Protective Effects of N-acetylcystenine and Selenium against Doxorubicin Toxicity in Rats

Yeo-sung Yoon,Sun-don Kim,Min-hye Lee,Heung-shik S.Lee,In-se Lee,Je-kyung Sung,Eun-sung Park 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

Effects of N-acetylcysteine and Selenium against Doxorubicin Toxicity in RatsEun-sung Park, Sun-don Kim1, Min-hye Lee, Heung-shik S. Lee, In-se Lee, Je-kyung Sung and Yeo-sung Yoon*

노인의 영적 간호요구

최미혜,김경희,김귀옥,김기숙,김수강,김정신,김춘숙,노흥진,박지연,성혜연,오명선,이선희,이원옥,이윤영,이현수,장명재,차혜경,채정선,홍상희 중앙대학교 의과대학 간호학과 간호과학연구소 2001 중앙간호논문집 Vol.5 No.1

This study was designed to exam the aged's needs for spiritual nursing care. The purpose was to serve as a basis for the development of spiritual nursing practice. The major findings are as follows : 1. The degree of needs for spiritual nursing care as area was that needs of love and relationship mean 22.0, needs of meaning and object mean 28.2, needs of forgiving mean 13.5. Total needs for spiritual nursing care mean 63.7, which was on the upper middle level. The needs of meaning and object was rated highest. 2. Among the general characteristics of the subjects, needs of love and relatiohship wasn't significanlty different. 3. Among the general characteristics of the subjects, needs of meaning and object was significantly different according to two factors : age(F=7.260, p=0.001), religion(F=5.275, p=0.001). Higher needs of meaning and object was possessed by the older than the younger, by the one who have religion than the other. 4. Among the general characteristics of the subjects, four factors made a significantly difference to needs of forgiving : sex(t=-2.851, p=0.006), age(F=8.201, p=0.001), religion(F=6.928, p=0.000), disease(t=2.327, p=0.024). Higher needs of forgiving was possessed by man than woman, by the older than the younger, by the one who have religion than the other, by the one who have disease than the other.

Streptomyces albulus 세정균체에 의한 polylysine의 대량생산

선흥석,김광섭,안치민,박찬영 全南大學校 觸媒硏究所 1997 觸媒硏究 論文集 Vol.19 No.-

Streptomyces albulus 세정균체를 이용하여 항세균물질인 폴리리신의 대량생산 가능성에 대하여 조사하였다. 발효기 배양에서 배양액 pH는 6.8에서 3.2로 감소하는 동안에 pH 4.0에서 4.5사이에서 폴리리신이 최대로 축적되므로 대수말기의 균체를 멸균증류수로 세척하여 마련한 세정균체를 아미노산 생산을 향상할수 있는 구연산을 2%첨가하고 pH를 최적인 4.2로 조정한 배지로 옮겨 배양하였다. 이러한 2단계공정으로 세정균체를 배양한 경우 배양액내의 폴리리신은 일반 1단계 단순 배양에 비하여 최대 6배의 축적량을 나타내었다. The feasibility of mass production of polylysine, an antibacterial substance, employing a washed mycelium of Streptomyces albulus has been investigated. Since the maximum accumulation of polylysine had appeared between 4.0 to 4.5 of pH during fermentor cultivation of which the pH of the broth has declined to 3.2 from 6.8, the strain growing in the broth on late log phase had been washed with sterilized water, then the sole mycelium had been transferred to another medium containing 2% citric acid having pH adjusted with NaOH to optimum of 4.2 to improve the production of the amino acid. The total accumulation of polylysine by washed mycelium of Streptomyces albulus from this two step procedure has exhibited 6 times more than the normal production of the simple one step fermentation.

중소기업 및 벤처기업을 위한 정보관리 시스템

한기흥,이순흠 순천향대학교 부설 산업기술연구소 1999 순천향 산업기술연구소논문집 Vol.5 No.2

This paper describes an informtion management system which effectively supports business of small to medium size enterprises in local area, using web agent and web application technology. The information management system is designed based on work flow analyses of diverse enterprises in Communication and Information Soonchunhyang Venture Center. The designed 3-tiered system includes clients executing GUI logic, an application server serving business logic, and a component supporting conventional database applications. The system can be used as a effective business supporting system for small to medium size ventures.

