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( Zheng Jun Li ),( Dae Kyoung Choi ),( Kyung Cheol Sohn ),( Seul Ki Lim ),( Myung Im ),( Young Lee ),( Young Joon Seo ),( Chang Deok Kim ),( Jeung Hoon Lee ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.5
Background: Interleukin-17A (IL-17A) is mainly secreted from Th17 cells that are activated by various stimuli including CpG oligodeoxynucleotide, a Toll-like receptor 9 (TLR9) ligand. Recently, it has been demonstrated that keratinocytes play an important role in the pathogenesis of psoriasis. Objective: To investigate the potential role of keratinocytes, we examined whether TLR9 ligand CpG induces IL-17A expression in keratinocytes. Methods: We used HaCaT keratinocytes as a model system, and determined CpG-induced IL-17A using enzyme-linked immunosorbent assay and Western blot. Results: When HaCaT keratinocytes were treated with CpG, the expression of several cytokines including IL-17A, tumor necrosis factor-α and CCL20 was markedly increased. Treatment with nuclear factor (NF)-κB inhibitor significantly blocked the CpG-induced IL-17A production, indicating that CpG induced IL-17A expression through the NF-κB signaling pathway. In addition, IL-17A secreted from keratinocytes stimulated the CD4+ T cells, resulting in strong induction of IL-22 production. Conclusion: Since IL-22 is an important mediator for psoriatic inflammation, our data suggest that keratinocytes can participate in the pathogenesis of psoriasis via the TLR9-dependent IL-17A production. (Ann Dermatol 28(5) 579∼585, 2016)
Zheng, Liang Jun,Kang, Dong Hee,Kim, Na Kyong,Youn, Young Jik,Kang, Hyun Wook Elsevier 2019 INTERNATIONAL JOURNAL OF HEAT AND MASS TRANSFER - Vol.143 No.-
<P><B>Abstract</B></P> <P>Theoretical model of thermoelectric generator (TEG) cooled by direct evaporative cooling technology is developed. In the theoretical model, thermoelectric material properties depending on temperature change and effects of heat loss by radiation, conduction, and Thomson phenomenon are considered. To investigate the effect of evaporative cooling to the efficiency of TEG, the simulation conditions are set as hot-side temperature of 40–120 °C and 1 mm thickness of thin water film covering for cold-side. The ambient temperature is 25 °C and the relative humidity of the air is set from 25% to 75%. Based on the developed theoretical model, the output power of TEG is increased as increasing hot side temperature under fixed relative humidity or as decreasing relative humidity under fixed hot-side temperature. Consequently, the maximum output power of 130.69 W m<SUP>−2</SUP> and an efficiency of 1.63% are obtained with 25% relative humidity and 120 °C for the hot-side temperature condition. The results show that the output power and efficiency are increased 100.53 and 10.53 times higher than without evaporative cooling (natural convection case, output power of 1.30 W m<SUP>−2</SUP> and efficiency of 0.1548%), respectively.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Theoretical model of TEG cooled by direct evaporative cooling technology. </LI> <LI> Thermophysical relations in TEG system and cooling process at theoretical model. </LI> <LI> Analyzing thermal resistance network for quantifying heat flow rates and heat dissipation rates. </LI> <LI> Increasing TEG performance by applying evaporative cooling technology. </LI> <LI> TEG performance evaluation based on hot-side temperature and relative humidity. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Jun-Hui Zheng,Jian-Fen Liu 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.3
In this paper, a robust kalman filter is designed for the uncertainty time-varying discrete systems with state delay in process and output matrices combined with the possibility of missing measurements. The uncertainties are expected in the process, output and white noise covariance matrices. A formula for a candidate upper bound on the actual state estimation error variances for all admissible parameter uncertainties and possible missing measurements is obtained. The filter parameters are optimized to give a minimal upper bound on the state estimation error covariance for all admissible uncertainties and missing measurements.
Jun Zheng,Sai Krishna Chigurupati 한국통신학회 2019 ICT Express Vol.5 No.3
Smudge attacks are a threat specifically targeting Android pattern unlock. Current solutions improve the security of pattern unlock by significantly reducing its usability. In this paper, we propose a novel scheme called M-Pattern to improve the security of pattern unlock against smudge attacks without significantly compromising the usability. A security analysis was performed to demonstrate that M-Pattern can have significantly stronger security than normal pattern unlock by just using two simple patterns. A pilot user study was also carried out to investigate the usability of M-Pattern.
