왜소음경증과 남성 성기능에 관한 연구

송윤섭,김민의,이남규,박영호,전윤수,김응구 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Micropenis is defined as a normally formed penis with a size greater than 2 standard deviations below the mean. Twenty three patients with micropenis were managed at Soonchunhyang University Hospital from January 1988 to December 1995 We interviewed and examined them with micropenis to investigate the cause of micropenis, concomitant diseases, the efficacy of treatment and their sexual activity in postpubertal men. The patients were divided into 2 groups: 16 prepubertal and 7 postpubertal men. 9 patients had cryptorchidism, 3 of them were bilateral and 5 patients had hypospadias. Etiology was determined by hormonal assay including HCG stimulation test ; 8 as hypogonadotrophic hypogonadism, 4 as primary testicular dysfunction and 5 as idiopathic. However etiology was undetermined in 6 patients. All patients had endocrine therapy using HCG or depot testosterone. All except 4 cases responded satisfactorily. All postpubertal patients(group 2) were below the 10th percentile. Puberty was delayed in 3 patients in the older group. All patients were heterosexual and they have had erections and orgasms. Five patients have had ejaculations, 3 of them were sexually active and they have experienced vaginal penetration, Nevertheless, their sexual partners have had complaints and the patients themselves have felt ashamed and dissatisfied. Fortunately, they were mentally healthy. None of these patients were married or had a child.

완충 용액의 유산 농도와 pH가 법랑질의 재광화에 미치는 영향

권중원,서덕규,송윤정,이윤,이찬영 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.6

There are considerable in vitro and in vivo evidences for remineralization and demineralization occurring Simul-taneously in incipient enamel caries. In order to "heal" the incipient dental caries, many experiments have been carried out to determine the optimal conditions for remineralization. It was shown that remineralization is affected by different pH, lactic acid concentrations, chemical composition of the enamel, fluoride concentrations, etc. Eighty specimens from sound permanent teeth without demineralization or cracks, 0.15 mm in thickness, were immersed in lactic acid buffered demineralization solutions for 3 days. Dental caries with a surface zone and subsurface lesion were artificially produced. Groups of 10 specimens were immersed for 10 or 12 days in lactic acid buffered remineralization solutions consisting of pH 4.3 or pH 6.0, and 100, 50, 25, or 10 mM lactic acid. After demineralization and remineralization, images were taken by polarizing microscopy (×100) and micro-computed tomography. The results were obtained by observing images of the specimens and the density of the caries lesions was determined. 1.As the lactic acid concentration of the remineralization solutions with pH 4.3 was higher, the surface zone of the carious enamel increased and an isotropic zone of the subsurface lesion was found. However, the total decalcification depth increased at the same time 2.In the remineralization solutions with pH 6.0, only the surface zone increased slightly but there was no significant change in the total decalcification depth and subsurface zone. In the lactic acid buffer solutions with the lower pH and higher lactic acid concentration, there were dynamic changes at the deep area of the dental carious lesion. 본 연구의 목적은 유산 완충 용액의 pH및 유산 농도 변화가 법랑질에서 인공 우식 병소의 재광화 양상에 미치는 영향을 평가하기 위함이다. 유산 완충 용액을 이용하여 법랑질을 탈회시키고, 유산의 농도가 100, 50, 25, 10 mM이고 pH가 4.3인 네 가지 재광화 용액 (Group 1, 2, 3, 4)에 10일, pH 6.0인 네 가지 재광화 용액 (Group 5, 6, 7, 8)에 12일간 처리한 후 무기질의 양적 변화를 편광 현미경에서 얻은 상에서의 탈회 깊이의 변화, 우식 표면층 깊이의 변화로 측정하였다. 또한 micro-computed tomography (micro-CT)를 이용하여 탈회 후와 재광화 후를 촬영하여 얻은 상으로부터 lesion부위의 density를 비교하였다. 1. pH 4.3에서 유산 농도가 증가할수록 우식 표면층의 증가와 표층하 탈회부 중 심층부의 isotropic zone등의 재광화 현상을 보이나, 전체 탈회 깊이 역시 증가하였다. 2. pH 6.0에서 우식 표면층에 국한된 재광화 현상을 보이고, 전체 탈회 깊이는 변화가 없었다. 이상의 실험 결과로 미루어 포화도가 일정한 유산 완충 용액으로 재광화 유도시 pH가 낮고 유산의 농도가 높을수록 표면으로부터 심층부 동역학적 변화에 더 영향을 주었으며, micro-CT를 이용한 우식 병소부위의 density 확인을 통해 무기질의 침착과 방출 현상을 객관적으로 평가할 수 있었다.

