Serial values for hematologic and biochemical analysis after myocardial infarction in rats

( Mi Jin Lee ),( Hyun Jin Tae ),( Ying Hua Li ),( Do Hyeon Yu ),( In Ae Han ),( Seok Won Lee ),( Dong Choon Ahn ),( In Shik Kim ),( Jin Ho Park ) 한국가축위생학회 2008 韓國家畜衛生學會誌 Vol.31 No.2

To diagnose acute myocardial infarction(MI), many cardiac markers have been used in hematologic and biochemical analysis, and many studies have been published for hema-tologic and biochemical analysis associated with human acute MI. However, after occurrence of acute MI, the serial investigation for values in hematologic and bioche-mical analysis including chronic MI has rarely been performed. To observe the change of the serial values in hematologic and biochemical analysis, we induced artificial MI. The left main descending artery(LMDA) of the left coronary artery was ligated during the progression(day 1, 3, 5, 7, 14 and 30) of MI. Total 66 Sprague-Dawley rats were divided into the sham group(n=24, thoracotomy without LMDA ligation) and the experimental(MI) group(n=42, with LMDA ligation). And all individual in each group was sacrified at day 1, 3, 5, 7, 14 and 30 for the hematologic and biochemical analysis. In comparison of hematologic analysis between the sham and MI groups, the mean values of red blood cell(RBCs), hemoglobin and hematocrit(HCT) showed a steady increase. In biochemical analysis, the mean values of glucose, choles-terol, total creatine kinase(CK) and isoenzyme MB, and lactate dehydrogenase(LDH) were increased in all MI groups compared with the sham groups. The results of this study suggest that early hematologic and biochemical mean values occurred after acute MI are similar to those of human acute MI. In conclusion, we could observe the alterations and serial values in hematologic and biochemical analysis to the extent of chronic status after acute MI.

Serial values for hematologic and biochemical analysis after myocardial infarction in rats

Lee, Mi-Jin,Tae, Hyun-Jin,Li, Ying-Hua,Yu, Do-Hyeon,Han, In-Ae,Lee, Seok-Won,Ahn, Dong-Choon,Kim, In-Shik,Park, Jin-Ho The Korean Society of Veterinary Service 2008 韓國家畜衛生學會誌 Vol.31 No.2

To diagnose acute myocardial infarction (MI), many cardiac markers have been used in hematologic and biochemical analysis, and many studies have been published for hematologic and biochemical analysis associated with human acute MI. However, after occurrence of acute MI, the serial investigation for values in hematologic and biochemical analysis including chronic MI has rarely been performed. To observe the change of the serial values in hematologic and biochemical analysis, we induced artificial MI. The left main descending artery (LMDA) of the left coronary artery was ligated during the progression (day 1, 3, 5, 7, 14 and 30) of MI. Total 66 Sprague-Dawley rats were divided into the sham group (n=24, thoracotomy without LMDA ligation) and the experimental (MI) group (n=42, with LMDA ligation). And all individual in each group was sacrified at day 1, 3, 5, 7, 14 and 30 for the hematologic and biochemical analysis. In comparison of hematologic analysis between the sham and MI groups, the mean values of red blood cell (RBCs), hemoglobin and hematocrit (HCT) showed a steady increase. In biochemical analysis, the mean values of glucose, cholesterol, total creatine kinase (CK) and isoenzyme MB, and lactate dehydrogenase (LDH) were increased in all MI groups compared with the sham groups. The results of this study suggest that early hematologic and biochemical mean values occurred after acute MI are similar to those of human acute MI. In conclusion, we could observe the alterations and serial values in hematologic and biochemical analysis to the extent of chronic status after acute MI.

역행성 심정지 도관 삽입을 위한 술 중 경식도심초음파의 유용성

유미숙;최원주;김정원;박장수;김경태;김지연;어상일 인제대학교 2011 仁濟醫學 Vol.32 No.-

Background: Retrograde cardioplegia catheter (RCC) insertion is one of methods for administration of cardioplegics during cardiopulmonary bypass (CPB). However its success rate depends on only surgeon's experience. We thought the transesophageal echocardiography (TEE) can guide the R CC insertion, because TEE is commonly used for monitoring status of heart during cardiac surgery. This study was designed to evaluate the RC C insertion time by TEE guidance versus conventional method without T EE guidance. Methods: Sixty patients who were scheduled to undergo elective coronary artery bypass graft (CABG) surgery under general anesthesia were divided into groups as follows: group T [RCC insertion into coronary sinus (CS) by TEE guidance, n=30] and group C [RCC insertion into CS by conventional method, n=30]. We recorded the time of insertion of RCC in to CS in two groups. RCC insertion was done by TEE guidance in case that time was over two minutes by conventional methods in group C. Results: The overall time of RCC insertion into CS was 63.8 ± 23.6 seconds in the Group T and 102.3 ±55.7 seconds in the Group C, respectively (p=0.001). There were no complications during RCC into CS by T EE guidance. Conclusions: TEE guidance for RCC insertion into CS is shorten the time of insertion.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

