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Hao Wang,Xiang-Long Duan,Xiao-Li Qi,Lei Meng,Yi-Song Xu,Tong Wu,Peng-Gao Dai 한국분자세포생물학회 2017 Molecules and cells Vol.40 No.1
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the hypermethylation of a single Wnt antagonist and its role in regulating the activation of signaling. However, how the Wnt antagonists interacted to regulate the signaling pathway has not been reported. In the present study, we systematically investigated the methylation of some Wnt antagonist genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, and APC) and their regulatory role in carcinogenesis. We found that aberrant promoter methylation of SFRP2, SFRP4, DKK1, and DKK2 was significantly increased in gastric cancer. Moreover, concurrent hypermethylation of SFRP2 and DKK2 was observed in gastric cancer and this was significantly associated with increased expression of -catenin, indicating that the joint inactivation of these two genes promoted the activation of the Wnt signaling pathway. Further analysis using a multivariate Cox proportional hazards model showed that DKK2 methylation was an independent prognostic factor for poor overall survival, and the predictive value was markedly enhanced when the combined methylation status of SFRP2 and DKK2 was con-sidered. In addition, the methylation level of SFRP4 and DKK2 was correlated with the patient’s age and tumor differentiation, respectively. In conclusion, epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival.
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郝会娟 ( Hao¸ Huijuan ),孟晓 ( Meng¸ Xiao ) 성균관대학교 성균중국연구소 2021 중국사회과학논총 Vol.3 No.2
国际海域划界动态的分析可以帮助理清目前海洋划界发展趋势, 为中韩两国提供理论和实践指导。具体来说, 内容可包含中韩海域划界的主要争议问题, 即中韩两国在划界步骤和划界方法上的分歧及原因、划定单一边界是否可行、影响 中韩海域划界的地理性因素(海岸线、地质地貌、岛屿)和非地理性因素(社会经济、安全航行、生态环境)在中韩划界中的效力等。在对上述问题进行综合评估后, 笔者提出: 中韩海域划界可先寻求在200海里以内、在中韩海域争端比较突出的渔业纠纷、苏岩礁问题及海洋生态环境问题上作出临时安排; 然后通过三步划界法, 即首先根据地理性因素, 划定一条临时界线; 之后依据地质地貌因素和非地理因素等相关情况进行具体调整; 最后按照比例进行检视并最终完成划界, 以此实现中韩海域界限既能便于两国海域管辖又能兼顾公平原则。对于200海里外东海大陆架划界问题, 因牵扯中日韩三方利益与关切, 则需另行方案商讨解决。 The analysis of the dynamics of international maritime delimitation can help clarify the current development trend of maritime delimitation and provide theoretical and practical guidance for China and South Korea. Specifically, the content can include the main controversial issues of maritime delimitation between China and Korea, i.e., the differences between China and Korea on the delimitation steps and delimitation methods and their reasons, the feasibility of delimiting a single boundary, and the effectiveness of geographic factors (coastline, geological features, islands) and non-geographic factors (socio-economic, safety navigation, ecological environment) affecting the delimitation of maritime areas between China and Korea in the delimitation between China and Korea. After a comprehensive assessment of the above issues, the author proposes that: the delimitation of the sea area between China and South Korea can first seek to make provisional arrangements within 200 nautical miles, in the fishery disputes, the Suyan Reef issue and the marine ecological environment, which are more prominent in the disputes between China and South Korea; then, through a three-step delimitation method, i.e., firstly, a provisional boundary line is drawn based on geological and rational factors; afterwards, relevant circumstances such as geological and geomorphological factors and non-geographical factors are Finally, the delimitation will be reviewed and finalized in accordance with the proportion, so that the maritime boundary between China and South Korea can be easily and equitably delimited by both countries. As for the delimitation of the continental shelf in the East China Sea beyond 200 nautical miles, the interests and concerns of three parties, China, Japan and South Korea, are involved, s o a separate solution is needed.
