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      • Imaging Anatomy of Waldeyer's Ring and PET/CT and MRI Findings of Oropharyngeal Non-Hodgkin's Lymphoma

        Zhang, Chun-Xing,Liang, Long,Zhang, Bin,Chen, Wen-Bo,Liu, Hong-Jun,Liu, Chun-Ling,Zhou, Zheng-Gen,Liang, Chang-Hong,Zhang, Shui-Xing Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.8

        Background: This study was conducted to analyze positron emission tomography (PET) / computed tomography (CT) and magnetic resonance imaging (MRI) performance with oropharyngeal non-Hodgkin's lymphoma (ONHL).Materials and Methods: The complete image data of 30 ONHL cases were analyzed, all patients were performed PET / CT and MRI examination before the treatment, with the time interval of these two inspections not exceeding 14 days. The distribution, morphology, MRI signal characteristics, enhancement feature, standardized uptake value (SUV) max value and lymph node metastasis way of the lesions were analyzed. Results: Among the 30 cases, 23 cases were derived from the B-cell (76.7%), 5 cases were derived from the peripheral T cells (16.7%) and 2 cases were derived from the NK/T cells (6.7%). 19 cases exhibited the palatine tonsil involvement (63.3%). As for the lesion appearance, 10 cases appeared as mass, 8 cases were the diffused type and 12 cases were the mixed type. 25 cases exhibited the SUVmax value of PET / CT primary lesions as 11 or more (83.3%). MRI showed that all patients exhibited various degrees of parapharyngeal side-compressed narrowing, but MRI still exhibited the high-signal fat, and the oropharyngeal mucosa was intact. 25 cases were associated with the neck lymph node metastasis, among who 22 cases had no necrosis in the metastatic lymph nodes, while the rest 3 cases exhibited the central necrosis in the metastatic lymph nodes. Conclusions: PET / CT and MRI have important value in diagnosing and determining the lesion extent of ONHL.

      • KCI등재

        Tri-Axial Confining Numerical Test and Settlement Analysis of the Gravel Layer

        Liang Zhang,Zhengwei Guo,Zheng Liang 대한토목학회 2020 KSCE JOURNAL OF CIVIL ENGINEERING Vol.24 No.9

        The discrete element method (DEM) is used according to the discreteness of the gravel layer to analysis the gravel particle. This paper presents simulations of tri-axial experiment tests and settlement of gravel layer. The stress-strain curves of gravel layer were analysed with different confining pressure through tri-axial numerical test, and the effect with different particle parameters and confining pressures was analysed. The numerical model of gravel layer after the excavation was established by the DEM to statistically analyse the settlement of gravel layer. The analyses results show that confining pressure corresponds to axial pressure that be destroyed of gravel particle model. The static friction coefficient has little effect on the failure of the tri-axial confining experimental model. The experiment model with various particle sizes need higher axial stress that be destroyed than the same particle size. During the collapse of the gravel stratum, the gravels are closer to the top of the hole which have a larger shift of settlement and a faster sedimentation rate. If the gravel are further away from top of the hole which have a smaller shift of settlement and slower sedimentation rate. The settlement of gravel causes the forces variation in all directions.

      • KCI등재

        An Analysis on the Determinants of the Wage Gap by Education and Income Inequality in the Korean Manufacturing Industry

        Zheng-Liang Zhang,유일선 한국무역연구원 2023 무역연구 Vol.19 No.4

        Purpose – The purpose of this paper is to explore determinants that have a great impact on the wage gap of labors by education(wH /wL), and which factors lead to the extension of this and promote income inequality among workers in the Korean manufacturing industry since the 1990s. Design/Methodology/Approach – Based on human capital theory, labors are divided into highly-educated and low-educated labor. The effective labor function was established as a form of the CES function. The estimation equation consisting of the labor ratio by education(LH / LL), technical progress, and globalization can be derived as factors affecting the wage gap by education. Based on this estimation equation, an empirical analysis was implemented to analyze the wage gap factors of labors. A fully-modified ordinary least square was used as the method of estimation. Findings – In the Korean manufacturing industry, the absolute wage gap by education expanded while the relative wage gap narrowed due to an increase in LH / LL. It also expanded due to the effect of exogenous factors such as technical progress and globalization. Since the international financial crisis, the effect of LH / LL has decreased, and those of technical progress and globalization have increased, widening the relative wage gap which strengthens income inequality among workers. Research Implications – Currently, the wage gap by education has widened in the manufacturing industry, and income inequality has become a social issue. Under the de-manufacturing industrial structure, there are policy implications to promote technical progress that can create employment by expanding investment in the service industry and increasing the productivity of low-educated labor.

