남성화 암쥐의 모리스 수중 미로 수행력 : 성에 따른 공간기억력과 테스토르테론 효과의 차이

신성현,박제민,정우영,박문일,서유나,김성곤,강철중 大韓神經精神醫學會 2007 신경정신의학 Vol.46 No.5

Objectives : It is widely accepted that gonadal steroids are involved in organization and activation of sexual dimorphism in the brain areas related with spatial leaming. This study aimed to test the following hypothesis : 1) spatial memory is affected by sex, 2) this difference is related with brain differentiation by exposure to testosterone in the neonatal period, and/or 3) the sexual difference of spatial memory is the result of the interaction between organization of sexual dimorphism in the brain and the circulating testosterone after growing up. Methods : Testosterone enanthate 100 ㎍, ('androgenized') orvehicle ('control') was randomly administered to 28 female and 25 male rat pups within 24 hour of birth. The escape latencies (EL) in Morris water maze were measured in 15 and 16 week of age with vehicle ('baseline') and with 10 μmol/kg of testosterone ('with testosterone'), respectively. Each session Consis-ted of 10 trials, and means of the last 5 trials were analyzed. Results : The baseline EL of the males were significantly shorter than females regardless ofneonatal exposure to testosterone. With testosterone, EL of the androgenized females were significantly shorter than control females and comparable to those of males. Conclusion : Neonatal exposure to testosterone in female rats may develop a tesosterone-dependent male-like spatial leaming system.

Ruled Surface로 형성된 임펠러 블레이드 전용 CAD/CAM 시스템 개발 Ⅱ : 5-축 가공에 관한 연구 A Study on the 5-Axis Machining

조현덕,정대일,윤문철,최두선,신보성,이응숙,董玉革 한국공작기계학회 2002 한국생산제조학회지 Vol.11 No.3

This study is continuous with the study 1 (A Study on the Modeling) and the sample impeller of this study is defined by the modeling process of the exclusive CAD/CAM system developed in the study I. And, this study describes a method for the 5-axis machining of impeller blades formed by ruled surface. Therefore, the exclusive CAD/CAM system is the software for modeling and machining of impeller blades. By using the machining method suggested in this study, we could manufacture impeller blades on 5-axis CNC machining center and the machined impeller was very agreeable to the designed impeller. Thus, theories proposed in this study can be very useful for the 5-axis machining of impeller blades.

Ruled Surface로 형성된 임펠러 블레이드 전용 CAD/CAM 시스템 개발 Ⅰ : 모델링에 관한 연구 A Study on the Modeling

조현덕,정대일,윤문철,최두선,신보성,이응숙,董玉革 한국공작기계학회 2001 한국생산제조학회지 Vol.10 No.6

We have developed the exclusive CAD/CAM system for the machining of impeller blades. This study is about the modeling method for the effective machining of impeller blades formed by ruled surface. As the impeller is consisted of boss part and blade part, the boss is modeled by rotational surface of hub curve on z-axis and the blade is described by ruled-surfaces between hub curve and shroud curve. This modeling process can be carried out on the software developed in this study. And, the developed software can describe the impeller as a solid model through interface with Solid-Works software. The developed software containing the interface method proposed in this study was very effective for impeller modeling.