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Wang, Hao,Duan, Xiang-Long,Qi, Xiao-Li,Meng, Lei,Xu, Yi-Song,Wu, Tong,Dai, Peng-Gao Korean Society for Molecular and Cellular Biology 2017 Molecules and cells Vol.40 No.1
Aberrant hypermethylation of Wnt antagonists has been observed in gastric cancer. A number of studies have focused on the hypermethylation of a single Wnt antagonist and its role in regulating the activation of signaling. However, how the Wnt antagonists interacted to regulate the signaling pathway has not been reported. In the present study, we systematically investigated the methylation of some Wnt antagonist genes (SFRP2, SFRP4, SFRP5, DKK1, DKK2, and APC) and their regulatory role in carcinogenesis. We found that aberrant promoter methylation of SFRP2, SFRP4, DKK1, and DKK2 was significantly increased in gastric cancer. Moreover, concurrent hypermethylation of SFRP2 and DKK2 was observed in gastric cancer and this was significantly associated with increased expression of ${\beta}-catenin$, indicating that the joint inactivation of these two genes promoted the activation of the Wnt signaling pathway. Further analysis using a multivariate Cox proportional hazards model showed that DKK2 methylation was an independent prognostic factor for poor overall survival, and the predictive value was markedly enhanced when the combined methylation status of SFRP2 and DKK2 was considered. In addition, the methylation level of SFRP4 and DKK2 was correlated with the patient's age and tumor differentiation, respectively. In conclusion, epigenetic silencing of Wnt antagonists was associated with gastric carcinogenesis, and concurrent hypermethylation of SFRP2 and DKK2 could be a potential marker for a prognosis of poor overall survival.
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Effects of Ohmic Area Etching on Buffer Breakdown Voltage of AlGaN/GaN HEMT
Chong Wang,Xiao-Xiao Wel,Meng-Di Zhao,Yun-Long He,Xue-Feng Zheng,Wei Mao,Xiao-Hua Ma,Jin-Cheng Zhang,Yue Hao 한국전기전자재료학회 2017 Transactions on Electrical and Electronic Material Vol.18 No.3
This study is on how ohmic area etching affects the buffer breakdown voltage of AlGaN/GaN HEMT. The surfacemorphology of the ohmic metal can be improved by whole etching on the ohmic area. The buffer breakdown voltagesof the samples with whole etching on the ohmic area were improved by the suppression of the metal spikes formedunder the ohmic contact regions during high-temperature annealing. The samples with selective etching on theohmic area were investigated for comparison. In addition, the buffer leakage currents were measured on the differentradii of the wafer, and the uniformity of the buffer leakage currents on the wafer were investigated by PL mappingmeasurement.
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Jianping Jin,Xiao Liu,Shuai Yuan,Peng Gao,Yanjun Li,Hao Zhang,Xiangzhi Meng 한국공업화학회 2021 Journal of Industrial and Engineering Chemistry Vol.98 No.-
Red mud and coal gangue are industrial solid wastes discharged during alumina extraction and coalmining, respectively. As these are hazardous materials, their disposal leads to serious environmentalissues. In this study, an innovative utilization of red mud through co-roasting with coal gangue forseparation and recycling of iron and aluminum minerals is presented. Under optimum co-roastingconditions (550 C for 50 min), an iron concentrate containing 57.25% TFe (total iron content) with therecovery of 65.22%, and an aluminum-rich product containing 27.26% Al2O3 with the recovery of 71.37%were obtained after magnetic separation. The characteristics of mixed raw material and products allindicated that the goethite and hematite phases in the mixed raw material were transformed into amagnetite phase after co-roasting, although some of the magnetite generated during co-roasting wasoxidized to hematite again. This study demonstrates that co-roasting of coal gangue and red mud is apromising technology for the reduction of iron and activation of aluminum to realize resource recyclingwithout additional materials
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Lack of Effects of HER-2/neu on Prognosis in Colorectal Cancer: a Meta-analysis
Han, Jun,Meng, Qing-Yang,Liu, Xiao,Xi, Qiu-Lei,Zhuang, Qiu-Lin,Wu, Guo-Hao Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.14
