1. Amaranth, Brilliant Blue 및 Tartrazine이 鷄胎成長에 미치는 效果에 關한 硏究

이융창,예민해,이대부 忠南大學校 1972 論文集 Vol.11 No.-

The goal of this study is the analysis of the effects of amaranth, brilliant blue and tartrazine on the growth of chick embryos. On the 6th day of incubation, 2㎎ or 20㎎ of amaranth, brilliant blue or tartrazine was injected into the chorioalantoic membrane of each incubated egg. On 12th, 14th, 16th and 18th day of incubation, 10 treated eggs of each group were broken for weighing and the weights of body, brain, lung, heart and liver were measured. The authors used growth formula to analyse the growth pattern of eggs treated with respective color. The results are as follows: 1. Over dose of amaranth or brilliant blue produces remarkable growth inhibition in chick embryo. 2. The greater growth inhibition is occured in 20㎎ treated groups than in 2㎎ treated growth. 3. The growth inhibition produced by the over dose of tartrazine is a little more than nothing.

코드 수정을 통한 스크립트 형태의 악성 이동 코드 대응 기법

윤영태(Yung-tae Yoon),예홍진(Hong-Jin Yeh),조은선(Eun-Sun Cho),고재영(Jae-Young Koh) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅰ

현재의 스크립트 형태의 악성코드에 대한 대응 기법으로는 자바의 샌드박스(Sandbox) 모델과 흡사한 자원 제한 기법이 주로 사용된다. 하지만 이 기법의 경우 악의가 없는 스크립트 또한 제한되어 있는 자원을 사용할 수 없으며 이로 인하여 스크립트 본연의 취지인 전송된 스크립트를 통한 편의성 제공의 기능이 많은 제약을 받고 있다. 따라서 각각의 스크립트 코드의 유해 여부를 코드 수행 중에 결정하여 자원사용의 허용 여부를 결정하는 기법이 절실이 요구되며 본 논문에서는 전송되어온 코드의 위험 요소 부위를 자체 면역성을 가지도록 코드를 수정하는 기법을 제안하고자 한다.

A study on behavior of steel joints that combine high-strength bolts and fillet welds

Heui-Yung Chang,Ching-Yu Yeh 국제구조공학회 2019 Steel and Composite Structures, An International J Vol.31 No.4

In recent years, considerable attention has been paid to the research and development of high-strength steel plates, with particular emphasis on the enhancement of the seismic resistance of buildings and bridges. Many efforts have also been undertaken to improve the properties of high-strength bolts and weld materials. However, there are still different opinions on steel joints that combine high-strength bolts and fillet welds. Therefore, it is necessary to verify the design specifications and guidelines, especially for newly developed 1,400-MPa high-strength bolts, 570-MPa steel plates, and weld materials. This paper presents the results of literature reviews and experimental investigations. Test parameters include bolt strengths, weld orientations, and their combinations. The results show that advances in steel materials have increased the plastic deformation capacities of steel welds. That allows combination joints to gain their maximum strength before the welds have fracture failures. When in combination with longitudinal welds, high-strength bolts slip, come in contact with cover plates, and develop greater bearing strength before the joints reach their maximum strength. However, in the case of combinations with transverse welds, changes in crack angles cause the welds to provide additional strength. The combination joints can therefore develop strength greater than estimated by adding the strength of bolted joints in proportion to those of welded joints. Consequently, using the slip resistance as the available strength of high-strength bolts is recommended. That ensures a margin of safety in the strength design of combination joints.

Successful Electroconvulsive Therapy for a 74-year-old Female with Major Depressive Disorder and Tardive Tremor: A Case Report and Literature Review

Jia-Yin Yeh,Nien-Mu Chiu,Yung-Yee Chang,Pao-Yen Lin,Yu Lee 대한정신약물학회 2020 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.18 No.2

Tardive tremor is an infrequently form of tardive syndrome that is developed from prolonged treatment with dopamine receptor blocking agents. This condition presents as a prominent tremor that may cause significant distress but currently lacks effective treatment. Electroconvulsive therapy (ECT) has been applied to treat tardive syndrome. In this study, we report a 74-year-old female patient with major depressive disorder, whose tardive tremor and depressive symptoms showed remarkable improvement after receiving 10 sessions of ECT treatment.

