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李大富 慶北大學校 醫科大學 1963 慶北醫大誌 Vol.4 No.1
Author performed animal experimentation to find out the etiologic factors of urolithiasis. Author used white rats (200gm.body weight) for this experiment. A suprapubicb cystot omy was performed on each rat and a piece of zinc plate (weight 50㎎). was inserted winthin the bladder as a foreigh body. Rats were devided into two groups, control and experimental. Within the experimental group applied various factors over a period of 2 to 3 months till found foreign body cadculi in the bladder. On comparing the results of stone formation by foreign bodies in the bladder, found the following results: 1.Foreign body versus stone formation (zinc and lead); Zinc foreign bodies formed larger bladder stone than lead foreign bodies. 2.Sex versus stone formation; Male rats formed foreign bodies 11 times larger than those of the female group. 3.Diet Versus stone formation; a.Diet No. I group (spinach oleracea 5-10gm daily). This diet tended to accelerate slightly the formation of bladder stones. b.Diet NO. 2 group (grass 5-10gm daily). No apparent influence on formation of bladder stones. 4.Vitamin C versus stone formation; The experimental group received a total injection of 45-50㎎ of Vitamin C over a period of 62 days Stones in this group aged 50mg. however in the control group the average weight was 55.83mg. Vitamin C therefore would seem to have little influence on stone formation. 5.Insulin versus stone formation; The experimental group which received a total of 21 to 27.5 units of insulin over a period of 62 days showed a 35% increase over the average stone weight of the control group. 6.Estradiol Benzoate versus stone formation; An experimental group of male rats, after injection (over a 75 day period) of a total 1.2 to 2.35gm of estradiol benzoate. showed 70㎎ average stone weight, compared to 247㎎ weight for the control group, thus estradiol benzoate inhibits stone formation. 7.Testosterone propionate versus stone formation; An experimental group of female rats, after injection (over a 75 day period) of a total of 1.25 to 2.35gm of testosterone propionate showed 98.75㎎ average stone weight as compared to 69.0㎎ stone weight for the control group. Thus, testosterone propionate accelerates stone formation. 8.Stress versus stone formation; a.Cortisone; An experimental group of male rats, after injection (over 62 day period) of 6.3 to 8.25㎎ total of cortisone acetate, showed 140㎎ average stone weight as compared to 55.83㎎ for the control group. Thus cortisone accelerates stone formation. b.Cold; An experimental group of male rats refrigerated 60 minutes each day at 37℉, for 54 out of 62 days, showed 66.83㎎ average stone weight as compared with 55.83㎎ for the control group. Thus, short exposures to moderates cold have little effection stone formation. c.Ether anesthesia; Anesthesia, using ether-drip technique, was carried out on 46 of 64 days on a male rat experimental group. This group showed 140.83㎎ average stone weight as compared to 67.5㎎ for the control group. 9.Hyaluronidase(wydase) versus stone formation in male rats; After injection of a total of 330 to 345 TRU of hyaluronidase over a 78 day period, the experimental group showed 60.55㎎ stone weight as compared to 431.43㎎ for the control group. 10.Hyaluronidase(wydase) versus stone formation in female rats; Experimental group: 59.38 avetage stone reight, 705 TRU over 75 days. Control group: 69㎎ average stone weight. Thus hyaluronidase(wydase) greatly inhibits stone formation. 11.Climate versus stone formation; Stone formation was more accelerated in winter than in summer. Severe cold appears to be a stress ennancing formation.
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李神雄,李大富 忠南大學校 1973 論文集 Vol.12 No.-
This present experiment was performed to find out the etiologic factors of urolithiasis in the rats. We applied various factors to experimental group of rats over period of 60 days until foreign body calculi were formed in the bladder. Weight of stone of control group, inserted only zinc foreign body, was 38㎎ in male, 36㎎ in female. In the male group, stone formation was inhibited by cortisone, chlorpromazine and castration and was accelerated by estradiol. In the female group, it was accelerated by cortisone, testosterone, chlorpromazine and vitamin C.
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1. Amaranth, Brilliant Blue 및 Tartrazine이 鷄胎成長에 미치는 效果에 關한 硏究
이융창,예민해,이대부 忠南大學校 1972 論文集 Vol.11 No.-
The goal of this study is the analysis of the effects of amaranth, brilliant blue and tartrazine on the growth of chick embryos. On the 6th day of incubation, 2㎎ or 20㎎ of amaranth, brilliant blue or tartrazine was injected into the chorioalantoic membrane of each incubated egg. On 12th, 14th, 16th and 18th day of incubation, 10 treated eggs of each group were broken for weighing and the weights of body, brain, lung, heart and liver were measured. The authors used growth formula to analyse the growth pattern of eggs treated with respective color. The results are as follows: 1. Over dose of amaranth or brilliant blue produces remarkable growth inhibition in chick embryo. 2. The greater growth inhibition is occured in 20㎎ treated groups than in 2㎎ treated growth. 3. The growth inhibition produced by the over dose of tartrazine is a little more than nothing.
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