Cutaneous Sporotrichosis Presenting as Clinical Feature of Facial Cellulitis in an Adult

( Jun Gyu Song ),( You Bum Song ),( Sang Youl Yun ),( Moo Kyu Suh ),( Gyoung Yim Ha ),( Jung Ran Kim ),( Jong Soo Choi ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.4

조직배양 씨마늘과 주아의 소독 및 건조효과

송인규(Song In-Gyu),이정관(Lee Joung-Kwan),황세구(Hwang Se-Gu),윤태(Yun Tae),윤종선(Yun Jong-Sun) 한국원예학회 1998 원예과학기술지 Vol.16 No.3

Kerion Celsi Caused by Trichophyton verrucosum in an Adult

( Jun Gyu Song ),( Sang Youl Yun ),( You Bum Song ),( Moo Kyu Suh ),( Gyoung Yim Ha ),( Jong Im Lee ),( Jong Soo Choi ) 대한피부과학회 2016 大韓皮膚科學會誌 Vol.54 No.4

특발황반원공에 있어 Indocyanine green 염색을 이용한 내경계막제거술

송병용 ( Song Byeong Yong ) , 안규윤 ( An Gyu Yun ) , 서만성 ( Seo Man Seong ) 대한안과학회 2004 대한안과학회지 Vol.45 No.3

의이인탕 구성약물의 비만관련 연구 분석

송윤경 ( Yun Kyung Song ),차윤엽 ( Yun Yeop Cha ),고성규 ( Seong Gyu Ko ) 한방비만학회 2014 한방비만학회지 Vol.14 No.2

The purpose of this study is analyzed of exploratory research potential as anti-obesity agents of Euiiin-tang. Four Korean databases and 2 Korean Journals (Riss4U, KISS, OASIS, DBPIA, and Journal of Korean Rehabilitation Medicine, Journal of Korean Medicine of Obesity Research)were searched using search word ‘individual herbs’ and ‘obesity’, ‘weight loss’, ‘fat’, ‘hypertension’,‘hyperlipidemia’, ‘diabetes’. Clinical and Experimental Research published in the journal were analyzed, review research, studies of pharmacopunctures and studies of mixed herbalmedicine were excluded. We collected 23 studies. Seven studies of Coicis Semen, 10 stdies of Ephedra Herba, 2 study of Angelica gigas Nakai, 3 studies Atractylodis Rhizoma Alba, 1 studiesof Glycyrrhiza inflata Batal. Most studies were experiment researches which were composed ofin vivo or in vitro, and clinical trial was 5 studies of Ephedra Herba. Main constituent herb, CoicisSemen, Ephedra Herba were thought to represent an anti-obesity effect. Through the result, we can assume to be likely effect of Euiiin-tang as obesity medicine.