Jun Guan,Yu Xue,Rong-yu Zang,Ji-hong Liu,Jian-qing Zhu,Ying Zheng,Bo Wang,Hua-ying Wang,Xiao-jun Chen 대한부인종양학회 2021 Journal of Gynecologic Oncology Vol.32 No.4
Background: Sentinel lymph node (SLN) mapping has been recommended as an alternative staging approach to lymphadenectomy for apparent uterine-confined endometrial cancer (EC). However, the prognostic value of SLN mapping alone instead of systematic lymphadenectomy on EC patients remains unclear. Methods: A multi-center, open label, non-inferiority randomized controlled trial has been designed to identify if SLN mapping alone is not inferior to pelvic lymphadenectomy on prognosis of patients with intermediate-high-risk EC clinically confined to uterus. Eligible patients will be 1:1 randomly assigned to accept SLN mapping or pelvic lymphadenectomy. The primary endpoint is the 2-year progression-free survival (PFS). The second points are the 5-year PFS, 5-year overall survival, surgery-related adverse events and life quality. A total of 780 patients will be enrolled from 6 hospitals in China within 3-year period and followed up for 5 years. Trial Registration: ClinicalTrials.gov Identifier: NCT04276532
Zheng Jun,Huang Ju,Zhang Liang,Wang Mengna,Xu Lihong,Dou Xiaoyun,Leng Xiaojing,Fang Mingxiao,Sun Yang,Wang Zhigang 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Although programmed cell death protein 1 (PD-1)/ programmed cell death-ligand protein 1 (PD-L1) checkpoint blockade immunotherapy demonstrates great promise in cancer treatment, poor infiltration of T cells resulted from tumor immunosuppressive microenvironment (TIME) and insufficient accumulation of anti-PD-L1 (αPD-L1) in tumor sites diminish the immune response. Herein, we reported a drug-loaded microbubble delivery system to overcome these obstacles and enhance PD-L1 blockade immunotherapy.Docetaxel (DTX) and imiquimod (R837)-loaded microbubbles (RD@MBs) were synthesized via a typical rotary evaporation method combined with mechanical oscillation. The targeted release of drugs was achieved by using the directional "bursting" capability of ultrasound-targeted microbubble destruction (UTMD) technology. The antitumor immune response by RD@MBs combining αPD-L1 were evaluated on 4T1 and CT26 tumor models.The dying tumor cells induced by DTX release tumor-associated antigens (TAAs), together with R837, promoted the activation, proliferation and recruitment of T cells. Besides, UTMD technology and DTX enhanced the accumulation of αPD-L1 in tumor sites. Moreover, RD@MBs remolded TIME, including the polarization of M2-phenotype tumor-associated macrophages (TAMs) to M1-phenotype, and reduction of myeloid-derived suppressor cells (MDSCs). The RD@MBs + αPD-L1 synergistic therapy not only effectively inhibited the growth of primary tumors, but also significantly inhibited the mimic distant tumors as well as lung metastases.PD-L1 blockade immunotherapy was enhanced by RD@MBs delivery system.
Jun Zheng,Dongsong Sun,Tingdi Chen,Ruocan Zhao,Yuli Han,Zimu Li,Anran Zhou,Nannan Zhang 한국광학회 2018 Current Optics and Photonics Vol.2 No.2
A Scanning Rayleigh Doppler lidar for wind profiling based on a non-polarized beam splitter cube optically contacted FPI is developed for wind measurement from high troposphere to low stratosphere in 5-35 km. Non-polarized beam splitter cube optically contacted to the FPI are used for a stable optical receiver. Zero Doppler shift correction is used to correct for laser or FPI frequency jitter and drift and the timing sequence is designed. Stability of the receiver for Doppler shift discrimination is validated by measuring the transmissions of FPI in different days and analyzed the response functions. The maximal relative wind deviation due to the stability of the optical receiver is about 4.1% and the standard deviation of wind velocity is 1.6% due to the stability. Wind measurement comparison experiments were carried out in Jiuquan (39.741°N, 98.495°E), Gansu province of China in 2015, showing good agreement with radiosonde result data. Continuous wind field observation was performed from October 16th to November 12th and semi-continuous wind field of 19 nights are presented.