제 1형 신경섬유종증 환자에서 발생한 위장관 간질종양 1예

원경준,이준,변유미,조민근,한경택,김원,홍란,임성철,김경종,김영대,박찬국,김만우 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Gastrointestinal stromal tumor (GIST) is the most common non-epithelial neoplasm arising in the gastrointestinal tract, but this tumor is rarely seen in association with type l neurofibromatosis (NFl) Generally, the majority of GISTs are isolated neoplasm and they are sporadically found in the stomach, but the GISTs in NFl patients are usually multiple and usually found in the small intestine. We report a case of multiple GISTs in the jejunum of a 63-year-old woman diagnosed as NFl accompanied by complication of gastrointestinal bleeding, In this case, Patient had multiple cafe-au lait spots and neurofibroma on skin and had freckling on axilla and groin, and then, we made a diagnosis of NFl. Gastrointestinal bleeding is controlled by resection of multiple GISTs. Generally, only 3-5% of all gastrointestinal bleeding comes from the small bowel. Causes of small intestinal bleeding are angiodysplasia, neoplasm, NSAIDs induced ulcer etc. but, If patients have NFl accompanied by complication of gastrointestinal bleeding, GISTs on small bowel must be considered.

치경부 5급 와동 수복물의 표면 거칠기와 미세누출에 관한 연구 : 표면 전색의 효과

김민정,이미정,유미경,박수정,이광원 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.1

The purpose of this study was to compare the effect of surface sealing materials on microleakage and surface roughness in Class V composite restorations. Twenty five standardized Class V cavity preparations were made on the facial surface of human premolars and were randomly assigned to 5 groups. The teeth were restored with Z-250 after applying Single Bond. Following 7 days storage in distilled water at 37℃, the restorations were sealed as following systems : No sealing ; Single Bond Adhesive ; Biscover ; Fortify ; Optiguard. Then, toothbrush abrasion test was conducted using a wear testing machine. Surface roughness was measured by means of profilometer before and after toothbrushing and the results were statistically analysed by using a paired t-test and ANOVA. The bonded interfaces and the changes of surface roughness were examined by SEM. For microleakage test, specimens were stained in a 2% methylene blue solution, then longitudinally sectioned and analyzed for leakage at occlusal and cervical interfaces using stereomicroscope. The results were statistically analysed by using a Kruskal-Wallis and Mann-Whitney U test. Surface roughness was increasing in all groups after toothbrushing, but no statistically significant differences. In SEM observation, surface sealant was partially retained and partially detached in bonded interfaces. Especially, microgap was identified in cervical margins. In microleakage test, there was better seal in the enamel region and a significant difference between groups at occlusal margin. Control group and Single Bond group had significantly better marginal seal at enamel margin than cervical margin. 수복물의 변연 미세 누출과 마모 개선을 위해 표면 전색제가 개발되었으며 이의 효과에 대해 알아보기 위해, 규격화된 치경부 5급 와동을 25개의 소구치의 협면에 형성하고 Single Bond와 Z-250으로 수복한 뒤, 37℃의 증류수에 7일간 보관한 후 무작위로 5군으로 나누고 다음과 같은 재료로 제조사의 지시에 따라 표면 처리하였다 : No sealing ; Single Bond Adhesive ; Biscover ; Fortify ; Optiguard. 그 후 잇솔질 마모시험을 시행하였다. 표면 조도는 잇솔질 전후에 profilometer로 측정되었고 paired t-test와 ANOVA로 비교하였다. 접착면과 표면변화는 전자현미경으로 관찰하였다. 미세누출 평가를 위해 시편은 2% methylene blue 용액으로 염색한 뒤, 협설로 잘라 제작하였다. 입체현미경을 이용하여 교합면쪽과 치경부쪽 계면에서 미세누출을 관찰하고 Kruskal-Wallis와 Mann-Whitney U test를 이용하여 그 결과를 비교하였다. 표면 조도는 잇솔질 후 수치가 증가하였으나 통계학적으로 유의한 차이를 나타내지는 않았다. 전자 현미경 관찰 결과, 표면 전색제가 접착면에 부분적으로 남아있기도 하였으나 많은 부분에서 떨어져 나간 상태였다. 특히, 미세 틈새가 치경부쪽 변연에서 나타났다. 미세누출 실험에서는 법랑질에서 더 봉쇄효과가 좋았으며 교합면쪽 변연에서 군간에 유의할만한 차이를 나타내었다. 조절군과 Single Bond를 도포한 군에서는 치경부쪽 변연보다 법랑질쪽 변연에서 유의하게 좋은 변연 봉쇄 효과를 나타내었다.