대나무 분말의 항산화력과 돼지의 면역 활성에 미치는 영향

송윤오 ( Yun O Song ),추교문 ( Gyo Moon Chu ),장선희 ( Sun Hee Jang ),구애진 ( Ae Jin Goo ),고응규 ( Yeoung Gyu Ko ),하지희 ( Ji Hee Ha ),이재형 ( Jae Young Lee ),강석남 ( Suk Nam Kang ),송영민 ( Young Min Song ),조재현 ( Jae Hyeo 한국동물위생학회 2014 韓國家畜衛生學會誌 Vol.37 No.2

본 연구는 대나무 분말의 항산화 활성이 비육돈에서 면역조절 효과에 미치는 영향을 구명하기 위해 실시하였으며, 이를 위해 대나무 분말 추출물의 항산화능을 검정하기 위하여, 총페놀 함량, 플라보노이드함량 및 DHHP, ABST, hydroxyl radical 등의 소거활성능을 알아보았다. 대나무 추출물의 항산화능은 높게 나타났으며, DPPH와 ABTS, HRSA 라디칼 소거능은 12∼21%였으며, 추출물의 유효성분으로 총페놀 함량은 171 mg/g이었으며, 플라보노이드 함량은 127.mg/g으로 나타났다. 다음으로 대나무 분말이 함유된 배합사료 급여시 돼지의 면역력에 미치는 영향을 알아보았다. 처리구에는 일반사료를 급여하였고, 시험구는 일반사료에 대나무분말을 1.0%, 2.0% 및 3.0%을 첨가하여 급여하였다. 대나무분말 첨가수준에 따라 혈액의 혈구계수 중 백혈구, 적혈구, 헤마토크리트 함량에서 유의적인 수준의 차이를 나타내지 않았다. 하지만 헤모글로빈 함량이 무처리 대조구에 비교하여 증가하였으며 특히 2∼3%의 처리구에서 헤모글로빈 함량은 높게 나타났다. 혈액 내 총단백질, 혈중알부민의 농도를 분석한 결과 처리구와 무처리구간에 유의적인 차이를 나타내지 않았다. AST, ALT 함량은 대나무 분말 처리군에서 무처리군보다 약간 높게 나타나지만 정상적인 범위내에서의 변화를 보였다. immunoglobulin에서 IgA와 IgG 농도는 무처리구에 비교하여 대나무 분말 처리구에서 높게 나타나고, IgA는 처리구 간의 차이가 나타나지 않았지만 IgG 농도에서는 대나무 추출물 2%, 3% 처리구가 1% 처리구에 비해 높은 수준을 나타냈다. TNF-α의 경우 무첨가구와 첨가구 사이의 유의적인 차이가 없었지만, 대나무 분말 첨가구에서 interferon-γ의 함량은 모든 첨가구에서 무처리 군보다 유의적으로 높게 나타났다. 특히 2%, 3% 처리구가 1%의 처리구 보다도 높은 interferon-γ의 함량을 나타내었다. 이는 대나무의 페놀, 또는 플라보노이드 성분에 기초한 높은 항산화력에 의하거나, 또는 대나무에 포함된 돼지 초기 면역반응을 활성화시킬 수 있는 물질에 의한 면역활성 증강에 따른 것으로 사료된다. 결론적으로 대나무 분말의 높은 항산화력은 돼지 면역력 향상에 기여하였으며, 특히 2∼3% 대나무 분말 첨가 사료는 돼지 생리활성을 크게 증강시키는 것으로 사료된다. The present study was designed to explore the antioxidant effect of Bamboo powder and its immunoreactivity in pigs. We investigated the functional properties of Bamboo extracts by means of measuring the contents of total polyphenols and flavonoid as well as determining ABST, DPPH radical scavenging activity, and hydroxyl radical scavenging activity and anticancer activity. The total phenolic compound and flavonoids contents of Bamboo extracts were 171.25 mg/g and 127.5 mg/g, respectively. The DPPH radical, hydroxyl radical, ABST radical scavenging activity of Bamboo extracts were 17.3%, 12.5% and 21.5%, respectively. Evidenced by MTT and cell cycle assay, Bamboo dose-dependently inhibited the cell proliferation and induced G0/G1-phase arrest in CHO cells at concentrations of 100, 250, and 500 μg/ml Bamboo extracts. More than 80% of apoptotic cells were observed by staining with annexin V in 500 μg/ml Bamboo-treated CHO cells, indicating that Bamboo had potent anticancer activities. Next, to investigate the effect of Bamboo on cytokine, immunoglobulin concentration, and blood compositions, flatting pigs were fed with Bamboo powder for 38 days. Flatting pigs were divided into 4 groups; basal diet (control), basal diet supplemented with 1% Bamboo powder (T1), 2% Bamboo powder (T2), and 3% Bamboo powder (T3). The level of hemoglobin increased in the all Bamboo-fed groups compared with the normal control group. In particular, platelet levels in the all Bamboo-treated groups increased by approximately 90% compared with the levels from pig on a normal control. Serum levels of immunoglobulins (IgG, IgA) in the pigs fed Bamboo powder were modestly increased, and the interferon-γ level also was strongly increased in 2% or 3% Bamboo-fed groups compared with the levels in control groups. Together, these results demonstrated that Bamboo extracts had an effective capacity of scavenging for ABTS, DPPH, and hydroxyl radicals and showed correlation with potent phenol and flavonoid contents, thus suggesting its antioxidant potential. Moreover, administration of Bamboo in 2∼3% improved blood parameters and platelets, and especially immunity-related ones such as IgG, IgA, and interferon- γ, leading to be potential feed additives in flatting pigs.