Alpinate Oxyphyllae Fructus Inhibits IGFII-Related Signaling Pathway to Attenuate Ang II-Induced Pathological Hypertrophy in H9c2 Cardiomyoblasts

Chuan-Te Tsai,Yung-Ming Chang,Shu-Luan Lin,Yueh-Sheng Chen,Yu-Lan Yeh,Viswanadha Vijaya Padma,Chin-Chuan Tsai,Ray-Jade Chen,Tsung-Jung Ho,Chih-Yang Huang 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.3

Angiotensin II (Ang II) is a very important cardiovascular disease inducer and may cause cardiac pathological hypertrophy and remodeling. We evaluated a Chinese traditional medicine, alpinate oxyphyllae fructus (AOF), for therapeutic efficacy for treating Ang II-induced cardiac hypertrophy. AOF has been used to treat patients with various symptoms accompanying hypertension and cerebrovascular disorders in Korea. We investigated its protective effect against Ang II-induced cytoskeletal change and hypertrophy in H9c2 cells. The results showed that treating cells with Ang II resulted in pathological hypertrophy, such as increased expression of transcription factors NFAT-3/p-NFAT-3, hypertrophic response genes (atrial natriuretic peptide [ANP] and b-type natriuretic peptide [BNP]), and Gαq down-stream effectors (PLCβ3 and calcineurin). Pretreatment with AOF (60–100 μg/mL) led to significantly reduced hypertrophy. We also found that AOF pretreatment significantly suppressed the cardiac remodeling proteins, metalloproteinase (MMP9 and MMP2), and plasminogen activator, induced by Ang II challenge. In conclusion, we provide evidence that AOF protects against Ang II-induced pathological hypertrophy by specifically inhibiting the insulin-like growth factor (IGF) II/IIR-related signaling pathway in H9c2 cells. AOF might be a candidate for cardiac hypertrophy and ventricular remodeling prevention in chronic cardiovascular diseases.

Robust Control Design Based-on Integral Sliding-Mode for Systems with Norm-Bounded Uncertainties

Chieh-Chuan Feng,Yung-Yeh Lin 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10

Based on the integral sliding-mode control that copes with norm-bounded matched uncertainties, a robust control of L₂-gain performance measure subsequently applied to the system is proposed to handle both nonlinearities and unmatched uncertainties. The similar issue through the use of higher order multimode model has been relaxed. Instead of using exact known multi-mode to express the uncertain system, the norm-bound convex set is a concise way of expressing the model and hence, higher order models needed in the computation can be avoided. In this paper integral sliding-mode control robustly nullifies the matched uncertainties from the first beginning of the process and then, once in the sliding mode, the nonlinearities and unmatched uncertainties are further compensated by the quadratic stability with L₂-gain performance measure to not only stabilize the system but also ensure the satisfaction of performance. The effectiveness is shown in a numerical example.

The Performance Study of a Virtualized Multicore Web System

( Chien-te Lu ),( C. -s. Eugene Yeh ),( Yung-chung Wang ),( Chu-sing Yang ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.11

Enhancing the performance of computing systems has been an important topic since the invention of computers. The leading-edge technologies of multicore and virtualization dramatically influence the development of current IT systems. We study performance attributes of response time (RT), throughput, efficiency, and scalability of a virtualized Web system running on a multicore server. We build virtual machines (VMs) for a Web application, and use distributed stress tests to measure RTs and throughputs under varied combinations of virtual cores (VCs) and VM instances. Their gains, efficiencies and scalabilities are also computed and compared. Our experimental and analytic results indicate: 1) A system can perform and scale much better by adopting multiple single-VC VMs than by single multiple-VC VM. 2) The system capacity gain is proportional to the number of VM instances run, but not proportional to the number of VCs allocated in a VM. 3) A system with more VMs or VCs has higher physical CPU utilization, but lower vCPU utilization. 4) The maximum throughput gain is less than VM or VC gain. 5) Per-core computing efficiency does not correlate to the quality of VCs or VMs employed. The outcomes can provide valuable guidelines for selecting instance types provided by public Cloud providers and load balancing planning for Web systems.

