큰 효과가 있었다. 이상과 같은 CASE 프로그램의 성공적인 결과는 현행 우리나라 과학교육과정 개정과 교수방법 개선에 시사하는 바가 많다. In an attempt to accelerate the development of formal reasoning ability of students, 'Thinking Science' activities developed by the Cognitive Acceleration through Science Education(CASE) project were implemented to 841 students in 7th grade aged 12+ in six middle schools over a period of two years. Homogeneity between the CASE group and control group was tested with SRT Ⅱ, while the improvement of formal reasoning ability of the students was tested with SRT Ⅶ. The results were analyzed by treatment, gender, and cognitive levels of the students. Statistically significant gains were shown in the CASE group compared with those in the control group. Cognitive level of girls in the CASE group significantly increased as compared with the control group, while there was moderate effect in boys. These results implied that the thinking science activities were effective in cognitive acceleration of girls aged 12+. It was shown that much more CASE students in pre or concrete operational level shifted. to formal operational level as compared with the control group while there were significant effects in all levels (ES=0.31∼1.10) without showing any tendency.