      • KCI등재

        An Integrated Nomogram Combining Clinical Factors and Microtubule-Associated Protein 1 Light Chain 3B Expression to Predict Postoperative Prognosis in Patients with Intrahepatic Cholangiocarcinoma

        Liang Chen,Hongyuan Fu,Tongyu Lu,Jianye Cai,Wei Liu,Jia Yao,Jinliang Liang,Hui Zhao,Jiebin Zhang,Jun Zheng,Yingcai Zhang,Yang Yang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2

        Purpose Microtubule-associated protein 1 light chain 3B (LC3B) serves as a key component of autophagy, which is associated with the progression of carcinoma. Yet, it is still unclear whether LC3B is also an independent risk factor for intrahepatic cholangiocarcinoma (ICC). We aim to explore the predictive value of LC3B on prognosis of ICC, and to establish a novel and available nomogram to predict relapse-free survival (RFS) and overall survival (OS) for these patients after curative-intent hepatectomy. Materials and Methods From August 2004 to March 2017, 105 ICC patients were eligibly enrolled in the Third Affiliated Hospital of Sun Yat-sen University. Preoperative clinical information of enrolled patients was collected. Expression LC3B in the ICC specimen was detected by immunohistochemistry. Results The 5-year RFS and OS in this cohort were 15.7% and 29.6%, respectively. On multivariate Cox regression analysis, independent risk factors for 5-year OS were cancer antigen 125, microvascular invasion, LC3B expression and lymph node metastasis. Except for the above 4 factors, neutrophil/lymphocyte ratio and tumor differentiation were independent factors for 5-year RFS. The area under the curve of nomograms for OS and RFS were 0.820 and 0.747, respectively. Conclusion The nomograms based on LC3B can be considered as effective models to predict postoperative survival for ICC patients.

      • Prognostic Value of C-Reactive Protein in Esophageal Cancer: a Meta-analysis

        Zheng, Tian-Liang,Cao, Ke,Liang, Cui,Zhang, Kai,Guo, Hai-Zhou,Li, De-Ping,Zhao, Song Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

        Background: The classical inflammatory biomarker, C-reactive protein (CRP), has been identified to be related to progression of esophageal cancer. Some research showed that elevated pretreatment serum CRP indicated a poor prognosis, but results have been inconsistent. Materials and Methods: We searched the Medline, Embase and the Cochrane Central Search Library for suitable studies and a meta-analysis of eleven (1,886 patients) was conducted to examine the relationship between elevated serum CRP level and overall survival (OS) in esophageal cancer cases. Moreover, correlation analyses were conducted to assess links between pretreatment serum CRP level and tumor node metastasis (TNM) stage as well as T, N, M grade, respectively. Results: The pooled analysis showed that elevated pretreatment serum CRP level was significantly associated with poorer overall survival (HR 2.09, 95%CI 1.52-2.87, p<0.01). Subgroup analyses were conducted by "country", "cut-off value", "treatment" and "number of patients", and no single factor could alter the result. Elevated pretreatment serum CRP was significantly correlated with more advanced TNM stage and T, N, M grade respectively. Conclusions: Elevated pretreatment serum CRP levels are associated with poorer prognosis in esophageal cancer patients, and could serve as a useful biomarker for outcome prediction.

      • Fast Thresholding Based on Improved Minimum Cross Entropy

        Yong-Liang Zhang,Wen Zhang,Gang Xiao,Jia-Fa Mao,Shan-Shan Huang,Xiao-Wei Zheng 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10

        Image segmentation is an important and classic problem in image processing and computer vision. Thresholding is applied to many fields, because of its less computation and stable performance. The key of thresholding method is to determine the adaptive threshold. In order to segment biological image effectively, a new adaptive thresholding method is proposed. First, two dimension minimum entropy is computed based on gray-gradient co-occurrence matrix; and then the genetic algorithm is applied to encode the two-dimension threshold vector; Finally, the optimum threshold is calculated based on fitness function and uniformity measurement(UM). Experimental results show that this method has three advantages: 1) improve computational efficiency so that it can run in real time; 2) retain more object and edge information so that it can meet the practical requirement; 3) robust to the uneven distribution of light.