포스터 발표 : 경구스테로이드 투여로 치료한 특발성 후복막강섬유증 1예

이은규 ( Lee Eun Gyu ),오윤규 ( O Yun Gyu ),이중건 ( Lee Jung Geon ),이준승 ( Lee Jun Seung ),이영규 ( Lee Yeong Gyu ),송창섭 ( Song Chang Seob ),조성범 ( Jo Seong Beom ) 대한신장학회 2002 춘계학술대회 초록집 Vol.21 No.1

Fructosyltransferase 와 Glucose isomerase 혼합효소계를 이용한 프락토 올리고당의 생산

송승구,윤종원,이민규,노지선 한국화학공학회 1993 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.31 No.6

프락토 올리고당 생산 효소인 fructosyltransferase와 glucose isomerase와의 혼합효소계를 이용하여 새로운 조성의 프락토 올리고당 생산을 검토하였다. Fructosyltransferase의 효소화학적 특성인 glucose 저해현상을 glucose isomerase에 의해 낮추어 주었음에도 불구하고 프락토 올리고당의 전환률을 크게 증가시킬 수 없었다. 이 현상을 설명하기 위한 수학적 모델을 제안하고 실험을 통해 확인한 결과, fructosyltransferase 단일효소계와 비교할 때 혼합효소계의 경우 여러 가지 기질에 대한 동력학적 상수(K_m, K_l)의 값이 현저하게 달라짐을 알 수 있었다. Glucose isomerase에 의해 생성된 fructose는 fructosyltransferase에 의해 전이되지 않아 프락토 올리고당의 농도를 증가시켜 주지 못하는 것으로 보아 프락토 올리고당의 생산반응은 fluctosyltransferase의 selftransfer 반응에 의해서만 생성된다는 결론을 얻었다. The production of fructo-oligosaccharides having new composition was investigated using the mixed-enzyme system of fructosyltransferase and glucose isomerase. Despite of decrease in glucose concentration which acts as an inhibitor of fructosyltransferase during the production of fructo-oligosaccharides, the concentration of fructo-oligosaccharides was not high due to the altered kinetic parameters in the mixed-enzyme system. To confirm these results, a mathematical model for the mixed-enzyme system was proposed and compared with the experimental results, which showed good agreement with experimental data. Surprisingly, the K_m values and inhibition constant of glucose(K_(iG)) for fructosyltransferase in the mixed-enzyme system were different from those of fructosyltransferase alone. The fructose isomerized from glucose by glucose isomerase did not act as a sucrose acceptor, which meant the isomerized fructose did not play a part in the production of fructo-oligosaccharides.