XML/EDI를 이용한 인터넷쇼핑몰 구축관련연구

김화선,안경희,김흥식 인제대학교기초과학연구소 2002 자연과학 Vol.6 No.-

인터넷 이용의 급증에 따라 전자상거래(Electronic Commerce)가 지식, 정보기반시대의 새로운 패러다임으로 부각됨에 따라, 시장규모도 이례 없이 증가되고 있다. 인터넷의 판도를 바꾸어준 HTML(Hyper Text Markup Language)의 한계성을 극복하기 위한 사용자의 다양한 요구는 XML(eXtensible Markup Language)를 전자상거래의 표준으로 자리잡게 하였으며, XML의 등장으로 기존의 EDI 시스템을 통합하고 그 효율성을 최대화시키고자 하는 노력으로 XML/EDI 기술도 눈부신 발전을 하고 있다. 이 기술은 별개가 아닌 각각의 기술적 특성과 장점을 이용한 통합 시스템으로 정의할 수 있다. 본 연구에서는 XML/EDI를 기반으로 하는 인터넷 전자상거래 시스템의 구축현황 및 방안에 대해 논의하면서, 이러한 서비스를 바탕으로 제공하는 기존의 인터넷쇼핑몰 시스템을 새로운 방식으로 설계하여 실제적으로 사용할 수 있게 구현 하였다. In relevance to the increasing usage of the Internet, Electronic Commerce, a new paradigm in this knoeledge, information society, is increasing in market share accordingly. The various demands of users have brought a change from HTML(Hyper Text Markup Language) to the standardized XML(eXtensible Markup Language). With the development of XML, EDI system was integated and in order to maximize efficiency, XML/EDI thchology was developed at an astonis hing rate. This thchology can be characterized not as separate entities, but as an assimilation of each thchological advencement and strengths as a integrated system. During this research, I discussed the establishment procedures and plans of XML/EDI based internet electronic commerce system, establishing and designing a practical and usable computer shopping-mall system based on these systems.

정신분열병 환자의 인터류킨-2 생산능

이선미,박주홍,김동인,은헌정,김임,김경용 大韓神經精神醫學會 1996 신경정신의학 Vol.35 No.4

급성기 및 관해상태의 정신분열병 환자와 정상 대조군의 IL-2 생산능을 비교함으로써, 정신분열병의 여러 발병원인 중 자가면역 병인론의 증거인 세포성 면역방응의 저하 및 질병상태와 관련한 세포성 면역기능의 변화를 일부 한국인 정신분열병 환자에서 조사에서 조사하고자 하였다. 방 법 : DSM-IV의 정신분열병 진단기준에 적합한 급성기 환자 19명(남 : 10, 여 : 9)과 관해상태의 환자 21명(남 :12, 여: 9) 및 정상대조군 40명(남 : 20, 여 : 20)을 연구대상으로 하였다. 피험자로부터 채혈한 혈액에서 임파구를 분리하여 phytohemagglutinin으로 T임파구를 자극하고 세포배양하여 증식시킨후 IL-2immunoassay kit을 이용하여 T임파구의 IL-2 생산능을 측정하였다. 결 과 : IL-2 생산능은 성별에 관계없이 정신분열병 환자군에서 정상 대조군에 비하여 유의하게 감소하였다. (t=5. 97, p<0.001). 질병상태에 따라 급성기 정신분열병 환자군 및 관해상태 정신분열병 환자군으로 구분하여 정상대조군의 IL-2 생산능과 비교한 결과, IL-2 생산능이 정상 대조군에서 가장 높았고 다음은 관해상태 환자군이었으며 급성기 환자군에서 가장 낮았다. 세 군 사이에는 모두 유의한 차이가 있었다. (F=35.35, p<0.001). 결 론: 일부 한국인 정신분열병 환자에서 질병상태와 유의하게 관련된 세포성 면역기능의 저하가 관찰되며, 이는 정신분열병의 다양한 원인중 자가면역 기전에 의한 발병을 시사한다. Objects : This study was designed to examine the decreased cellular immune response and the change in cellular immunity related to to clinical status in Korean schizophrenic patients. Methods : The subjects were 19 acute schizophrenics and 21 remitted schizophrenics who met the DSM-IV criteria of schizophrenia and 40 healthy volunteers as the normal control. After the lymphocyte was separated from blood which had been drawn from the subjects and then T lymphocyte was stimulated by PHA and proliferated by cell culture, the examiner measured IL-2 productivity by IL-2 immunoassay kit. Results : IL-2 productivity of the schizophrenics was significantly lower than that of the normal controls. There was no significant difference between male and female in two groups. In the comparison by clinical status, acute schizophrenic group was the lowest, remitted schizophrenic group was next, and normal control group was the highest in the IL-2 productivity, with statistically significant difference among the groups(p<0.001). Conclusion : We suggest that there is a decrease in the cellular immune response which is significantly related to clinical status in some Korean schizophrenics. This finding supports that onset of schizophrenia may be the result of autoimmune mechanism, which is one of the various etiologic factors in schizophrenia.

