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이상윤,라병욱,박동수,황인헌,이덕동,신영남,박성배,이동욱,박용석,박형근,손상호,권태근,채경락,정경득 慶北大學校 自然科學大學 1986 自然科學論文集 Vol.4 No.-
An Ac-type Plasma Display Panel (PDP) operating with Ne-Ar(0.1%) Penning mixture gas is fabicated. The characterics of the panel with electrodes covered with thin and thick dielectric layers are studied. The brightness of the Neon-orange light emitted by the panel measured as function of applied voltage and frequency. As an application, a graphic display system equipped with PDP showing still and moving pictures is made.
조경신,허영문,남상윤 전주대학교 1999 論文集 Vol.24 No.2
CD30 is a member of the tumour necrosis factor receptor(TNFR) superfamily, and was originally recognized on Reed-Sternberg cells of Hodgkin's disease and, subsequently, on neoplastic cells of non-Hodgkin's disease and normal activated T, B, NK cells and macrophages. Several studies on CD30 expression of malignant cells suggest that CD30 may define relevant subgroups within the main tumor or lymphoma categories. Despite many controversial reports, it is noteworthy that CD30 is expressed solely on Th2 cells but not on Th1 cells after complete differentiation, because, so far, any specific markers of Thl or Th2 cells have not been demonstrated. Expression and its maintenance of CD30 is also dependent upon IL 4 which is a pivotal cytokine for Th2 differentiation and downregulated by FNv, a Thl type cytokine. These observations implicate that CD30 may regulate Th2 cell differentiation or proliferation. At the clonal level, CD30 was revealed to promote Th2 differentiation. Various functions of CD30 from in vitro studies have been described: induction of cell proliferation, apoptosis and cytokine production, inhibition of cell cytotoxicity, enhancement of B cell growth and Ig secretion, induction of NF-KB activation and induction of HIV expression in chronically infected T cells. Although the function of CD30 in vivo is largely unknown, several exciting findings are emerging from recent studies. Mice deficient in CD30 showed a mild impairment in thymic negative selection. Recently, it has been suggested that CD30 protects the body from autoimmunity by limiting the proliferative potential of autoreactive cytotoxic T cells. Taken together, CD30 studies may provide important knowledge for elucidation of the immunopathogenesis of and development of therapeutic regimen of AIDS, autoimmunity and other Th2-related diseases.
Shin Hyunjae,Lee Ha Seok,Noh Ji Yun,고준영,Kim So-Young,Park Jeayeon,Chung Sung Won,Hur Moon Haeng,Park Min Kyung,Lee Yun Bin,Kim Yoon Jun,Yoon Jung-Hwan,Ko Jae-Hoon,Peck Kyong Ran,Song Joon Young,Shin E 대한면역학회 2023 Immune Network Vol.23 No.5
Coronavirus disease 2019 (COVID-19) vaccination may non-specifically alter the host immune system. This study aimed to evaluate the effect of COVID-19 vaccination on hepatitis B surface Ag (HBsAg) titer and host immunity in chronic hepatitis B (CHB) patients. Consecutive 2,797 CHB patients who had serial HBsAg measurements during antiviral treatment were included in this study. Changes in the HBsAg levels after COVID-19 vaccination were analyzed. The dynamics of NK cells following COVID-19 vaccination were also examined using serial blood samples collected prospectively from 25 healthy volunteers. Vaccinated CHB patients (n=2,329) had significantly lower HBsAg levels 1–30 days post-vaccination compared to baseline (median, −21.4 IU/ml from baseline), but the levels reverted to baseline by 91–180 days (median, −3.8 IU/ml). The velocity of the HBsAg decline was transiently accelerated within 30 days after vaccination (median velocity: −0.06, −0.39, and −0.04 log10 IU/ml/year in pre-vaccination period, days 1–30, and days 31–90, respectively). In contrast, unvaccinated patients (n=468) had no change in HBsAg levels. Flow cytometric analysis showed that the frequency of NK cells expressing NKG2A, an NK inhibitory receptor, significantly decreased within 7 days after the first dose of COVID-19 vaccine (median, −13.1% from baseline; p<0.001). The decrease in the frequency of NKG2A+ NK cells was observed in the CD56dimCD16+ NK cell population regardless of type of COVID-19 vaccine. COVID-19 vaccination leads to a rapid, transient decline in HBsAg titer and a decrease in the frequency of NKG2A+ NK cells.