行列多項式 Liapunov 函數 構成에 依한 誘導電動機의 安定度 解析

李鉉雨,黃有燮,李浚析,文在星 慶南大學校 附設 工業技術硏究所 1988 硏究論文集 Vol.6 No.-

非線形 시스템을 나타내는 狀態空間의 動特性 모델로부터, 定常狀態 값들이 알려지면, 行列多項式에 依해, Scalar Type의 Liapunov 函數를 構成하고 이를 誘導電動機의 安定解析에 適用시킨다. 線形 시스템에 對한 Liapunov 函數의 構成法은 잘 알려져 있으나, 非線形 시스템의 Liapunov 函數 構成法은 아직 體系化되어 있지 못하다. 따라서, 本 論文에서는, 從來의 定常狀態 附近에서의 Taylor 展開에 依한 線形化 技法에 依存하지 않고, 非線形性을 나타내는 項을 分離하여, 行列變換시킴으로서, 線形시스템의 Liapunov 函數 構成法을 살리고, 非線形性이 强한 誘導電動機의 狀態空間모델에 適用시켰다. 그 結果, 求해진 安定領域은, 線形化에 依한 것보다는 훨씬 넓은 5次元의 超空間으로 表現되는 誘導電動機의 漸近安定領域이 되었다. In this paper, when the steady state values for multidimensional and nonlinear Dynamic Models of State Space Representations are given, Liapunov functions of scalar types using matrix quadratic polynomials are constructed by Special Matrix Transformation Techniques and are applied to Stability Analysis of Induction Motors. Futhermore, Liapunov function construction precedures for linear systems can be specified in detail. But, unfortunately, for nonlinear systems, there are no the complete construction techniques. In this paper, differently from conventional methods using Linearization obtained from Taylor series expansions about steady state operating points. Linear terms and nonlinear ones are individually seperated, and by special matrix transformation techniques, similiar construction procedurs such as in the cases of linear systems, are introduced, and are applied to Stability Analysis of Induction Motor. The hyperspaces of multidimensional stability region, obtained from these techniques, were larger than the obtained ones from conventional linearlization techniques about equilibrium points and were assured to be Asymptotic Stability Region ensuring the stable operation of Induction Motor.

남성유방에서 발생한 침윤성 선암종 1 예 : Report of a case

정유경,문현준,전호종 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Male breast cancer is rare compared to female breast cancer, about 1% or all breast cane or. The cause of male breast cancer is as poorly understood, but several etiologic factors have been suggested in the literature. Proposed risk factors include exogenous estrogen exposure, Klinefelter’s syndrome, gynecomastia and familial clustering. All of the microscopic types identified in the female breast have been encountered in males : the most common type is infiltrating duct carcinoma. Most often, it presents as a painless lump and subareolar in origin. Comparison with female breast cancer reveals no difference with regard to incidence of positive axillary lymph nodes. However there is a sightly lower survival rate for men. The stage of disease is the only parameter that significantly affects outcome. We report a case of breast cancer arising right subareolar area in a 57 year-old male. There were no familial history, Klinefelter's syndrome and microscopic evidence of gynecomastia. Histologically, this tumor was infiltrating duct carcinoma disposed in nests sometimes glands .

폐렴 구균(Streptococcus pneumoniae)에 의한 척수 경막외 농양 1예

이지영,위유미,손경목,기현균,문치숙,오원섭,백경란,송재훈 대한감염학회 2004 감염과 화학요법 Vol.36 No.6

폐렴구균은 보통 폐렴이나 뇌막염을 일으키는 균으로 척수 경막외 농양을 일으키는 경우는 매우 드물다. 본 저자들은 폐렴 구균에 의한 척수 경막 외 농양을 경험하여 보고하는 바이다. 과거 건강했던 36세 남자 환자로 사다리에서 낙상한 후 요통 및 고열, 신경학적 이상으로 내원하여 자기 공명 촬영 결과 척수 경막 외 농양으로 진단받고 항균제 투여와 함께 응급 수술을 시행하였다. 농 배양 결과 페니실린 감수성인 폐렴 구균이 분리 되었고, 수술 요법과 항생제 투여 후 농양은 치유되었으나 신경학적 이상은 호전 없는 상태로 타원으로 전원되었다. Pneumonia and meningitis are the most frequent manifestations of pneumococcal infections. Pneumococcal spinal epidural abscesses have been rarely reported. Spinal epidural abscess by Streptococcus pneumoniae has been diagnosed among the patients with diabetes mellitus, alcoholism, corticosteroid therapy, intravenous drug use, chronic renal failure, AIDS, and history of spinal surgery. Recently, we experienced a case of pneumococcal spinal epidural abscess after spinal trauma. A 36-year-old male patient was admitted with back pain, fever, and paraplegia which occurred 5 days after the trauma. Spine MRI revealed spinal epidural abscess at the level from T2 to T9. He was treated with antimicrobial agents and surgical exploration for spinal epidural abscess. Pus culture grew S. pneumoniae which was susceptible to penicillin. Despite early surgical treatment, neurologic sequelae remained. Considering the high mortality and morbidity of pneumococcal spinal epidural abscess, early diagnosis and aggressive treatment including surgical intervention and antibiotics therapy should be implemented immediately.