학습자 말뭉치를 이용한 한국어 학습자 오류 분석 연구

김유미 연세대학교 한국어학당 2002 외국어로서의 한국어교육 Vol.27 No.-

Teaching Korean as a Foreign Language, 27, 141∼168. Developing Korean learners' corpus of Korean as a foreign language and analyzing its learners' errors enable to figure out the properties of their interlanguage. However the previous studies are lack of researched without many relevant materials or resources, so it was hard to draw some generalization. In addition, they limit the themselves in reviewing or analyzing the restricted linguistic facts by disregarding various data, but focused on small numbers of linguistic materials. In order to overcome this difficulty, a corpus can be used ; it does not only retain a large amounts of materials, but also studies diverse linguistic capabilities in Korean studying. To develop Korean learners corpus, it needs to collect materials such as writing tests and papers from language education centers of three domestic universities and develop a raw corpus by entering those materials in the database system. Furthermore, it is required to mark up the personal information for the raw corpus, and tag the grammatical annotation for Korean education. For this, it is necessary to create a collection or dictionary of Korean errors in usage, attach error tags and classify them. First, researching the occurrence rate of errors and the usage frequency by part of speech should be surveyed. Then the errors by the spearkers of different mother tongues such as English and Japanese can be analyzed. The particles among lexical categories are investigated for the analysis of errors. Case particles, auxiliary particles, and conjunctive articles are included. Case particles such as nominative, objective, possessive, and adverbial are divided by omission, addition, and replacement to analyse error patterns. The main factors of errors are interference of mother tongue, simplification, and the overgeneralization affected by the compound of target language structures. Besides, avoidance is regarded as a psychological factor for the errors. To determine how the error patterns of particles are related with learners' level of the study in Korean. We analyzed the data of Korean learners based on the Japanese language culture. The errors rate decreases as the level goes up to the advanced. In addition, the repeated study is essential sauce the some error pattern shown a the level of the beginners still appears in the advanced level. To prevent the particle errors, it is desirable to provide the beginners with the basic grammar explanations and the example of actual errors to the beginners. For the intermediate and the advanced, the corpus concordance, the information of sentence patterns including particles related to specific verbs can be given in term of the corpus concordance. (KyungHee University)

스포츠 센터의 실내공기오염(미세먼지)에 관한 연구

김유미,이한경 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.14 No.2

In this study, to present materials that could cognize problems on influence environment of center to directors's, exerciser's health, and standard materials which keeping indoor envronment comfort, selected 7 sports centers in Seoul, Keunggido at random, then measured micro-mote concentration, temperature, humidity, noise and so on. The result of this study is followed. 1) The mean micro-mote concentration for total measurement time each sports center is different by ventilation facilities regardless of the ground, underground floors. The centers under 150㎍/㎥ standard value are W2(67.58±13.65㎍/㎥), G(102.95±33.04㎍/㎥). Classified by time zone, the result of two-way ANOVA for interaction plot each center, Classified by time zone, the result of two-way ANOVA for interaction plot each center,centers relate to interaction among time zone(p<.01) is voluntary statistically. Each center micro-mote concentration(p<.01) is voluntary statistically, micro-mote concentration among time zone(p>.05) isn't voluntary statistically 2) The mean temperature for total measurement time each sports center is the higher or lower about ±1°C than standard extent of indoor temperature, 19~22°C. Classified by time zone, the result of two-way ANOVA for interaction plot each center, centers relate to interaction among time zone(p<.01) is voluntary statistically. Each center temperature(p<.01) is voluntary statistically, temperature among time zone(p<.01) is voluntary statistically. 3) Classified by time zone, the result of two-way ANOVA for interaction plot each center, centers relate to interaction among time zone(p<.01) is voluntary statistically. Each center humidity(p<.01) is voluntary statistically, humidity among time zone(p<.01) is voluntary statistically. 4) The mean noise for total measurement time each sports center is the higher than standard extent of noise, daytime 65~75㏈, nighttime 55~70㏈. Classified by time zone, the result of two-way ANOVA for interaction plot each center, centers relate to interaction among time zone(p<.01) is voluntary statistically. Each center noise(p<.01) is voluntary statistically, noise among time zone(p<.01) is voluntary statistically. 5) Interrelation the number of Occupants and micro-mote concentration of centers is approved to passive interrelation in nighttime(r=0.24734, p<0.001), isn't in A.M.(r=0.01739), P.M.(r=0.07494).