Background: The prognostic value of human epidermal growth factor receptor-2 (HER-2/neu) for survival of patients with colorectal cancer (CRC) is still ambiguous. We therefore performed a meta-analysis to evaluate its prognostic significance. Materials and Methods: We searched the MEDLINE and EMBASE databases for published literature investigating associations between HER-2/neu status and overall survival of patients with CRC. A meta-analysis was performed using a DerSimonian-Laird model and publication bias was investigated by Begg's and Egger's tests. Subgroup analysis was also conducted according to the study design type, study quality score, cut-off value for HER-2/neu overexpression, publication region, patient number and publication year. Results: A total of 17 eligible studies involving 2,347 patients were identified for this meta-analysis. The combined hazard ratio (HR) was 1.31 (95% confidence interval (CI): 0.96-1.79), suggesting that HER-2/neu overexpression was not significantly associated with overall survival of patients with CRC. However, subgroup analysis revealed that HER-2/neu overexpression had an unfavorable impact on survival when the analysis was restricted to subgroups of study quality score ${\leq}5 $(HR=1.56, 95%CI: 1.17-2.10), Asian patients (HR=1.74, 95%CI: 1.22-2.49), patient number ${\leq}106$ (HR=1.57, 95%CI: 1.01-2.44), publication year before 2003 (HR=1.59, 95%CI: 1.02-2.49), and prospectively designed study (HR=3.62, 95%CI: 1.42-9.24). The effect disappeared in subgroups of study quality scores > 5 (HR=0.69, 95%CI: 0.33-1.44), non Asian patients (HR=1.14, 95%CI: 0.77-1.70), patients' number > 106 (HR=1.07, 95%CI: 0.67-1.72), publication year after 2003 (HR=1.13, 95%CI: 0.76-1.69), and retrospectively designed study (HR=1.22, 95%CI: 0.89-1.67). Conclusions: Our meta-analysis suggests that HER-2/neu overexpression might not be a significantly prognostic indicator for patients with CRC. Further studies are required to confirm these results.
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Effects of Ohmic Area Etching on Buffer Breakdown Voltage of AlGaN/GaN HEMT
Wang, Chong,Wel, Xiao-Xiao,Zhao, Meng-Di,He, Yun-Long,Zheng, Xue-Feng,Mao, Wei,Ma, Xiao-Hua,Zhang, Jin-Cheng,Hao, Yue The Korean Institute of Electrical and Electronic 2017 Transactions on Electrical and Electronic Material Vol.18 No.3
This study is on how ohmic area etching affects the buffer breakdown voltage of AlGaN/GaN HEMT. The surface morphology of the ohmic metal can be improved by whole etching on the ohmic area. The buffer breakdown voltages of the samples with whole etching on the ohmic area were improved by the suppression of the metal spikes formed under the ohmic contact regions during high-temperature annealing. The samples with selective etching on the ohmic area were investigated for comparison. In addition, the buffer leakage currents were measured on the different radii of the wafer, and the uniformity of the buffer leakage currents on the wafer were investigated by PL mapping measurement.
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Bandwidth-Related Optimization in High-Speed Frequency Dividers using SiGe Technology
Chao-Zhou Nan,Xiao-Peng Yu,Wei-Meng Lim,Bo-Yu Hu,Zheng-Hao Lu,Yang Liu,Kiat-Seng Yeo 대한전자공학회 2012 Journal of semiconductor technology and science Vol.12 No.1
In this paper, the trade-off related to bandwidth of high-speed common-mode logic frequency divider is analyzed in detail. A method to optimize the operating frequency, band-width as well as power consumption is proposed. This method is based on bipolar device characteristics, whereby a negative resistance model can be used to estimate the optimal normalized upper frequency and lower frequency of frequency dividers under different conditions, which is conventionally ignored in literatures. This method provides a simple but efficient procedure in designing high performance frequency dividers for different applications. To verify the proposed method, a static divide-by-2 at millimeter wave ranges is implemented in 180 ㎚ SiGe technology. Measurement results of the divider demonstrate significant improvement in the figure of merit as compared with literatures.
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