Tissue Quality Comparison Between Heparinized Wet Suction and Dry Suction in Endoscopic Ultrasound-Fine Needle Biopsy of Solid Pancreatic Masses: A Randomized Crossover Study

Lin Meng-Ying,Wu Cheng-Lin,Su Yung-Yeh,Huang Chien-Jui,Chang Wei-Lun,Sheu Bor-Shyang 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2

Background/Aims: A high-quality sample allows for next-generation sequencing and the administration of more tailored precision medicine treatments. We aimed to evaluate whether heparinized wet suction can obtain higher quality samples than the standard dry-suction method during endoscopic ultrasound (EUS)-guided biopsy of pancreatic masses. Methods: A prospective randomized crossover study was conducted. Patients with a solid pancreatic mass were randomly allocated to receive either heparinized wet suction first or dry suction first. For each method, two needle passes were made, followed by a switch to the other method for a total of four needle punctures. The primary outcome was the aggregated white tissue length. Histological blood contamination, diagnostic performance and adverse events were analyzed as secondary outcomes. In addition, the correlation between white tissue length and the extracted DNA amount was analyzed. Results: A total of 50 patients were enrolled, and 200 specimens were acquired (100 with heparinized wet suction and 100 with dry suction), with one minor bleeding event. The heparinized wet suction approach yielded specimens with longer aggregated white tissue length (11.07 mm vs 7.96 mm, p=0.001) and less blood contamination (p=0.008). A trend towards decreasing tissue quality was observed for the 2nd pass of the dry-suction method, leading to decreased diagnostic sensitivity and accuracy, although the accumulated diagnostic performance was comparable between the two suction methods. The amount of extracted DNA correlated positively to the white tissue length (p=0.001, Spearman̕s ρ=0.568). Conclusions: Heparinized wet suction for EUS tissue acquisition of solid pancreatic masses can yield longer, bloodless, DNA-rich tissue without increasing the incidence of adverse events (ClinicalTrials.gov. identifier NCT04707560).

The mitogen-activated protein kinase phosphatase-1 (MKP-1) gene is a potential methylation biomarker for malignancy of breast cancer

Fang-Ming Chen,Hsueh-Wei Chang,Sheau-Fang Yang,Ya-Fang Huang,Pei-Yung Nien,Yao-Tsung Yeh,Ming-Feng Hou 생화학분자생물학회 2012 Experimental and molecular medicine Vol.44 No.5

The mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1) belongs to the MAPK cascades which are central to cell proliferation and apoptosis. The carcinogenic role of MKP-1 has been reported in many types of cancer but it has rarely been investigated in breast cancer. The present study was designed to evaluate the MKP-1 mRNA expression and its possible regulation by methylation of MKP-1 promoter in the model of several breast cancer cell lines and tissues as well as controls. Our data demonstrate MKP-1mRNA expression significantly decreased in five breast cancer cell lines compared to breast controls (P <0.01). Using the methylation-specific PCR (MSP) analysis,the unmethylated reaction (U) is dominant in both normal cell lines and benign breast tumors (100% vs. 86.2%), whereas the methylated reaction (M) is dominant in both breast cancer cell lines and invasive breast tumors (100% vs. 57.2%). In terms of methylation ratio (M/M+U), methylation level in MKP-1 promoter is significantly higher in the invasive breast tumor tissues (n = 152) than in benign breast tumor tissues (n = 29)(P < 0.0001). Assessing the methylation ratio of the promoter of MKP-1 gene to diagnose the breast malignancy (invasive vs. benign), the area under the receiver-operating characteristic (ROC) curve was 0.809(95% CI: 0.711-0.906, P < 0.001). The best performance for this prediction has a sensitivity of 76.32% and a specificity of 82.76% at the cutoff value of 0.38. Taken together, we firstly demonstrated that the promoter methylation of MKP-1 gene is a potential breast cancer biomarker for breast malignancy.

직장 남성 의복행동과 개인주의적 성향과의 상관성 연구

김경원,노재희,박종원,심정은,양은애,예세란,윤현주,이진영,장윤진,정문이 연세대학교 생활과학대학 1995 婦學 Vol.28 No.-