Acylthiocholine의 합성

정두희,이지현,박유미,정대일,곽문정,신영주 東亞大學校附設基礎科學硏究所 1998 基礎科學硏究論文集 Vol.15 No.2

Choline esters that are used with substrate of EE-AChE-catalyzed hydrolyses were synthesized by two methods. 2-Chloroethyl thiohexanoate 4a, 2-chloroethyl thioheptanoate 4c, and 2-chloroethyl thiooctanoate 4b were synthesized by treatment of hexanoyl chloride 3a, heptanoyl chloride 3c, and octanoyl chloride 3b with ethylene sulfide 2. Hexanoylthiocholine 6a and octanoylthiocholine 6b were synthesized by using 4a and 4b with trimethylamine 5. Secondly after reaction ethylene sulfide 2 with dimethyl amine 7 and acylation by acid anhydride 8, heptanoylthiocholine 6c, decanoylthiocholine 6d were synthesized by treatment of methyl iodide.

신규간호사와 프리셉터가 인지하는 프리셉터의 교수효율성 비교

김지양,김영선,김춘실,박현숙,신미영,윤연숙,조유숙,박미미,유문숙 한국간호과학회 간호행정학회 2009 간호행정학회지 Vol.15 No.2

Objective: The purpose of this study was to compare preceptors and new graduate nurses on their perception of preceptor teaching effectiveness. Methods: The participants were 90 new nurses and 90 preceptors who worked in A medical center. The data were collected from July 1 to September 30, 2008. A cross-sectional descriptive survey was done using a structured questionnaire. Results: New nurses' perception (4.07±.44) of the preceptor teaching effectiveness was significantly higher than perception of the preceptors (3.57±.37). Fifty five percent of new graduate nurses reported a lack of coherence in the preceptor's practice guidelines. For 5 causal factors classified on the teaching effectiveness, the factor of 'Professional knowledge and ability' showed the highest score, but 'Interpersonal and communication skill' got lowest score for both group. Preceptors responded that they did not have enough time to teach well because of their heavy workloads. Conclusions: These results suggest that the preceptors need appropriate compensation and education opportunities, and new graduate nurses need consistent education by the teaching professionals. Therefore, it is important to give preceptors full charge of the preceptorship. Also, it will be necessary to develop education programs to enhance interpersonal and communication skill for preceptors and new nurses.

폐결핵으로 오인된 SIADH를 동반한 편평상피 세포폐암 1예

김순제,류하근,김선두,이길도,박봉안,류주성,유재등,김인숙,신현준,문언수 대한노인병학회 1999 Annals of geriatric medicine and research Vol.3 No.4

Highly concentrated hylauornic acid filler effects in the usage of correcting nasolabial folds: a 24-month extension study

( Hyun Ji Kang ),( Tai Kyung Noh ),( Hye Rim Moon ),( Ji Su Yu ),( Sung Eun Chang ),( Ik Jun Moon ),( Sun Young Choi ),( Won Jong Oh ),( Chong Hyun Won ),( Beom Joon Kim ),( Yang Won Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2

Background: A six-month study using the novel hyaluronic acid (HA) filler, PP-501-B, presented improvement of nasolabial fold (NLF) with increased tolerability. Objectives: This study aims to report the long-term efficacy, durability, and safety of a highly more concentrated HA filler, PP-501-B, in the correction of NLFs. Methods: Subjects completing the initial 6-month study were enrolled in this 24-month extension, randomized, multicenter, patient/evaluator-blind, split-face study. The injection areas and treatment procedures were identical to the one used in the previous study - each subject was injected with PP-501-B in one NLF, and Restylane Perlane (Q-med) on the contralateral NLF. All participants were reassessed for wrinkle improvement (using 5-point Wrinkle Severity Rating Scale, WSRS) and changes in Global Aesthetic Improvement Scale (GAIS) at 12, 18, and 24 months after their initial treatment. Results: The study enrolled 81 patients; 72 completed the study. In both groups, the WSRS score significantly decreased from baseline throughout the follow-up period after the retreatment. There was no significant difference in the WSRS scores between the two groups at 24 month. Both fillers were well tolerated with neither severe complication nor adverse reactions. Conclusion: The new HA filler, PP-501-B, is safe and effective in the long-term usage of correcting moderate to severe nasolabial folds after a second treatment.