간의 국소결정성과형성 : 3중 시기 CT 소견 Triple-phasic CT Features

김영선,서흥석,조온구,고병희,임현철,이승로 한양대학교 의과대학 2000 한양의대 학술지 Vol.20 No.1

Focal nodular hyperplasia is a rare benign tumor of the liver. It shares a lot of features with a fibrolamellar hepatocellular carcinoma in their gross morphology and predisposing ages. But differential diagnosis is invaluable because their treatment modality is absolutely contrary. We experienced a case of focal nodular hyperplasia in a young woman, incidentally found at the ultrasonographic examination for the acute appendicitis, and was difficult to differentiate it from fibrolamellar hepatocellular carcinoma radiologically. Dynamic CT, hepatic arteriographic, and pathologic findings will be discussed, especially in a view of their differential diagnostic point from a fibrolamellar hepatocellular carcinoma.

儀式으로 본 通度寺 空間動線 조사 연구

오흥선,이영한,박기홍,문종만,노정선 서울産業大學校 1999 논문집 Vol.49 No.2

This study deals mainly with relationships between the spatial composition and the Buddhist rituals of monks at the Tongdosa temple. The results of study are summarized as followed. Many of rituals are performed in the Sangrohjun(上爐殿) and, in particular, handled in the Sulbujun(說法殿), but not performed in the Jungrohjun(上爐殿) and Harohjun(下爐殿) except for the time of Buddhist mass held in the every morning and night. The main activities of all rituals were based on the Kumkang Stupa in the past and such a tendency continues in the present time. The characteristics of temple space reflected by the movement of monks and believers who take advantage of the Kumkang Stupa's Structure in the significant rituals such as the entrance of priesthood, reception of Buddhist confirmation, Buddha's Birthday and establishment of Tongdosa Temple.

VOD에 적용 가능한 인증 프로토콜 실현

염흥열,윤호선,김상필 순천향대학교 부설 산업기술연구소 1997 순천향 산업기술연구소논문집 Vol.3 No.2

In this paper, we present the access control technique which is one of the essential functions for VOD. As the BISDN widely spreads, need for VOD services will rapidly be increased. Access control technique is needed to allow VOD system to prevent the unauthorized persons from using the unauthorized service. We have implemented the authentication scheme with C language on UNIX. We have used 768-bit RSA signature scheme and MD5 hash function for implementing the authentication scheme.

수종 치과재료의 제I급 와동에서의 변연 누출에 관한 실험적 연구

이선희,손흥규,최형준 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.1

Microleakage is a problem of all filling materials of losted teeth structure and is clinically undetectable. Because marginal leakage may be responsible for pulp irritation, pulp inflammation, necrosis and recurrent caries, it is essential to prevent and control it. For the evaluations of microleakage of various class I filling materials, 175 extracted teeth were filled with amalgam, light curing composite resin, glass inomer cement, IRM and Fermit-N. After thermocycling, speciemens were placed in 1% methylene blue dye solution for 24 hours in an incubator set 37℃. The teeth were sectioned at filling body center and margin and degree of dye penetration was observed with a stereomicroscope. The following results were obtained. 1. Light cured composite resin has the excellent results and microleakage is increased in the order of amalgam, IRM, Fermit-N, glass ionomer cement.(SAS-6.0 system) and there was a statistically significancy in marginal leakage for each filling materials.(Kruskal-Wallis analysis, P<0.05) 2. Microleakage of the center and margin was statistically insignificant (Mann-Whitney analysis P<0.05) 3. There was less microleakage for amalgam than light cured composite resin but was statistically insignificant (Mann-Whitney analysis, P<0.05) and also showed less marginal leakage for Fermit-N compared to glass ionomer cement but also was statistically insignificant. (Mann-Whitney analysis, P<0.05).