申允卿,羅濬國,任奭中,孟琦錫 忠南大學校 1965 論文集 Vol.4 No.-
Catalytic oxidation of ammonia is as familiar to us as "Ostwald Process" in which platinum is adapted as a catalyst. Owing to the expensiveness of platinum, catalysts of base metal oxides are developed. The mixt ures of iron and bismuth oxide, iron and cobaltoxide, etc. are well known to give a good oxidation coefficient in the temperature range of 600℃~ 800℃. But their heat resistance is not so good and catalytic activity connot be maintained for a long period at high temperatures. Therefore oxidation of ammonia at low temperature with the base metal oxides is the important questions for consideration. The catalytic activities of the Fe-Bi-Ca three component system catalysts at low temperatures are examined. The results of the preliminary and main experiments are summarized as follows. Using the catalysts of the Fe-Bi-Ca three component system, the following similarities are found. Oxides of nitrogen begin to be generated at a temperature of 300℃; at a temperature of 400℃, the oxidation coefficient of ammonia to oxides exceeds 10% ; above the temperature of 400℃, the higher the temperature, the greater the reaction of the oxidation coefficient of ammonia to the oxides. Among the catalysts of the Fe-Bi-Ca three component system, the Fe:Bi ratio is fixed to 97.5: 2.5 and only the calcium percentage is variable. Catalyst composed of Fe(96.3%), Bi(2.72%) and Ca(0. 98%), shows the highest oxidation coefficient and as the calcium percentage increases in the ternary system, the catalytic activity decreases. Oxidation of ammonia is remarkably influenced by the variation of flow rate of mixed gas. Considering the oxidation coefficient to nitrogen oxides and the decomposition coefficient separately, the oxidation coefficient to the oxides is gradually raised with the increase of the flow rate. On the other hand, the coeffiicent is decreased as the flow rate increases. The total oxidation coefficient is reduced as the result of summation of the two factors above. And the unchanged percentage of ammonia increases with the increase of flow rate.
돼지에서 정맥, 근육 그리고 경구 투여시의 enrofloxacin의 약물동태학
윤효인,김무열,박승춘,조준형,박병권,이내경,노상석,장범수,신광순,조명행 충남대학교 수의과대학 동물의과학연구소 1996 動物醫科學硏究誌 Vol.4 No.-
In order to characterize pharmacokinetic profiles according to route of a new enrofloxacin salt form (Enrotil®), it was given to 4 healthy pigs via oral (p.o.), intramuscular (i.m.) or intravenous (i.v.) administrations at a dose rate of 5 ㎎/㎏ body weight. Enrofloxacin (ENFX) in serum was detected by bioassay using E. coli BE1186 as a test organism. The biological elimination half-lives (t_1/2(β)) of ENFX were 6.76±0.99 h (i.v.), 7.16±2.30 h (i.m.) and 11.45±3.90 h (p.o.), Volume of distribution (Vd) of enrofloxacin was 2.20±0.31 L/㎏ (i.v.), 2.52±0.60 L/㎏ (i.m.) and 1.88±0.33 L/㎏ (i.m.). Mean residence time (MRT) was 8.77±1.26 h after i.v. injection and the maximal concentration time (Tmax) following p.o. and i.m. administration was 0.76±0.09 h and 0.60±0.12 h, indicating a rapid absorption from these routes. Bioavailibility (F) was calculated as 64.1% for p.o. administration and 59.71% for i.m. injections. In summary, the newly formulated enrofloxacin salt form has shown a high water solubility, rapid absorption and large tissue distribution, suggesting a potential antibacterials for oral application on a large scale in veterinary sectors.
Kyong Min Park(박경민),Jae-Wook Chung(정재욱),Jun-Koo Kang(강준구),Teak Jun Shin(신택준),Se Yun Kwon(권세윤),Hyun Chan Jang(장현찬),Yun-Sok Ha(하윤석),Seock Hwan Choi(최석환),Wonho Jung(정원호),Jun Nyung Lee(이준녕),Byung Hoon Kim 대한비뇨기종양학회 2020 대한비뇨기종양학회지 Vol.18 No.1
Purpose: The aim of this study was to analyze the perioperative complications and oncological outcomes of radical prostatectomy (RP) in patients who underwent multiple prostate biopsies. Materials and Methods: A total of 1,112 patients who underwent RP between January 2009 and April 2016 at 4 different centers were included in this study. We divided these patients into 2 groups: patients who underwent only 1st biopsy, and those who underwent 2nd or more repeated biopsies. The association between the number of prior biopsies and perioperative complications and biochemical recurrence (BCR) was analyzed. Results: Of 1,112 patients, 1,046 patients (94.1%) underwent only 1st biopsy, and 66 (5.9%) underwent 2nd or more repeated biopsies. There were no significant differences in preoperative prostate-specific antigen levels, operation times, blood loss volumes, or hospital stay durations (all p>0.05). Patients who underwent multiple prostate biopsies presented with a localized tumor significantly more often (p<0.05). The Gleason score and rate of positive surgical margins were significantly lower in patients with multiple biopsies (all p<0.05). The Cox proportional hazards model analysis indicated that there was no association between the number of prior prostate biopsies and BCR (p>0.05). Kaplan-Meier curve analysis indicated that BCR-free survival rates between the 2 groups were similar (p>0.05). Conclusions: Multiple prostate biopsies are not associated with an increased risk of perioperative complications, adverse pathological outcomes, or higher rates of BCR in patients who have undergone RP.