      • KCI등재
      • KCI등재

        Liquid Chromatography-Tandem Mass Spectrometry-Based Metabolomics Analysis of Indigo Naturalis Treatment of Ulcerative Colitis in Mice

        Zheng Wang,Yanni Liang,Anqi Fan,Bao-Long Hou,Zhishu Tang,Ting Wang,Dongbo Zhang 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.12

        Ulcerative colitis (UC), often known as UC, is an inflammatory disease of the intestines that has frequent andlong-lasting flare-ups. It is unknown precisely how the traditional Chinese drug Indigo Naturalis (IN) heals inflammatorybowel disease, despite its long-standing use in China and Japan. Finding new metabolite biomarkers linked to UC couldimprove our understanding of the disease, speed up the diagnostic process, and provide insight into how certain drugs work totreat the condition. Our work is designed to use a metabolomic method to analyze potential alterations in endogenoussubstances and their impact on metabolic pathways in a mouse model of UC. To determine which biomarkers and metabolismsare more frequently connected with IN’s effects on UC, liquid chromatography-tandem mass spectrometry analysis ofthe serum metabolomics of UC mice and normal mice was performed. The outcomes demonstrated that IN boosted the healthof UC mice and reduced the severity of their metabolic dysfunction. In the UC model, it was also found that IN changed theway 17 biomarkers and 3 metabolisms functioned.

      • KCI등재

        Plasma metabolites associated with physiological and biochemical indexes indicate the effect of caging stress on mallard ducks (Anas platyrhynchos)

        Zheng Chao,Wu Yan,Liang Zhen Hua,Pi Jin Song,Cheng Shi Bin,Wei Wen Zhuo,Liu Jing Bo,Lu Li Zhi,Zhang Hao 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.2

        Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks. Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database. Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism. Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted. Objective: Cage rearing has critical implications for the laying duck industry because it is convenient for feeding and management. However, caging stress is a type of chronic stress that induces maladaptation. Environmental stress responses have been extensively studied, but no detailed information is available about the comprehensive changes in plasma metabolites at different stages of caging stress in ducks. We designed this experiment to analyze the effects of caging stress on performance parameters and oxidative stress indexes in ducks.Methods: Liquid chromatography tandem mass spectrometry (LC/MS-MS) was used to determine the changes in metabolites in duck plasma at 5 (CR5), 10 (CR10), and 15 (CR15) days after cage rearing and traditional breeding (TB). The associated pathways of differentially altered metabolites were analyzed using Kyoto encyclopedia of genes and genomes (KEGG) database.Results: The results of this study indicate that caging stress decreased performance parameters, and the plasma total superoxide dismutase levels were increased in the CR10 group compared with the other groups. In addition, 1,431 metabolites were detected. Compared with the TB group, 134, 381, and 190 differentially produced metabolites were identified in the CR5, CR10, and CR15 groups, respectively. The results of principal component analysis (PCA) show that the selected components sufficiently distinguish the TB group and CR10 group. KEGG analysis results revealed that the differentially altered metabolites in duck plasma from the CR5 and TB groups were mainly associated with ovarian steroidogenesis, biosynthesis of unsaturated fatty acids, and phenylalanine metabolism.Conclusion: In this study, the production performance, blood indexes, number of metabolites and PCA were compared to determine effect of the caging stress stage on ducks. We inferred from the experimental results that caging-stressed ducks were in the sensitive phase in the first 5 days after caging, caging for approximately 10 days was an important transition phase, and then the duck continually adapted.

      • KCI등재

        Application of a High-Resolution Spectrometer in a Broadband Optical Monitor for Film Coating

        Liang-Yao Chen,Yun-Fei Wu,Qing-Yuan Cai,Yu-Xiang Zheng,Rong-Jun Zhang 한국물리학회 2008 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.53 No.4

        The broadband optical monitoring (BOM) method for the thin-film coating proces has become more popular due to its having a higher efficiency than other methods and the ability to precisely control the film coating proces at any thicknes. A high-resolution spectrometer working in the broadband spectral range has to be used for the BOM method to monitor the growth proces of a narow bandpas thin-film filter. In this paper, we show the application of a high-resolution spectrometer in BOM for the narow bandpas thin-film filter-coating proces and away to eliminate effectively the interference eror of the substrate. We also describe an experimental setup that can be used to grow a narow bandpas filter in a real BOM proces.

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