흡연 대학생의 식생활 태도 및 식사의 질에 관한 연구

김은미,장유경 漢陽大學校 韓國生活科學硏究所 2000 韓國 生活 科學 硏究 Vol.- No.18

It has been proposed that differences in diet between smokers and nonsmokers may partially explain the positive association between cigarette smoking and chronic diseases such as cancer and coronary heart disease. In order to investigate the effect of smoking on nutrient intake and dietary attitude in 220 college men, interviews using questionnaires were done. Dietary intake was determined by a 24-hour recall method. Dietary habit score was not significantly different between smoker and nonsmoker group. But there was improved irregularity of meal and overeating in the diet of smokers group. There was fair score of dietary behaviors in smokers(62.10) and nonsmokers(62.86) groups. The overall diet quality was assessed by RDA(recommendation dietary allowance) for Korea, NAR(nutrient adequacy ratio), MAR(mean adequacy ratio) and INQ(index of nutritional quality). Ca was seriously deficient nutrient in smokers and nonsmokers. Fe, vitamin A, niacin and vitamin C intakes were lowered both smokers and nonsmokers groups. Smoking dose was negatively associated with vitamin A and β-carotene intakes. Periods of smoking was negatively with exercise and irregularity of meal intakes. Therefore, the increased ingestion of vitamin A , C and β-carotene, regularity of meal intake and exercise may help to prevent risk of cancer and coronary heart disease.

근관 내 불규칙 확장부에서 sealer 적용방법에 따른 충전 효과 평가

김성용,이미정,문장원,이세준,유미경 大韓齒科保存學會 2005 Restorative Dentistry & Endodontics Vol.30 No.1

본 실험은 resin 시편을 이용하여 미리 제작한 근관 내 불규칙 확장부에서 근관 충전용 sealer의 적용 방법에 따른 충전 효과를 평가해 보았다. Endo-training Bloc을 절단하여 사십 개의 규격화된 resin 블록 시편을 획득하였다. 각각의 시편에 $, 08taper GT 파일을 사용하여 근관을 형성하였고 근관에 손상이 가지 않도록 시편을 양분한 후 양분된 시편의 한 쪽 근관 벽에 다양한 근관 내 확장부를 표현하는 구를 형성하였다. 양분된 시편을 결찰하고 절단 부위를 밀봉하였으며 AH26 sealer를 사용하여 단일 cone 충전법으로 근관을 충전하였다. 네 가지의 근관 충전용 sealer의 적용방법을 이용하였다: A군,$ K-file : B군, ultrasonic file : C군, lentulo spiral: D군. EZ-Fill bi-directioanl spiral. 모든 시편은 37˚상대습도에서 1주일간 보관한 후 각 시편을 근단에서 3mm, 4mm, 5mm 부위에서 수평으로 절단하고 각각의 절단면을 위상차현미경과 디지털 카메라를 이용하여 30배율로 관찰하고 촬영하였다. 관찰된 절단면은 scoring system을 이용하여 점수를 산정하였고 각 군 간의 통계적인 유의성 유무는 Fisher's Exact Test를 이용하여 시행하였다. The aim of this study was to evaluate the effectiveness of sealer placement in simulated root canal extensions. Forty resin blocks were attained from the Endo-training Bloc. In each block. The simulated root canal was made with $, 80taper GT file. After each block was longitudinally split into two halves, a standardized groove was prepared on one canal wall of two halves to simulate the canal extensions with various irregularities. The two halves of each block were assembled and all simulated root canals were obturated by single cone method with AH26 sealer. Four different methods of sealer placement were used: group A, $ K-file; group B, ultrasonic file; group C, lentulo spiral; group D, EZ-Fill bi-directional spiral. All obturated blocks were stored in 100% humidity at 37℃ for 1 week, Using a low speed saw, each block was sectioned horizontally. Images of the sections were taken using a stereomicroscope at 30 magnification and a digital camera. The amount of the sealer in the groove was evaluated using a scoring system, a higher score indicated better sealing effectiveness. The data was statistically analysed by Fisher's Exact Test. The sealing score was the lowest, specially at the middle area of canal extensions in group A, and that was statistically significant difference from other groups. In conclusion, the ultrasonic file, lentulo spiral and EZ-Fill bi-directional spiral were effective methods of sealer placement in simulated canal extensions. The K file was the least effective method, specially at the middle area of canal extensions.